IN2012DN00551A - - Google Patents
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- Publication number
- IN2012DN00551A IN2012DN00551A IN551DEN2012A IN2012DN00551A IN 2012DN00551 A IN2012DN00551 A IN 2012DN00551A IN 551DEN2012 A IN551DEN2012 A IN 551DEN2012A IN 2012DN00551 A IN2012DN00551 A IN 2012DN00551A
- Authority
- IN
- India
- Prior art keywords
- radioimmunoconjugate
- relates
- methods
- radioimmvmoconjugate
- hum195
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 3
- 229940051022 radioimmunoconjugate Drugs 0.000 abstract 2
- 238000002372 labelling Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22771009P | 2009-07-22 | 2009-07-22 | |
| PCT/US2010/042885 WO2011011592A1 (fr) | 2009-07-22 | 2010-07-22 | Procédés de génération de radioimmunoconjugués |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN00551A true IN2012DN00551A (fr) | 2015-06-12 |
Family
ID=43499411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN551DEN2012 IN2012DN00551A (fr) | 2009-07-22 | 2010-07-22 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9603954B2 (fr) |
| EP (1) | EP2456472B1 (fr) |
| JP (2) | JP5985392B2 (fr) |
| CN (2) | CN102596258B (fr) |
| CA (1) | CA2768658C (fr) |
| IN (1) | IN2012DN00551A (fr) |
| RU (2) | RU2565402C2 (fr) |
| WO (1) | WO2011011592A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201208309D0 (en) * | 2012-05-11 | 2012-06-27 | Algeta As | Complexes |
| US20150157742A1 (en) * | 2013-12-11 | 2015-06-11 | The European Atomic Energy Community (Euratom), Represented By The European Commission | SYNTHESIS OF BIOLOGICAL COMPOUNDS LABELED WITH THE ALPHA EMITTER Ac-225 |
| EP3142710A4 (fr) * | 2014-05-16 | 2018-04-25 | Memorial Sloan Kettering Cancer Center | Marquage en une étape par actinium-225 d'anticorps pour obtenir une haute activité spécifique |
| US11149059B2 (en) * | 2015-09-08 | 2021-10-19 | Waters Technologies Corporation | Multidimensional chromatography method for analysis of antibody-drug conjugates |
| US11896683B2 (en) | 2016-12-16 | 2024-02-13 | The Australian National University | Radiolabelled material for targeted administration |
| ES2960030T3 (es) | 2017-01-12 | 2024-02-29 | Radiomedix Inc | Tratamiento de células cancerosas que sobreexpresan receptores de somatostatina utilizando derivados de ocreótido quelados con radioisótopos |
| EP4592320A3 (fr) * | 2017-07-31 | 2025-09-24 | Actinium Pharmaceuticals, Inc. | Traitements pour une malignité hématologique |
| CN109550061A (zh) * | 2017-09-26 | 2019-04-02 | 南京江原安迪科正电子研究发展有限公司 | 一种用于放射性核素标记抗体的试剂盒及应用 |
| US20230390424A1 (en) * | 2020-09-11 | 2023-12-07 | Actinium Pharmaceuticals, Inc. | Trophoblast glycoprotein radioimmunotherapy for the treatment of solid cancers |
| US12447218B1 (en) * | 2021-02-09 | 2025-10-21 | Actinium Pharmaceuticals, Inc. | Radioconjugates directed to MHC-complexed antigens in cancer |
| EP4490197A2 (fr) | 2022-03-24 | 2025-01-15 | Actinium Pharmaceuticals, Inc. | Anticorps anti-cd45 humanisés |
| CA3252793A1 (fr) | 2022-03-30 | 2025-07-07 | Nihon Medi-Physics Co., Ltd. | Procédé de production de complexe |
| CA3258344A1 (fr) | 2022-06-07 | 2023-12-14 | Actinium Pharmaceuticals, Inc. | Chélateurs et conjugués bifonctionnels |
| CN120225566A (zh) | 2022-08-22 | 2025-06-27 | 雅博得乐医疗公司 | Dll3结合分子及其用途 |
| US20250388688A1 (en) | 2024-04-04 | 2025-12-25 | Ethyreal Bio, Inc. | Anti-tshr antibodies and uses thereof |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4001387A (en) | 1973-07-30 | 1977-01-04 | Medi-Physics, Inc. | Process for preparing radiopharmaceuticals |
| US4305922A (en) | 1978-10-04 | 1981-12-15 | University Patents, Inc. | Labeling proteins with 99m-Tc by ligand exchange |
| US4296785A (en) | 1979-07-09 | 1981-10-27 | Mallinckrodt, Inc. | System for generating and containerizing radioisotopes |
| US4454106A (en) | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
| US4472509A (en) | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4732864A (en) | 1983-10-06 | 1988-03-22 | E. I. Du Pont De Nemours And Company | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules |
| US4894364A (en) | 1983-10-26 | 1990-01-16 | Greer Sheldon B | Method and materials for sensitizing neoplastic tissue to radiation |
| US4828991A (en) | 1984-01-31 | 1989-05-09 | Akzo N.V. | Tumor specific monoclonal antibodies |
| US4663129A (en) | 1985-01-30 | 1987-05-05 | The United States Of America As Represented By The United States Department Of Energy | Isotopic generator for bismuth-212 and lead-212 from radium |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5306509A (en) | 1987-03-17 | 1994-04-26 | Turner Robert E | Prevention and treatment of oral lesions |
| IL87405A0 (en) | 1987-08-12 | 1989-01-31 | Immunomedics Inc | Radiolabeled agents and methods and kits for the production thereof |
| US4833329A (en) | 1987-11-20 | 1989-05-23 | Mallinckrodt, Inc. | System for generating and containerizing radioisotopes |
| US5612016A (en) * | 1988-04-01 | 1997-03-18 | Immunomedics, Inc. | Conjugates of antibodies and bifunctional ligands |
| US4923985A (en) | 1988-05-25 | 1990-05-08 | The United States Of America As Represented By The Department Of Health & Human Services | Process for synthesizing macrocyclic chelates |
| DE68925904T2 (de) | 1988-05-25 | 1996-10-31 | The United States Of America, Represented By The Secretary, U.S. Department Of Commerce, Springfield, Va. | Makrocyclische chelate und verwendungsverfahren |
| US5292868A (en) | 1989-05-26 | 1994-03-08 | Akzo N.V. | Chelating agents for attaching metal ions to proteins |
| ES2053196T3 (es) | 1989-06-19 | 1994-07-16 | Akzo Nv | Metodo para la produccion de un radioinmunoconjugado. |
| JP3194433B2 (ja) | 1989-07-12 | 2001-07-30 | マリンクロッド・インコーポレイテッド | 放射線診断用気体放射性核種の製造方法および放射線診断用気体放射性核種の製造装置 |
| US5443816A (en) | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| LU87684A1 (de) | 1990-02-23 | 1991-10-08 | Euratom | Verfahren zur erzeugung von aktinium-225 und wismut-213 |
| US5038046A (en) | 1990-07-10 | 1991-08-06 | Biotechnetics | Method and generator for producing radioactive lead-212 |
| US6403771B1 (en) | 1991-02-19 | 2002-06-11 | Actinium Pharmaceuticals, Limited | Method and means for site directed therapy |
| CA2100709C (fr) | 1992-07-27 | 2004-03-16 | Maurits W. Geerlings | Methode et moyens pour une therapie ciblee |
| IL113610A0 (en) * | 1994-06-03 | 1995-08-31 | Immunomedics Inc | A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same |
| CA2328528C (fr) | 1998-05-20 | 2009-07-21 | Immunomedics, Inc. | Medicament renfermant un anticorps bispecifique antipathogene/anti-chaine invariante de la classe ii du systeme hla |
| DE69937797D1 (de) * | 1998-05-26 | 2008-01-31 | Sloan Kettering Inst Cancer | Alpha-emittierende konstrukte sowie deren verwendung |
| CA2690395C (fr) | 1998-06-22 | 2013-11-05 | Immunomedics, Inc. | Utilisation d'anticorps bi-specifiques pour diagnostic et therapie de pre-ciblage |
| CA2422291C (fr) * | 2000-09-15 | 2011-03-08 | Sloan-Kettering Institute For Cancer Research | Therapie par particules alpha ciblees utilisant des conjugues d'actinium-225 |
| US6670456B2 (en) * | 2001-02-28 | 2003-12-30 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
| WO2002080987A1 (fr) * | 2001-04-09 | 2002-10-17 | Progenics Pharmaceuticals, Inc. | Immunotoxines anti-cd19 |
| US7666414B2 (en) * | 2001-06-01 | 2010-02-23 | Cornell Research Foundation, Inc. | Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen |
| IL162201A0 (en) * | 2002-01-03 | 2005-11-20 | Schering Ag | New methods for diagnosis and treatment of tumours |
| US20040022726A1 (en) * | 2002-06-03 | 2004-02-05 | Goldenberg David M. | Methods and compositions for intravesical therapy of bladder cancer |
| US20030086868A1 (en) * | 2002-08-12 | 2003-05-08 | Dangshe Ma | Actinium-225 complexes and conjugates for radioimmunotherapy |
| US20060058218A1 (en) * | 2004-09-10 | 2006-03-16 | General Electric Company | Solid phase conjugation of complexing agents and targeting moieties |
| US7736647B2 (en) * | 2005-06-15 | 2010-06-15 | Monoclonal Antibodies Therapeutics | Anti-CD71 monoclonal antibodies and uses thereof for treating malignant tumor cells |
| CA2650953A1 (fr) * | 2006-05-03 | 2007-11-15 | Bayer Schering Pharma Aktiengesellschaft | Combinaison d'un anticorps l19-sip anti domaine ed-b de la fibronectine et d'un anticorps anti-egfr |
-
2010
- 2010-07-22 IN IN551DEN2012 patent/IN2012DN00551A/en unknown
- 2010-07-22 WO PCT/US2010/042885 patent/WO2011011592A1/fr not_active Ceased
- 2010-07-22 JP JP2012521780A patent/JP5985392B2/ja active Active
- 2010-07-22 RU RU2012106301/15A patent/RU2565402C2/ru active
- 2010-07-22 CA CA2768658A patent/CA2768658C/fr active Active
- 2010-07-22 US US13/386,316 patent/US9603954B2/en active Active
- 2010-07-22 EP EP10802893.7A patent/EP2456472B1/fr active Active
- 2010-07-22 CN CN201080036704.4A patent/CN102596258B/zh active Active
- 2010-07-22 RU RU2015137512A patent/RU2704802C2/ru active
- 2010-07-22 CN CN201510083376.8A patent/CN104710504B/zh active Active
-
2016
- 2016-08-03 JP JP2016152696A patent/JP2016199583A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2456472A4 (fr) | 2014-08-27 |
| CN102596258A (zh) | 2012-07-18 |
| JP2016199583A (ja) | 2016-12-01 |
| CN104710504B (zh) | 2019-09-13 |
| RU2704802C2 (ru) | 2019-10-31 |
| CN104710504A (zh) | 2015-06-17 |
| EP2456472A1 (fr) | 2012-05-30 |
| WO2011011592A1 (fr) | 2011-01-27 |
| CA2768658C (fr) | 2018-04-03 |
| EP2456472C0 (fr) | 2024-03-27 |
| EP2456472B1 (fr) | 2024-03-27 |
| JP5985392B2 (ja) | 2016-09-06 |
| RU2015137512A (ru) | 2018-12-25 |
| CN102596258B (zh) | 2015-01-28 |
| CA2768658A1 (fr) | 2011-01-27 |
| US20120220754A1 (en) | 2012-08-30 |
| HK1211304A1 (en) | 2016-05-20 |
| RU2565402C2 (ru) | 2015-10-20 |
| RU2012106301A (ru) | 2013-08-27 |
| JP2013500258A (ja) | 2013-01-07 |
| RU2015137512A3 (fr) | 2019-04-02 |
| US9603954B2 (en) | 2017-03-28 |
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