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IL89535A0 - Process and novel intermediates for the preparation of 1-cyclopropyl-quinolone-carboxylic acids and their derivatives - Google Patents

Process and novel intermediates for the preparation of 1-cyclopropyl-quinolone-carboxylic acids and their derivatives

Info

Publication number
IL89535A0
IL89535A0 IL89535A IL8953589A IL89535A0 IL 89535 A0 IL89535 A0 IL 89535A0 IL 89535 A IL89535 A IL 89535A IL 8953589 A IL8953589 A IL 8953589A IL 89535 A0 IL89535 A0 IL 89535A0
Authority
IL
Israel
Prior art keywords
quinolone
cyclopropyl
derivatives
preparation
carboxylic acids
Prior art date
Application number
IL89535A
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL89535A0 publication Critical patent/IL89535A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL89535A 1988-03-11 1989-03-08 Process and novel intermediates for the preparation of 1-cyclopropyl-quinolone-carboxylic acids and their derivatives IL89535A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3808118A DE3808118A1 (en) 1988-03-11 1988-03-11 METHOD FOR PRODUCING 1-CYCLOPROPYL-QUINOLON CARBONIC ACIDS AND THEIR DERIVATIVES

Publications (1)

Publication Number Publication Date
IL89535A0 true IL89535A0 (en) 1989-09-10

Family

ID=6349471

Family Applications (1)

Application Number Title Priority Date Filing Date
IL89535A IL89535A0 (en) 1988-03-11 1989-03-08 Process and novel intermediates for the preparation of 1-cyclopropyl-quinolone-carboxylic acids and their derivatives

Country Status (8)

Country Link
EP (1) EP0332930A2 (en)
JP (1) JPH01268679A (en)
KR (1) KR890014489A (en)
CN (1) CN1037335A (en)
DE (1) DE3808118A1 (en)
FI (1) FI891123A7 (en)
IL (1) IL89535A0 (en)
PT (1) PT89956A (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT67395A (en) * 1993-07-13 1995-04-28 Somfai Method for the n-cyclopropylation of primary and secondary aromatic amines
WO1999032450A1 (en) * 1997-12-22 1999-07-01 Pharmacia & Upjohn Company 4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents
CN104788328B (en) 2004-06-24 2017-09-12 沃泰克斯药物股份有限公司 The adjusting control agent of ATP combination cassette transporters
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
CN1305849C (en) * 2004-12-29 2007-03-21 江苏正大天晴药业股份有限公司 Method for preparing 3-methylamino piperidine and its salt
CN100457737C (en) * 2005-04-05 2009-02-04 中国人民解放军军事医学科学院毒物药物研究所 Quinolyl amide derivative and its prepn process and use
WO2007079139A2 (en) 2005-12-28 2007-07-12 Vertex Pharmaceuticals, Inc. Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
MX2008011633A (en) 2006-03-13 2008-12-16 Activx Biosciences Inc Aminoquinolones as gsk-3 inhibitors.
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US8071591B2 (en) 2009-03-11 2011-12-06 Kyorin Pharmaceutical Co., Ltd. 7-cycloalkylaminoquinolones as GSK-3 inhibitors
SG10201504084QA (en) 2009-03-20 2015-06-29 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
CN109966264A (en) 2012-02-27 2019-07-05 沃泰克斯药物股份有限公司 Pharmaceutical compositions and their administration
US9701639B2 (en) 2014-10-07 2017-07-11 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
CN107602465A (en) * 2016-07-12 2018-01-19 重庆大学 A kind of carbostyril derivative and its application

Also Published As

Publication number Publication date
FI891123L (en) 1989-09-12
EP0332930A2 (en) 1989-09-20
CN1037335A (en) 1989-11-22
KR890014489A (en) 1989-10-24
DE3808118A1 (en) 1989-09-21
FI891123A0 (en) 1989-03-09
FI891123A7 (en) 1989-09-12
PT89956A (en) 1989-11-10
JPH01268679A (en) 1989-10-26

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