IN2015KN00015A - - Google Patents
Info
- Publication number
- IN2015KN00015A IN2015KN00015A IN15KON2015A IN2015KN00015A IN 2015KN00015 A IN2015KN00015 A IN 2015KN00015A IN 15KON2015 A IN15KON2015 A IN 15KON2015A IN 2015KN00015 A IN2015KN00015 A IN 2015KN00015A
- Authority
- IN
- India
- Prior art keywords
- masp
- inhibitory agent
- disease
- subject
- administered
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 abstract 11
- 102100026061 Mannan-binding lectin serine protease 1 Human genes 0.000 abstract 9
- 101001055956 Homo sapiens Mannan-binding lectin serine protease 1 Proteins 0.000 abstract 6
- 101710117390 Mannan-binding lectin serine protease 1 Proteins 0.000 abstract 3
- 102100026046 Mannan-binding lectin serine protease 2 Human genes 0.000 abstract 3
- 101710117460 Mannan-binding lectin serine protease 2 Proteins 0.000 abstract 3
- 230000024203 complement activation Effects 0.000 abstract 2
- 230000001419 dependent effect Effects 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000009137 Behcet syndrome Diseases 0.000 abstract 1
- 206010018378 Glomerulonephritis rapidly progressive Diseases 0.000 abstract 1
- 208000004451 Membranoproliferative Glomerulonephritis Diseases 0.000 abstract 1
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 abstract 1
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 abstract 1
- 206010035669 Pneumonia aspiration Diseases 0.000 abstract 1
- 208000034841 Thrombotic Microangiopathies Diseases 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 206010064930 age-related macular degeneration Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 201000009807 aspiration pneumonia Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000005637 crescentic glomerulonephritis Diseases 0.000 abstract 1
- 208000022401 dense deposit disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000009190 disseminated intravascular coagulation Diseases 0.000 abstract 1
- 206010014801 endophthalmitis Diseases 0.000 abstract 1
- 208000002780 macular degeneration Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002956 necrotizing effect Effects 0.000 abstract 1
- 208000008795 neuromyelitis optica Diseases 0.000 abstract 1
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 abstract 1
- 230000009529 traumatic brain injury Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Ophthalmology & Optometry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
Abstract
In one aspect, the invention provides methods and compositions for inhibiting MASP-3 -dependent complement activation in a subject suffering from or at risk for developing, a disease or disorder selected from the group consisting of paroxysmal nocturnal hemoglobinuria, age-related macular degeneration, arthritis, disseminated intravascular coagulation, thrombotic microangiopathy, asthma, dense deposit disease, pauci-immune necrotizing crescentic glomerulonephritis, traumatic brain injury, aspiration pneumonia, endophthalmitis, neuromyelitis optica and Behcet's disease by administering to the subject a composition comprising an amount of a MASP-3 inhibitory agent in an amount effective to inhibit MASP-3 -dependent complement activation. In some embodiments, the subject is administered a MASP-2 inhibitory agent and a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent administered, a MASP-3 inhibitory agent and a MASP-1 inhibitory agent, or a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261661167P | 2012-06-18 | 2012-06-18 | |
| PCT/US2013/046432 WO2013192240A2 (en) | 2012-06-18 | 2013-06-18 | Compositions and methods of inhibiting masp-1 and/or masp-2 and/or masp-3 for the treatment of various diseases and disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015KN00015A true IN2015KN00015A (en) | 2015-07-31 |
Family
ID=49769678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN15KON2015 IN2015KN00015A (en) | 2012-06-18 | 2013-06-18 |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US20130344073A1 (en) |
| EP (5) | EP3878865A3 (en) |
| JP (5) | JP6445972B2 (en) |
| KR (4) | KR20200015952A (en) |
| CN (4) | CN104717975A (en) |
| AU (3) | AU2013277309B2 (en) |
| BR (1) | BR112014031522A2 (en) |
| CA (2) | CA3214532A1 (en) |
| CL (2) | CL2014003455A1 (en) |
| CY (1) | CY1124234T1 (en) |
| DK (1) | DK2861246T3 (en) |
| ES (1) | ES2864857T3 (en) |
| HR (1) | HRP20210559T1 (en) |
| HU (1) | HUE053727T2 (en) |
| IL (2) | IL236327B (en) |
| IN (1) | IN2015KN00015A (en) |
| LT (1) | LT2861246T (en) |
| MX (4) | MX381048B (en) |
| NZ (1) | NZ629473A (en) |
| PL (1) | PL2861246T3 (en) |
| PT (1) | PT2861246T (en) |
| RS (1) | RS61755B1 (en) |
| RU (2) | RU2019140356A (en) |
| SI (1) | SI2861246T1 (en) |
| WO (1) | WO2013192240A2 (en) |
| ZA (1) | ZA201500094B (en) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8937046B2 (en) | 2008-09-22 | 2015-01-20 | The Regents Of The University Of Colorado, A Body Corporate | Modulating the alternative complement pathway |
| WO2012139081A2 (en) | 2011-04-08 | 2012-10-11 | University Of Leicester | Methods for treating conditions associated with masp-2 dependent complement activation |
| JP6774164B2 (en) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | Mouse FcγRII specific Fc antibody |
| US9217042B2 (en) * | 2012-10-23 | 2015-12-22 | Abbott Cardiovascular Systems Inc. | Method of reducing MACE in diabetic patients subsequent to stent placement |
| WO2014144542A2 (en) | 2013-03-15 | 2014-09-18 | Omeros Corporation | Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same |
| US20140363433A1 (en) | 2013-03-15 | 2014-12-11 | Omeros Corporation | Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same |
| KR20210130260A (en) | 2013-04-02 | 2021-10-29 | 추가이 세이야쿠 가부시키가이샤 | Fc region variant |
| EP2983710B1 (en) * | 2013-04-09 | 2019-07-31 | Annexon, Inc. | Methods of treatment for neuromyelitis optica |
| WO2014197885A2 (en) | 2013-06-07 | 2014-12-11 | Duke University | Inhibitors of complement factor h |
| SG11201510316UA (en) | 2013-07-09 | 2016-01-28 | Annexon Inc | Anti-complement factor c1q antibodies and uses thereof |
| KR102677379B1 (en) | 2013-10-17 | 2024-06-24 | 오메로스 코포레이션 | Methods for treating conditions associated with masp-2 dependent complement activation |
| US10155983B2 (en) | 2014-03-31 | 2018-12-18 | Machaon Diagnostics, Inc. | Method of diagnosis of complement-mediated thrombotic microangiopathies |
| AU2015269348C1 (en) * | 2014-06-05 | 2021-11-18 | The Regents Of The University Of Colorado, A Body Corporate | MAp44 polypeptides and constructs based on natural antibodies and uses thereof |
| PL3215527T3 (en) | 2014-11-05 | 2025-04-28 | Annexon, Inc. | Humanized anti-complement factor c1q antibodies and uses thereof |
| US10639307B2 (en) | 2015-05-15 | 2020-05-05 | Children's Medical Center Corporation | Methods relating to the diagnosis and treatment of preeclampsia comprising administration of ADAMTS13 polypeptides |
| EP3302578A4 (en) * | 2015-06-03 | 2019-03-13 | Coyne Scientific, LLC | Methods for establishing threshold limits for a chemical or biological agent in a target species |
| AR106018A1 (en) * | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | ARYL, HETEROARYL AND HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS |
| EP3340983B1 (en) | 2015-08-26 | 2023-10-04 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders |
| WO2017035405A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amino compounds for treatment of immune and inflammatory disorders |
| WO2017035401A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amide compounds for treatment of immune and inflammatory disorders |
| IL259225B (en) | 2015-11-09 | 2022-09-01 | Omeros Corp | Preparations containing antibodies that suppress masp-2 and antigen-binding fragments for use in the treatment of tma associated with hematopoietic stem cell transplantation |
| AU2016361517C1 (en) | 2015-11-24 | 2024-06-06 | Annexon, Inc. | Anti-complement factor C1q Fab fragments and uses thereof |
| IL294411B2 (en) * | 2016-01-05 | 2025-10-01 | Omeros Corp | Masp-2 inhibitors for use in inhibiting fibrosis |
| MA44518A (en) * | 2016-03-31 | 2019-02-06 | Omeros Corp | ANGIOGENESIS INHIBITION PROCESSES IN A SUBJECT THAT NEEDS IT |
| JOP20170154B1 (en) * | 2016-08-01 | 2023-03-28 | Omeros Corp | Compositions and methods of inhibiting masp-3 for the treatment of various diseases and disorders |
| JOP20170170B1 (en) | 2016-08-31 | 2022-09-15 | Omeros Corp | High concentration, low viscosity MASP-2 inhibitory antibody formulations, kits, and methods |
| WO2018160891A1 (en) | 2017-03-01 | 2018-09-07 | Achillion Pharmaceutical, Inc. | Pharmaceutical compounds for treatment of medical disorders |
| WO2018160892A1 (en) | 2017-03-01 | 2018-09-07 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for treatment of medical disorders |
| WO2018160889A1 (en) | 2017-03-01 | 2018-09-07 | Achillion Pharmaceuticals, Inc. | Aryl, heteroary, and heterocyclic pharmaceutical compounds for treatment of medical disorders |
| JP7409871B2 (en) * | 2017-04-03 | 2024-01-09 | 中外製薬株式会社 | Anti-MASP-1 antibody and its use |
| CN111278863A (en) * | 2017-08-25 | 2020-06-12 | 奥默罗斯公司 | Highly concentrated low viscosity MASP-2 inhibitory antibody formulations, kits and methods of treating subjects with atypical hemolytic syndrome |
| CN111556895B (en) | 2017-11-14 | 2024-09-13 | 中外制药株式会社 | Anti-C1S antibodies and methods of use |
| MX2020010528A (en) * | 2018-04-13 | 2020-11-06 | Chugai Pharmaceutical Co Ltd | Anti-complement component antibodies and methods of use. |
| CN119350433A (en) | 2018-05-29 | 2025-01-24 | 奥默罗斯公司 | MASP-2 inhibitors and methods of use |
| WO2019246367A1 (en) * | 2018-06-22 | 2019-12-26 | Omeros Corporation | Compositions and methods of inhibiting masp-2 for the treatment of various thrombotic diseases and disorders |
| MX2021002640A (en) | 2018-09-06 | 2021-07-16 | Achillion Pharmaceuticals Inc | Morphic forms of complement factor d inhibitors. |
| WO2020051532A2 (en) | 2018-09-06 | 2020-03-12 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for the treatment of medical disorders |
| AU2019346464A1 (en) | 2018-09-25 | 2021-04-08 | Achillion Pharmaceuticals, Inc. | Morphic forms of complement factor D inhibitors |
| GB2583560A (en) | 2018-12-11 | 2020-11-04 | Admirx Inc | Fusion protein constructs for complement associated disease |
| CA3123583A1 (en) | 2018-12-17 | 2020-06-25 | Achillion Pharmaceuticals, Inc. | Targeted dosing for the treatment of complement mediated disorders |
| BR112021018456A2 (en) | 2019-03-22 | 2021-11-23 | Achillion Pharmaceuticals Inc | Pharmaceutical compounds for the treatment of complement-mediated disorders |
| BR112021021188A2 (en) * | 2019-05-07 | 2021-12-14 | Bayer Ag | Masp inhibitor compounds and uses thereof |
| AU2020275348A1 (en) | 2019-05-15 | 2021-12-09 | Chugai Seiyaku Kabushiki Kaisha | An antigen-binding molecule, a pharmaceutical composition, and a method |
| US11807641B2 (en) | 2019-12-04 | 2023-11-07 | Omeros Corporation | MASP-2 inhibitors and methods of use |
| US12110288B2 (en) | 2019-12-04 | 2024-10-08 | Omeros Corporation | MASP-2 inhibitors and methods of use |
| IL293551A (en) | 2019-12-04 | 2022-08-01 | Omeros Corp | Masp-2 inhibitor compounds, compositions comprising same and uses thereof |
| WO2021113698A1 (en) | 2019-12-04 | 2021-06-10 | Omeros Corporation | Masp-2 inhibitors and methods of use |
| CN112237630A (en) * | 2020-02-21 | 2021-01-19 | 中国人民解放军军事科学院军事医学研究院 | Application of MASP-2, coronavirus N protein or their combined substances in the preparation of drugs for diseases caused by coronavirus |
| TWI867422B (en) * | 2020-03-06 | 2024-12-21 | 美商奥默羅斯公司 | Methods of inhibiting masp-2 for the treatment and/or prevention of acute respiratory distress syndrome, pneumonia or some other pulmonary manifestation of influenza virus infection induced by influenza virus |
| CA3189666A1 (en) | 2020-08-18 | 2022-02-24 | William Jason Cummings | Monoclonal antibodies, compositions and methods for detecting complement factor d |
| CN115215937B (en) | 2021-04-15 | 2023-05-26 | 上海麦济生物技术有限公司 | Anti-human MASP-2 antibody, preparation method and application thereof |
| WO2023108028A2 (en) | 2021-12-10 | 2023-06-15 | Omeros Corporation | Therapeutic antibodies that bind to the serine protease domain of masp-2 and uses thereof |
| US12486322B2 (en) | 2021-12-13 | 2025-12-02 | Annexon, Inc. | Anti-complement factor C1q antibodies with single binding arms and uses thereof |
| CN114989259B (en) * | 2022-05-27 | 2023-06-09 | 成都佩德生物医药有限公司 | Small molecule peptide Ped4 and application thereof |
| CN115125299A (en) * | 2022-08-09 | 2022-09-30 | 大连珍奥药业股份有限公司 | Application of Masp1 in screening of drugs for preventing and/or treating cardiovascular diseases |
| WO2024118840A1 (en) | 2022-11-30 | 2024-06-06 | Omeros Corporation | Fused pyrimidines as masp-2 inhibitors |
| EP4677366A1 (en) * | 2023-03-03 | 2026-01-14 | The City University Of New York | Use of extracellular vesicles as biomarkers for age-related macular degeneration |
| US20250122225A1 (en) | 2023-10-06 | 2025-04-17 | Omeros Corporation | Masp-2 inhibitors and methods of use |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5211657A (en) | 1988-11-07 | 1993-05-18 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
| EP0438803B1 (en) | 1990-01-26 | 1997-03-12 | Immunomedics, Inc. | Vaccines against cancer and infectious diseases |
| JP3218637B2 (en) | 1990-07-26 | 2001-10-15 | 大正製薬株式会社 | Stable aqueous liposome suspension |
| JP2958076B2 (en) | 1990-08-27 | 1999-10-06 | 株式会社ビタミン研究所 | Multilamellar liposome for gene transfer and gene-captured multilamellar liposome preparation and method for producing the same |
| DE69329974T2 (en) | 1992-12-04 | 2001-07-19 | Medical Research Council, London | MULTIVALENTS AND MULTI-SPECIFIC BINDING PROTEINS, THEIR PRODUCTION AND USE |
| US5856121A (en) | 1994-02-24 | 1999-01-05 | Case Western Reserve University | Growth arrest homebox gene |
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| US5741516A (en) | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5738868A (en) | 1995-07-18 | 1998-04-14 | Lipogenics Ltd. | Liposome compositions and kits therefor |
| WO2001040451A2 (en) * | 1999-12-02 | 2001-06-07 | Jens Christian Jensenius | Masp-3, a complement-fixing enzyme, and uses for it |
| SG98393A1 (en) | 2000-05-19 | 2003-09-19 | Inst Materials Research & Eng | Injectable drug delivery systems with cyclodextrin-polymer based hydrogels |
| AU2003215524A1 (en) * | 2002-03-15 | 2003-09-29 | Natimmune A/S | Pharmaceutical compositions comprising mannose binding lectin |
| KR101101261B1 (en) | 2002-07-19 | 2012-01-04 | 인스티튜트 오브 머티어리얼스 리서치 & 엔지니어링 | Biodegradable triblock copolymers, methods of synthesis thereof, and hydrogels and biomaterials prepared therefrom |
| US7666627B2 (en) * | 2002-08-08 | 2010-02-23 | Targetex Kft. | Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof |
| CN1750844B (en) * | 2003-02-21 | 2010-09-08 | 健泰科生物技术公司 | Use of a lectin pathway-specific complement inhibitor in the preparation of a medicament for preventing or inhibiting tissue damage |
| ES2360399T3 (en) * | 2003-07-08 | 2011-06-03 | Umc Utrecht Holding B.V. | THERAPEUTIC USE OF LPI, AN INHIBITOR OF THE ROUTE OF LECTINES OF STAPHILOCOCICAL ORIGIN, IN INFLAMMATORY DISEASES. |
| US8840893B2 (en) * | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| DK2446900T3 (en) * | 2004-06-10 | 2017-07-10 | Omeros Corp | Methods for treating conditions associated with MASP-2-dependent complement activation |
| US7919094B2 (en) | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| CN100518905C (en) * | 2004-11-02 | 2009-07-29 | 浙江欧美环境工程有限公司 | Turning type electric desalinization device |
| BRPI0615026A8 (en) | 2005-08-19 | 2018-03-06 | Abbott Lab | double variable domain immunoglobulin and its uses |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| CA2626356C (en) * | 2005-10-21 | 2017-08-22 | Catalyst Biosciences, Inc. | Modified proteases that inhibit complement activation |
| KR101513308B1 (en) * | 2006-03-08 | 2015-04-28 | 아케믹스 엘엘씨 | Complement-aptamers and anti-C5 agents useful for the treatment of ocular diseases |
| WO2009029315A2 (en) | 2007-05-31 | 2009-03-05 | University Of Washington | Inducible mutagenesis of target genes |
| EP3121197A1 (en) * | 2008-11-10 | 2017-01-25 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
| US20110002931A1 (en) * | 2009-06-23 | 2011-01-06 | Alexion Pharmaceuticals, Inc. | Bispecific antibodies that bind to complement proteins |
| WO2011006982A2 (en) * | 2009-07-17 | 2011-01-20 | Rigshospitalet | Inhibitors of complement activation |
| HUE030897T2 (en) * | 2009-10-16 | 2017-06-28 | Omeros Corp | Methods for treating disseminated intravascular coagulation by inhibiting masp-2 dependent complement activation |
| AU2011222883B2 (en) * | 2010-03-05 | 2016-05-26 | Omeros Corporation | Chimeric inhibitor molecules of complement activation |
| US8795973B2 (en) * | 2010-11-29 | 2014-08-05 | University of Leceister | Methods for identifying inhibitors of mannan-binding lectin associated serine protease (MASP) proteins and uses thereof |
| WO2012139081A2 (en) * | 2011-04-08 | 2012-10-11 | University Of Leicester | Methods for treating conditions associated with masp-2 dependent complement activation |
| IN2014KN02324A (en) * | 2012-04-06 | 2015-05-01 | Omeros Corp | |
| JOP20170154B1 (en) * | 2016-08-01 | 2023-03-28 | Omeros Corp | Compositions and methods of inhibiting masp-3 for the treatment of various diseases and disorders |
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