[go: up one dir, main page]

IL67721A0 - Production of human mono-clonal antibodies - Google Patents

Production of human mono-clonal antibodies

Info

Publication number
IL67721A0
IL67721A0 IL67721A IL6772183A IL67721A0 IL 67721 A0 IL67721 A0 IL 67721A0 IL 67721 A IL67721 A IL 67721A IL 6772183 A IL6772183 A IL 6772183A IL 67721 A0 IL67721 A0 IL 67721A0
Authority
IL
Israel
Prior art keywords
production
clonal antibodies
human mono
mono
human
Prior art date
Application number
IL67721A
Other versions
IL67721A (en
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IL67721A0 publication Critical patent/IL67721A0/en
Publication of IL67721A publication Critical patent/IL67721A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • C12N5/12Fused cells, e.g. hybridomas
    • C12N5/16Animal cells
    • C12N5/166Animal cells resulting from interspecies fusion
    • C07K16/108

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL67721A 1982-01-22 1983-01-20 Hybridoma cell lines,their preparation and their use for the production of human monoclonal antibodies IL67721A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH409/82A CH652145A5 (en) 1982-01-22 1982-01-22 METHOD FOR IN VITRO PRODUCTION OF HYBRID OMEN WHAT human monoclonal antibodies GENERATE.

Publications (2)

Publication Number Publication Date
IL67721A0 true IL67721A0 (en) 1983-05-15
IL67721A IL67721A (en) 1986-04-29

Family

ID=4186382

Family Applications (1)

Application Number Title Priority Date Filing Date
IL67721A IL67721A (en) 1982-01-22 1983-01-20 Hybridoma cell lines,their preparation and their use for the production of human monoclonal antibodies

Country Status (17)

Country Link
US (1) US4634664A (en)
JP (3) JPS58128323A (en)
AT (1) AT388932B (en)
CH (1) CH652145A5 (en)
CY (1) CY1488A (en)
DE (1) DE3301249A1 (en)
DK (1) DK23183A (en)
FI (1) FI83538C (en)
FR (1) FR2522679B1 (en)
GB (1) GB2113715B (en)
HK (1) HK52589A (en)
IL (1) IL67721A (en)
IT (1) IT1160468B (en)
KE (1) KE3884A (en)
MY (1) MY8700169A (en)
SE (1) SE502344C2 (en)
SG (1) SG28189G (en)

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1247538A (en) * 1982-05-21 1988-12-28 Mark C. Glassy Human-human hybridomas for solid tumors
US4613576A (en) * 1983-03-09 1986-09-23 Sloan-Kettering Institute For Cancer Research Human monoclonal antibodies to cancer cells
EP0148644A3 (en) * 1984-01-06 1987-06-03 The Board Of Trustees Of The Leland Stanford Junior University A novel fusion partner and its products
US4634666A (en) * 1984-01-06 1987-01-06 The Board Of Trustees Of The Leland Stanford Junior University Human-murine hybridoma fusion partner
US4764465A (en) * 1984-04-26 1988-08-16 Cetus Corporation Human monoclonal antibody against group A red blood cells
JPS6187630A (en) * 1984-10-08 1986-05-06 Teijin Ltd Human monoclonal antibody to simple herpes virus, and its preparation
WO1986002092A1 (en) * 1984-09-28 1986-04-10 Teijin Limited Mouse human hybridoma producing antivirus human antibody, process for its preparation, and antivirus human monoclonal antibody
US4693975A (en) * 1984-11-20 1987-09-15 The Wistar Institute Human hybridroma fusion partner for production of human monoclonal antibodies
JPS61155398A (en) * 1984-12-28 1986-07-15 Teijin Ltd Anti-pseudomonas aeruginosa human monoclonal anti-body, preparation thereof and remedy containing said antibody as active component
US4677070A (en) * 1985-04-26 1987-06-30 Cetus Corporation Pseudomonas aeruginosa exotoxin A antibodies, their preparation and use
USH1198H (en) 1985-04-26 1993-06-01 Cetus Corporation Pseudomonas aeruginosa type-specific human monoclonal antibodies, their preparation and use
CH670098B (en) * 1985-05-23 1989-05-12
JPH0720885B2 (en) * 1985-09-27 1995-03-08 帝人株式会社 Agent for preventing or treating herpes simplex virus infection
NZ218499A (en) * 1985-12-10 1990-04-26 Genetic Systems Corp Monoclonal antibodies against pseudomonas aeruginosa, pharmaceutical compositions and detection methods
AU7281787A (en) * 1986-04-01 1987-10-20 Genelabs Incorporated Immortalized cells which produce tissue-specific products
AU613310B2 (en) * 1986-04-01 1991-08-01 Genelabs Incorporated Immortalized virus-specific tissue cells
US5565354A (en) * 1986-09-05 1996-10-15 Sandoz Ltd. Production of human monoclonal antibodies specific for hepatitis B surface antigen
US5646041A (en) * 1987-02-12 1997-07-08 Harfeldt; Elisabeth Monoclonal antibody to herpes simplex virus and cell line producing same
US5001065A (en) * 1987-05-27 1991-03-19 Cetus Corporation Human cell line and triomas, antibodies, and transformants derived therefrom
JPH01101896A (en) * 1987-10-14 1989-04-19 Teijin Ltd Human-monoclonal antibody to fungi of genus candida and production thereof
US5215913A (en) 1987-11-30 1993-06-01 Roger Williams General Hospital IgG-1 human monoclonal antibody reactive with an HIV-1 antigen and methods of use
IT1226477B (en) * 1988-07-04 1991-01-16 Genetik Mab S R L N OMAS CELLULAR LINES AS A MEANS FOR IMMORTALING CELLS PRODUCING SUBSTANCES OF ANY ANIMAL SPECIES.
US7041871B1 (en) 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
JP2535455B2 (en) * 1991-02-07 1996-09-18 帝人株式会社 A hybridoma producing human monoclonal antibody against cytomegalovirus
IL102490A0 (en) * 1991-07-15 1993-01-14 Wellcome Found Production of antibodies
JPH05276984A (en) * 1991-09-05 1993-10-26 Teijin Ltd Hybridoma producing human monoclonal antibody against Candida
JPH05260961A (en) * 1992-05-21 1993-10-12 Teijin Ltd Hybridoma producing human monoclonal antibody against cytomegalovirus
PL302438A1 (en) * 1992-06-26 1994-07-25 Aetsrn Human anti-rh(d) monoclonal antibodies and cellular lines producing them
EP0583980A1 (en) * 1992-08-20 1994-02-23 Eli Lilly And Company Method for generating monoclonal antibodies from rabbits
HUT72546A (en) * 1992-11-06 1996-05-28 Sandoz Ag Production of human monoclonal antibodies active against hepatitis b surface antigen
US5750106A (en) * 1993-01-28 1998-05-12 Novartis Ag Human monoclonal antibodies to cytomegalovirus
AU2527397A (en) * 1996-03-13 1997-10-01 Protein Design Labs, Inc. Fas ligand fusion proteins and their uses
ATE443141T1 (en) 1997-02-07 2009-10-15 Us Gov Health & Human Serv ACTIVITY DEPENDENT NEUROTROPIC FACTOR III (ADNF III)
US7179892B2 (en) 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US6197582B1 (en) 1998-03-18 2001-03-06 The Trustees Of Columbia University In The City Of New York Development of human monoclonal antibodies and uses thereof
UA81216C2 (en) 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
WO2001032712A2 (en) * 1999-11-03 2001-05-10 Maxygen, Inc. Antibody diversity generation
US7060802B1 (en) * 2000-09-18 2006-06-13 The Trustees Of Columbia University In The City Of New York Tumor-associated marker
TWI255272B (en) 2000-12-06 2006-05-21 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
IL158419A0 (en) 2001-04-19 2004-05-12 Scripps Research Inst Methods and composition for the production of orthoganal trna-aminoacyl trna synthetase pairs
US7084257B2 (en) * 2001-10-05 2006-08-01 Amgen Inc. Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
WO2003030831A2 (en) * 2001-10-11 2003-04-17 Protein Design Labs, Inc. Treatment of prostate cancer by inhibitors of atp synthase
EP1572121B1 (en) 2002-08-01 2012-01-11 The Regents of The University of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
US8506959B2 (en) 2002-11-01 2013-08-13 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
TW200509968A (en) 2002-11-01 2005-03-16 Elan Pharm Inc Prevention and treatment of synucleinopathic disease
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
US20050025763A1 (en) 2003-05-08 2005-02-03 Protein Design Laboratories, Inc. Therapeutic use of anti-CS1 antibodies
US7709610B2 (en) 2003-05-08 2010-05-04 Facet Biotech Corporation Therapeutic use of anti-CS1 antibodies
WO2005013889A2 (en) 2003-05-19 2005-02-17 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in lewy body disease
US7358331B2 (en) 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
EP2581093B1 (en) 2003-06-16 2015-03-18 MedImmune, LLC Influenza hemagglutinin and neuraminidase variants
EP2410331B1 (en) 2003-06-18 2015-09-23 The Scripps Research Institute Aminoacyl-tRNA synthetase for aminoacylation tRNA with unnatural amino acids
CA2568015C (en) 2004-05-25 2013-08-27 Medimmune Vaccines, Inc. Influenza hemagglutinin and neuraminidase variants
US7973134B2 (en) * 2004-07-07 2011-07-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
EA013752B1 (en) 2004-08-09 2010-06-30 Элан Фармасьютикалз, Инк. Prevention and treatment of synucleinopathic and amyloidogenic disease
US7935790B2 (en) * 2004-10-04 2011-05-03 Cell Singaling Technology, Inc. Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways
US7807789B2 (en) * 2004-12-21 2010-10-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
WO2007094754A2 (en) 2005-01-27 2007-08-23 The Regents Of The University Of Califordnia Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
CN101107007B (en) 2005-01-27 2011-08-17 奥克兰儿童医院及研究中心 GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis
ES2527503T3 (en) 2005-03-08 2015-01-26 Medimmune, Llc Reordering influenza viruses
US20090099340A1 (en) * 2007-10-12 2009-04-16 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
CA2617637C (en) * 2005-08-02 2017-07-18 Xbiotech Inc. Diagnosis, treatment, and prevention of vascular disorders using il-1.alpha. autoantibodies
EP1934867A2 (en) * 2005-08-31 2008-06-25 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
US20100151495A9 (en) * 2005-08-31 2010-06-17 Cell Signaling Technolgy, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
DOP2006000277A (en) 2005-12-12 2007-08-31 Bayer Pharmaceuticals Corp ANTI MN ANTIBODIES AND METHODS FOR USE
US7910798B2 (en) 2006-03-31 2011-03-22 Medarex, Inc. Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
DE602007007071D1 (en) 2006-04-13 2010-07-22 Medical & Biol Lab Co Ltd FUSION PARTNER CELLS
WO2007127335A2 (en) * 2006-04-27 2007-11-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in atm and atr kinase signaling pathways
US20110008282A1 (en) * 2006-05-15 2011-01-13 Xbiotech, Inc. IL-1alpha immunization induces autoantibodies protective against atherosclerosis
CN102580086A (en) * 2006-05-22 2012-07-18 埃克斯生物科技公司 Treatment of cancer with anti-IL-1[alpha] antibodies
JP2009543579A (en) 2006-07-19 2009-12-10 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア WSX-1 / p28 as a target for anti-inflammatory response
US7939636B2 (en) * 2006-08-11 2011-05-10 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in c-Src signaling pathways
US20090258442A1 (en) * 2006-08-31 2009-10-15 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
US8080645B2 (en) * 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US9481912B2 (en) 2006-09-12 2016-11-01 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and identifying nucleic acid sequences in biological samples
US8652782B2 (en) 2006-09-12 2014-02-18 Longhorn Vaccines & Diagnostics, Llc Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
US8440185B2 (en) * 2006-12-26 2013-05-14 The Johns Hopkins University Compositions and methods for the treatment of immunologic disorders
US7989173B2 (en) 2006-12-27 2011-08-02 The Johns Hopkins University Detection and diagnosis of inflammatory disorders
US20090142342A1 (en) * 2006-12-27 2009-06-04 Johns Hopkins University B7-h4 receptor agonist compositions and methods for treating inflammation and auto-immune diseases
EP2124998B8 (en) * 2006-12-27 2015-05-06 The Johns Hopkins University Methods for detecting inflammation and auto-immune diseases
PL2583978T3 (en) 2007-02-23 2016-07-29 Prothena Biosciences Ltd Co Prevention and treatment of synucleinopathic and amyloidogenic disease
ES2546863T3 (en) 2007-02-23 2015-09-29 Prothena Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
US20090081659A1 (en) 2007-03-07 2009-03-26 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
EP1975184A3 (en) 2007-03-26 2008-11-26 Cell Signaling Technology, Inc. Serine or threonine phosphorylation sites
US20080238709A1 (en) * 2007-03-28 2008-10-02 Faramarz Vaziri One-way communication apparatus with dynamic key generation
EP2145902A3 (en) 2007-04-19 2010-09-29 Peter Hornbeck Tyrosine phosphorylation sites and antibodies specific for them
US7977462B2 (en) 2007-04-19 2011-07-12 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
EP1983003A3 (en) 2007-04-19 2009-03-11 Peter Hornbeck Tyrosine phosphorylation sites and antibodies specific for them
US20090053831A1 (en) 2007-05-01 2009-02-26 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
EP2185718B1 (en) 2007-08-03 2017-10-04 MUSC Foundation For Research Development Human monoclonal antibodies and methods for producing the same
US9624309B2 (en) 2007-08-15 2017-04-18 Bayer Intellectual Property Gmbh Monospecific and multispecific antibodies and method of use
US9683256B2 (en) 2007-10-01 2017-06-20 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system
US11041215B2 (en) 2007-08-24 2021-06-22 Longhorn Vaccines And Diagnostics, Llc PCR ready compositions and methods for detecting and identifying nucleic acid sequences
EP2772267B1 (en) 2007-08-27 2016-04-27 Longhorn Vaccines and Diagnostics, LLC Immunogenic compositions and methods
US10004799B2 (en) 2007-08-27 2018-06-26 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
US11041216B2 (en) 2007-10-01 2021-06-22 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples
DK2195466T3 (en) 2007-10-01 2013-01-14 Longhorn Vaccines & Diagnostics Llc Method for storing biological samples
JP2010540953A (en) 2007-10-05 2010-12-24 ナショナル インスティテュート フォー バイオプロセッシング リサーチ アンド トレーニング リミテッド Glycosylation markers for pancreatitis, sepsis and pancreatic cancer
US20090203043A1 (en) 2007-11-21 2009-08-13 Peter Hornbeck Protein phosphorylation by basophilic serine/threonine kinases in insulin signaling pathways
US20090169549A1 (en) * 2007-12-19 2009-07-02 The Board Of Regents Of The University Of Texas System Conformational isomers of alpha-synuclein, antibodies thereto and methods of their manufacture and use
US20090220991A1 (en) * 2008-02-29 2009-09-03 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
EP3023502A1 (en) 2008-04-10 2016-05-25 Cell Signaling Technology, Inc. Compositions and methods for detecting egfr mutations in cancer
WO2009148575A1 (en) * 2008-05-30 2009-12-10 Xbiotech, Inc. Interleukin-1 alpha abs and methods of use
EP2309264A4 (en) * 2008-06-06 2011-11-23 Univ Toyama Nat Univ Corp DEVICE FOR DETECTING INFLUENZA VIRUS
CA2730408A1 (en) 2008-07-11 2010-01-14 Chin-Fen Yang Influenza hemagglutinin and neuraminidase variants
JP5976319B2 (en) * 2008-09-12 2016-08-23 エックスバイオテク, インコーポレイテッドXbiotech, Inc. Targeting pathogenic monocytes
US20100260752A1 (en) 2009-01-23 2010-10-14 Biosynexus Incorporated Opsonic and protective antibodies specific for lipoteichoic acid of gram positive bacteria
SG173642A1 (en) 2009-02-12 2011-09-29 Medimmune Llc Influenza hemagglutinin and neuraminidase variants
US9309325B2 (en) 2009-05-07 2016-04-12 The Regents Of The University Of California Antibodies and methods of use thereof
EP2473523A2 (en) 2009-08-31 2012-07-11 Amplimmune, Inc. Methods and compositions for the inhibition of transplant rejection
WO2011075185A1 (en) 2009-12-18 2011-06-23 Oligasis Targeted drug phosphorylcholine polymer conjugates
DK2582391T3 (en) 2010-06-18 2019-01-21 Xbiotech Inc ARTHRITIS TREATMENT
KR101910760B1 (en) 2010-08-23 2018-10-22 엑스바이오테크, 인크. Treatment for neoplastic diseases
KR20220011811A (en) 2010-12-06 2022-01-28 씨젠 인크. Humanized antibodies to liv-1 and use of same to treat cancer
KR102004554B1 (en) 2011-04-01 2019-10-01 엑스바이오테크, 인크. Treatment for dermatological pathologies
US9724409B2 (en) 2011-04-01 2017-08-08 Xbiotech, Inc. Treatment of inflammatory skin disease
US9809649B2 (en) 2011-09-23 2017-11-07 Xbiotech, Inc. Cachexia treatment
EP2806890A4 (en) 2012-01-26 2015-09-02 Longhorn Vaccines & Diagnostics Llc COMPOSITE ANTIGENIC SEQUENCES AND VACCINES
US20130309223A1 (en) 2012-05-18 2013-11-21 Seattle Genetics, Inc. CD33 Antibodies And Use Of Same To Treat Cancer
UA105278C2 (en) 2012-09-06 2014-04-25 Інститут Біології Клітини Нан України Process for the production of catalytically-active antibodies (abzymes) with sialidase activity
US9545441B2 (en) 2012-09-18 2017-01-17 Xbiotech, Inc. Treatment of diabetes
CN104684929A (en) 2012-10-04 2015-06-03 埃克斯生物科技公司 Treatment of vascular disease and its complications
UA118441C2 (en) 2012-10-08 2019-01-25 Протена Біосаєнсиз Лімітед Antibodies recognizing alpha-synuclein
PE20152004A1 (en) 2013-03-13 2016-02-07 Prothena Biosciences Ltd IMMUNOTHERAPY TAU
JP6450381B2 (en) 2013-07-05 2019-01-09 ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション Soluble MIC neutralizing monoclonal antibody for treating cancer
WO2015004632A1 (en) 2013-07-12 2015-01-15 Neotope Biosciences Limited Antibodies that recognize iapp
US9951131B2 (en) 2013-07-12 2018-04-24 Prothena Biosciences Limited Antibodies that recognize IAPP
WO2015035342A2 (en) 2013-09-08 2015-03-12 Oligasis Llc Factor viii zwitterionic polymer conjugates
EP3116911B8 (en) 2014-03-12 2019-10-23 Prothena Biosciences Limited Anti-mcam antibodies and associated methods of use
TW201623331A (en) 2014-03-12 2016-07-01 普羅帝納生物科學公司 Anti-MCAM antibodies and associated methods of use
US10059761B2 (en) 2014-03-12 2018-08-28 Prothena Biosciences Limited Anti-Laminin4 antibodies specific for LG4-5
US20170158755A1 (en) 2014-03-12 2017-06-08 Prothena Biosciences Limited Anti-laminin4 antibodies specific for lg1-3
JP6744856B2 (en) 2014-04-08 2020-08-19 プロセナ・バイオサイエンシズ・リミテッド Blood-brain barrier shuttle containing antibody that recognizes α-synuclein
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
US20160075772A1 (en) 2014-09-12 2016-03-17 Regeneron Pharmaceuticals, Inc. Treatment of Fibrodysplasia Ossificans Progressiva
KR20210013299A (en) 2014-10-17 2021-02-03 코디악 사이언시스 인코포레이티드 Butyrylcholinesterase zwitterionic polymer conjugates
TWI786505B (en) 2015-01-28 2022-12-11 愛爾蘭商普羅佘納生物科技有限公司 Anti-transthyretin antibodies
TWI718121B (en) 2015-01-28 2021-02-11 愛爾蘭商普羅佘納生物科技有限公司 Anti-transthyretin antibodies
TWI711631B (en) 2015-01-28 2020-12-01 愛爾蘭商普羅佘納生物科技有限公司 Anti-transthyretin antibodies
AU2016255768B2 (en) 2015-04-29 2022-03-10 Regeneron Pharmaceuticals, Inc. Treatment of fibrodysplasia ossificans progressiva
EP3294448A4 (en) 2015-05-14 2018-12-12 Longhorn Vaccines and Diagnostics, LLC Rapid methods for the extraction of nucleic acids from biological samples
WO2017046774A2 (en) 2015-09-16 2017-03-23 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis
JP2018530540A (en) 2015-09-16 2018-10-18 プロセナ バイオサイエンシーズ リミテッド Use of anti-MCAM antibodies for the treatment or prevention of giant cell arteritis, polymyalgia rheumatica or Takayasu arteritis
NZ783685A (en) 2015-12-30 2025-09-26 Kodiak Sciences Inc Antibodies and conjugates thereof
WO2017149513A1 (en) 2016-03-03 2017-09-08 Prothena Biosciences Limited Anti-mcam antibodies and associated methods of use
IL261188B (en) 2016-03-04 2022-08-01 Jn Biosciences Llc Anti-tigit antibody that binds to a tigit polypeptide on one or more amino acid residues
WO2017153953A1 (en) 2016-03-09 2017-09-14 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases
WO2017153955A1 (en) 2016-03-09 2017-09-14 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases
US10906964B2 (en) 2016-05-02 2021-02-02 Prothena Biosciences Limited Antibodies recognizing tau
UA124148C2 (en) 2016-05-02 2021-07-28 Протена Біосайенсіс Лімітед ANTIBODIES THAT RECOGNIZE TAU
WO2017208210A1 (en) 2016-06-03 2017-12-07 Prothena Biosciences Limited Anti-mcam antibodies and associated methods of use
EP3478714A2 (en) 2016-07-02 2019-05-08 Prothena Biosciences Limited Anti-transthyretin antibodies
WO2018007923A2 (en) 2016-07-02 2018-01-11 Prothena Biosciences Limited Anti-transthyretin antibodies
EP3478716A2 (en) 2016-07-02 2019-05-08 Prothena Biosciences Limited Anti-transthyretin antibodies
AU2017292172A1 (en) 2016-07-06 2019-01-03 Prothena Biosciences Limited Assay for detecting total and S129 phosphorylated alpha-synuclein
EP3582813A4 (en) 2017-02-16 2020-12-30 XBiotech, Inc TREATMENT OF HIDRADENITIS SUPPURATIVA
WO2018191548A2 (en) 2017-04-14 2018-10-18 Kodiak Sciences Inc. Complement factor d antagonist antibodies and conjugates thereof
MX2019013045A (en) 2017-05-02 2020-02-12 Prothena Biosciences Ltd Antibodies recognizing tau.
WO2018222675A1 (en) 2017-05-30 2018-12-06 The Board Of Regents Of The University Of Oklahoma Anti-doublecortin-like kinase 1 antibodies and methods of use
BR112020001255A2 (en) 2017-07-21 2020-07-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services immunogenic compositions of neisseria meningitidis
EP3691626A4 (en) 2017-10-06 2021-06-30 Prothena Biosciences Limited Methods of detecting transthyretin
SG11202002590VA (en) 2017-11-02 2020-04-29 Bayer Ag Bispecific antibodies binding alk-1 and bmpr-2
SG11202008242XA (en) 2018-03-02 2020-09-29 Kodiak Sciences Inc Il-6 antibodies and fusion constructs and conjugates thereof
US20220023348A1 (en) 2018-11-28 2022-01-27 Forty Seven, Inc. Genetically modified hspcs resistant to ablation regime
TW202045206A (en) 2019-02-27 2020-12-16 美商健生生物科技公司 Antibody formulation
CN113544149B (en) 2019-03-03 2024-11-15 普罗塞纳生物科学有限公司 Antibodies that recognize tau
AU2020364071A1 (en) 2019-10-10 2022-05-26 Kodiak Sciences Inc. Methods of treating an eye disorder
WO2021142191A1 (en) 2020-01-08 2021-07-15 Regeneron Pharmaceuticals, Inc. Treatment of fibrodysplasia ossificans progressiva
US12485166B2 (en) 2020-02-06 2025-12-02 Longhorn Vaccines And Diagnostics, Llc Vaccines for the treatment and prevention of zoonotic infections
WO2021211924A1 (en) 2020-04-16 2021-10-21 Janssen Biotech, Inc. Treatment of atopic dermatitis
TW202210514A (en) 2020-06-02 2022-03-16 美商阿克思生物科學有限公司 Antibodies to tigit
CN116249717A (en) 2020-06-24 2023-06-09 普罗塞纳生物科学有限公司 Antibodies that recognize Sortilin
CA3095676A1 (en) 2020-10-07 2022-04-07 Xbiotech Inc. True human antibody specific for interleukin 1 alpha (il-1a)
CA3095740A1 (en) 2020-10-07 2022-04-07 Xbiotech Inc. True human antibody specific for interleukin alpha (il-1a)
CA3095675A1 (en) 2020-10-07 2022-04-07 Xbiotech Inc. True human antibody specific for interleukin 1 alpha (il-1a)
KR20230091978A (en) 2020-10-20 2023-06-23 롱혼 백신즈 앤드 다이어그나스틱스, 엘엘씨 immunogenic antigen
MX2023008628A (en) 2021-01-22 2023-09-22 Bayer Ag Lrrc15 antibodies and conjugates thereof.
US20240238427A1 (en) 2021-04-14 2024-07-18 Kodiak Sciences Inc. Methods of treating an eye disorder
WO2022265912A1 (en) 2021-06-16 2022-12-22 Gundersen Lutheran Medical Foundation, Inc. Antibodies targeting an amphiregulin-derived cell surface neo-epitope
WO2025006737A1 (en) 2023-06-30 2025-01-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Genetically detoxified mutant of neisseria and outer membrane vesicle (omv) vaccine
EP4527851A1 (en) 2023-09-22 2025-03-26 Bayer Aktiengesellschaft Bispecific antibodies binding ltbr and lrrc15

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2757169A1 (en) * 1977-12-22 1979-07-05 Hoechst Ag METHOD OF OBTAINING INSULIN-PRODUCING ANIMAL CELLS
ZA806506B (en) * 1979-11-01 1981-09-30 Bio Response Inc A method for production of monoclonal antibodies
EP0043718B1 (en) * 1980-07-07 1984-11-28 National Research Development Corporation Improvements in or relating to cell lines
GB2079313A (en) * 1980-07-07 1982-01-20 Nat Res Dev Improvements in or relating to rat myeloma cell lines
JPS57502090A (en) * 1980-07-18 1982-11-25
JPS586475B2 (en) * 1980-08-23 1983-02-04 株式会社 林原生物化学研究所 Method for producing human chorionic gonadotropin
JPS6045849B2 (en) * 1980-08-25 1985-10-12 林原 健 Method for producing human erythropoietin
JPS5743696A (en) * 1980-08-27 1982-03-11 Hayashibara Biochem Lab Inc Preparation of human luteinizing hormone
JPS585671B2 (en) * 1980-08-27 1983-02-01 株式会社 林原生物化学研究所 Method for producing human follicle stimulating hormone
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4529694A (en) * 1982-04-16 1985-07-16 The Children's Medical Center Corporation Cell fusion

Also Published As

Publication number Publication date
IL67721A (en) 1986-04-29
DK23183D0 (en) 1983-01-20
JPH03236794A (en) 1991-10-22
SE8300290L (en) 1983-07-23
FR2522679B1 (en) 1986-05-09
GB8301384D0 (en) 1983-02-23
JPS58128323A (en) 1983-07-30
DK23183A (en) 1983-07-23
JPH0471520B2 (en) 1992-11-13
MY8700169A (en) 1987-12-31
JPH0365148B2 (en) 1991-10-09
US4634664A (en) 1987-01-06
JPH0690753A (en) 1994-04-05
SG28189G (en) 1989-08-11
GB2113715B (en) 1986-06-04
IT8319234A0 (en) 1983-01-21
IT1160468B (en) 1987-03-11
AT388932B (en) 1989-09-25
ATA19583A (en) 1989-02-15
KE3884A (en) 1989-08-11
CH652145A5 (en) 1985-10-31
FR2522679A1 (en) 1983-09-09
HK52589A (en) 1989-07-07
FI830190L (en) 1983-07-23
GB2113715A (en) 1983-08-10
FI830190A0 (en) 1983-01-20
CY1488A (en) 1989-12-08
FI83538C (en) 1991-07-25
SE502344C2 (en) 1995-10-09
FI83538B (en) 1991-04-15
JPH0789909B2 (en) 1995-10-04
DE3301249C2 (en) 1990-04-05
SE8300290D0 (en) 1983-01-20
DE3301249A1 (en) 1983-09-22

Similar Documents

Publication Publication Date Title
IL67721A0 (en) Production of human mono-clonal antibodies
GB8327018D0 (en) Making of bags
GB8428321D0 (en) Production of antibodies
GB8305104D0 (en) Conjugates of proteins
DE3372476D1 (en) Preparation of p-nitrosodiphenylamine
GB2096146B (en) Process for the production of human antibodies
DE3168691D1 (en) Immunoassay of proteins
GB2121038B (en) Preparation of 6a 10a-trans-hexahydrodibenzopyranones
GB8415316D0 (en) Treatment of footrot
GB8324788D0 (en) Production of chlorophosphanes etc
GB8317345D0 (en) Preparation of arylethylamines
GB8727030D0 (en) Production of monoclonal antibodies
IL69322A (en) Preparation of substituted thiadiazolyloxyacetamides
IL86960A0 (en) Preparation of human monoclonal antibodies
DE3360784D1 (en) Preparation of nitro-olefins
GB2120656B (en) Preparation of thio-bis-phenols
GB8304857D0 (en) Manufacture of nitrophenetoles
GB2145113B (en) Production of human monoclonal antibodies
GB8332254D0 (en) Production of protein fibres
GB8300977D0 (en) Preparation of substituted chloroacentanilides
JPS57206625A (en) Manufacture of non-anticomplement igg
ZA832380B (en) Sanitere en/of onmatige voering
GB2121405B (en) Preparation of bischoline naphathalene-disulphonates
GB2117767B (en) Synthesis of hydroxyethyltetrazolethiol
GB2128874B (en) Sterlisation of milk

Legal Events

Date Code Title Description
KB Patent renewed