[go: up one dir, main page]

IL71620A0 - Use of yeast homologous signals to secrete heterologous proteins - Google Patents

Use of yeast homologous signals to secrete heterologous proteins

Info

Publication number
IL71620A0
IL71620A0 IL71620A IL7162084A IL71620A0 IL 71620 A0 IL71620 A0 IL 71620A0 IL 71620 A IL71620 A IL 71620A IL 7162084 A IL7162084 A IL 7162084A IL 71620 A0 IL71620 A0 IL 71620A0
Authority
IL
Israel
Prior art keywords
heterologous proteins
yeast homologous
secrete heterologous
homologous signals
signals
Prior art date
Application number
IL71620A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL71620A0 publication Critical patent/IL71620A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL71620A 1983-04-25 1984-04-24 Use of yeast homologous signals to secrete heterologous proteins IL71620A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48833783A 1983-04-25 1983-04-25

Publications (1)

Publication Number Publication Date
IL71620A0 true IL71620A0 (en) 1984-07-31

Family

ID=23939341

Family Applications (1)

Application Number Title Priority Date Filing Date
IL71620A IL71620A0 (en) 1983-04-25 1984-04-24 Use of yeast homologous signals to secrete heterologous proteins

Country Status (9)

Country Link
EP (1) EP0127304A1 (xx)
JP (1) JPS6041488A (xx)
KR (1) KR840008697A (xx)
AU (1) AU2721884A (xx)
DK (1) DK204884A (xx)
ES (1) ES8602137A1 (xx)
IL (1) IL71620A0 (xx)
NZ (1) NZ207925A (xx)
ZA (1) ZA843061B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8334261D0 (en) * 1983-12-22 1984-02-01 Bass Plc Fermentation processes
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
DE3436818A1 (de) * 1984-10-06 1986-04-10 Hoechst Ag, 6230 Frankfurt Synthetische signalsequenz zum transport von proteinen in expressionssystemen
DE3578435D1 (de) * 1984-12-06 1990-08-02 Labofina Sa Promotoren fuer die expression von fremden genen in hefe, plasmide, die diese promotoren enthalten, sowie deren verwendung zur herstellung von polypeptiden.
US5198345A (en) * 1985-04-15 1993-03-30 Gist-Brocades N.V. Vectors in use in filamentous fungi
WO1986006097A1 (en) * 1985-04-15 1986-10-23 Allelix, Inc. Promoters of filamentous fungi and use thereof
US5024941A (en) * 1985-12-18 1991-06-18 Biotechnica International, Inc. Expression and secretion vector for yeast containing a glucoamylase signal sequence
EP0255153B1 (en) * 1986-06-03 1995-01-18 Unilever N.V. Production of guar alpha-galactosidase by hosts transformed by recombinant DNA methods
CA1339101C (en) * 1986-06-03 1997-07-29 Nicolaas Overbeeke Production of guar alpha-galactosidase and immunologically related alpha-galactosidases by host organisms transformed with recombinant dna methods
IL83435A (en) * 1986-09-23 1993-01-14 Miles Lab Dna construct for expression of genes in yeast, an expression vector containing it and yeast transformed with said expression vector
DE3635867A1 (de) * 1986-10-22 1988-05-11 Boehringer Ingelheim Int Neue hefeexpressionsvektoren fuer ifn-omega, verfahren zu ihrer herstellung und deren verwendung
JPH01240191A (ja) * 1988-02-16 1989-09-25 Green Cross Corp:The 酵母で機能する新規シグナルペプチドおよびこれを用いた異種蛋白質の分泌発現
ATE135045T1 (de) * 1988-07-23 1996-03-15 Delta Biotechnology Ltd Sekretorische leader-sequenzen
CU22722A1 (es) * 1996-10-03 2002-02-28 Ct Ingenieria Genetica Biotech Sistema de transformación para la expresión de genes heterólogos en la levadura candida utilis
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
JP4955764B2 (ja) 2006-06-20 2012-06-20 モガム バイオテクノロジー リサーチ インスティチュート 酵母発現系における組み換え外来タンパク質の分泌効率を増強するための方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast

Also Published As

Publication number Publication date
ES531897A0 (es) 1985-12-01
AU2721884A (en) 1984-11-01
DK204884D0 (da) 1984-04-24
ES8602137A1 (es) 1985-12-01
JPS6041488A (ja) 1985-03-05
EP0127304A1 (en) 1984-12-05
KR840008697A (ko) 1984-12-17
DK204884A (da) 1984-12-07
ZA843061B (en) 1984-11-28
NZ207925A (en) 1988-05-30

Similar Documents

Publication Publication Date Title
GB8306285D0 (en) Processing and secretion of heterologous proteins by yeast
GB8308483D0 (en) Secretion of gene products
IL72643A0 (en) Microbial expression of interleukin ii
ZA843061B (en) Use of yeast homologous signals to secrete heterologous proteins
AU7474787A (en) Secretion of heterologous proteins from yeast
IL74751A0 (en) Preparation of cephalosporins
JPS57208989A (en) Production of single cell protein
IL73569A0 (en) Preparation of protease inhibitors
GB2143822B (en) Preparation of 3-exomethylene cephalosporins
PH19817A (en) Preparation of sauerkraut utilizing hydrolyzed protein
AU3672984A (en) Ether of n-propanolamine derivative
EP0130007A3 (en) Preparation of amino-polyols
AU562717B2 (en) Preparation of cyanotetrachlorobenzenes
AU3388184A (en) Preparation of carrier-bound fibrin
GB2142933B (en) Method of culture
GB8328854D0 (en) Pneumatic gathering of milled peat
AU574347B2 (en) Preparation of esters
IE841001L (en) Use of yeast homologous signals to secrete heterologous¹proteins
AU567734B2 (en) Preparation of 20-keto-delta 16 - steroids and intermediates
GB8314001D0 (en) Preparation of alphahaloalkyl esters
AU3422584A (en) Preparation of 2-acyl-5-acyl substituted aryl-3- hydroxycyclohex--2-en-1-ones
AU2760784A (en) Bonding of rubber to metal
JPS57181653A (en) Production of protein isolate
SU1147747A1 (en) Method of growing yeast
JPS5711992A (en) Manufacture of protein isolate