IS8117A - 3-Flúr-píperidín sem NMDA/NR2B mótlyf - Google Patents

3-Flúr-píperidín sem NMDA/NR2B mótlyf

Info

Publication number: IS8117A
Authority: IS; Iceland
Prior art keywords: nmda; piperidine; fluoro; nr2b antagonist; nr2b
Prior art date: 2003-06-04

Application number

IS8117A

Other languages

English (en)

Inventor

L. Liverton Nigel

F. Claiborne Christopher

A. Claremon David

A. Mccauley John

Original Assignee

Merck & Co., Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-04

Filing date

2005-11-07

Publication date

2005-11-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33511734&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS8117(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-11-07 Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.

2005-11-07 Publication of IS8117A publication Critical patent/IS8117A/is

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Addiction (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Molecular Biology (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Biotechnology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)

IS8117A 2003-06-04 2005-11-07 3-Flúr-píperidín sem NMDA/NR2B mótlyf IS8117A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US47593803P	2003-06-04	2003-06-04
PCT/US2004/017175 WO2004108705A1 (en)	2003-06-04	2004-05-28	3-fluoro-piperidines as nmda/nr2b antagonists

Publications (1)

Publication Number	Publication Date
IS8117A true IS8117A (is)	2005-11-07

Family

ID=33511734

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS8117A IS8117A (is)	2003-06-04	2005-11-07	3-Flúr-píperidín sem NMDA/NR2B mótlyf

Country Status (30)

Country	Link
EP (1)	EP1648882B1 (is)
JP (1)	JP3927228B2 (is)
KR (1)	KR20060017839A (is)
CN (1)	CN1798744A (is)
AR (1)	AR044579A1 (is)
AT (1)	ATE403651T1 (is)
AU (1)	AU2004245522B2 (is)
BR (1)	BRPI0410837A (is)
CA (1)	CA2527093C (is)
CL (1)	CL2004001365A1 (is)
CO (1)	CO5700762A2 (is)
DE (1)	DE602004015610D1 (is)
DK (1)	DK1648882T3 (is)
EC (1)	ECSP056192A (is)
ES (1)	ES2309540T3 (is)
HR (1)	HRP20080490T3 (is)
IS (1)	IS8117A (is)
MA (1)	MA27781A1 (is)
MX (1)	MXPA05013151A (is)
MY (1)	MY138547A (is)
NO (1)	NO20060020L (is)
PE (1)	PE20050245A1 (is)
PL (1)	PL1648882T3 (is)
PT (1)	PT1648882E (is)
RU (1)	RU2339630C2 (is)
SI (1)	SI1648882T1 (is)
TW (1)	TW200510378A (is)
UA (1)	UA81319C2 (is)
WO (1)	WO2004108705A1 (is)
ZA (1)	ZA200509000B (is)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2021005A4 (en) *	2006-05-03	2009-11-25	Cnsbio Pty Ltd	METHOD AND COMPOSITION FOR THE TREATMENT OF INFLAMMATORY PAIN
ES2400710T3 (es) *	2007-04-23	2013-04-11	Janssen Pharmaceutica, N.V.	Tia(dia)zoles como antagonistas del receptor de dopamina 2 de disociación rápida
US20100316678A1 (en) *	2007-06-28	2010-12-16	Cnsbio Pty Ltd.	Combination methods and compositions for treatment of neuropathic pain
CN102762554A (zh)	2010-02-16	2012-10-31	辉瑞大药厂	5-ht4受体的部分激动剂(r)-4-((4-((4-(四氢呋喃-3-基氧基)苯并[d]异*唑-3-基氧基)甲基)哌啶-1-基)甲基)四氢-2h-吡喃-4-醇
AU2013251079B2 (en)	2012-04-20	2017-03-23	Ucb Pharma S.A.	Methods for treating Parkinson's disease
CN103936663B (zh) *	2013-01-23	2016-12-28	艾琪康医药科技（上海）有限公司	一种1-r1-3,3-二氟(或3-氟)-4-r2-4-氨甲基哌啶及其衍生物的制备方法
US9187506B2 (en)	2014-01-09	2015-11-17	Bristol-Myers Squibb Company	(R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one and its prodrugs for the treatment of psychiatric disorders
US9221796B2 (en)	2014-01-09	2015-12-29	Bristol-Myers Squibb Company	Selective NR2B antagonists
JP2017516836A (ja)	2014-06-04	2017-06-22	リューゲンホールディングス（ケイマン）リミテッド	Ｎｒ２ｂｎｍｄａ受容体アンタゴニストとしてのジフルオロエチルピリジン誘導体
EP3194403B1 (en)	2014-09-15	2019-02-06	Rugen Holdings (Cayman) Limited	Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists
US20180271869A1 (en) *	2014-09-22	2018-09-27	Jie Liu	Treatment of anxiety disorders and autism spectrum disorders
EP3237399B1 (en) *	2014-12-23	2022-11-30	Avalo Therapeutics, Inc.	Compounds, compositions and methods
US10221182B2 (en)	2015-02-04	2019-03-05	Rugen Holdings (Cayman) Limited	3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists
CN107849010B (zh) *	2015-06-01	2021-11-09	卢郡控股(开曼)有限公司	作为nr2b nmda受体拮抗剂的3,3‐二氟哌啶氨基甲酸酯杂环化合物
KR20180063306A (ko)	2015-10-14	2018-06-11	브리스톨-마이어스 스큅 컴퍼니	선택적 nr2b 길항제
WO2017066368A1 (en)	2015-10-14	2017-04-20	Bristol-Myers Squibb Company	Selective nr2b antagonists
US10227349B2 (en)	2016-08-31	2019-03-12	Eisai R&D Management Co., Ltd.	Pyrazolo[1,5-a]pyrimidine compound
WO2018098128A1 (en)	2016-11-22	2018-05-31	Rugen Holdings (Cayman) Limited	Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU64303A (sh) *	2001-02-23	2006-05-25	Merck & Co.Inc.	N-supstituisani nearil-heterociklični antagonisti nmda/nr2b

2004
- 2004-05-28 AT AT04753896T patent/ATE403651T1/de not_active IP Right Cessation
- 2004-05-28 SI SI200430845T patent/SI1648882T1/sl unknown
- 2004-05-28 JP JP2006515051A patent/JP3927228B2/ja not_active Expired - Lifetime
- 2004-05-28 WO PCT/US2004/017175 patent/WO2004108705A1/en not_active Ceased
- 2004-05-28 UA UAA200511411A patent/UA81319C2/uk unknown
- 2004-05-28 PT PT04753896T patent/PT1648882E/pt unknown
- 2004-05-28 ES ES04753896T patent/ES2309540T3/es not_active Expired - Lifetime
- 2004-05-28 DE DE602004015610T patent/DE602004015610D1/de not_active Expired - Lifetime
- 2004-05-28 CA CA002527093A patent/CA2527093C/en not_active Expired - Lifetime
- 2004-05-28 RU RU2005137704/04A patent/RU2339630C2/ru not_active IP Right Cessation
- 2004-05-28 HR HR20080490T patent/HRP20080490T3/xx unknown
- 2004-05-28 PL PL04753896T patent/PL1648882T3/pl unknown
- 2004-05-28 DK DK04753896T patent/DK1648882T3/da active
- 2004-05-28 EP EP04753896A patent/EP1648882B1/en not_active Expired - Lifetime
- 2004-05-28 BR BRPI0410837-0A patent/BRPI0410837A/pt not_active IP Right Cessation
- 2004-05-28 AU AU2004245522A patent/AU2004245522B2/en not_active Expired
- 2004-05-28 KR KR1020057023218A patent/KR20060017839A/ko not_active Ceased
- 2004-05-28 CN CNA2004800153228A patent/CN1798744A/zh active Pending
- 2004-05-28 MX MXPA05013151A patent/MXPA05013151A/es active IP Right Grant
- 2004-05-31 AR ARP040101878A patent/AR044579A1/es unknown
- 2004-05-31 MY MYPI20042091A patent/MY138547A/en unknown
- 2004-06-01 PE PE2004000552A patent/PE20050245A1/es not_active Application Discontinuation
- 2004-06-03 TW TW093115972A patent/TW200510378A/zh unknown
- 2004-06-03 CL CL200401365A patent/CL2004001365A1/es unknown
2005
- 2005-11-07 IS IS8117A patent/IS8117A/is unknown
- 2005-11-07 ZA ZA200509000A patent/ZA200509000B/en unknown
- 2005-11-28 MA MA28626A patent/MA27781A1/fr unknown
- 2005-11-29 EC EC2005006192A patent/ECSP056192A/es unknown
- 2005-11-30 CO CO05121658A patent/CO5700762A2/es not_active Application Discontinuation
2006
- 2006-01-03 NO NO20060020A patent/NO20060020L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HRP20080490T3 (en)	2008-11-30
PL1648882T3 (pl)	2008-12-31
ECSP056192A (es)	2006-04-19
RU2005137704A (ru)	2006-05-27
CO5700762A2 (es)	2006-11-30
MY138547A (en)	2009-06-30
AR044579A1 (es)	2005-09-21
UA81319C2 (en)	2007-12-25
PT1648882E (pt)	2008-10-20
JP3927228B2 (ja)	2007-06-06
AU2004245522B2 (en)	2009-10-29
KR20060017839A (ko)	2006-02-27
WO2004108705A1 (en)	2004-12-16
PE20050245A1 (es)	2005-04-13
NO20060020L (no)	2006-03-03
RU2339630C2 (ru)	2008-11-27
CN1798744A (zh)	2006-07-05
JP2006526650A (ja)	2006-11-24
SI1648882T1 (sl)	2009-02-28
DE602004015610D1 (de)	2008-09-18
DK1648882T3 (da)	2008-11-24
ATE403651T1 (de)	2008-08-15
CA2527093A1 (en)	2004-12-16
CA2527093C (en)	2009-10-20
CL2004001365A1 (es)	2005-05-06
MXPA05013151A (es)	2006-03-17
ZA200509000B (en)	2006-12-27
EP1648882A1 (en)	2006-04-26
AU2004245522A1 (en)	2004-12-16
EP1648882B1 (en)	2008-08-06
MA27781A1 (fr)	2006-02-01
TW200510378A (en)	2005-03-16
ES2309540T3 (es)	2008-12-16
BRPI0410837A (pt)	2006-06-27

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ITMI20041252A1 (it)	2004-09-22	Composizioni perfluoroelastomeriche
IL199668A0 (en)	2011-08-01	New benzimidazole derivatives
DE602004025473D1 (de)	2010-03-25	Mehrkomponentiges spinnvlies
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