[go: up one dir, main page]

IN2014DN10236A - - Google Patents

Download PDF

Info

Publication number
IN2014DN10236A
IN2014DN10236A IN10236DEN2014A IN2014DN10236A IN 2014DN10236 A IN2014DN10236 A IN 2014DN10236A IN 10236DEN2014 A IN10236DEN2014 A IN 10236DEN2014A IN 2014DN10236 A IN2014DN10236 A IN 2014DN10236A
Authority
IN
India
Prior art keywords
terpenes
methods
produced
microbial fermentation
pathway enzymes
Prior art date
Application number
Inventor
Wendy Chen
Fungmin Liew
Michael Koepke
Original Assignee
Lanzatech New Zealand Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49670710&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DN10236(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lanzatech New Zealand Ltd filed Critical Lanzatech New Zealand Ltd
Publication of IN2014DN10236A publication Critical patent/IN2014DN10236A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1229—Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01088—Hydroxymethylglutaryl-CoA reductase (1.1.1.88)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01267—1-Deoxy-D-xylulose-5-phosphate reductoisomerase (1.1.1.267)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y117/00—Oxidoreductases acting on CH or CH2 groups (1.17)
    • C12Y117/07—Oxidoreductases acting on CH or CH2 groups (1.17) with an iron-sulfur protein as acceptor (1.17.7)
    • C12Y117/07001—(E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthase (1.17.7.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01007—1-Deoxy-D-xylulose-5-phosphate synthase (2.2.1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
    • C12Y203/0301—Hydroxymethylglutaryl-CoA synthase (2.3.3.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/0101—(2E,6E)-Farnesyl diphosphate synthase (2.5.1.10), i.e. geranyltranstransferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/0109—All-trans-octaprenyl-diphosphate synthase (2.5.1.90)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01036—Mevalonate kinase (2.7.1.36)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01148—4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (2.7.1.148)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/04—Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C12Y207/04002—Phosphomevalonate kinase (2.7.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/0706—2-C-Methyl-D-erythritol 4-phosphate cytidylyltransferase (2.7.7.60)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01033—Diphosphomevalonate decarboxylase (4.1.1.33), i.e. mevalonate-pyrophosphate decarboxylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03027—Isoprene synthase (4.2.3.27)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03046—Alpha-farnesene synthase (4.2.3.46)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y406/00—Phosphorus-oxygen lyases (4.6)
    • C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
    • C12Y406/01012—2-C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (4.6.1.12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/03—Intramolecular oxidoreductases (5.3) transposing C=C bonds (5.3.3)
    • C12Y503/03002—Isopentenyl-diphosphate DELTA-isomerase (5.3.3.2)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Terpenes are valuable commercial products used in a diverse number of industries. Terpenes may be produced from petrochemical sources and from terpene feed stocks such as turpentine. However these production methods are expensive unsustainable and often cause environmental problems including contributing to climate change. Microbial fermentation provides an alternative option for the production of terpenes. One or more terpenes and/or precursors can be produced by microbial fermentation of a substrate comprising CO. Recombinant microorganisms may be used in such methods. Carboxydotrophic acetogenic recombinant microorganisms can be used in such methods. The recombinant microorgnsims may contain exogenous mevalonate (MVA) pathway enzymes and/or DXS pathway enzymes for example.
IN10236DEN2014 2012-06-01 2013-06-04 IN2014DN10236A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261654412P 2012-06-01 2012-06-01
PCT/NZ2013/000095 WO2013180584A1 (en) 2012-06-01 2013-06-04 Recombinant microorganisms and uses therefor

Publications (1)

Publication Number Publication Date
IN2014DN10236A true IN2014DN10236A (en) 2015-08-07

Family

ID=49670710

Family Applications (1)

Application Number Title Priority Date Filing Date
IN10236DEN2014 IN2014DN10236A (en) 2012-06-01 2013-06-04

Country Status (10)

Country Link
US (5) US20130323820A1 (en)
EP (3) EP3795680A1 (en)
JP (2) JP6643083B2 (en)
CN (3) CN111218418A (en)
DK (2) DK2855662T3 (en)
EA (1) EA028892B1 (en)
ES (2) ES2674984T3 (en)
IN (1) IN2014DN10236A (en)
PL (2) PL3346008T3 (en)
WO (1) WO2013180584A1 (en)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130323820A1 (en) * 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
CN104919038A (en) 2012-10-23 2015-09-16 积水化学工业株式会社 Recombinant cells and methods for producing isoprene
RU2013146377A (en) * 2013-10-17 2015-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING ISOPRENE USING BACTERIA OF THE GENUS Bacillus
CA2936251C (en) 2014-01-28 2017-11-07 Lanzatech New Zealand Limited Method of producing a recombinant microorganism
KR20220056885A (en) 2014-01-30 2022-05-06 란자테크 엔지, 인크. Recombinant microorganisms and methods of use thereof
JP6325862B2 (en) * 2014-03-25 2018-05-16 積水化学工業株式会社 Recombinant cells and method for producing cyclic monoterpenes
JP2016059313A (en) * 2014-09-17 2016-04-25 積水化学工業株式会社 Recombinant cells and methods for producing isoprene or cyclic isoprenoids
KR102726007B1 (en) 2014-10-22 2024-11-04 란자테크 엔지, 인크. Gas testing unit and method
BR112017008128B1 (en) 2014-10-22 2023-03-14 Lanzatech Nz, Inc MULTI-STEP PROCESS TO CONVERT C1 CARBON SOURCE INTO A FINAL PRODUCT, AND, MULTI-STAGE BIOLOGICAL PROCESS TO CONVERT CO INTO ETHANOL
PT3230459T (en) * 2014-12-08 2020-12-18 Lanzatech New Zealand Ltd Recombinant microorganisms exhibiting increased flux through a fermentation pathway
US10131884B2 (en) 2015-02-23 2018-11-20 Lanzatech New Zealand Limited Recombinant acetogenic bacterium for the conversion of methane to products
DE102015103608A1 (en) * 2015-03-11 2016-09-15 Basf Se Process for the microbial de novo synthesis of terpenes
WO2017029553A2 (en) 2015-08-17 2017-02-23 Conradie Alex Van Eck Methods, cells and reagents for production of isoprene, derivatives and intermediates thereof
WO2017029549A2 (en) 2015-08-17 2017-02-23 Conradie Alex Van Eck Methods, hosts, and reagents related thereto for production of unsaturated pentahydrocarbons, derivatives and intermediates thereof
CA3151146C (en) 2015-10-13 2024-03-19 Lanzatech Nz, Inc. Genetically engineered bacterium comprising energy-generating fermentation pathway
JPWO2017094053A1 (en) * 2015-11-30 2018-09-13 積水化学工業株式会社 Recombinant cells, methods for producing recombinant cells, and methods for producing organic compounds
KR20180127632A (en) 2015-12-03 2018-11-29 란자테크 뉴질랜드 리미티드 Arginine supplementation to improve efficiency in gas fermentation acetogen
US10358661B2 (en) 2015-12-28 2019-07-23 Lanzatech New Zealand Limited Microorganism with modified hydrogenase activity
WO2017136478A1 (en) 2016-02-01 2017-08-10 Lanzatech New Zealand Limited Integrated fermentation and electrolysis process
WO2017147555A1 (en) 2016-02-26 2017-08-31 Lanzatech New Zealand Limited Crispr/cas systems for c-1 fixing bacteria
KR102514023B1 (en) 2016-05-14 2023-03-23 란자테크, 인크. Aldehyde:ferredoxin oxidoreductase activity altered microorganisms and related methods
WO2018070141A1 (en) * 2016-10-13 2018-04-19 積水化学工業株式会社 Obligately anaerobic acetic acid-producing microorganism, and recombinant microorganism
KR102000755B1 (en) * 2016-12-27 2019-07-17 한국과학기술원 A recombinant microorganism introduced exotic genes and a method for producing useful product from carbon dioxide and formic acid using the recombinant microorganism
GB201701548D0 (en) * 2017-01-31 2017-03-15 Univ Manchester Process for producing monoterpenes
US11261450B2 (en) 2017-02-27 2022-03-01 Sekisui Chemical Co., Ltd. Recombinant cell, method for producing recombinant cell, and method for producing isoprene or terpene
WO2019006255A1 (en) 2017-06-30 2019-01-03 Invista North America S.A.R.L. Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof
US11162115B2 (en) 2017-06-30 2021-11-02 Inv Nylon Chemicals Americas, Llc Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons
BR112020004591A2 (en) 2017-09-08 2020-09-08 Lanzatech, Inc. process to produce one or more fermentation products
US11505809B2 (en) 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
CN109722404B (en) * 2017-10-30 2021-03-12 中国石油化工股份有限公司 Engineering strain and method for preparing farnesene using cellulose
JP2021505154A (en) 2017-12-07 2021-02-18 ザイマージェン インコーポレイテッド Designed biosynthetic pathway for producing (6E) -8-hydroxygeraniol by fermentation
US11555209B2 (en) 2017-12-19 2023-01-17 Lanzatech, Inc. Microorganisms and methods for the biological production of ethylene glycol
WO2019126778A1 (en) 2017-12-21 2019-06-27 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
WO2019157507A1 (en) 2018-02-12 2019-08-15 Lanzatech, Inc. A process for improving carbon conversion efficiency
KR102122898B1 (en) * 2018-02-26 2020-06-15 주식회사 엠디헬스케어 Nanovesicles derived from Blautia bacteria and Use thereof
AU2019257224B2 (en) 2018-04-20 2024-12-19 Lanzatech, Inc. Intermittent electrolysis streams
US11097967B2 (en) 2018-11-19 2021-08-24 Lanzatech, Inc. Integration of fermentation and gasification
CA3129223C (en) 2019-02-08 2023-07-11 Lanzatech, Inc. Process for recovering close boiling products
CN109666683B (en) * 2019-02-27 2021-10-29 昆明理工大学 Acetyl-CoA acetyltransferase gene RKAcaT2 and its application
EP3942058A1 (en) 2019-03-20 2022-01-26 Global Bioenergies Improved means and methods for producing isobutene from acetyl-coa
CN109777815B (en) * 2019-03-28 2021-10-29 昆明理工大学 HMG-CoA synthase gene RKHMGCS and its application
EP4450146A2 (en) 2019-07-11 2024-10-23 LanzaTech , Inc. Methods for optimizing gas utilization
CN110702821B (en) * 2019-11-26 2022-06-07 四川大学华西医院 Typing detection kit for chronic obstructive pulmonary disease
CN115427581A (en) 2020-02-17 2022-12-02 财富科学家股份有限公司 Method for incorporating formaldehyde into biomass
US11932818B2 (en) 2020-03-16 2024-03-19 Lanzatech, Inc. Tail gas of gas fermentation to dry gasification feedstock
CA3171681A1 (en) 2020-03-18 2021-09-23 Fungmin Liew Fermentative production of 2-phenylethanol from gaseous substrates
EP4143325A4 (en) 2020-04-29 2024-09-11 Lanzatech, Inc. FERMENTATIVE PRODUCTION OF BETA-KETOADIPATE FROM GASEOUS SUBSTRATES
KR102863395B1 (en) 2020-06-06 2025-09-23 란자테크, 인크. Microorganisms that have a knockin in the acetolactate decarboxylase gene
EP4208554A4 (en) 2021-02-08 2024-03-20 Lanzatech, Inc. RECOMBINANT MICROORGANISMS AND USES THEREOF
CN115181803B (en) * 2021-04-07 2025-03-21 暨南大学 Taqman probe qPCR primer set for detecting Ichthyophthirius multifida and its application
BR112023020761A2 (en) 2021-04-09 2023-12-12 Lanzatech Inc PROCESS FOR PROVIDING A RAW MATERIAL, AND, APPARATUS FOR PROVIDING A GASEOUS FERMENTATION RAW MATERIAL
US12241105B2 (en) 2021-07-20 2025-03-04 Lanzatech, Inc. Recombinant microorganisms and uses therefor
TW202307202A (en) 2021-08-06 2023-02-16 美商朗澤科技有限公司 Microorganisms and methods for improved biological production of ethylene glycol
EP4144838A1 (en) 2021-09-06 2023-03-08 Global Bioenergies Organisms producing less crotonic acid
EP4399284A1 (en) 2021-09-06 2024-07-17 Global Bioenergies Organisms producing less crotonic acid
US12091648B2 (en) 2021-11-03 2024-09-17 Lanzatech, Inc. System and method for generating bubbles in a vessel
US12280331B2 (en) 2022-04-29 2025-04-22 Lanzatech, Inc. Low residence time gas separator
US12077800B2 (en) 2022-06-16 2024-09-03 Lanzatech, Inc. Liquid distributor system and process of liquid distribution
AU2023286621A1 (en) 2022-06-21 2025-01-09 Lanzatech, Inc. Microorganisms and methods for the continuous co-production of tandem repeat proteins and chemical products from c1-substrates
JP2025525381A (en) 2022-06-21 2025-08-05 ランザテク，インコーポレイテッド Microorganisms and methods for continuous co-production of high-value specialty proteins and chemical products from C1 substrates
US12129503B2 (en) 2022-08-10 2024-10-29 Lanzatech, Inc. Carbon sequestration in soils with production of chemical products
US12281344B2 (en) 2023-06-05 2025-04-22 Lanzatech, Inc. Integrated gas fermentation
WO2024253883A1 (en) * 2023-06-05 2024-12-12 Lanzatech, Inc. Integrated gas fermentation and carbon black processes
CN119876212A (en) * 2025-03-25 2025-04-25 江西农业大学 Prokaryotic expression purification method of rumen vibrio butyrate RnfC protein

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2002A (en) 1841-03-12 Tor and planter for plowing
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
US5593886A (en) 1992-10-30 1997-01-14 Gaddy; James L. Clostridium stain which produces acetic acid from waste gases
EP2305825B1 (en) * 1998-07-06 2015-01-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
UA72220C2 (en) 1998-09-08 2005-02-15 Байоенджініерінг Рісорсиз, Інк. Water-immiscible mixture solvent/cosolvent for extracting acetic acid, a method for producing acetic acid (variants), a method for anaerobic microbial fermentation for obtaining acetic acid (variants), modified solvent and a method for obtaining thereof
ES2267794T3 (en) 2000-07-25 2007-03-16 Emmaus Foundation, Inc. METHOD TO INCREASE THE PRODUCTION OF ETHANOL FROM MICROBIOAN FERMENTATION.
US6989257B2 (en) * 2001-06-06 2006-01-24 Dsm Ip Assets B.V. Isoprenoid production
NZ546496A (en) 2006-04-07 2008-09-26 Lanzatech New Zealand Ltd Gas treatment process
WO2007136847A2 (en) * 2006-05-19 2007-11-29 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
US7704723B2 (en) 2006-08-31 2010-04-27 The Board Of Regents For Oklahoma State University Isolation and characterization of novel clostridial species
EP2066778B1 (en) * 2006-09-26 2016-01-27 The Regents of The University of California Production of isoprenoids and isoprenoid precursors
NZ553984A (en) 2007-03-19 2009-07-31 Lanzatech New Zealand Ltd Alcohol production process
US8609385B2 (en) * 2007-05-01 2013-12-17 Zuvachem, Inc. Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism
US20090082495A1 (en) * 2007-09-20 2009-03-26 Rene Jean Zimmer Pneumatic Tire
CN101868532A (en) * 2007-09-20 2010-10-20 阿迈瑞斯生物技术公司 Preparation of isoprenoids
EP2217696B1 (en) 2007-11-13 2015-09-16 Lanzatech New Zealand Limited Novel bacteria and methods of use thereof
EP3354740A1 (en) * 2007-12-13 2018-08-01 Danisco US Inc. Compositions and methods for producing isoprene
JP2011509691A (en) * 2008-01-22 2011-03-31 ジェノマティカ， インコーポレイテッド Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
WO2009111513A1 (en) * 2008-03-03 2009-09-11 Joule Biotechnologies, Inc. Engineered co2 fixing microorganisms producing carbon-based products of interest
NZ589632A (en) 2008-06-09 2013-03-28 Lanzatech New Zealand Ltd Production of butanediol by anaerobic microbial fermentation
US8609371B2 (en) * 2008-08-12 2013-12-17 Allylix, Inc. Isoprenoid compounds
MY161071A (en) * 2008-12-30 2017-04-14 Danisco Us Inc Methods of producing isoprene and a co-product
TWI427149B (en) * 2009-06-17 2014-02-21 Danisco Us Inc Improved isoprene production using the dxp and mva pathway
US8759047B2 (en) * 2009-09-16 2014-06-24 Coskata, Inc. Process for fermentation of syngas from indirect gasification
WO2011076261A1 (en) 2009-12-22 2011-06-30 Global Bioenergies Process for the production of isoprenol from mevalonate employing a diphosphomevalonate decarboxylase
WO2011112103A1 (en) 2010-03-10 2011-09-15 Lanzatech New Zealand Limited Acid production by fermentation
US8143037B2 (en) 2010-03-19 2012-03-27 Coskata, Inc. Ethanologenic Clostridium species, Clostridium coskatii
US8933282B2 (en) * 2010-06-17 2015-01-13 Danisco Us Inc. Fuel compositions comprising isoprene derivatives
US8987431B2 (en) * 2010-07-01 2015-03-24 Coskata, Inc. Essential genes encoding conserved metabolic pathway function in autotrophic solventogenic clostridial species
WO2012015317A1 (en) 2010-07-28 2012-02-02 Lanzatech New Zealand Limited Novel bacteria and methods of use thereof
US20120045812A1 (en) * 2010-08-06 2012-02-23 Danisco Us Inc. PRODUCTION OF ISOPRENE UNDER NEUTRAL pH CONDITIONS
EP2606138A2 (en) 2010-08-19 2013-06-26 Lanzatech New Zealand Limited A process for producing chemicals using microbial fermentation of substrates comprising carbon monoxide
US20130157322A1 (en) 2010-08-26 2013-06-20 Lanzatech New Zealand Limited Process for producing ethanol and ethylene via fermentation
WO2012034023A2 (en) * 2010-09-10 2012-03-15 University Of Delaware Recombinant clostridia that fix co2 and co and uses thereof
US20110236941A1 (en) * 2010-10-22 2011-09-29 Lanzatech New Zealand Limited Recombinant microorganism and methods of production thereof
US20110256600A1 (en) * 2011-02-02 2011-10-20 Lanzatech New Zealand Limited Recombinant Microorganisms and Methods of Use Thereof
KR102121886B1 (en) 2011-02-25 2020-06-15 란자테크 뉴질랜드 리미티드 Recombinant microorganisms and uses therefor
CA2844064A1 (en) 2011-08-04 2013-02-07 Danisco Us Inc. Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-coa synthase
CN103781912A (en) 2011-09-08 2014-05-07 新西兰郎泽科技公司 a method of fermentation
WO2013052914A2 (en) * 2011-10-07 2013-04-11 Danisco Us Inc. Methods for increasing microbial production of isoprene, isoprenoids, and isoprenoid precursor molecules using glucose and acetate co-metabolism
CA2851265A1 (en) 2011-10-07 2013-05-10 Danisco Us Inc. Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
WO2013053824A1 (en) 2011-10-11 2013-04-18 Metabolic Explorer New biosynthesis pathway for prenol in a recombinant microorganism
CN104508136A (en) 2012-05-30 2015-04-08 新西兰郎泽科技公司 Recombinant microorganisms and uses thereof
WO2013181647A2 (en) * 2012-06-01 2013-12-05 Danisco Us Inc. Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms
US20130323820A1 (en) * 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
CN113186144A (en) 2012-06-08 2021-07-30 朗泽科技新西兰有限公司 Recombinant microorganisms and uses thereof
US9347076B2 (en) 2012-06-21 2016-05-24 Lanzatech New Zealand Limited Recombinant microorganisms that make biodiesel
US9284564B2 (en) 2012-08-28 2016-03-15 Lanzatech New Zealand Limited Recombinant microorganisms comprising stereospecific diol dehydratase enzyme and methods related thereto
US20150152441A1 (en) 2013-11-29 2015-06-04 Lanzatech New Zealand Limited Methods and systems for improving fermentation efficiency
PT3230459T (en) 2014-12-08 2020-12-18 Lanzatech New Zealand Ltd Recombinant microorganisms exhibiting increased flux through a fermentation pathway
CA3151146C (en) 2015-10-13 2024-03-19 Lanzatech Nz, Inc. Genetically engineered bacterium comprising energy-generating fermentation pathway
EP3430151A4 (en) 2016-03-16 2020-09-02 William Marsh Rice University MICROBIAL SYNTHESIS OF ISOPRENOID PRECURSORS, ISOPRENOIDS AND DERIVATIVES INCLUDING PRENYLATED AROMATIC COMPOUNDS
US11555209B2 (en) 2017-12-19 2023-01-17 Lanzatech, Inc. Microorganisms and methods for the biological production of ethylene glycol

Also Published As

Publication number Publication date
JP2018110584A (en) 2018-07-19
DK3346008T3 (en) 2021-01-11
CN111218418A (en) 2020-06-02
EA201492206A1 (en) 2015-09-30
JP2015519065A (en) 2015-07-09
US20180142265A1 (en) 2018-05-24
EP2855662B1 (en) 2018-03-21
PL2855662T3 (en) 2018-08-31
US20210062229A1 (en) 2021-03-04
EA028892B1 (en) 2018-01-31
US20230013524A1 (en) 2023-01-19
US10913958B2 (en) 2021-02-09
US12286660B2 (en) 2025-04-29
EP3795680A1 (en) 2021-03-24
CN104822823B (en) 2020-02-14
US20130323820A1 (en) 2013-12-05
EP2855662A4 (en) 2015-12-30
EP2855662A1 (en) 2015-04-08
US11459589B2 (en) 2022-10-04
CN104822823B8 (en) 2020-05-22
JP6643083B2 (en) 2020-02-12
ES2841725T3 (en) 2021-07-09
CN104822823A (en) 2015-08-05
EP3346008A1 (en) 2018-07-11
WO2013180584A1 (en) 2013-12-05
EP3346008B1 (en) 2020-10-07
ES2674984T3 (en) 2018-07-05
CN111304260A (en) 2020-06-19
US20150191747A1 (en) 2015-07-09
DK2855662T3 (en) 2018-06-25
JP6636550B2 (en) 2020-01-29
PL3346008T3 (en) 2021-04-19

Similar Documents

Publication Publication Date Title
IN2014DN10236A (en)
PH12019501410A1 (en) Novel fermentation systems and methods
NZ604846A (en) Processing biomass
AU2018271755A1 (en) Method for culturing natural killer cell, using transformed T cell
IN2014DN10507A (en)
MX2012008738A (en) Microorganisms and methods for the biosynthesis of p-toluate and terephthalate.
WO2015031441A3 (en) Microorganisms engineered to use unconventional sources of phosphorus or sulfur
IN2014CN03467A (en)
NZ590750A (en) Methods and compositions for improving the production of products in microorganisms, especially clostridium phytofermentans
MY168208A (en) Recombinant microorganisms and uses therefor
WO2014200598A3 (en) Conversion of carbon dioxide utilizing chemoautotrophic microorganisms
WO2009002772A3 (en) Bioreactor
WO2013181647A3 (en) Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms
CA3010562A1 (en) Lactic acid-utilizing bacteria genetically modified to secrete polysaccharide-degrading enzymes
MY173663A (en) Compositions and methods for biological production of fatty acid derivatives
MY161621A (en) Methods and systems for the production of hydrocarbon products
MX351722B (en) Composition comprising an activated microbial biomass.
MY153054A (en) Bioprocessing
IN2014DN07980A (en)
EP3999078A4 (en) Methods for culturing mesenchymal stem cells, products thereof, and applications thereof
EP4389904A3 (en) Microorganisms for producing 4c-5c compounds with unsaturation and methods related thereto
MY160960A (en) Filamentous fungi having an altered viscosity phenotype
WO2010073083A3 (en) Methods of processing ensiled biomass
AR091107A1 (en) PROCESS TO FERMENT GASEOUS SUBSTRATES CONTAINING CARBON MONOXIDE
MX378401B (en) Co-cultivation of propionibacterium and yeast