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IS8843A - Hálfmálmaprótínasa hindra mót - Google Patents

Hálfmálmaprótínasa hindra mót

Info

Publication number
IS8843A
IS8843A IS8843A IS8843A IS8843A IS 8843 A IS8843 A IS 8843A IS 8843 A IS8843 A IS 8843A IS 8843 A IS8843 A IS 8843A IS 8843 A IS8843 A IS 8843A
Authority
IS
Iceland
Prior art keywords
alkyl
alkylaryl
cor
optionally substituted
bond
Prior art date
Application number
IS8843A
Other languages
English (en)
Inventor
Simon Gaines
Ian Peter Holmes
Stephen Lewis Martin
Stephen Paul Watson
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IS8843A publication Critical patent/IS8843A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Soft Magnetic Materials (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IS8843A 2003-09-13 2009-08-19 Hálfmálmaprótínasa hindra mót IS8843A (is)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0321538.1A GB0321538D0 (en) 2003-09-13 2003-09-13 Therapeutically useful compounds

Publications (1)

Publication Number Publication Date
IS8843A true IS8843A (is) 2009-08-19

Family

ID=29227079

Family Applications (2)

Application Number Title Priority Date Filing Date
IS8268A IS2622B (is) 2003-09-13 2006-01-26 Hálfmálmprótínasa hindra mót
IS8843A IS8843A (is) 2003-09-13 2009-08-19 Hálfmálmaprótínasa hindra mót

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IS8268A IS2622B (is) 2003-09-13 2006-01-26 Hálfmálmprótínasa hindra mót

Country Status (28)

Country Link
US (3) US7601729B2 (is)
EP (3) EP2295408A1 (is)
JP (3) JP2007505081A (is)
KR (3) KR20060120648A (is)
CN (1) CN1849306B (is)
AT (2) ATE502922T1 (is)
AU (1) AU2004272280C1 (is)
BR (1) BRPI0413791A (is)
CA (1) CA2538315C (is)
CY (1) CY1109400T1 (is)
DE (2) DE602004017622D1 (is)
DK (1) DK1663970T3 (is)
ES (2) ES2314436T3 (is)
GB (1) GB0321538D0 (is)
HR (1) HRP20080668T3 (is)
IL (1) IL173305A (is)
IS (2) IS2622B (is)
MA (1) MA28039A1 (is)
MX (1) MXPA06002458A (is)
NO (1) NO20060540L (is)
NZ (2) NZ573479A (is)
PL (1) PL1663970T3 (is)
PT (1) PT1663970E (is)
RU (2) RU2370488C2 (is)
SG (1) SG145685A1 (is)
SI (1) SI1663970T1 (is)
WO (1) WO2005026120A1 (is)
ZA (1) ZA200602070B (is)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0321538D0 (en) * 2003-09-13 2003-10-15 Glaxo Group Ltd Therapeutically useful compounds
MX2007010185A (es) * 2005-02-22 2007-12-06 Ranbaxy Lab Ltd Derivados de acido 5-fenil-pentanoico como inhibidores de metaloproteinasa de matriz para el tratamiento de asma y otras enfermedades.
AU2013200728B2 (en) * 2006-08-22 2014-12-18 Sun Pharmaceutical Industries Limited Matrix metalloproteinase inhibitors
JP5399902B2 (ja) * 2006-08-22 2014-01-29 ランバクシー ラボラトリーズ リミテッド マトリックスメタロプロテイナーゼ阻害剤
EP2532643A1 (en) 2007-06-08 2012-12-12 MannKind Corporation IRE-1A Inhibitors
FR2949463B1 (fr) * 2009-08-26 2011-09-16 Commissariat Energie Atomique Inhibiteurs de mmp
JP2013537533A (ja) 2010-07-30 2013-10-03 ランバクシー ラボラトリーズ リミテッド マトリックスメタロプロテイナーゼ阻害剤
US20140148459A1 (en) 2010-09-24 2014-05-29 Ranbaxy Laboratories Limited Matrix metalloproteinase inhibitors
US20160045463A1 (en) 2012-11-28 2016-02-18 Universidad De Salamanca Use of metalloprotease inhibitors in the treatment of polycystic liver diseases
DK3413892T3 (da) 2016-02-12 2022-05-23 Cytokinetics Inc Tetrahydroisoquinolinderivater
CN110769866B (zh) * 2017-06-13 2022-07-29 爱惜康有限责任公司 具有可控愈合的外科缝合器

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
WO1995029901A1 (en) * 1994-04-28 1995-11-09 Uniroyal Chemical Company, Inc. Fungicidal azole derivatives
JP2000501700A (ja) * 1995-12-06 2000-02-15 アストラ・フアーマシユウテイカルズ・リミテツド 化合物
PL192561B1 (pl) * 1996-04-19 2006-11-30 Akzo Nobel Nv Podstawione benzyloaminy, ich zastosowanie i kompozycja farmaceutyczna
HRP970246B1 (en) * 1996-05-15 2002-04-30 Bayer Ag Substituted oxobutric acids as matrix metalloprotease inhibitors
US6096904A (en) 1996-12-03 2000-08-01 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US6242616B1 (en) 1996-12-03 2001-06-05 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US5789605A (en) 1996-12-03 1998-08-04 Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
US20050065353A1 (en) 1996-12-03 2005-03-24 Smith Amos B. Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
US6870058B2 (en) 1996-12-03 2005-03-22 The Trustees Of The University Of Pennsylvania Compounds which mimic the chemical and biological properties of discodermolide
US5804581A (en) * 1997-05-15 1998-09-08 Bayer Corporation Inhibition of matrix metalloproteases by substituted phenalkyl compounds
US6608052B2 (en) * 2000-02-16 2003-08-19 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as anti-inflammatory agents
MXPA03009361A (es) * 2001-04-13 2004-01-29 Boehringer Ingelheim Pharma Compuestos de urea utilies como agentes anti-inflamatorios.
AU2003261319A1 (en) * 2002-08-01 2004-02-23 Bristol-Myers Squibb Company Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme
RU2005119167A (ru) * 2002-11-19 2006-01-20 Галдерма Ресерч Энд Девелопмент, С.Н.С. (Fr) Новые биароматические соединения-активаторы рецепторов типа ppary и их применение в косметических или фармацевтических композициях
GB0312654D0 (en) 2003-06-03 2003-07-09 Glaxo Group Ltd Therapeutically useful compounds
GB0314488D0 (en) 2003-06-20 2003-07-23 Glaxo Group Ltd Therapeutically useful compounds
GB0319069D0 (en) 2003-08-14 2003-09-17 Glaxo Group Ltd Therapeutically useful compounds
GB0321538D0 (en) * 2003-09-13 2003-10-15 Glaxo Group Ltd Therapeutically useful compounds
MX2007010185A (es) 2005-02-22 2007-12-06 Ranbaxy Lab Ltd Derivados de acido 5-fenil-pentanoico como inhibidores de metaloproteinasa de matriz para el tratamiento de asma y otras enfermedades.
JP5399902B2 (ja) 2006-08-22 2014-01-29 ランバクシー ラボラトリーズ リミテッド マトリックスメタロプロテイナーゼ阻害剤

Also Published As

Publication number Publication date
AU2004272280C1 (en) 2011-10-27
ATE413384T1 (de) 2008-11-15
IL173305A (en) 2011-01-31
US8343986B2 (en) 2013-01-01
GB0321538D0 (en) 2003-10-15
JP2012107031A (ja) 2012-06-07
PT1663970E (pt) 2009-01-09
RU2006106850A (ru) 2007-10-20
IL173305A0 (en) 2006-06-11
EP2042488A1 (en) 2009-04-01
US8263602B2 (en) 2012-09-11
EP2042488B1 (en) 2011-03-23
DE602004031991D1 (de) 2011-05-05
CA2538315C (en) 2014-04-08
ES2362954T3 (es) 2011-07-15
NZ573479A (en) 2010-09-30
US20100029699A1 (en) 2010-02-04
KR20130079628A (ko) 2013-07-10
EP1663970B1 (en) 2008-11-05
NO20060540L (no) 2006-04-04
ZA200602070B (en) 2007-05-30
ES2314436T3 (es) 2009-03-16
SI1663970T1 (sl) 2009-04-30
KR20060120648A (ko) 2006-11-27
WO2005026120A1 (en) 2005-03-24
HRP20080668T3 (hr) 2009-02-28
JP2007505081A (ja) 2007-03-08
NZ545211A (en) 2009-01-31
US20090082377A1 (en) 2009-03-26
IS2622B (is) 2010-05-15
CA2538315A1 (en) 2005-03-24
DK1663970T3 (da) 2009-01-12
IS8268A (is) 2006-01-26
HK1092141A1 (en) 2007-02-02
EP1663970A1 (en) 2006-06-07
AU2004272280A1 (en) 2005-03-24
MA28039A1 (fr) 2006-07-03
US20060293353A1 (en) 2006-12-28
CN1849306B (zh) 2014-01-29
RU2008146479A (ru) 2010-06-20
AU2004272280B2 (en) 2011-04-21
CY1109400T1 (el) 2014-07-02
DE602004017622D1 (de) 2008-12-18
ATE502922T1 (de) 2011-04-15
CN1849306A (zh) 2006-10-18
BRPI0413791A (pt) 2006-11-07
PL1663970T3 (pl) 2009-04-30
MXPA06002458A (es) 2006-06-20
EP2295408A1 (en) 2011-03-16
US7601729B2 (en) 2009-10-13
KR20120007566A (ko) 2012-01-20
JP2011231118A (ja) 2011-11-17
SG145685A1 (en) 2008-09-29
RU2370488C2 (ru) 2009-10-20

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