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IL84876A0 - Stable formulations of ricin toxin a chain and of rta-immunoconjugates and stabilizer screening methods therefor - Google Patents

Stable formulations of ricin toxin a chain and of rta-immunoconjugates and stabilizer screening methods therefor

Info

Publication number
IL84876A0
IL84876A0 IL84876A IL8487687A IL84876A0 IL 84876 A0 IL84876 A0 IL 84876A0 IL 84876 A IL84876 A IL 84876A IL 8487687 A IL8487687 A IL 8487687A IL 84876 A0 IL84876 A0 IL 84876A0
Authority
IL
Israel
Prior art keywords
immunoconjugates
rta
chain
screening methods
methods therefor
Prior art date
Application number
IL84876A
Other languages
English (en)
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of IL84876A0 publication Critical patent/IL84876A0/xx

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02Food
    • G01N33/14Beverages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817Toxins
    • A61K47/6819Plant toxins
    • A61K47/6825Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
    • A61K47/6827Ricin A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/861Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgG3, IgG4, IgA, or IgY

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Botany (AREA)
  • Analytical Chemistry (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
IL84876A 1986-12-19 1987-12-18 Stable formulations of ricin toxin a chain and of rta-immunoconjugates and stabilizer screening methods therefor IL84876A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/944,347 US4808705A (en) 1986-12-19 1986-12-19 Stable formulations of ricin toxin a chain and of RTA-immunoconjugates and stabilizer screening methods therefor

Publications (1)

Publication Number Publication Date
IL84876A0 true IL84876A0 (en) 1988-06-30

Family

ID=25481236

Family Applications (1)

Application Number Title Priority Date Filing Date
IL84876A IL84876A0 (en) 1986-12-19 1987-12-18 Stable formulations of ricin toxin a chain and of rta-immunoconjugates and stabilizer screening methods therefor

Country Status (11)

Country Link
US (1) US4808705A (xx)
EP (1) EP0271918A3 (xx)
JP (1) JPS63258426A (xx)
AU (1) AU593489B2 (xx)
CA (1) CA1305417C (xx)
DK (1) DK670587A (xx)
FI (1) FI875608A7 (xx)
HU (1) HUT45401A (xx)
IE (1) IE873452L (xx)
IL (1) IL84876A0 (xx)
NO (1) NO875232L (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5393512A (en) * 1985-01-14 1995-02-28 Vanderheyden; Jean-Luc Stable therapeutic radionuclide compositions and methods for preparation thereof
US5116944A (en) * 1989-12-29 1992-05-26 Neorx Corporation Conjugates having improved characteristics for in vivo administration
US5270057A (en) * 1990-03-20 1993-12-14 Akzo N.V. Stabilized gonadotropin containing preparations
KR100361933B1 (ko) * 1993-09-08 2003-02-14 라 졸라 파마슈티칼 컴파니 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
ES2178854T3 (es) * 1997-11-07 2003-01-01 Conjuchem Inc Bibliotecas de marcadores de afinidad para albumina de suero humano.
US6458953B1 (en) * 1998-12-09 2002-10-01 La Jolla Pharmaceutical Company Valency platform molecules comprising carbamate linkages
US20070020662A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computerized control of high-throughput experimental processing and digital analysis of comparative samples for a compound of interest
US20070021929A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computing methods for control of high-throughput experimental processing, digital analysis, and re-arraying comparative samples in computer-designed arrays
HK1054684A1 (zh) * 2000-06-08 2003-12-12 La Jolla Pharmaceutical 包含高分子量聚环氧乙烷的多价平台分子
PT1343518E (pt) * 2000-11-07 2009-08-03 Novartis Vaccines & Diagnostic Composições de interferão estabilizadas
WO2003009817A2 (en) 2001-07-25 2003-02-06 Protein Design Labs, Inc. Stable lyophilized pharmaceutical formulation of igg antibodies
US20100210027A9 (en) * 2002-11-04 2010-08-19 Hongming Chen Method for determining effect of preformulation forms on their dissolution rates
SG144160A1 (en) * 2003-07-24 2008-07-29 Bracco Imaging Spa Stable radiopharmaceutical compositions and methods for their preparation
FR2877565A1 (fr) * 2004-11-09 2006-05-12 Oreal Utilisation d'un sulfate de dextran de haut poids moleculaire comme agent apaisant
EP1909838A2 (en) * 2005-07-29 2008-04-16 Amgen Inc. Formulations that inhibit protein aggregation
EP1980853A1 (en) * 2007-04-11 2008-10-15 Alfresa Pharma Corporation Method of preventing precipitation of a reactive substance-bound microparticle, and reagent containing the micro particle
US20080261328A1 (en) * 2007-04-19 2008-10-23 Alfresa Pharma Corporation Method of preventing precipitation of a reactive substance-bound microparticle, and reagent containing the micro particle
US8747848B2 (en) 2008-06-20 2014-06-10 Novartis Ag Immunoglobulins with reduced aggregation
CA2794628A1 (en) 2010-03-31 2011-10-06 Universite De Geneve Stabilized antibody preparations and uses thereof
EP2552482A2 (en) 2010-03-31 2013-02-06 Université de Genève Stabilized antibody preparations and uses thereof
GB201717966D0 (en) 2017-10-31 2017-12-13 Xenikos Bv Immunotoxins, formulations thereof and their use in medicine
CN111781345A (zh) * 2020-06-30 2020-10-16 上海透景生命科技股份有限公司 化学发光标记物标记抗原稳定剂及其应用
CN119498456A (zh) * 2024-12-10 2025-02-25 山东海创工贸有限公司 一种利用奶制品和肉产品作为原料的宠物湿粮及其制作方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4439181A (en) * 1981-01-26 1984-03-27 Regents Of The University Of Minnesota Polyol-hormone mixture for use in chronic parenteral hormone administration
JPS59116229A (ja) * 1982-12-24 1984-07-05 Teijin Ltd 細胞毒性複合体を活性成分とする癌治療用剤およびその製造法
US4664911A (en) * 1983-06-21 1987-05-12 Board Of Regents, University Of Texas System Immunotoxin conjugates employing toxin B chain moieties
AU609380B2 (en) * 1985-11-29 1991-05-02 Consolidated Pharmaceuticals Limited Ricin-antibody conjugates

Also Published As

Publication number Publication date
HUT45401A (en) 1988-07-28
AU8280187A (en) 1988-06-23
IE873452L (en) 1988-06-19
US4808705A (en) 1989-02-28
JPS63258426A (ja) 1988-10-25
DK670587A (da) 1988-06-20
AU593489B2 (en) 1990-02-08
CA1305417C (en) 1992-07-21
FI875608A0 (fi) 1987-12-18
NO875232D0 (no) 1987-12-15
EP0271918A2 (en) 1988-06-22
NO875232L (no) 1988-06-20
DK670587D0 (da) 1987-12-18
EP0271918A3 (en) 1989-12-13
FI875608A7 (fi) 1988-06-20

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