IS3030B - Stórhringlaga kínasólín afleiður sem hemla á frumuskiptingu - Google Patents

Stórhringlaga kínasólín afleiður sem hemla á frumuskiptingu

Info

Publication number: IS3030B
Authority: IS; Iceland
Prior art keywords: macrocylic; antiproliferative agents; quinazoline derivatives; quinazoline; derivatives
Prior art date: 2003-05-27

Application number

IS8077A

Other languages

English (en)

Other versions

IS8077A (is

Inventor

Eddy Freyne

Timothy Perera

Peter Buijnsters

Marc Willems

Gaston Marvella

Werner EMBRECHTS

Peter Holte

Frederk Rombouts

Carsten Schulz-Fademrecht

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-05-27

Filing date

2005-10-14

Publication date

2021-06-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33493782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS3030(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-10-14 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2005-10-14 Publication of IS8077A publication Critical patent/IS8077A/is

2021-06-15 Publication of IS3030B publication Critical patent/IS3030B/is

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/93—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IS8077A 2003-05-27 2005-10-14 Stórhringlaga kínasólín afleiður sem hemla á frumuskiptingu IS3030B (is)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP0305723		2003-05-27
EP0310266		2003-09-15
EP0351061		2003-12-18
PCT/EP2004/005621 WO2004105765A1 (en)	2003-05-27	2004-05-25	Macrocyclic quinazoline derivatives as antiproliferative agents

Publications (2)

Publication Number	Publication Date
IS8077A IS8077A (is)	2005-10-14
IS3030B true IS3030B (is)	2021-06-15

Family

ID=33493782

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS8077A IS3030B (is)	2003-05-27	2005-10-14	Stórhringlaga kínasólín afleiður sem hemla á frumuskiptingu

Country Status (31)

Country	Link
US (4)	US7648975B2 (is)
EP (2)	EP1633365B1 (is)
JP (1)	JP4887151B2 (is)
KR (1)	KR101143878B1 (is)
CN (1)	CN102718775B (is)
AR (2)	AR045687A1 (is)
AT (1)	ATE544454T1 (is)
AU (1)	AU2004243487B2 (is)
BR (1)	BRPI0410714B8 (is)
CA (1)	CA2525214C (is)
CL (1)	CL2004001267A1 (is)
CO (1)	CO5640038A2 (is)
CY (1)	CY1113002T1 (is)
DK (1)	DK1633365T3 (is)
EA (1)	EA009064B1 (is)
ES (1)	ES2381976T3 (is)
HR (1)	HRP20120351T1 (is)
IL (3)	IL172154A0 (is)
IS (1)	IS3030B (is)
JO (1)	JO2785B1 (is)
MX (1)	MXPA05012762A (is)
MY (1)	MY148633A (is)
NO (1)	NO334209B1 (is)
NZ (1)	NZ544154A (is)
PA (1)	PA8603801A1 (is)
PL (1)	PL1633365T3 (is)
PT (1)	PT1633365E (is)
SI (1)	SI1633365T1 (is)
TW (3)	TWI468372B (is)
UA (1)	UA84010C2 (is)
WO (1)	WO2004105765A1 (is)

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JP4936897B2 (ja)	2003-12-18	2012-05-23	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	抗増殖剤としてのピリド−およびピリミドピリミジン誘導体
JO3088B1 (ar) *	2004-12-08	2017-03-15	Janssen Pharmaceutica Nv	مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف
MY169441A (en)	2004-12-08	2019-04-11	Janssen Pharmaceutica Nv	2,4, (4,6) pyrimidine derivatives
NI200700147A (es) *	2004-12-08	2019-05-10	Janssen Pharmaceutica Nv	Derivados de quinazolina inhibidores de cinasas dirigidos a multip
PT1854789E (pt)	2005-02-23	2013-10-23	Shionogi & Co	Derivado de quinazolina possuindo actividade inibidora de tirosina-cinase
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ES2900243T3 (es)	2008-10-22	2022-03-16	Array Biopharma Inc	Compuestos de pirazolo[1,5-a]pirimidina sustituidos como inhibidores de trk quinasa
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CN104513253A (zh) *	2013-10-01	2015-04-15	南京波尔泰药业科技有限公司	用于治疗增殖性疾病的大环化合物
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MA39822A (fr)	2014-04-03	2018-02-06	Janssen Pharmaceutica Nv	Dérivés de pyrimidine bicycle
MA39823A (fr)	2014-04-03	2018-01-09	Janssen Pharmaceutica Nv	Dérivés de pyridine macrocyclique
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KR20180086187A (ko)	2015-10-05	2018-07-30	더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕	자가포식 유동의 활성체 및 포스포리파제 d 및 타우를 포함하는 단백질 응집물의 클리어런스 및 단백질질환의 치료
EP3368039A1 (en)	2015-10-26	2018-09-05	The Regents of The University of Colorado, A Body Corporate	Point mutations in trk inhibitor-resistant cancer and methods relating to the same
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JOP20190092A1 (ar)	2016-10-26	2019-04-25	Array Biopharma Inc	عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
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2004
- 2004-05-24 JO JO200466A patent/JO2785B1/en active
- 2004-05-24 PA PA20048603801A patent/PA8603801A1/es unknown
- 2004-05-25 AU AU2004243487A patent/AU2004243487B2/en not_active Expired
- 2004-05-25 KR KR1020057022189A patent/KR101143878B1/ko not_active Expired - Lifetime
- 2004-05-25 JP JP2006529915A patent/JP4887151B2/ja not_active Expired - Lifetime
- 2004-05-25 HR HRP20120351TT patent/HRP20120351T1/hr unknown
- 2004-05-25 BR BRPI0410714A patent/BRPI0410714B8/pt not_active IP Right Cessation
- 2004-05-25 SI SI200431864T patent/SI1633365T1/sl unknown
- 2004-05-25 CL CL200401267A patent/CL2004001267A1/es unknown
- 2004-05-25 PL PL04739341T patent/PL1633365T3/pl unknown
- 2004-05-25 NZ NZ544154A patent/NZ544154A/en not_active IP Right Cessation
- 2004-05-25 EA EA200501866A patent/EA009064B1/ru unknown
- 2004-05-25 MX MXPA05012762A patent/MXPA05012762A/es active IP Right Grant
- 2004-05-25 US US10/558,007 patent/US7648975B2/en not_active Expired - Lifetime
- 2004-05-25 MY MYPI20042004A patent/MY148633A/en unknown
- 2004-05-25 UA UAA200510181A patent/UA84010C2/ru unknown
- 2004-05-25 DK DK04739341.8T patent/DK1633365T3/da active
- 2004-05-25 PT PT04739341T patent/PT1633365E/pt unknown
- 2004-05-25 CN CN201210144221.7A patent/CN102718775B/zh not_active Expired - Lifetime
- 2004-05-25 CA CA2525214A patent/CA2525214C/en not_active Expired - Lifetime
- 2004-05-25 WO PCT/EP2004/005621 patent/WO2004105765A1/en not_active Ceased
- 2004-05-25 EP EP04739341A patent/EP1633365B1/en not_active Expired - Lifetime
- 2004-05-25 ES ES04739341T patent/ES2381976T3/es not_active Expired - Lifetime
- 2004-05-25 AT AT04739341T patent/ATE544454T1/de active
- 2004-05-25 EP EP10192741A patent/EP2305687A1/en not_active Withdrawn
- 2004-05-26 TW TW101115204A patent/TWI468372B/zh not_active IP Right Cessation
- 2004-05-26 AR ARP040101806A patent/AR045687A1/es active IP Right Grant
- 2004-05-26 TW TW101115205A patent/TWI468397B/zh not_active IP Right Cessation
- 2004-05-26 TW TW093114851A patent/TWI379835B/zh not_active IP Right Cessation
2005
- 2005-10-14 IS IS8077A patent/IS3030B/is unknown
- 2005-11-24 CO CO05119403A patent/CO5640038A2/es active IP Right Grant
- 2005-11-24 IL IL172154A patent/IL172154A0/en active IP Right Grant
- 2005-12-27 NO NO20056196A patent/NO334209B1/no unknown
2009
- 2009-11-24 US US12/624,637 patent/US8394786B2/en not_active Expired - Lifetime
2012
- 2012-05-08 CY CY20121100428T patent/CY1113002T1/el unknown
2013
- 2013-01-18 US US13/744,878 patent/US9273013B2/en not_active Expired - Lifetime
- 2013-08-15 AR ARP130102897A patent/AR092137A2/es unknown
2014
- 2014-06-10 IL IL233046A patent/IL233046A0/en active IP Right Grant
- 2014-06-10 IL IL233045A patent/IL233045B/en active IP Right Grant
2016
- 2016-01-21 US US15/003,124 patent/US20160207938A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN102718775A (zh)	2012-10-10
MXPA05012762A (es)	2006-02-13
IL233046A0 (en)	2014-07-31
US20100105668A1 (en)	2010-04-29
NZ544154A (en)	2009-01-31
CN102718775B (zh)	2016-02-17
UA84010C2 (en)	2008-09-10
EP1633365B1 (en)	2012-02-08
IL233045B (en)	2018-07-31
AR045687A1 (es)	2005-11-09
MY148633A (en)	2013-05-15
IL233045A0 (en)	2014-07-31
HK1176350A1 (zh)	2013-07-26
TWI379835B (en)	2012-12-21
CA2525214A1 (en)	2004-12-09
CY1113002T1 (el)	2016-04-13
IS8077A (is)	2005-10-14
US7648975B2 (en)	2010-01-19
BRPI0410714A (pt)	2006-06-13
JP2007504276A (ja)	2007-03-01
US20130178624A1 (en)	2013-07-11
BRPI0410714B8 (pt)	2021-05-25
TW201245111A (en)	2012-11-16
DK1633365T3 (da)	2012-05-14
US20060247237A1 (en)	2006-11-02
KR101143878B1 (ko)	2012-05-24
PL1633365T3 (pl)	2012-07-31
TWI468372B (zh)	2015-01-11
AU2004243487A1 (en)	2004-12-09
PT1633365E (pt)	2012-05-07
CO5640038A2 (es)	2006-05-31
EP2305687A1 (en)	2011-04-06
ATE544454T1 (de)	2012-02-15
NO20056196L (no)	2005-12-28
HRP20120351T1 (hr)	2012-05-31
BRPI0410714B1 (pt)	2019-09-24
EA200501866A1 (ru)	2006-06-30
AU2004243487B2 (en)	2009-12-03
TW200510431A (en)	2005-03-16
TW201245160A (en)	2012-11-16
JP4887151B2 (ja)	2012-02-29
KR20060014415A (ko)	2006-02-15
SI1633365T1 (sl)	2012-06-29
AR092137A2 (es)	2015-03-25
CL2004001267A1 (es)	2005-04-22
ES2381976T3 (es)	2012-06-04
IL172154A0 (en)	2006-04-10
EA009064B1 (ru)	2007-10-26
WO2004105765A1 (en)	2004-12-09
PA8603801A1 (es)	2004-12-16
TWI468397B (zh)	2015-01-11
US9273013B2 (en)	2016-03-01
EP1633365A1 (en)	2006-03-15
JO2785B1 (en)	2014-03-15
CA2525214C (en)	2012-11-27
US8394786B2 (en)	2013-03-12
US20160207938A1 (en)	2016-07-21
NO334209B1 (no)	2014-01-13

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PL378245A1 (pl)	2006-03-20	Pochodne pirolopirydazyny
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