IL270906A - Methods and compositions for promoting non-natural amino acid-containing protein production - Google Patents

Methods and compositions for promoting non-natural amino acid-containing protein production

Info

Publication number: IL270906A
Authority: IL; Israel
Prior art keywords: compositions; methods; amino acid; natural amino; protein production
Prior art date: 2017-06-02

Application number

IL270906A

Other languages

Hebrew (he)

Original Assignee

Ambrx Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-06-02

Filing date

2019-11-25

Publication date

2020-01-30

2019-11-25 Application filed by Ambrx Inc filed Critical Ambrx Inc

2020-01-30 Publication of IL270906A publication Critical patent/IL270906A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
- C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/48—Regulators of apoptosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Cell Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Mycology (AREA)
Reproductive Health (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Oncology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL270906A 2017-06-02 2019-11-25 Methods and compositions for promoting non-natural amino acid-containing protein production IL270906A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201762514754P	2017-06-02	2017-06-02
PCT/US2018/035764 WO2018223108A1 (en)	2017-06-02	2018-06-02	Methods and compositions for promoting non-natural amino acid-containing protein production

Publications (1)

Publication Number	Publication Date
IL270906A true IL270906A (en)	2020-01-30

Family

ID=62749186

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL270906A IL270906A (en)	2017-06-02	2019-11-25	Methods and compositions for promoting non-natural amino acid-containing protein production

Country Status (23)

Country	Link
US (2)	US11851662B2 (en)
EP (2)	EP4382124A3 (en)
JP (3)	JP7245786B2 (en)
KR (3)	KR20240140174A (en)
CN (2)	CN110959041B (en)
AU (1)	AU2018275152B2 (en)
BR (1)	BR112019025476A2 (en)
CA (1)	CA3065137A1 (en)
DK (1)	DK3630977T5 (en)
ES (1)	ES2978044T3 (en)
FI (1)	FI3630977T3 (en)
HR (1)	HRP20240344T1 (en)
HU (1)	HUE067136T2 (en)
IL (1)	IL270906A (en)
LT (1)	LT3630977T (en)
MX (2)	MX2019014286A (en)
MY (1)	MY202215A (en)
PL (1)	PL3630977T3 (en)
PT (1)	PT3630977T (en)
RS (1)	RS65370B1 (en)
SI (1)	SI3630977T1 (en)
SM (1)	SMT202400125T1 (en)
WO (1)	WO2018223108A1 (en)

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PT3630977T (en) *	2017-06-02	2024-04-24	Ambrx Inc	Methods and compositions for promoting non-natural amino acid-containing protein production
IL320375A (en)	2018-03-29	2025-06-01	Ambrx Inc	Humanized anti-prostate-specific membrane antigen (psma) antibody drug conjugates and use thereof for reducing or inhibiting tumor growth or progression in a psma-expressing cancer or cancer cell
SG11202102427XA (en)	2018-09-11	2021-04-29	Ambrx Inc	Interleukin-2 polypeptide conjugates and their uses
AU2019403313A1 (en) *	2018-12-21	2021-07-15	Genentech, Inc.	Methods of producing polypeptides using a cell line resistant to apoptosis
CN111117944B (en) *	2019-11-22	2022-05-24	中农威特生物科技股份有限公司	Anti-apoptosis MDCK host cell strain for large-scale suspension culture and establishment method thereof
MX2022016453A (en) *	2020-06-24	2023-02-01	Genentech Inc	Apoptosis resistant cell lines.
CN112375774A (en) *	2020-10-26	2021-02-19	浙江新码生物医药有限公司	Construction method of engineering strain for recombinant protein expression
CN112575005A (en) *	2021-01-04	2021-03-30	昆明理工大学	Method for improving heavy metal cadmium stress resistance of tobacco and reducing cadmium enrichment
EP4477674A1 (en)	2022-02-09	2024-12-18	Daiichi Sankyo Company, Limited	Environmentally responsive masked antibody and use thereof
WO2023202967A1 (en) *	2022-04-19	2023-10-26	F. Hoffmann-La Roche Ag	Improved production cells
KR20250134670A (en)	2023-01-16	2025-09-11	암브룩스, 인코포레이티드	anti-CD70 antibody-drug conjugate
WO2024241086A1 (en)	2023-05-24	2024-11-28	Ambrx, Inc.	Pegylated bovine interferon lambda and methods of use thereof
WO2025041055A1 (en)	2023-08-22	2025-02-27	Ambrx, Inc.	Anti-psma adc conjugate compositions and methods of use thereof
WO2025147710A1 (en) *	2024-01-05	2025-07-10	Northwestern University	Orthogonal translation systems and methods for identifying components thereof

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2018
- 2018-06-02 PT PT187343595T patent/PT3630977T/en unknown
- 2018-06-02 SI SI201831076T patent/SI3630977T1/en unknown
- 2018-06-02 FI FIEP18734359.5T patent/FI3630977T3/en active
- 2018-06-02 CA CA3065137A patent/CA3065137A1/en active Pending
- 2018-06-02 KR KR1020247030044A patent/KR20240140174A/en active Pending
- 2018-06-02 MX MX2019014286A patent/MX2019014286A/en unknown
- 2018-06-02 JP JP2019565862A patent/JP7245786B2/en active Active
- 2018-06-02 LT LTEPPCT/US2018/035764T patent/LT3630977T/en unknown
- 2018-06-02 HR HRP20240344TT patent/HRP20240344T1/en unknown
- 2018-06-02 EP EP24158417.6A patent/EP4382124A3/en active Pending
- 2018-06-02 ES ES18734359T patent/ES2978044T3/en active Active
- 2018-06-02 CN CN201880049275.0A patent/CN110959041B/en active Active
- 2018-06-02 BR BR112019025476-5A patent/BR112019025476A2/en unknown
- 2018-06-02 PL PL18734359.5T patent/PL3630977T3/en unknown
- 2018-06-02 MY MYPI2019007098A patent/MY202215A/en unknown
- 2018-06-02 KR KR1020247014001A patent/KR102705871B1/en active Active
- 2018-06-02 EP EP18734359.5A patent/EP3630977B1/en active Active
- 2018-06-02 AU AU2018275152A patent/AU2018275152B2/en not_active Expired - Fee Related
- 2018-06-02 DK DK18734359.5T patent/DK3630977T5/en active
- 2018-06-02 RS RS20240405A patent/RS65370B1/en unknown
- 2018-06-02 HU HUE18734359A patent/HUE067136T2/en unknown
- 2018-06-02 KR KR1020197038544A patent/KR102662379B1/en active Active
- 2018-06-02 SM SM20240125T patent/SMT202400125T1/en unknown
- 2018-06-02 WO PCT/US2018/035764 patent/WO2018223108A1/en not_active Ceased
- 2018-06-02 CN CN202311164969.8A patent/CN117286182A/en active Pending
- 2018-06-02 US US16/958,152 patent/US11851662B2/en active Active
2019
- 2019-11-25 IL IL270906A patent/IL270906A/en unknown
- 2019-11-28 MX MX2023004927A patent/MX2023004927A/en unknown
2023
- 2023-03-13 JP JP2023038441A patent/JP7617162B2/en active Active
- 2023-11-10 US US18/506,836 patent/US20240167044A1/en active Pending
2025
- 2025-01-06 JP JP2025001705A patent/JP2025061014A/en active Pending

Also Published As

Publication number	Publication date
JP7617162B2 (en)	2025-01-17
NZ760107A (en)	2024-03-22
KR20240140174A (en)	2024-09-24
HUE067136T2 (en)	2024-10-28
KR20200011979A (en)	2020-02-04
SI3630977T1 (en)	2024-05-31
DK3630977T3 (en)	2024-04-15
HRP20240344T1 (en)	2024-05-24
DK3630977T5 (en)	2024-09-02
MX2019014286A (en)	2020-01-27
EP3630977A1 (en)	2020-04-08
KR102705871B1 (en)	2024-09-11
EP4382124A2 (en)	2024-06-12
LT3630977T (en)	2024-04-25
PL3630977T3 (en)	2024-06-24
RS65370B1 (en)	2024-04-30
CN110959041A (en)	2020-04-03
FI3630977T3 (en)	2024-04-24
SMT202400125T1 (en)	2024-05-14
CA3065137A1 (en)	2018-12-06
PT3630977T (en)	2024-04-24
JP2023075254A (en)	2023-05-30
KR102662379B1 (en)	2024-04-29
MY202215A (en)	2024-04-17
JP2025061014A (en)	2025-04-10
AU2018275152A1 (en)	2020-01-16
US20210017527A1 (en)	2021-01-21
EP4382124A3 (en)	2024-10-16
CN117286182A (en)	2023-12-26
MX2023004927A (en)	2023-05-17
US11851662B2 (en)	2023-12-26
EP3630977B1 (en)	2024-02-21
JP2020522247A (en)	2020-07-30
US20240167044A1 (en)	2024-05-23
CN110959041B (en)	2023-09-29
JP7245786B2 (en)	2023-03-24
WO2018223108A1 (en)	2018-12-06
KR20240063184A (en)	2024-05-09
AU2018275152B2 (en)	2025-01-23
BR112019025476A2 (en)	2020-06-23
ES2978044T3 (en)	2024-09-04

Publication	Publication Date	Title
IL270906A (en)	2020-01-30	Methods and compositions for promoting non-natural amino acid-containing protein production
IL262321A (en)	2018-11-29	Compositions and methods for selective protein expression
EP3217807A4 (en)	2018-09-12	Methods and compositions for egg white protein production
GB201419109D0 (en)	2014-12-10	Incorporation of unnatural amino acids into proteins
PT3240895T (en)	2022-03-02	Compositions and methods for protein glycosylation
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