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IN2014DE02197A - - Google Patents

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Publication number
IN2014DE02197A
IN2014DE02197A IN2197DE2014A IN2014DE02197A IN 2014DE02197 A IN2014DE02197 A IN 2014DE02197A IN 2197DE2014 A IN2197DE2014 A IN 2197DE2014A IN 2014DE02197 A IN2014DE02197 A IN 2014DE02197A
Authority
IN
India
Prior art keywords
hot
melt
hpmcas
drug
melt extrusion
Prior art date
Application number
Inventor
Naosuke Maruyama
Shogo Warashina
Fumie Kusaki
Sakae Obara
Kazuki Kikuchi
Original Assignee
Shinetsu Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51225402&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DE02197(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shinetsu Chemical Co filed Critical Shinetsu Chemical Co
Publication of IN2014DE02197A publication Critical patent/IN2014DE02197A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

ABSTRACT OF DISCLOSURE Provided are a hot-melt ex trudate excellent in uniform miscibility with a drug; and a method for producing a hot-melt extrudate capable of smoothly feeding a powder in hot-melt extrusion. More specifically, provided are hypromellose acetate succinate (HPMCAS) for use as a hot-melt extrusion carrier having a volume average particle size (D50) of from 70 to 300 ?m as measured by dry laser diffraction and a loose bulk density of from 0.25 to 0.40 g/cm3; and a hot-melt extrusion composition comprising the HPMCAS and a drug. Also provided is a method for producing a hot-melt extrudate comprising the steps of: hot-melting the hot-melt extrusion composition at a hot-melt temperature equal to or higher than a melting temperature of the HPMCAS, or at a hot-melt temperature equal to or higher than a temperature at which both of the HPMCAS and the drug become melt; and extruding the hot-melted composition.
IN2197DE2014 2013-08-12 2014-08-01 IN2014DE02197A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2013167572 2013-08-12

Publications (1)

Publication Number Publication Date
IN2014DE02197A true IN2014DE02197A (en) 2015-06-19

Family

ID=51225402

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2197DE2014 IN2014DE02197A (en) 2013-08-12 2014-08-01

Country Status (6)

Country Link
US (1) US11090295B2 (en)
EP (1) EP2837391B1 (en)
JP (1) JP6162662B2 (en)
KR (1) KR102089112B1 (en)
CN (1) CN104371030B (en)
IN (1) IN2014DE02197A (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6203702B2 (en) * 2014-11-18 2017-09-27 信越化学工業株式会社 Solution for spray drying using hypromellose acetate succinate and method for producing solid dispersion
US10604588B2 (en) 2016-04-05 2020-03-31 Shin-Etsu Chemical Co., Ltd. Hypromellose acetate succinate powder excellent in dissolved state and production method thereof, and production methods for composition for solid dispersion, coating composition, drug-containing particle, and solid preparation
WO2017032908A1 (en) * 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
JP6683561B2 (en) * 2016-07-12 2020-04-22 信越化学工業株式会社 Composition for enteric hard capsule and method for producing enteric hard capsule
JP6742197B2 (en) * 2016-08-29 2020-08-19 信越化学工業株式会社 Process for producing hypromellose phthalate ester
JP6644656B2 (en) * 2016-08-29 2020-02-12 信越化学工業株式会社 Method for producing hypromellose acetate succinate
US20190038754A1 (en) 2017-08-07 2019-02-07 SE Tylose, USA, Inc. Pharmaceutical composition in solid extruded form
TR201722852A2 (en) * 2017-12-29 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Oral pharmaceutical compositions of mesalazine
JP6905035B2 (en) * 2019-11-29 2021-07-21 Ｎｉｓｓｈａ株式会社 Manufacturing method of edible film, film preparation and edible film
JP7399061B2 (en) * 2020-10-01 2023-12-15 信越化学工業株式会社 Method for producing hydroxypropyl methylcellulose phthalate
EP4497760A1 (en) * 2023-07-26 2025-01-29 Shin-Etsu Chemical Co., Ltd. Hydroxypropyl methylcellulose acetate succinate powder, and method of producing the same
CN120938940A (en) * 2025-10-15 2025-11-14 成都药宜立康医药科技有限公司 A melogabalin benzyl sulfonate pharmaceutical composition and its preparation method

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US4226981A (en) 1977-09-28 1980-10-07 Shin-Etsu Chemical Co., Ltd. Ether-ester derivatives of cellulose and their applications
JPS5951562B2 (en) 1977-10-25 1984-12-14 信越化学工業株式会社 Method for producing acidic succinyl and aliphatic monoacyl mixed ester of cellulose ether
JPS5535031A (en) * 1978-09-04 1980-03-11 Shin Etsu Chem Co Ltd Enteric coating composition
JP2528706B2 (en) 1988-05-30 1996-08-28 ゼリア新薬工業株式会社 Pharmaceutical composition of dihydropyridine compound
JP2925346B2 (en) 1991-03-18 1999-07-28 田辺製薬株式会社 Enteric-coated preparation and its production method
JP2527107B2 (en) 1991-04-16 1996-08-21 日本新薬株式会社 Method for producing solid dispersion
JPH0920663A (en) * 1995-07-07 1997-01-21 Teikoku Seiyaku Co Ltd Sustained release fine granules containing ibudilast and method for producing the same
JP4290817B2 (en) 1999-07-29 2009-07-08 株式会社金門製作所 Gas meter
ATE279186T1 (en) * 1999-08-31 2004-10-15 Gruenenthal Gmbh SUSTAINED-RELEASE PHARMACEUTICAL FORM CONTAINING TRAMADOL ACCHARINATE
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CN101121755B (en) * 2006-08-08 2012-04-11 信越化学工业株式会社 Low-substituted hydroxypropyl cellulose powder and preparation method thereof
CN101702878B (en) * 2007-05-11 2012-11-28 弗·哈夫曼-拉罗切有限公司 Pharmaceutical Compositions of Poorly Soluble Drugs
JP2009089982A (en) * 2007-10-11 2009-04-30 Ohara Yakuhin Kogyo Kk Method of granular material for making tablets
NZ588460A (en) 2008-04-15 2012-07-27 Schering Corp Oral pharmaceutical compositions in a solid dispersion comprising preferably posaconazole and hpmcas
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WO2009132208A1 (en) 2008-04-24 2009-10-29 Evestra, Inc. Oral contraceptive dosage forms comprising a progestogen dispersed in an enteric polymer and further comprising an estrogen
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AU2010232670B2 (en) * 2009-04-03 2015-07-09 F. Hoffmann-La Roche Ag Propane- I-sulfonic acid {3- [5- (4 -chloro-phenyl) -1H-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof
JP5324302B2 (en) * 2009-04-22 2013-10-23 信越化学工業株式会社 High moldability, high fluidity, low substituted hydroxypropyl cellulose and solid preparation containing the same
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EP2524688B1 (en) 2011-05-11 2013-05-01 ratiopharm GmbH Composition for modified release comprising ranolazine
CN103083240B (en) * 2011-10-28 2015-12-09 沈阳药科大学 The solid dispersion of paclitaxel and homologue thereof and the preparation of oral formulations thereof

Also Published As

Publication number Publication date
EP2837391B1 (en) 2017-05-10
KR102089112B1 (en) 2020-03-13
JP2015057380A (en) 2015-03-26
KR20150020073A (en) 2015-02-25
CN104371030A (en) 2015-02-25
CN104371030B (en) 2017-08-08
US11090295B2 (en) 2021-08-17
US20150044289A1 (en) 2015-02-12
EP2837391A1 (en) 2015-02-18
JP6162662B2 (en) 2017-07-12

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