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IN2014DN07531A - - Google Patents

Info

Publication number
IN2014DN07531A
IN2014DN07531A IN7531DEN2014A IN2014DN07531A IN 2014DN07531 A IN2014DN07531 A IN 2014DN07531A IN 7531DEN2014 A IN7531DEN2014 A IN 7531DEN2014A IN 2014DN07531 A IN2014DN07531 A IN 2014DN07531A
Authority
IN
India
Prior art keywords
biological sample
composite image
generating
providing
image
Prior art date
Application number
Inventor
Antti E Seppo
Fiona Ginty
Kevin B Kenny
David Lavan Henderson
Michael J Gerdes
Moreno Adriana I Larriera
Xiaofeng Liu
Alex D Corwin
Stephen E Zingelewicz
Thomas Ha
Rjun Natalie
Ainura Kyshtoobayeve
Hewgley Denise A Hollman
Ying Li
Original Assignee
Clarient Diagnostic Services Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clarient Diagnostic Services Inc filed Critical Clarient Diagnostic Services Inc
Publication of IN2014DN07531A publication Critical patent/IN2014DN07531A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N33/5752—
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G01N33/575—
    • G01N33/57515—
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A method for providing a composite image of a single biological sample comprising the steps of generating a first image of the biological sample generating a second image of the biological sample and generating a composite image that provides the relative location of both the target protein and the target nucleic acid. Also provided is a method of analyzing a biological sample comprising providing a composite image of the biological sample according to the method for providing a composite image and analyzing the expression of the protein and the nucleic acid sequences of interest from the composite image. Further provided are system and kit that comprise the means for executing the novel methods.
IN7531DEN2014 2012-03-30 2013-03-21 IN2014DN07531A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261618132P 2012-03-30 2012-03-30
PCT/US2013/033249 WO2013148448A1 (en) 2012-03-30 2013-03-21 Immunoflu0rescence and fluorescent-based nucleic acid analysis on a single sample

Publications (1)

Publication Number Publication Date
IN2014DN07531A true IN2014DN07531A (en) 2015-04-24

Family

ID=48050953

Family Applications (1)

Application Number Title Priority Date Filing Date
IN7531DEN2014 IN2014DN07531A (en) 2012-03-30 2013-03-21

Country Status (12)

Country Link
US (2) US20150065371A1 (en)
EP (1) EP2831591B1 (en)
JP (1) JP6225163B2 (en)
KR (1) KR20140142715A (en)
CN (1) CN104520713A (en)
AU (1) AU2013240127B2 (en)
CA (1) CA2867508C (en)
IN (1) IN2014DN07531A (en)
NZ (1) NZ630091A (en)
RU (1) RU2014137129A (en)
SG (1) SG11201406105UA (en)
WO (1) WO2013148448A1 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
CN108267581A (en) 2012-08-24 2018-07-10 耶鲁大学 For the systems, devices and methods of high-throughput multi detection
US10088658B2 (en) 2013-03-18 2018-10-02 General Electric Company Referencing in multi-acquisition slide imaging
WO2015124737A1 (en) * 2014-02-24 2015-08-27 Ventana Medical Systems, Inc. Methods, kits, and systems for scoring the immune response to cancer by simultaneous detection of cd3, cd8, cd20 and foxp3
CN104980558B (en) * 2014-04-01 2019-01-01 中国移动通信集团公司 A kind of method, apparatus of information processing, mobile phone pet client and mobile terminal
WO2015157246A2 (en) * 2014-04-07 2015-10-15 Massachusetts Institute Of Technology Use of microparticle additives to simultaneously enable artifact-free image registration, auto-focusing, and chromatic aberration correction in microscopy
CN107076980A (en) * 2014-08-18 2017-08-18 维斯科技有限公司 System and method for embedded images in the micro- scanning in big visual field
WO2016090148A1 (en) * 2014-12-03 2016-06-09 IsoPlexis Corporation Analysis and screening of cell secretion profiles
US11353448B2 (en) 2015-02-13 2022-06-07 California Institute Of Technology Methods and compositions for quantifying metabolites and proteins from single cells
US10706536B2 (en) * 2015-07-20 2020-07-07 Min Xu Photon structure and chemometrics pathologic system
EP3396375B1 (en) * 2015-12-24 2021-08-04 Konica Minolta, Inc. Image processing device and program
CN107419001A (en) * 2016-05-23 2017-12-01 益善生物技术股份有限公司 BRCA1, PTEN gene unconventionality detection kit and detection method
JP6231709B1 (en) * 2016-05-31 2017-11-15 シスメックス株式会社 Fluorescence image analyzer and analysis method
WO2017212055A1 (en) * 2016-06-10 2017-12-14 F. Hoffmann-La Roche Ag System for bright field image simulation
CN106290878A (en) * 2016-09-10 2017-01-04 天津大学 The preparation method of pancreatic tumour mark CA242 immuno-chromatographic test paper strip based on quantum dot
CN109964126B (en) 2016-09-12 2022-12-27 伊索普莱克西斯公司 Systems and methods for multiplex analysis of cell therapeutics and other immunotherapeutics
EP4300099A3 (en) * 2016-09-26 2024-03-27 Becton, Dickinson and Company Measurement of protein expression using reagents with barcoded oligonucleotide sequences
CN110199196B (en) 2016-11-11 2022-09-30 伊索普莱克西斯公司 Compositions and methods for simultaneous genomic, transcript and proteomic analysis of single cells
EP3545284A4 (en) 2016-11-22 2020-07-01 Isoplexis Corporation SYSTEMS, DEVICES AND METHODS FOR CELL DETECTION AND METHODS FOR THE PRODUCTION THEREOF
JP7116175B2 (en) * 2018-08-22 2022-08-09 オリンパス株式会社 IMAGE PROCESSING APPARATUS, IMAGING SYSTEM, OPERATING METHOD OF IMAGE PROCESSING APPARATUS, AND OPERATING PROGRAM OF IMAGE PROCESSING APPARATUS
US10921223B2 (en) * 2018-10-12 2021-02-16 Shenzhen Prs Limited Process record slide for staining and method of using the same
CN110498858B (en) * 2019-07-26 2024-01-23 深圳市达科为生物工程有限公司 Method for dynamically detecting secretion condition of single-cell exoprotein
JP7420950B2 (en) * 2019-12-17 2024-01-23 アプライド マテリアルズ インコーポレイテッド Systems and methods for acquiring and processing multiplex fluorescence in situ hybridization images
CN115702349A (en) * 2020-05-07 2023-02-14 领先细胞医疗诊断有限公司 Method and kit for simultaneously detecting target nucleic acid and protein
WO2022020340A1 (en) * 2020-07-20 2022-01-27 Akoya Biosciences, Inc. Processing and imaging tissue samples
EP4196906A1 (en) * 2020-08-13 2023-06-21 Ventana Medical Systems, Inc. Automated identification of necrotic regions in digital images of multiplex immunofluorescence stained tissue
CN116194590A (en) * 2020-09-18 2023-05-30 10X基因组学有限公司 Sample processing apparatus and image registration method
CN112415198B (en) * 2020-11-20 2022-11-11 四川大学华西医院 Application of GP1BB detection reagent in preparation of lung cancer screening kit
CN113310963B (en) * 2021-05-31 2023-12-01 四川大学华西医院 An improved immunofluorescence detection method for neutrophil NETs
JP2024545363A (en) 2021-11-16 2024-12-05 ソティオ・バイオテック・インコーポレイテッド Treatment of Patients with Myxoid/Round Cell Liposarcoma
WO2023147133A1 (en) * 2022-01-28 2023-08-03 University Of Southern California Liquid biopsy analytes to define cancer stages
EP4469788A4 (en) * 2022-01-28 2025-12-24 Univ Southern California IDENTIFICATION OF NON-DISCOVERY PATIENTS USING A DISEASE-ASSOCIATED TEST AND ANALYSIS IN LIQUID BIOPSY

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6404906B2 (en) 1997-03-03 2002-06-11 Bacus Research Laboratories,Inc. Method and apparatus for acquiring and reconstructing magnified specimen images from a computer-controlled microscope
US6993169B2 (en) * 2001-01-11 2006-01-31 Trestle Corporation System and method for finding regions of interest for microscopic digital montage imaging
US7629125B2 (en) * 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
WO2010005991A2 (en) * 2008-07-07 2010-01-14 The Board Of Regents Of The University Of Texas System Circulating tumor and tumor stem cell detection using genomic specific probes
US8269827B2 (en) * 2009-09-29 2012-09-18 General Electric Company System and methods for mapping fluorescent images into a bright field color space

Also Published As

Publication number Publication date
KR20140142715A (en) 2014-12-12
US20250102507A1 (en) 2025-03-27
WO2013148448A1 (en) 2013-10-03
JP2015514212A (en) 2015-05-18
NZ630091A (en) 2016-03-31
EP2831591B1 (en) 2019-05-08
US20150065371A1 (en) 2015-03-05
EP2831591A1 (en) 2015-02-04
RU2014137129A (en) 2016-05-27
AU2013240127A1 (en) 2014-10-02
CN104520713A (en) 2015-04-15
AU2013240127B2 (en) 2018-07-12
SG11201406105UA (en) 2014-10-30
JP6225163B2 (en) 2017-11-01
CA2867508A1 (en) 2013-10-03
CA2867508C (en) 2021-05-18

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