[go: up one dir, main page]

IN2012DN02535A - - Google Patents

Download PDF

Info

Publication number
IN2012DN02535A
IN2012DN02535A IN2535DEN2012A IN2012DN02535A IN 2012DN02535 A IN2012DN02535 A IN 2012DN02535A IN 2535DEN2012 A IN2535DEN2012 A IN 2535DEN2012A IN 2012DN02535 A IN2012DN02535 A IN 2012DN02535A
Authority
IN
India
Prior art keywords
specificity
fab
antigen
interest
disulfide bond
Prior art date
Application number
Inventor
Adams Ralph
Hancock Laura
Philip Heywood Sam
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2009/002310 external-priority patent/WO2010035012A1/en
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Publication of IN2012DN02535A publication Critical patent/IN2012DN02535A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest which are a VH/VL pair, wherein the two single domain antibodies are linked by a disulfide bond. Also provided are particular dual specificity antibody fusion proteins and other antibody fragments which are stabilised by a disulfide bond.
IN2535DEN2012 2009-09-25 2010-09-24 IN2012DN02535A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/GB2009/002310 WO2010035012A1 (en) 2008-09-26 2009-09-25 Biological products
GBGB1005063.1A GB201005063D0 (en) 2010-03-25 2010-03-25 Biological products
PCT/GB2010/001803 WO2011036460A1 (en) 2009-09-25 2010-09-24 Disulfide stabilised multivalent antibodies

Publications (1)

Publication Number Publication Date
IN2012DN02535A true IN2012DN02535A (en) 2015-08-28

Family

ID=42228366

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2535DEN2012 IN2012DN02535A (en) 2009-09-25 2010-09-24

Country Status (12)

Country Link
US (1) US20120316324A1 (en)
EP (1) EP2480577B1 (en)
JP (2) JP5931730B2 (en)
CN (2) CN105315374A (en)
BR (1) BR112012006492A2 (en)
CA (1) CA2773286C (en)
EA (1) EA201200526A1 (en)
ES (1) ES2736649T3 (en)
GB (1) GB201005063D0 (en)
IN (1) IN2012DN02535A (en)
TR (1) TR201910213T4 (en)
WO (1) WO2011036460A1 (en)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2622460T3 (en) 2007-09-26 2017-07-06 Ucb Biopharma Sprl Fusions of antibodies with double specificity
EA201100527A1 (en) 2008-09-26 2011-10-31 Юсб Фарма С.А. BIOLOGICAL PRODUCTS
EP2475682B1 (en) 2009-09-10 2018-01-31 UCB Biopharma SPRL Multivalent antibodies
GB201005064D0 (en) * 2010-03-25 2010-05-12 Ucb Pharma Sa Biological products
ES2813432T3 (en) * 2011-08-17 2021-03-23 Glaxo Group Ltd Modified proteins and peptides
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
JP5986207B2 (en) * 2011-09-06 2016-09-06 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ Method for analyzing biopolymer complexes and uses thereof
MX351502B (en) * 2011-11-11 2017-10-18 Ucb Pharma Sa Albumin binding antibodies and binding fragments thereof.
UA112203C2 (en) 2011-11-11 2016-08-10 Юсб Фарма С.А. Fusion protein of a biospecific antibody that binds to human OX40 and serum human albumin
US9212227B2 (en) 2012-04-30 2015-12-15 Janssen Biotech, Inc. ST2L antibody antagonists for the treatment of ST2L-mediated inflammatory pulmonary conditions
GB201223276D0 (en) * 2012-12-21 2013-02-06 Ucb Pharma Sa Antibodies and methods of producing same
US9844607B2 (en) 2013-02-05 2017-12-19 Sanofi Immuno imaging agent for use with antibody-drug conjugate therapy
WO2014122529A1 (en) * 2013-02-05 2014-08-14 Sanofi Immuno imaging agent for use with antibody-drug conjugate therapy
SG11201506053VA (en) * 2013-02-05 2015-08-28 Sanofi Sa Immuno imaging agent for use with antibody-drug conjugate therapy
US9989524B2 (en) 2013-02-05 2018-06-05 Sanofi Immuno imaging agent for use with antibody-drug conjugate therapy
EP2954056A4 (en) 2013-02-08 2016-09-21 Stemcentrx Inc Novel multispecific constructs
RU2015140917A (en) * 2013-02-26 2017-04-03 Роше Гликарт Аг BSPECIFIC ANTI-BINDING MOLECULES ACTIVATING T-CELLS
BR112015017800A2 (en) * 2013-02-26 2017-11-21 Roche Glycart Ag t-cell activating bispecific antigen binding molecules, polynucleotide, polypeptide, vector, host cell, method of making the t-cell activating bispecific antigen binding molecule, pharmaceutical composition and use of the t-cell activating bispecific antigen binding molecule
EP3632930A1 (en) * 2013-08-30 2020-04-08 Aprilbio Co., Ltd An anti serum albumin fab-effector moiety fusion construct
PL3065774T3 (en) 2013-11-06 2021-12-13 Janssen Biotech, Inc Anti-ccl17 antibodies
TWI713453B (en) 2014-06-23 2020-12-21 美商健生生物科技公司 Interferon alpha and omega antibody antagonists
GB201411320D0 (en) 2014-06-25 2014-08-06 Ucb Biopharma Sprl Antibody construct
GB201506869D0 (en) * 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method
GB201506870D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method
CN107921128B (en) 2015-08-05 2022-04-26 詹森生物科技公司 anti-CD 154 antibodies and methods of use thereof
AU2016371034A1 (en) 2015-12-17 2018-05-31 Janssen Biotech, Inc. Antibodies specifically binding HLA-DR and their uses
IL304871A (en) * 2016-01-11 2023-10-01 Inhibrx Inc Multivalent and multispecific 41bb-binding fusion proteins, compositions comprising same and uses thereof
WO2018014260A1 (en) * 2016-07-20 2018-01-25 Nanjing Legend Biotech Co., Ltd. Multispecific antigen binding proteins and methods of use thereof
WO2018068201A1 (en) 2016-10-11 2018-04-19 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against ctla-4
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
CN107674122A (en) * 2016-12-28 2018-02-09 天津天锐生物科技有限公司 A kind of single domain antibody for identifying human serum albumins
US11365240B2 (en) 2017-06-05 2022-06-21 Numab Therapeutics AG Anti-HSA antibodies
WO2018224439A1 (en) * 2017-06-05 2018-12-13 Numab Innovation Ag Novel anti-hsa antibodies
AU2018292438B2 (en) 2017-06-30 2024-11-14 Zymeworks Bc Inc. Stabilized chimeric fabs
WO2019129221A1 (en) 2017-12-28 2019-07-04 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against tigit
EP3740507A4 (en) 2018-01-15 2022-08-24 Nanjing Legend Biotech Co., Ltd. SINGLE-DOMAIN ANTIBODIES AND VARIANTS THEREOF AGAINST PD-1
CN110551216B (en) * 2018-05-31 2022-11-18 信达生物制药(苏州)有限公司 Multivalent anti-OX40 antibody and use thereof
TWI818276B (en) * 2020-06-30 2023-10-11 大陸商和鉑醫藥（上海）有限責任公司 Binding protein of Fab-HCAb structure
WO2022002038A1 (en) * 2020-06-30 2022-01-06 和铂医药(上海)有限责任公司 Multispecific binding protein of immune cell engager, preparation therefor and application thereof
US11859001B2 (en) 2020-08-05 2024-01-02 Synthekine, Inc. IL12RB1-Binding molecules and methods of use
US12077594B2 (en) 2020-08-05 2024-09-03 Synthekine, Inc. IL2RG binding molecules and methods of use
US12234291B2 (en) 2020-08-05 2025-02-25 Synthekine, Inc. IL2RB binding molecules and methods of use
WO2022031890A1 (en) 2020-08-05 2022-02-10 Synthekine, Inc. Ifngr2 binding molecules and methods of use
WO2022032025A1 (en) * 2020-08-05 2022-02-10 Synthekine, Inc. Ifngr binding synthetic cytokines and methods of use
KR20230061393A (en) 2020-08-05 2023-05-08 신테카인, 인크. IL10Rb Binding Molecules and Methods of Use
WO2022032042A1 (en) 2020-08-05 2022-02-10 Synthekine, Inc. Il12 receptor synthetic cytokines and methods of use
KR20250159059A (en) 2020-08-05 2025-11-07 신테카인, 인크. Compositions and methods related to il27 receptor binding
US12012457B1 (en) 2020-08-05 2024-06-18 Synthekine, Inc. IL23R binding molecules and methods of use
US12157773B2 (en) 2020-08-05 2024-12-03 Synthekine, Inc. IL27RAlpha binding molecules and methods of use
US12122839B2 (en) 2020-08-05 2024-10-22 Synthekine, Inc. IFNGR binding synthetic cytokines and methods of use
KR20230061394A (en) 2020-08-05 2023-05-08 신테카인, 인크. IL10Ra Binding Molecules and Methods of Use
JP7743500B2 (en) 2020-08-05 2025-09-24 シンセカイン インコーポレイテッド IL10 receptor binding molecules and methods of use
EP4192862A4 (en) 2020-08-05 2025-01-08 Synthekine, Inc. GP130 BINDING MOLECULES AND METHODS OF USE
MX2023004436A (en) 2020-10-15 2023-05-08 UCB Biopharma SRL Binding molecules that multimerise cd45.

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
DE68927933T2 (en) 1988-09-02 1997-08-14 Dyax Corp PRODUCTION AND SELECTION OF RECOMBINANT PROTEINS WITH DIFFERENT BINDING POINTS
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
EP0368684B2 (en) 1988-11-11 2004-09-29 Medical Research Council Cloning immunoglobulin variable domain sequences.
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US6267964B1 (en) 1989-08-01 2001-07-31 Affibody Technology Sweden Ab Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives
SE509359C2 (en) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Use of stabilized protein or peptide conjugates for the preparation of a drug
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
AU7247191A (en) 1990-01-11 1991-08-05 Molecular Affinities Corporation Production of antibodies using gene libraries
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
ES2284161T3 (en) 1990-01-12 2007-11-01 Amgen Fremont Inc. GENERATION OF XENOGENIC ANTIBODIES.
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
WO1992002551A1 (en) 1990-08-02 1992-02-20 B.R. Centre Limited Methods for the production of proteins with a desired function
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
DE69133476T2 (en) 1990-08-29 2006-01-05 GenPharm International, Inc., Palo Alto Transgenic mice capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
CA2405246A1 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with alterred binding properties
CA2108147C (en) 1991-04-10 2009-01-06 Angray Kang Heterodimeric receptor libraries using phagemids
GB9113120D0 (en) 1991-06-18 1991-08-07 Kodak Ltd Photographic processing apparatus
ES2341666T3 (en) 1991-12-02 2010-06-24 Medimmune Limited PRODUCTION OF AUTHORTIC BODIES OF REPERTORIES OF ANTIQUE RPOS SEGMENTS EXPRESSED ON THE FAGOS SURFACE.
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
PT1589107E (en) 1992-08-21 2010-03-29 Univ Bruxelles IMMUNOGLOBULINS FOR LIGHT CHAINS
GB9221657D0 (en) * 1992-10-15 1992-11-25 Scotgen Ltd Recombinant bispecific antibodies
US5747654A (en) * 1993-06-14 1998-05-05 The United States Of America As Represented By The Department Of Health And Human Services Recombinant disulfide-stabilized polypeptide fragments having binding specificity
WO1995015982A2 (en) 1993-12-08 1995-06-15 Genzyme Corporation Process for generating specific antibodies
EP0744958B1 (en) 1994-01-31 2003-06-25 Trustees Of Boston University Polyclonal antibody libraries
US5516637A (en) 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
JP2978435B2 (en) 1996-01-24 1999-11-15 チッソ株式会社 Method for producing acryloxypropyl silane
EP0904107B1 (en) 1996-03-18 2004-10-20 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
DE19653722C2 (en) 1996-12-10 2000-06-29 Brose Fahrzeugteile Adjustment device acting on both sides
BR9807464A (en) 1997-02-21 2000-05-09 Genentech Inc Conjugate, composition, nucleic acid molecule, expression vector, host cell, method for producing a polypeptide and polypeptide.
GB9720054D0 (en) 1997-09-19 1997-11-19 Celltech Therapeutics Ltd Biological products
GB9812545D0 (en) 1998-06-10 1998-08-05 Celltech Therapeutics Ltd Biological products
WO2000044777A1 (en) * 1999-01-29 2000-08-03 Imclone Systems Incorporated Antibodies specific to kdr and uses thereof
US20060228364A1 (en) 1999-12-24 2006-10-12 Genentech, Inc. Serum albumin binding peptides for tumor targeting
DE60041564D1 (en) 1999-12-24 2009-03-26 Genentech Inc Methods and compositions for extending the disposal half-life of bioactive compounds
JP4955185B2 (en) 2000-06-29 2012-06-20 アボット・ラボラトリーズ Bispecific antibodies and methods for making and using the same
CA2440582A1 (en) 2001-03-09 2002-10-03 Dyax Corp. Serum albumin binding moieties
WO2004058821A2 (en) 2002-12-27 2004-07-15 Domantis Limited Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
WO2004001064A2 (en) 2002-06-21 2003-12-31 Dyax Corporation Serum protein-associated target-specific ligands and identification method therefor
EP1600459A3 (en) 2002-06-28 2005-12-07 Domantis Limited Ligand
EP2301967A3 (en) 2002-11-08 2011-07-13 Ablynx N.V. Single domain antibodies for nasal administration
AU2003285578B2 (en) 2002-12-03 2010-07-15 Ucb Pharma S.A. Assay for identifying antibody producing cells
GB0230201D0 (en) 2002-12-27 2003-02-05 Domantis Ltd Retargeting
GB0230203D0 (en) 2002-12-27 2003-02-05 Domantis Ltd Fc fusion
GB0312481D0 (en) 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
CA2529819A1 (en) 2003-06-30 2004-09-23 Domantis Limited Pegylated single domain antibodies
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
ES2551439T5 (en) 2003-07-01 2018-11-08 Ucb Biopharma Sprl Fab fragments of modified antibodies
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
BRPI0511755A (en) 2004-06-01 2008-01-02 Domantis Ltd drug compositions, fusions and conjugates and methods of production, treatment and use
CA2608770C (en) 2005-05-18 2017-05-30 Ablynx Nv Improved nanobodies against tumor necrosis factor-alpha
BRPI0615026A8 (en) 2005-08-19 2018-03-06 Abbott Lab double variable domain immunoglobulin and its uses
SG170750A1 (en) * 2006-03-17 2011-05-30 Biogen Idec Inc Stabilized polypeptide compositions
UA101142C2 (en) * 2006-03-17 2013-03-11 Байоджэн Айдэк Ма Инк. Method for antibody designing
ES2622460T3 (en) * 2007-09-26 2017-07-06 Ucb Biopharma Sprl Fusions of antibodies with double specificity
EA201100527A1 (en) * 2008-09-26 2011-10-31 Юсб Фарма С.А. BIOLOGICAL PRODUCTS

Also Published As

Publication number Publication date
JP2016106126A (en) 2016-06-16
BR112012006492A2 (en) 2016-11-22
CA2773286C (en) 2020-10-20
US20120316324A1 (en) 2012-12-13
CA2773286A1 (en) 2011-03-31
EP2480577B1 (en) 2019-04-10
EP2480577A1 (en) 2012-08-01
ES2736649T3 (en) 2020-01-03
TR201910213T4 (en) 2019-07-22
CN102549018B (en) 2015-11-25
CN102549018A (en) 2012-07-04
GB201005063D0 (en) 2010-05-12
JP5931730B2 (en) 2016-06-08
WO2011036460A1 (en) 2011-03-31
CN105315374A (en) 2016-02-10
JP2013505923A (en) 2013-02-21
EA201200526A1 (en) 2012-11-30

Similar Documents

Publication Publication Date Title
IN2012DN02535A (en)
EA201100527A1 (en) BIOLOGICAL PRODUCTS
EP2535351A3 (en) Dual specificity antibody fusions
EA201391159A1 (en) HLA-Restricted Peptidospecific Antigen Binding Proteins
WO2008097817A3 (en) Multivariable antigens complexed with targeting humanized monoclonal antibody
WO2016154047A3 (en) Monoclonal antigen-binding proteins to intracellular oncogene products
NZ709390A (en) Folate receptor 1 antibodies and immunoconjugates and uses thereof
WO2013054331A8 (en) Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam)
AR077088A1 (en) BISPECIFIC PROTEINS OF ANTIGEN UNION
AU2010234031A8 (en) Trivalent, bispecific antibodies
RU2011148913A (en) IMMUNOGLOBULIN WITH TWO VARIABLE DOMAINS AND ITS APPLICATION
CY1118709T1 (en) ANTIGENIC Peptides of the Stimulating Colony Stimulating Factor (GM-CSF) AND ANTIBODIES FOR TON GM-CSF
NZ623706A (en) Anti-il-17a/il-17f cross-reactive antibodies and methods of use thereof
IL186948A0 (en) Monoclonal antibodies and methods for their use in the detection of cervical disease
WO2008098917A3 (en) Novel antibodies against igf-ir
NO20071436L (en) Humanized Anti-5T4 Antibodies and Anti-5T4 Antibody / Calicheamicin Conjugates
WO2011064257A3 (en) Monospecific polypeptide reagents
MX2010001237A (en) Novel antibodies.
WO2007067596A3 (en) Methods and compositions for needleless delivery of antibodies
EP3300739A3 (en) Antibodies and related molecules that bind to 161p2f10b proteins
WO2008140487A3 (en) Improved staphylococcal protein a mono- and bispecific antibodies and methods of their use
MX2009008754A (en) Novel antibodies against igf-ir.
WO2005065711A3 (en) Mammalian receptor proteins; related reagents and methods
WO2017062966A8 (en) Antibodies specific for 4,6-diamino-5-(formylamino) pyrimidine and uses thereof
WO2008143702A3 (en) Anti-mrp3 antibodies and methods of use