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IN2014DN07923A - - Google Patents

Info

Publication number
IN2014DN07923A
IN2014DN07923A IN7923DEN2014A IN2014DN07923A IN 2014DN07923 A IN2014DN07923 A IN 2014DN07923A IN 7923DEN2014 A IN7923DEN2014 A IN 7923DEN2014A IN 2014DN07923 A IN2014DN07923 A IN 2014DN07923A
Authority
IN
India
Prior art keywords
present
optically active
bicyclic compound
active bicyclic
enzyme
Prior art date
Application number
Inventor
Yoshitaka Nakamura
Yukito Furuya
Kousei Shimada
Yoshiyuki Onishi
Original Assignee
Daiichi Sankyo Companyltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Companyltd filed Critical Daiichi Sankyo Companyltd
Publication of IN2014DN07923A publication Critical patent/IN2014DN07923A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/12—Formation of amino and carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/32—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/85—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The problem addressed by the present invention is to efficiently produce an optically active bicyclic compound. The present invention efficiently produces an optically active bicyclic compound using an enzyme.
IN7923DEN2014 2012-04-10 2013-04-08 IN2014DN07923A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012089481 2012-04-10
PCT/JP2013/060597 WO2013154066A1 (en) 2012-04-10 2013-04-08 Optical resolution method for bicyclic compound using enzyme

Publications (1)

Publication Number Publication Date
IN2014DN07923A true IN2014DN07923A (en) 2015-05-01

Family

ID=49327629

Family Applications (1)

Application Number Title Priority Date Filing Date
IN7923DEN2014 IN2014DN07923A (en) 2012-04-10 2013-04-08

Country Status (13)

Country Link
US (1) US9394235B2 (en)
EP (1) EP2837689B1 (en)
JP (1) JP6023794B2 (en)
KR (1) KR101976891B1 (en)
CN (1) CN104245951B (en)
BR (1) BR112014025158B1 (en)
CA (1) CA2869994C (en)
ES (1) ES2624314T3 (en)
HU (1) HUE033397T2 (en)
IL (1) IL235002B (en)
IN (1) IN2014DN07923A (en)
TW (1) TWI639702B (en)
WO (1) WO2013154066A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI635071B (en) 2013-07-08 2018-09-11 第一三共股份有限公司 OPTICALLY ACTIVE BICYCLIC γ-AMINO ACID AND PREPARATION METHOD FOR THE SAME
US10150723B2 (en) * 2015-05-27 2018-12-11 Novassay S.A. Separation of enantiomers of 3-ethylbicyclo[3.2.0]hept-3-en-6-one
CN116903468B (en) * 2023-07-14 2024-01-26 山东新时代药业有限公司 Preparation method of milbelin intermediate
WO2025118134A1 (en) * 2023-12-05 2025-06-12 浙江天宇药业股份有限公司 Method for synthesizing mirogabalin besilate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60169434A (en) * 1984-02-14 1985-09-02 Ube Ind Ltd Preparation of optically active bicycloketone
US6635673B1 (en) 1997-10-27 2003-10-21 Warner-Lambert Company Cyclic amino acids and derivatives thereof useful as pharmaceutical agents
HN2000000224A (en) 1999-10-20 2001-04-11 Warner Lambert Co BICYCLE AMINO ACIDS AS PHARMACEUTICAL AGENTS
DE60235619D1 (en) 2001-04-19 2010-04-22 Warner Lambert Co CONCENTRATED BICYCLIC OR TRICYCLIC AMINO ACIDS
JP2005536507A (en) 2002-07-11 2005-12-02 メルク　エンド　カムパニー　インコーポレーテッド Treatment of neuropathic pain with 6H-pyrrolo [3,4-d] pyridazine compounds
ES2531324T3 (en) * 2007-09-28 2015-03-13 Daiichi Sankyo Co Ltd Intermediate to produce a bicyclic gamma-amino acid derivative
WO2010084798A1 (en) * 2009-01-21 2010-07-29 第一三共株式会社 Tricyclic compound
WO2010110361A1 (en) 2009-03-26 2010-09-30 第一三共株式会社 Method for producing bicyclic γ-amino acid derivative
ES2649968T3 (en) * 2011-06-08 2018-01-16 Daiichi Sankyo Company, Limited Production procedure of a bicyclic compound via Claisen transposition
BR112013031360B1 (en) * 2011-06-08 2022-01-25 Daiichi Sankyo Company, Limited Method to make a compound

Also Published As

Publication number Publication date
BR112014025158B1 (en) 2021-09-21
EP2837689B1 (en) 2017-02-15
US9394235B2 (en) 2016-07-19
KR101976891B1 (en) 2019-05-09
US20150038738A1 (en) 2015-02-05
CA2869994C (en) 2017-05-30
EP2837689A4 (en) 2015-09-09
JP6023794B2 (en) 2016-11-09
WO2013154066A1 (en) 2013-10-17
BR112014025158A2 (en) 2017-07-18
CN104245951B (en) 2018-08-24
KR20150004804A (en) 2015-01-13
TWI639702B (en) 2018-11-01
ES2624314T3 (en) 2017-07-13
EP2837689A1 (en) 2015-02-18
HK1205192A1 (en) 2015-12-11
JPWO2013154066A1 (en) 2015-12-17
CN104245951A (en) 2014-12-24
TW201346036A (en) 2013-11-16
HUE033397T2 (en) 2017-12-28
CA2869994A1 (en) 2013-10-17
IL235002B (en) 2018-04-30

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