IN2001KN01110A - - Google Patents
Info
- Publication number
- IN2001KN01110A IN2001KN01110A IN1110KON2001A IN2001KN01110A IN 2001KN01110 A IN2001KN01110 A IN 2001KN01110A IN 1110KON2001 A IN1110KON2001 A IN 1110KON2001A IN 2001KN01110 A IN2001KN01110 A IN 2001KN01110A
- Authority
- IN
- India
- Prior art keywords
- group
- integer
- compound
- so2nhcor12
- cr15and
- Prior art date
Links
- 229910052799 carbon Inorganic materials 0.000 abstract 5
- 229910052760 oxygen Inorganic materials 0.000 abstract 5
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The present invention discloses a compound comprising a carboxylic acid derivative of the structure wherein Y, at each occurrence, is independently selected from the group consisting of C(O), N, CR1, C(R2)(R3), NR5, CH, O and S; q is an integer of from 3 to 10; A is selected from the group consisting of O, S, C(R16)(R) and NR6; 10 E is selected from the group consisting of CH2, O, S, and NR7; J is selected from the group consisting of O, S and NR6; T is selected from the group consisting of C(O) and (CH2)b wherein b is an integer of from 0 to 3; M is selected from the group consisting of C(R9)(R10) and (CH12)u, wherein u is an integer of from 0 to 3; L is selected from the group consisting of O, NR11, S, and (CH2), wherein n is an integer of 0 or 1; X is selected from the group consisting of CO2B, PO3H2, SO3H, SO2NH2, SO2NHCOR12, OPO3H2, C(O)NHC(O)R13, C(O)NHSO2R14, hydroxyl, tetrazolyl and hydrogen; W is selected from the group consisting of C, CR15and N; and B, B, R1 R2, R3, R4, R5, R6, R7, R8, R9, R10 R11, R, 12R,13 R,14 R,15, R16 and R17 are as defined in the specification with the proviso that when A is C(R16)(R17), E is not NR7 and pharmaceutical compounds comprising the compound.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13297199P | 1999-05-07 | 1999-05-07 | |
| PCT/US2000/012303 WO2000067746A1 (en) | 1999-05-07 | 2000-05-05 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2001KN01110A true IN2001KN01110A (en) | 2015-06-05 |
Family
ID=22456441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1110KON2001 IN2001KN01110A (en) | 1999-05-07 | 2000-11-16 |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1176956B1 (en) |
| JP (1) | JP5132855B2 (en) |
| AT (1) | ATE383153T1 (en) |
| AU (1) | AU5267900A (en) |
| CA (1) | CA2373360C (en) |
| CY (1) | CY1107438T1 (en) |
| CZ (1) | CZ303312B6 (en) |
| DE (1) | DE60037726T2 (en) |
| DK (1) | DK1176956T3 (en) |
| ES (1) | ES2296625T3 (en) |
| IL (2) | IL146311A0 (en) |
| IN (1) | IN2001KN01110A (en) |
| MX (1) | MXPA01011340A (en) |
| NO (1) | NO324421B1 (en) |
| NZ (1) | NZ515248A (en) |
| PL (1) | PL205322B1 (en) |
| RO (1) | RO122246B1 (en) |
| RU (1) | RU2263109C2 (en) |
| SI (1) | SI20744B (en) |
| SK (1) | SK286696B6 (en) |
| TR (2) | TR200201920T2 (en) |
| WO (1) | WO2000067746A1 (en) |
| ZA (1) | ZA200108774B (en) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| US6723711B2 (en) * | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
| AR026748A1 (en) | 1999-12-08 | 2003-02-26 | Vertex Pharma | A CASPASE INHIBITING COMPOUND, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, A METHOD FOR THE SYNTHESIS OF THE SAME AND AN INTERMEDIATE COMPOUND PARADICHA SYNTHESIS |
| ES2200617B1 (en) | 2001-01-19 | 2005-05-01 | Almirall Prodesfarma, S.A. | DERIVATIVES OF UREA AS ANTAGONISTS OF INTEGRINAS ALPHA 4. |
| SI21096B (en) * | 2001-10-09 | 2012-05-31 | Encysive Pharmaceuticals Inc | Carboxylic acid derivatives that inhibit the binding of integrins to,their receptors |
| ATE448784T1 (en) * | 2002-02-14 | 2009-12-15 | Pharmacia Corp | SUBSTITUTED PYRIDINONES AS MODULATORS FOR P38 MAP KINASE |
| US7553852B2 (en) | 2002-06-28 | 2009-06-30 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| CN1703395A (en) | 2002-08-09 | 2005-11-30 | 特兰斯泰克制药公司 | Aryl and heteroaryl compounds and methods to modulate coagulation |
| BR0316104A (en) * | 2002-11-08 | 2005-09-27 | Schering Corp | Combination products with carboxylic acid derivatives that inhibit the binding of integrins to their receptors and other therapeutic compounds |
| US7612091B2 (en) | 2002-12-20 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| PE20050159A1 (en) | 2003-05-27 | 2005-04-19 | Vertex Pharma | DERIVATIVES OF 3- [2- (3-AMINO-2-OXO-2H-PYRIDIN-1-IL) -ACETILAMINO] -4-OXO-PENTANOICO AS CASPASE INHIBITORS |
| US7459472B2 (en) | 2003-08-08 | 2008-12-02 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| US7208601B2 (en) | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
| CN1832920A (en) | 2003-08-08 | 2006-09-13 | 特兰斯泰克制药公司 | Aryl and heteroaryl compounds, compositions, and methods of use |
| WO2007022964A2 (en) | 2005-08-24 | 2007-03-01 | Abbott Gmbh & Co. Kg | Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-ht5-receptors |
| CA2680366C (en) * | 2007-03-09 | 2016-06-21 | University Health Network | Inhibitors of carnitine palmitoyltransferase and treating cancer |
| WO2009015485A1 (en) | 2007-08-01 | 2009-02-05 | University Health Network | Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer |
| JP2012525336A (en) * | 2009-04-27 | 2012-10-22 | エラン ファーマシューティカルズ，インコーポレイテッド | Alpha-4 integrin pyridinone antagonist |
| WO2011031658A1 (en) | 2009-09-09 | 2011-03-17 | E. I. Du Pont De Nemours And Company | Herbicidal pyrimidone derivatives |
| WO2012033548A2 (en) * | 2010-09-07 | 2012-03-15 | E. I. Du Pont De Nemours And Company | Herbicidal bis-nitrogen-containing oxo and sulfono heterocycles |
| TWI537259B (en) * | 2012-01-31 | 2016-06-11 | 第一三共股份有限公司 | Pyridone derivative |
| JP6537500B2 (en) | 2013-09-20 | 2019-07-03 | ビオマリン プハルマセウトイカル インコーポレイテッド | Glucosylceramide synthase inhibitors for the treatment of diseases |
| KR20170052526A (en) | 2014-03-13 | 2017-05-12 | 프로테나 바이오사이언시즈 리미티드 | Combination treatment for multiple sclerosis |
| CA2943363A1 (en) * | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Anti-fibrotic pyridinones |
| US10246451B2 (en) * | 2017-04-26 | 2019-04-02 | Aviara Pharmaceuticals, Inc. | Propionic acid derivatives and methods of use thereof |
| US10875875B2 (en) * | 2017-04-26 | 2020-12-29 | Aviara Pharmaceuticals, Inc. | Propionic acid derivatives and methods of use thereof |
| CA3061174C (en) | 2017-04-28 | 2024-06-04 | Texas Children's Hospital | Targeting nanoparticles |
| SI3746441T1 (en) * | 2018-02-02 | 2023-08-31 | Genentech Inc. | THE PHARMACEUTICAL COMPOUND, ITS SALTS, ITS FORMULATIONS AND PROCEDURE FOR THEIR PRODUCTION AND USE |
| MX2021005050A (en) | 2018-10-30 | 2021-06-15 | Gilead Sciences Inc | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS. |
| ES2987796T3 (en) | 2018-10-30 | 2024-11-18 | Gilead Sciences Inc | N-benzoyl-phenylalanine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases |
| KR102641718B1 (en) | 2018-10-30 | 2024-02-29 | 길리애드 사이언시즈, 인코포레이티드 | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| CN112969504B (en) | 2018-10-30 | 2024-04-09 | 吉利德科学公司 | Compounds for inhibiting α4β7 integrin |
| US11578069B2 (en) | 2019-08-14 | 2023-02-14 | Gilead Sciences, Inc. | Compounds for inhibition of α4 β7 integrin |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2614189A1 (en) * | 1976-04-02 | 1977-10-20 | Hoechst Ag | Analgesic, antiinflammatory and antipyretic thiazolyl-urea derivs. - prepd. by reacting an isocyanato-carboxylic acid cpd. with an amino-or hydrazino-thiazole |
| US5220017A (en) * | 1991-04-10 | 1993-06-15 | Merck & Co., Inc. | Cholecystokinin antagonists |
| CA2159450C (en) * | 1993-03-31 | 2002-01-08 | Norman Anthony Abood | 1-amidinophenyl-pyrrolidones piperidinones azetinones as platelet aggregation inhibitors |
| US5534529A (en) * | 1993-06-30 | 1996-07-09 | Sankyo Company, Limited | Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses |
| US5770573A (en) * | 1993-12-06 | 1998-06-23 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
| JPH07304755A (en) * | 1994-05-12 | 1995-11-21 | Yamanouchi Pharmaceut Co Ltd | Condensed diazepine derivative |
| US5610296A (en) * | 1994-12-05 | 1997-03-11 | G. D. Searle & Co. | Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs |
| US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| DK0912901T3 (en) * | 1996-05-15 | 2002-02-25 | Searle & Co | Method and Reagent for Monitoring Blood Levels of Antibody Compounds |
| JP2001500875A (en) * | 1996-09-18 | 2001-01-23 | メルク エンド カンパニー インコーポレーテッド | Combination therapy to reduce cardiovascular disease-related risks |
| US6025358A (en) * | 1998-06-11 | 2000-02-15 | G. D. Searle & Co. | Double prodrugs of potent GP IIb/IIIa antagonists |
| AU5991699A (en) * | 1998-09-21 | 2000-04-10 | Biochem Pharma Inc. | Quinolizinones as integrin inhibitors |
-
2000
- 2000-05-05 PL PL351396A patent/PL205322B1/en unknown
- 2000-05-05 IL IL14631100A patent/IL146311A0/en active IP Right Grant
- 2000-05-05 SI SI200020021A patent/SI20744B/en not_active IP Right Cessation
- 2000-05-05 NZ NZ515248A patent/NZ515248A/en not_active IP Right Cessation
- 2000-05-05 AT AT00937527T patent/ATE383153T1/en active
- 2000-05-05 RO ROA200101210A patent/RO122246B1/en unknown
- 2000-05-05 CA CA2373360A patent/CA2373360C/en not_active Expired - Lifetime
- 2000-05-05 CZ CZ20013963A patent/CZ303312B6/en not_active IP Right Cessation
- 2000-05-05 DE DE60037726T patent/DE60037726T2/en not_active Expired - Lifetime
- 2000-05-05 DK DK00937527T patent/DK1176956T3/en active
- 2000-05-05 RU RU2001133360/04A patent/RU2263109C2/en not_active IP Right Cessation
- 2000-05-05 MX MXPA01011340A patent/MXPA01011340A/en active IP Right Grant
- 2000-05-05 SK SK1608-2001A patent/SK286696B6/en not_active IP Right Cessation
- 2000-05-05 ES ES00937527T patent/ES2296625T3/en not_active Expired - Lifetime
- 2000-05-05 TR TR2002/01920T patent/TR200201920T2/en unknown
- 2000-05-05 EP EP00937527A patent/EP1176956B1/en not_active Expired - Lifetime
- 2000-05-05 TR TR2001/03178T patent/TR200103178T2/en unknown
- 2000-05-05 AU AU52679/00A patent/AU5267900A/en not_active Abandoned
- 2000-05-05 WO PCT/US2000/012303 patent/WO2000067746A1/en not_active Ceased
- 2000-05-05 JP JP2000616772A patent/JP5132855B2/en not_active Expired - Fee Related
- 2000-11-16 IN IN1110KON2001 patent/IN2001KN01110A/en unknown
-
2001
- 2001-10-24 ZA ZA200108774A patent/ZA200108774B/en unknown
- 2001-11-01 IL IL146311A patent/IL146311A/en not_active IP Right Cessation
- 2001-11-06 NO NO20015418A patent/NO324421B1/en not_active IP Right Cessation
-
2008
- 2008-03-05 CY CY20081100253T patent/CY1107438T1/en unknown
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