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IN2013MU03442A - - Google Patents

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Publication number
IN2013MU03442A
IN2013MU03442A IN3442MU2013A IN2013MU03442A IN 2013MU03442 A IN2013MU03442 A IN 2013MU03442A IN 3442MU2013 A IN3442MU2013 A IN 3442MU2013A IN 2013MU03442 A IN2013MU03442 A IN 2013MU03442A
Authority
IN
India
Prior art keywords
glycerol
present
phenylbutyrate
reacting
iii
Prior art date
Application number
Inventor
Sanket Pandurang Jadhav
Deepak Puna Mahajan
Sagar Purushottam Nehate
Himanshu Madhav Godbole
Girij Pal Singh
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Priority to PCT/IB2014/065578 priority Critical patent/WO2015063659A1/en
Priority to IN3442MU2013 priority patent/IN2013MU03442A/en
Publication of IN2013MU03442A publication Critical patent/IN2013MU03442A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to the process for the preparation of glycerol phenylbutyrate (I) by reacting phenylbutyryl chloride (II) with glycerol (III) in presence of organic base in C1-C5 chlorinated solvent. Glycerol phenylbutyrate (I) prepared according the process of the present invention is having HPLC purity >99%.
IN3442MU2013 2013-10-30 2014-10-24 IN2013MU03442A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/IB2014/065578 WO2015063659A1 (en) 2013-10-30 2014-10-24 Process for the preparation of glycerol phenylbutyrate
IN3442MU2013 IN2013MU03442A (en) 2013-10-30 2014-10-24

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN3442MU2013 IN2013MU03442A (en) 2013-10-30 2014-10-24

Publications (1)

Publication Number Publication Date
IN2013MU03442A true IN2013MU03442A (en) 2015-07-17

Family

ID=51982661

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3442MU2013 IN2013MU03442A (en) 2013-10-30 2014-10-24

Country Status (2)

Country Link
IN (1) IN2013MU03442A (en)
WO (1) WO2015063659A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2760479B1 (en) 2011-09-30 2017-05-03 Horizon Therapeutics, LLC Nitrogen scavenging drug for use in a method of treating a nitrogen retention disorder
US9914692B2 (en) 2016-05-25 2018-03-13 Horizon Therapeutics, Llc Procedure for the preparation of 4-phenyl butyrate and uses thereof
CN106117045A (en) * 2016-06-22 2016-11-16 北京阳光诺和药物研究有限公司 A kind of purification process of phenylbutyric acid
US20190076383A1 (en) * 2017-09-08 2019-03-14 Horizon Therapeutics, Llc Methods for treating urea cycle disorders
US10668040B2 (en) 2017-09-11 2020-06-02 Horizon Therapeutics, Llc Treatment of urea cycle disorders in neonates and infants
WO2020070760A1 (en) * 2018-10-04 2020-04-09 Msn Laboratories Private Limited, R&D Center An improved process for the preparation of 1,2,3-propanetriyl tris(4-phenylbutanoate)
CN113845420B (en) * 2021-10-22 2024-04-16 安徽沃泰生物医药有限公司 Synthesis process of phenylbutyrate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69612755T2 (en) 1995-02-07 2001-08-23 Brusilow Enterprises, Llc TRIGLYCERIDES AND ETHYLESTERS OF PHENYLALKOIC ACIDS AND PHENYLALKOIC ACIDS FOR THE TREATMENT OF VARIOUS DISEASES
IT1317073B1 (en) 2000-12-12 2003-05-26 Mini Ricerca Scient Tecnolog Production of phenylbutyric acid esters for therapeutic use
EP2607366A1 (en) 2011-12-21 2013-06-26 Lunamed AG Glycerol phenyl butyrate esters

Also Published As

Publication number Publication date
WO2015063659A1 (en) 2015-05-07

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