IS3873A - Hliðstæð aðferð til framleiðslu á kristölluðum oxaþíólan afleiðum - Google Patents

Hliðstæð aðferð til framleiðslu á kristölluðum oxaþíólan afleiðum

Info

Publication number: IS3873A
Authority: IS; Iceland
Prior art keywords: oxathiol; crystalline; derivatives; production; analogous method
Prior art date: 1991-06-03

Application number

IS3873A

Other languages

English (en)

Other versions

IS1867B (is

Inventor

Ravenscroft Paul

Evans Paul

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-03

Filing date

1992-06-02

Publication date

1992-12-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10696001&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS3873(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-06-02 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

1992-12-04 Publication of IS3873A publication Critical patent/IS3873A/is

2003-05-02 Publication of IS1867B publication Critical patent/IS1867B/is

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Secondary Cells (AREA)

IS3873A 1991-06-03 1992-06-02 Hliðstæð aðferð til framleiðslu á kristölluðum oxaþíólan afleiðum IS1867B (is)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB919111902A GB9111902D0 (en)	1991-06-03	1991-06-03	Chemical compounds

Publications (2)

Publication Number	Publication Date
IS3873A true IS3873A (is)	1992-12-04
IS1867B IS1867B (is)	2003-05-02

Family

ID=10696001

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IS3873A IS1867B (is)	1991-06-03	1992-06-02	Hliðstæð aðferð til framleiðslu á kristölluðum oxaþíólan afleiðum
IS4268A IS4268A (is)	1991-06-03	1992-12-04	Kristallaðar oxathiolane afleiður

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IS4268A IS4268A (is)	1991-06-03	1992-12-04	Kristallaðar oxathiolane afleiður

Country Status (30)

Country	Link
US (1)	US5905082A (is)
EP (2)	EP0517145B1 (is)
JP (1)	JP2851480B2 (is)
KR (1)	KR100244008B1 (is)
AP (1)	AP300A (is)
AT (1)	ATE212630T1 (is)
AU (2)	AU656379B2 (is)
BG (1)	BG60914B1 (is)
CA (2)	CA2311988C (is)
CZ (1)	CZ284513B6 (is)
DE (1)	DE69232387T2 (is)
DK (1)	DK0517145T3 (is)
ES (1)	ES2171158T3 (is)
GB (1)	GB9111902D0 (is)
GE (1)	GEP19991834B (is)
IE (2)	IE921780A1 (is)
IL (1)	IL102073A (is)
IS (2)	IS1867B (is)
MX (1)	MX9202619A (is)
NO (1)	NO301713B1 (is)
NZ (1)	NZ242981A (is)
OA (1)	OA09913A (is)
PT (1)	PT517145E (is)
RU (1)	RU2102393C1 (is)
SG (1)	SG52455A1 (is)
SK (1)	SK281249B6 (is)
TW (1)	TW254939B (is)
UA (1)	UA41265C2 (is)
WO (1)	WO1992021676A1 (is)
ZA (1)	ZA924007B (is)

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US4581979A (en) *	1983-07-01	1986-04-15	Automotive Products Plc	Shipping and installation restraining clip for master cylinder input member
US6069252A (en) *	1990-02-01	2000-05-30	Emory University	Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers
US5276151A (en) *	1990-02-01	1994-01-04	Emory University	Method of synthesis of 1,3-dioxolane nucleosides
US5914331A (en)	1990-02-01	1999-06-22	Emory University	Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5204466A (en) *	1990-02-01	1993-04-20	Emory University	Method and compositions for the synthesis of bch-189 and related compounds
US5444063A (en) *	1990-12-05	1995-08-22	Emory University	Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US6812233B1 (en)	1991-03-06	2004-11-02	Emory University	Therapeutic nucleosides
US5817667A (en) *	1991-04-17	1998-10-06	University Of Georgia Research Foudation	Compounds and methods for the treatment of cancer
GB9116601D0 (en) *	1991-08-01	1991-09-18	Iaf Biochem Int	1,3-oxathiolane nucleoside analogues
US6177435B1 (en)	1992-05-13	2001-01-23	Glaxo Wellcome Inc.	Therapeutic combinations
US20020120130A1 (en)	1993-09-10	2002-08-29	Gilles Gosselin	2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) *	1994-01-28	1996-12-24	Univ. Of Ga Research Foundation	L-nucleosides
IL115156A (en)	1994-09-06	2000-07-16	Univ Georgia	Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US6391859B1 (en)	1995-01-27	2002-05-21	Emory University	[5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en)	1995-01-27	1997-12-30	Emory University	Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) *	1995-01-30	1998-09-15	Yale University	L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
JP4413996B2 (ja)	1995-06-07	2010-02-10	エモリー・ユニバーシティ	抗ｂ型肝炎ウィルス活性を有するヌクレオシド
US5914332A (en) *	1995-12-13	1999-06-22	Abbott Laboratories	Retroviral protease inhibiting compounds
CA2258956A1 (en)	1996-06-25	1997-12-31	Glaxo Group Limited	Combinations comprising vx478, zidovudine, ftc and/or 3tc for use in the treatment of hiv
US5753789A (en) *	1996-07-26	1998-05-19	Yale University	Oligonucleotides containing L-nucleosides
TW536403B (en) *	1997-03-24	2003-06-11	Glaxo Group Ltd	An ethanol and ethylenediaminetetraacetic acid free pharmaceutical composition comprising lamivudine and exhibiting antimicrobial preservative efficacy
US6436948B1 (en)	2000-03-03	2002-08-20	University Of Georgia Research Foundation Inc.	Method for the treatment of psoriasis and genital warts
US6723728B2 (en) *	2001-03-01	2004-04-20	Gilead Sciences, Inc.	Polymorphic and other crystalline forms cis-FTC
CA2351049C (en)	2001-06-18	2007-03-13	Brantford Chemicals Inc.	Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers
WO2003027106A1 (en) *	2001-09-25	2003-04-03	Cadila Healthcar Limited	Process for the preparation of crystalline polymorph ii of lamivudine
EP1490090A4 (en)	2002-02-22	2006-09-20	New River Pharmaceuticals Inc	SYSTEMS FOR DELIVERING ACTIVE AGENTS AND METHODS FOR PROTECTING AND DELIVERING ACTIVE AGENTS
CA2505130C (en) *	2002-11-08	2009-10-06	Glaxo Group Limited	Pharmaceutical compositions
KR20080032014A (ko)	2003-01-14	2008-04-11	길리애드 사이언시즈, 인코포레이티드	복합 항바이러스 치료를 위한 조성물 및 방법
KR101330626B1 (ko) *	2004-11-10	2013-11-18	노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드	탈아미드화된 인터페론-베타
US20060242012A1 (en) *	2005-04-22	2006-10-26	Sumit Agarwal	Determining or scoring properties to solicit to join ad network using advertiser or aggregated advertiser interest
TWI375560B (en)	2005-06-13	2012-11-01	Gilead Sciences Inc	Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh)	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型
AU2007237818B2 (en) *	2006-04-18	2012-09-27	Lupin Limited	A novel crystalline form of lamivudine
AR068374A1 (es) *	2007-09-06	2009-11-11	Combino Pharm Sl	Nuevas composiciones farmaceuticas del complejo lamivudina beta - ciclodextrina
US20100190982A1 (en) *	2007-09-17	2010-07-29	Janardhana Rao Vascuri	Process for the preparation of lamivudine form i
WO2009069013A1 (en) *	2007-11-29	2009-06-04	Ranbaxy Laboratories Limited	Crystalline form i of lamivudine and its preparation
SI2225232T1 (sl) *	2007-11-29	2012-12-31	Ranbaxy Laboratories Limited	Postopek za pripravo substituiranih 1,3-oksatiolanov
WO2009069012A1 (en) *	2007-11-29	2009-06-04	Ranbaxy Laboratories Limited	Process and intermediates for the preparation of substituted 1, 3-oxathiolanes, especially lamivudine
WO2009127996A1 (en) *	2008-04-17	2009-10-22	Ranbaxy Laboratories Limited	Novel crystalline form of lamivudine
WO2010023676A2 (en) *	2008-09-01	2010-03-04	Hetero Research Foundation	Process for preparing lamivudine polymorph form
US20110288298A1 (en) *	2008-11-12	2011-11-24	Lupin Limited	novel polymorph of emtricitabine and a process for preparing of the same
CN101531656B (zh) *	2009-03-24	2010-12-08	福建广生堂药业有限公司	拉米夫定晶型及其制备方法
CN101993439B (zh) *	2009-03-24	2013-04-24	福建广生堂药业股份有限公司	拉米夫定晶型及其制备方法
EP2435052B1 (en) *	2009-05-27	2015-07-15	Hetero Research Foundation	Solid oral dosage forms of lamivudine with isomalt
US8710218B2 (en)	2009-07-15	2014-04-29	Lupin Limited	Process for preparation of Efavirenz
ES2540074T3 (es)	2009-10-14	2015-07-08	Mylan Laboratories Limited	Proceso para la preparación de lamivudina y nuevas sales en la fabricación de la misma
LT3494972T (lt)	2010-01-27	2024-03-12	Viiv Healthcare Company	Dolutegraviro ir lamivudino kompozicija živ infekcijai gydyti
WO2011095987A1 (en) *	2010-02-03	2011-08-11	Matrix Laboratories Ltd.	Novel process for the preparation of cis-nucleoside derivative
US8796452B2 (en)	2010-02-12	2014-08-05	Merck Sharp & Dohme Corp.	Preparation of lamivudine form I
CN104203275A (zh)	2010-06-09	2014-12-10	疫苗技术股份有限公司	用于增强抗逆转录病毒治疗的hiv感染者的治疗性免疫
WO2013021290A1 (en)	2011-08-05	2013-02-14	Lupin Limited	A stereoselective process for preparation of 1,3-oxathiolane nucleosides
WO2013168066A1 (en)	2012-05-05	2013-11-14	Lupin Limited	An improved process for the manufacture of lamivudine form i.
CN114099454B (zh) *	2020-08-31	2023-06-27	长春海悦药业股份有限公司	一种拉米夫定片及其制备方法

Family Cites Families (7)

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US5047407A (en) *	1989-02-08	1991-09-10	Iaf Biochem International, Inc.	2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
NZ228645A (en) *	1988-04-11	1991-09-25	Iaf Biochem Int	1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections
US5204466A (en) *	1990-02-01	1993-04-20	Emory University	Method and compositions for the synthesis of bch-189 and related compounds
GB9009861D0 (en) *	1990-05-02	1990-06-27	Glaxo Group Ltd	Chemical compounds
US5179104A (en) *	1990-12-05	1993-01-12	University Of Georgia Research Foundation, Inc.	Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides
US5248776A (en) *	1990-12-05	1993-09-28	University Of Georgia Research Foundation, Inc.	Process for enantiomerically pure β-L-1,3-oxathiolane nucleosides
JPH04358486A (ja) *	1991-06-04	1992-12-11	Toshiba Corp	高能率符号化信号処理装置

1991
- 1991-06-03 GB GB919111902A patent/GB9111902D0/en active Pending
1992
- 1992-02-06 UA UA93004068A patent/UA41265C2/uk unknown
- 1992-06-02 PT PT92109221T patent/PT517145E/pt unknown
- 1992-06-02 MX MX9202619A patent/MX9202619A/es active IP Right Grant
- 1992-06-02 DE DE69232387T patent/DE69232387T2/de not_active Expired - Lifetime
- 1992-06-02 NZ NZ242981A patent/NZ242981A/en not_active IP Right Cessation
- 1992-06-02 DK DK92109221T patent/DK0517145T3/da active
- 1992-06-02 RU RU93058495A patent/RU2102393C1/ru active
- 1992-06-02 AU AU17361/92A patent/AU656379B2/en not_active Expired
- 1992-06-02 GE GEAP19922654A patent/GEP19991834B/en unknown
- 1992-06-02 AU AU18810/92A patent/AU1881092A/en not_active Abandoned
- 1992-06-02 AT AT92109221T patent/ATE212630T1/de active
- 1992-06-02 CZ CS932612A patent/CZ284513B6/cs not_active IP Right Cessation
- 1992-06-02 ZA ZA924007A patent/ZA924007B/xx unknown
- 1992-06-02 EP EP92109221A patent/EP0517145B1/en not_active Expired - Lifetime
- 1992-06-02 JP JP4166809A patent/JP2851480B2/ja not_active Expired - Lifetime
- 1992-06-02 WO PCT/EP1992/001213 patent/WO1992021676A1/en not_active Ceased
- 1992-06-02 SK SK1257-93A patent/SK281249B6/sk not_active IP Right Cessation
- 1992-06-02 CA CA002311988A patent/CA2311988C/en not_active Expired - Lifetime
- 1992-06-02 AP APAP/P/1992/000395A patent/AP300A/en active
- 1992-06-02 US US07/892,029 patent/US5905082A/en not_active Expired - Lifetime
- 1992-06-02 SG SG1996004763A patent/SG52455A1/en unknown
- 1992-06-02 ES ES92109221T patent/ES2171158T3/es not_active Expired - Lifetime
- 1992-06-02 NO NO922182A patent/NO301713B1/no not_active IP Right Cessation
- 1992-06-02 CA CA002070230A patent/CA2070230C/en not_active Expired - Lifetime
- 1992-06-02 IL IL10207392A patent/IL102073A/en not_active IP Right Cessation
- 1992-06-02 TW TW081104300A patent/TW254939B/zh not_active IP Right Cessation
- 1992-06-02 IS IS3873A patent/IS1867B/is unknown
- 1992-06-02 KR KR1019920009537A patent/KR100244008B1/ko not_active Expired - Lifetime
- 1992-06-02 EP EP01200491A patent/EP1099700A1/en not_active Withdrawn
- 1992-07-01 IE IE178092A patent/IE921780A1/en not_active IP Right Cessation
- 1992-07-01 IE IE20020782A patent/IE20020782A1/en not_active IP Right Cessation
- 1992-12-04 IS IS4268A patent/IS4268A/is unknown
1993
- 1993-11-15 OA OA60437A patent/OA09913A/en unknown
- 1993-11-30 BG BG98254A patent/BG60914B1/bg unknown

Also Published As

Publication number	Publication date
AU1881092A (en)	1993-01-08
US5905082A (en)	1999-05-18
RU2102393C1 (ru)	1998-01-20
ES2171158T3 (es)	2002-09-01
IS1867B (is)	2003-05-02
NO922182L (no)	1992-12-04
UA41265C2 (uk)	2001-09-17
NZ242981A (en)	1994-04-27
TW254939B (is)	1995-08-21
CZ284513B6 (cs)	1998-12-16
CA2311988C (en)	2005-11-15
CA2311988A1 (en)	1992-12-04
AP9200395A0 (en)	1992-07-31
ATE212630T1 (de)	2002-02-15
EP1099700A1 (en)	2001-05-16
AP300A (en)	1994-01-20
BG60914B1 (bg)	1996-06-28
OA09913A (en)	1994-09-15
IL102073A0 (en)	1993-01-14
CA2070230C (en)	2004-08-03
IE20020782A1 (en)	2003-04-02
KR930000511A (ko)	1993-01-15
CZ261293A3 (en)	1994-04-13
GEP19991834B (en)	1999-11-05
IE921780A1 (en)	1992-12-16
WO1992021676A1 (en)	1992-12-10
NO922182D0 (no)	1992-06-02
HK1009599A1 (en)	1999-06-04
JP2851480B2 (ja)	1999-01-27
DE69232387T2 (de)	2002-09-26
IL102073A (en)	1996-05-14
CA2070230A1 (en)	1992-12-04
JPH06211848A (ja)	1994-08-02
AU1736192A (en)	1993-03-11
BG98254A (bg)	1994-07-29
GB9111902D0 (en)	1991-07-24
IS4268A (is)	1995-02-27
ZA924007B (en)	1993-04-28
EP0517145A1 (en)	1992-12-09
SG52455A1 (en)	1998-09-28
EP0517145B1 (en)	2002-01-30
DE69232387D1 (de)	2002-03-14
SK281249B6 (sk)	2001-01-18
NO301713B1 (no)	1997-12-01
AU656379B2 (en)	1995-02-02
DK0517145T3 (da)	2002-05-06
SK125793A3 (en)	1994-11-09
KR100244008B1 (ko)	2000-03-02
PT517145E (pt)	2002-07-31
MX9202619A (es)	1992-12-01

Publication	Publication Date	Title
IS3873A (is)	1992-12-04	Hliðstæð aðferð til framleiðslu á kristölluðum oxaþíólan afleiðum
IS3994A (is)	1993-10-17	Hliðstæð aðferð til framleiðslu á indole afleiðum
IS3915A (is)	1993-03-19	Aðferð til framleiðslu á benzanilíð afleiðum
IS3914A (is)	1993-03-19	Aðferð til framleiðslu á benzanilíð afleiðum
IS3871A (is)	1992-12-02	Hliðstæðar aðferðir til framleiðslu á Quinuclidine afleiðum
IS3954A (is)	1993-06-05	Hliðstæð aðferð við framleiðslu nýrra peptíðafleiða
IS4201A (is)	1995-03-01	Aðferð til framleiðslu á Benzofuran afleiðum
IS3945A (is)	1993-05-15	Aðferð til framleiðslu á ediksýruafleiðum
IS1708B (is)	1998-12-16	Hliðstæð aðferð til framleiðslu á vatnsuppleysanlegum kamptóþesín afleiðum
IS4148A (is)	1994-10-16	Hliðstæð aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum
IS3970A (is)	1993-07-22	Hliðstæð aðferð til framleiðslu á 1,5-benzódíazepín afleiðum
IS4121A (is)	1994-07-21	Hliðstæð aðferð til framleiðslu á 2,6-Díamínópúrín afleiðum
IS1895B (is)	2003-10-20	Hliðstæðuaðferð til framleiðslu á cytidine-afleiðum
IS1653B (is)	1997-06-20	Hliðstæð aðferð við framleiðslu nýrra sykursteraestera
MA22563A1 (fr)	1992-12-31	Procede de preparation de derives de tetrahydrocarbazole
FI893100L (fi)	1989-06-26	Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi
IS4219A (is)	1995-04-15	Aðferð til framleiðslu á Indole afleiðum
BG49939A3 (bg)	1992-03-16	Метод за получаване на 2-анилино-пиримидинови производни
FI940769A7 (fi)	1994-08-20	Menetelmä 2-aminoatsolijohdannaisten valmistamiseksi
IS3827A (is)	1992-09-28	Hliðstæð aðferð við framleiðslu á pýrról[2,3 b]pýridínum
FI920121A7 (fi)	1992-07-15	Menetelmä heterosyklisten hydroksyyliamiinien valmistamiseksi
IT1244234B (it)	1994-07-08	Metodo per la realizzazione di incarti tubolari.
IS4079A (is)	1993-06-20	Milliefni til framleiðslu á súbstitúeruðum bensimidasólum
FI910756A7 (fi)	1991-08-21	Fermentaatiomenetelmä staurosporiinin valmistamiseksi
FI921103A7 (fi)	1992-09-16	Menetelmä oksamidin valmistamiseksi