IN2012DN00855A - - Google Patents
Info
- Publication number
- IN2012DN00855A IN2012DN00855A IN855DEN2012A IN2012DN00855A IN 2012DN00855 A IN2012DN00855 A IN 2012DN00855A IN 855DEN2012 A IN855DEN2012 A IN 855DEN2012A IN 2012DN00855 A IN2012DN00855 A IN 2012DN00855A
- Authority
- IN
- India
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005116698 | 2005-04-14 | ||
| PCT/JP2006/308162 WO2006112464A1 (en) | 2005-04-14 | 2006-04-12 | Piperazine-substituted benzothiophenes for treatment of mental disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN00855A true IN2012DN00855A (en) | 2015-07-10 |
Family
ID=36645750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN855DEN2012 IN2012DN00855A (en) | 2005-04-14 | 2012-01-31 |
Country Status (27)
| Country | Link |
|---|---|
| US (14) | USRE48059E1 (en) |
| EP (1) | EP1869025B3 (en) |
| KR (1) | KR100937623B1 (en) |
| CN (1) | CN101155804B (en) |
| AR (1) | AR053577A1 (en) |
| AT (1) | ATE496911T3 (en) |
| AU (1) | AU2006237905C1 (en) |
| BE (1) | BE2018C037I2 (en) |
| BR (1) | BRPI0609785B8 (en) |
| CA (1) | CA2602247C (en) |
| CY (2) | CY1111206T1 (en) |
| DE (1) | DE602006019838D1 (en) |
| DK (1) | DK1869025T6 (en) |
| ES (1) | ES2358631T7 (en) |
| HU (2) | HUE011611T6 (en) |
| IL (1) | IL185909A (en) |
| IN (1) | IN2012DN00855A (en) |
| LT (1) | LTC1869025I2 (en) |
| LU (1) | LUC00086I2 (en) |
| MY (1) | MY142746A (en) |
| NL (1) | NL300946I2 (en) |
| PL (1) | PL1869025T6 (en) |
| PT (1) | PT1869025E (en) |
| SI (1) | SI1869025T1 (en) |
| TW (1) | TWI320783B (en) |
| WO (1) | WO2006112464A1 (en) |
| ZA (1) | ZA200708686B (en) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06000795A (en) | 2003-07-22 | 2006-08-23 | Arena Pharm Inc | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related therto. |
| SA05260357B1 (en) | 2004-11-19 | 2008-09-08 | ارينا فارماسيتو تيكالز ، أنك | 3-phenyle-pyrazole derivatives as modulators of the 5-ht 2a serotonin receptor useful for the treatment of disorders related thereto |
| TWI320783B (en) * | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| CN104761498B (en) | 2006-05-18 | 2017-12-26 | 艾尼纳制药公司 | The conditioning agent of 5 HT2A serotonin receptors |
| EP2527329A1 (en) | 2006-05-18 | 2012-11-28 | Arena Pharmaceuticals, Inc. | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-ht2a serotonin receptor |
| US8148417B2 (en) | 2006-05-18 | 2012-04-03 | Arena Pharmaceuticals, Inc. | Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| TWI415845B (en) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | Pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| WO2008047883A1 (en) * | 2006-10-13 | 2008-04-24 | Otsuka Pharmaceutical Co., Ltd. | Piperazine-substituted benzothiophenes for treatment of mental disorders |
| US20080186971A1 (en) * | 2007-02-02 | 2008-08-07 | Tarari, Inc. | Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic |
| US9567327B2 (en) | 2007-08-15 | 2017-02-14 | Arena Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| WO2009101018A2 (en) * | 2008-02-15 | 2009-08-20 | F. Hoffmann-La Roche Ag | 3-alkyl-piperazine derivatives and uses thereof |
| MX2010008921A (en) | 2008-02-22 | 2010-09-07 | Actelion Pharmaceuticals Ltd | Oxazolidinone derivatives. |
| US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US9034911B2 (en) | 2008-10-28 | 2015-05-19 | Arena Pharmaceuticals, Inc. | Composition of a 5-HT2A serotonin receptor modulator useful for the treatment of disorders related thereto |
| WO2010062321A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto |
| HRP20171415T4 (en) | 2009-06-25 | 2023-03-03 | Alkermes Pharma Ireland Limited | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS |
| US8980891B2 (en) | 2009-12-18 | 2015-03-17 | Arena Pharmaceuticals, Inc. | Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| CA2797708C (en) | 2010-05-04 | 2016-08-16 | Alkermes Pharma Ireland Limited | Process for synthesizing oxidized lactam compounds |
| ES2691671T3 (en) | 2010-06-24 | 2018-11-28 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
| TWI636784B (en) * | 2011-04-05 | 2018-10-01 | 大塚製藥股份有限公司 | Medicinal compositions and kits containing 7-[4-(4-benzo[b]thiophen-4-yl-piperidin-1-yl)butoxy]-1H-quinolin-2-one, and Use |
| CA2843241C (en) | 2011-07-28 | 2021-01-26 | Otsuka Pharmaceutical Co., Ltd. | Method for producing benzo[b]thiophene compound |
| JO3227B1 (en) | 2011-09-08 | 2018-03-08 | Otsuka Pharma Co Ltd | Piperazine-substituted benzothiophene deriveatives as antipsychotic agents |
| JO3753B1 (en) * | 2011-10-14 | 2021-01-31 | Otsuka Pharma Co Ltd | Tablet comprising 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof |
| AR088372A1 (en) * | 2011-10-19 | 2014-05-28 | Otsuka Pharma Co Ltd | SOLUTION FOR ORAL ADMINISTRATION |
| TW201332572A (en) * | 2011-12-28 | 2013-08-16 | Otsuka Pharma Co Ltd | Pharmaceutical preparation comprising substituted β -cyclodextrin |
| JOP20200109A1 (en) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | Injectable preparation |
| AR090775A1 (en) * | 2012-04-23 | 2014-12-03 | Otsuka Pharma Co Ltd | INJECTABLE PREPARATION |
| TWI562991B (en) * | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
| WO2013169964A1 (en) * | 2012-05-09 | 2013-11-14 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| JOP20210047A1 (en) | 2012-10-25 | 2017-06-16 | Otsuka Pharma Co Ltd | Prophylactic and/or therapeutic agent for behavioral and psychological symptoms associated with neurodegenerative disease or impulsive symptoms associated with mental disease containing brexpiprazole or salt thereof |
| EP2792359A1 (en) * | 2013-04-19 | 2014-10-22 | Merz Pharma GmbH & Co. KGaA | Treatment of L-DOPA-induced dyskinesia with OPC-14523 or OPC-34712 |
| KR101472916B1 (en) * | 2013-06-27 | 2014-12-16 | 한국과학기술연구원 | Pharmaceutical composition comprising morpholine or piperazine based compounds, and donepezil for preventing or treating cognitive impairment-related disease |
| CN104557896A (en) | 2013-10-18 | 2015-04-29 | 沈敬山 | Brexpiprezole, and preparation methods of key intermediate and salt thereof |
| CN104892589A (en) * | 2014-03-07 | 2015-09-09 | 中国科学院上海药物研究所 | Heterocyclic compound, preparation method therefor and use thereof |
| BR112016024510A2 (en) | 2014-04-22 | 2017-08-15 | H Lundbeck As | medicament, use of brexpiprazole or a pharmaceutically acceptable salt thereof, methods for preventing or treating a substance related disorder and for producing a pharmaceutical composition, pharmaceutical composition, and kit. |
| CN104447723A (en) * | 2014-11-28 | 2015-03-25 | 瑞阳制药有限公司 | Method for preparing 7-(4-(4-(benzo[b]thienyl)-1-piperazinyl) butoxy)-2(1H)-quinolinone |
| CN105461703B (en) * | 2014-12-29 | 2019-05-17 | 深圳市泛谷药业股份有限公司 | A kind of preparation method of brexpiprazole |
| CN105985314A (en) * | 2015-02-05 | 2016-10-05 | 苏州旺山旺水生物医药有限公司 | Preparation method of brexpiprazole analogue |
| CN104844586A (en) * | 2015-04-16 | 2015-08-19 | 重庆医药工业研究院有限责任公司 | Amorphous brexpiprazole and preparation method thereof |
| CN104829588B (en) * | 2015-04-30 | 2017-03-29 | 苏州苏旺森生物医药科技有限公司 | A kind of Preparation Method And Their Intermediate of benzo [b] thiophene |
| CN104829603A (en) * | 2015-05-19 | 2015-08-12 | 杭州新博思生物医药有限公司 | Crystal form A brexpiprazole hydrochloride and preparation method thereof |
| RU2017145976A (en) | 2015-06-12 | 2019-07-15 | Аксовант Сайенсиз Гмбх | Diaryl- and arylheteroarylurea derivatives applicable for the prevention and treatment of behavioral disturbances during the REM phase of sleep |
| EP3322415A4 (en) | 2015-07-15 | 2019-03-13 | Axovant Sciences GmbH | ARYLHERETOARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONINERGIC RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF HALLUCINATIONS ASSOCIATED WITH NEURODEGENERATIVE DISEASE |
| CN105061414B (en) * | 2015-07-21 | 2019-01-01 | 杭州新博思生物医药有限公司 | One kettle way prepares Brexpiprazole |
| WO2017025987A1 (en) | 2015-08-11 | 2017-02-16 | Mylan Laboratories Limited | Process for the preparation of brexpiprazole |
| EP3150591A1 (en) | 2015-10-02 | 2017-04-05 | Crystal Pharma S.A.U | Process and intermediates for the preparation of benzo[b]thiophene compounds |
| CN106749219A (en) * | 2015-11-20 | 2017-05-31 | 江苏恩华药业股份有限公司 | A kind of lactam derivative and its application |
| CN105440026A (en) * | 2015-12-04 | 2016-03-30 | 上海勋和医药科技有限公司 | Elopiprazole preparation method |
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| WO2017106641A1 (en) | 2015-12-17 | 2017-06-22 | Assia Chemical Industries Ltd. | Solid state forms of brexpiprazole |
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| US10464931B2 (en) | 2015-12-28 | 2019-11-05 | Honour (R&D) | Process for the preparation of Quinolin-2(1H)-one derivatives |
| CN106938982A (en) * | 2016-01-05 | 2017-07-11 | 连云港皓海医药科技有限公司 | The preparation method of the auspicious piperazine azoles of cloth and the compound for preparing the auspicious piperazine azoles of cloth |
| CN105399736B (en) * | 2016-01-07 | 2018-10-19 | 安徽省逸欣铭医药科技有限公司 | It is a kind of according to the new preparation method of piperazine azoles |
| US10501450B2 (en) | 2016-02-01 | 2019-12-10 | Hexal Ag | Anhydrate-free polymorphically pure micronized crystalline brexpiprazole di-hydrate for use in intramuscular injectable sustained release formulations |
| CN105541819B (en) * | 2016-02-04 | 2018-09-14 | 浙江永宁药业股份有限公司 | A kind of preparation method of the Preparation Method And Their Intermediate and intermediate of epirizole group |
| US20170320862A1 (en) | 2016-05-03 | 2017-11-09 | Cadila Healthcare Limited | Process for the preparation of brexpiprazole and intermediates thereof |
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| WO2017208251A1 (en) * | 2016-05-31 | 2017-12-07 | Cipla Limited | A new stable polymorph of brexpiprazole and process for preparation thereof |
| WO2017216661A1 (en) | 2016-06-17 | 2017-12-21 | Jubilant Generics Limited | Process for the preparation of brexpiprazole from 7-(4-chlorobutoxy)quinolin-2(1h)-one and 1-(benzo[b]thiophen-4-yl)piperazine |
| US10034861B2 (en) | 2016-07-04 | 2018-07-31 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
| PL233778B1 (en) | 2016-07-19 | 2019-11-29 | Adamed Spolka Z Ograniczona Odpowiedzialnoscia | Method for producing brexpiprazole, intermediate compounds used in this method and method for producing them |
| WO2018033481A1 (en) | 2016-08-16 | 2018-02-22 | H E X A L Aktiengesellschaft | Immediate release tablet of a benzothiophene compound |
| WO2018033484A1 (en) | 2016-08-16 | 2018-02-22 | Hexal Aktiengesellschaft | Pharmaceutical compositions of a benzothiophene compound |
| WO2018060916A1 (en) * | 2016-09-28 | 2018-04-05 | Alembic Pharmaceuticals Limited | Process for the preparation of brexpiprazole and intermediates thereof |
| CN107936005A (en) * | 2016-10-13 | 2018-04-20 | 上海科胜药物研发有限公司 | One kind is according to piperazine azoles novel crystal forms II and preparation method thereof |
| US11279696B2 (en) | 2016-11-09 | 2022-03-22 | Msn Laboratories Private Limited | Processes for the preparation of 7-{4-[4-(1-benzothiophen-4-yl) piperazin-1-yl]butoxy}quinolin-2(1H)-one |
| CN111233848A (en) * | 2016-12-14 | 2020-06-05 | 上海博志研新药物技术有限公司 | Epipprazole methanol compound, crystal form A, preparation method and application thereof |
| WO2018141886A1 (en) | 2017-02-02 | 2018-08-09 | Hexal Aktiengesellschaft | Crystalline brexpiprazole |
| WO2018172463A1 (en) | 2017-03-22 | 2018-09-27 | Amneal Pharmaceuticals Company Gmbh | Process for the preparation of brexpiprazole |
| WO2019073481A1 (en) * | 2017-10-12 | 2019-04-18 | Indoco Remedies Limited | Process for the preparation of brexpiprazole and its intermediates |
| SG11202005361RA (en) | 2017-12-14 | 2020-07-29 | H Lundbeck As | Combination treatments comprising administration of 1h-pyrazolo[4,3-b]pyridines |
| AR113926A1 (en) | 2017-12-14 | 2020-07-01 | H Lundbeck As | DERIVATIVES OF 1H-PYRAZOLE [4,3-B] PYRIDINES |
| EP3501506B1 (en) | 2017-12-19 | 2019-10-09 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising brexpiprazole |
| EP3728250A1 (en) | 2017-12-20 | 2020-10-28 | H. Lundbeck A/S | PYRAZOLO[3,4-beta]PYRIDINES AND IMIDAZO[1,5-beta]PYRIDAZINES AS PDE1 INHIBITORS |
| CN109988162A (en) * | 2017-12-29 | 2019-07-09 | 武汉兴华智慧医药科技有限公司 | One kind is according to piperazine Zole derivatives and preparation method thereof |
| EP3545950A1 (en) | 2018-03-26 | 2019-10-02 | Adamed sp. z o.o. | Pharmaceutical composition comprising brexpiprazole |
| JP2021531329A (en) * | 2018-06-21 | 2021-11-18 | シャンハイ インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ | Maleate of benzothiophene compound, its crystalline form and its use |
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