[go: up one dir, main page]

IL217409A0 - Method for genome editing - Google Patents

Method for genome editing

Info

Publication number
IL217409A0
IL217409A0 IL217409A IL21740912A IL217409A0 IL 217409 A0 IL217409 A0 IL 217409A0 IL 217409 A IL217409 A IL 217409A IL 21740912 A IL21740912 A IL 21740912A IL 217409 A0 IL217409 A0 IL 217409A0
Authority
IL
Israel
Prior art keywords
genome editing
editing
genome
Prior art date
Application number
IL217409A
Original Assignee
Sigma Aldrich Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/842,708 external-priority patent/US20110016540A1/en
Priority claimed from US12/842,719 external-priority patent/US20110016541A1/en
Priority claimed from US12/843,000 external-priority patent/US20120159654A1/en
Priority claimed from US12/842,993 external-priority patent/US20110023153A1/en
Priority claimed from US12/842,198 external-priority patent/US20110023139A1/en
Priority claimed from US12/842,886 external-priority patent/US20110023157A1/en
Priority claimed from US12/842,978 external-priority patent/US20110023149A1/en
Priority claimed from US12/842,219 external-priority patent/US20110023156A1/en
Priority claimed from US12/842,217 external-priority patent/US20110023141A1/en
Priority claimed from US12/842,980 external-priority patent/US20110023150A1/en
Priority claimed from US12/842,976 external-priority patent/US20120159653A1/en
Priority claimed from US12/842,897 external-priority patent/US20110023148A1/en
Priority claimed from US12/842,694 external-priority patent/US20110023146A1/en
Priority claimed from US12/842,991 external-priority patent/US20110023152A1/en
Priority claimed from US12/842,893 external-priority patent/US20110016546A1/en
Priority claimed from US12/842,666 external-priority patent/US20110023144A1/en
Priority claimed from US12/842,578 external-priority patent/US20110023143A1/en
Priority claimed from US12/842,982 external-priority patent/US20110023151A1/en
Priority claimed from US12/842,620 external-priority patent/US20110016539A1/en
Priority claimed from US12/842,188 external-priority patent/US20110023158A1/en
Priority claimed from US12/842,678 external-priority patent/US20110023145A1/en
Priority claimed from US12/842,204 external-priority patent/US20110023159A1/en
Priority claimed from US12/842,208 external-priority patent/US20110023140A1/en
Priority claimed from US12/842,999 external-priority patent/US20110016543A1/en
Priority claimed from US12/842,994 external-priority patent/US20110030072A1/en
Priority claimed from US12/842,839 external-priority patent/US20110016542A1/en
Priority claimed from US12/842,269 external-priority patent/US20110023154A1/en
Priority claimed from US12/842,713 external-priority patent/US20110023147A1/en
Application filed by Sigma Aldrich Co Llc filed Critical Sigma Aldrich Co Llc
Publication of IL217409A0 publication Critical patent/IL217409A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/103—Ovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/107—Rabbit
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/70—Invertebrates
    • A01K2227/706—Insects, e.g. Drosophila melanogaster, medfly

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL217409A 2009-07-24 2012-01-05 Method for genome editing IL217409A0 (en)

Applications Claiming Priority (41)

Application Number Priority Date Filing Date Title
US22841909P 2009-07-24 2009-07-24
US23262009P 2009-08-10 2009-08-10
US24587709P 2009-09-25 2009-09-25
US26369609P 2009-11-23 2009-11-23
US26390409P 2009-11-24 2009-11-24
US33600010P 2010-01-14 2010-01-14
US30808910P 2010-02-25 2010-02-25
US30972910P 2010-03-02 2010-03-02
US32371910P 2010-04-13 2010-04-13
US32369810P 2010-04-13 2010-04-13
US32370210P 2010-04-13 2010-04-13
US34328710P 2010-04-26 2010-04-26
US12/843,000 US20120159654A1 (en) 2008-12-04 2010-07-23 Genome editing of genes involved in adme and toxicology in animals
US12/842,993 US20110023153A1 (en) 2008-12-04 2010-07-23 Genomic editing of genes involved in alzheimer's disease
US12/842,198 US20110023139A1 (en) 2008-12-04 2010-07-23 Genomic editing of genes involved in cardiovascular disease
US12/842,886 US20110023157A1 (en) 2008-12-04 2010-07-23 Equine genome editing with zinc finger nucleases
US12/842,978 US20110023149A1 (en) 2008-12-04 2010-07-23 Genomic editing of genes involved in tumor suppression in animals
US12/842,219 US20110023156A1 (en) 2008-12-04 2010-07-23 Feline genome editing with zinc finger nucleases
US12/842,217 US20110023141A1 (en) 2008-12-04 2010-07-23 Genomic editing of genes involved with parkinson's disease
US12/842,980 US20110023150A1 (en) 2008-12-04 2010-07-23 Genome editing of genes associated with schizophrenia in animals
US12/842,976 US20120159653A1 (en) 2008-12-04 2010-07-23 Genomic editing of genes involved in macular degeneration
US12/842,897 US20110023148A1 (en) 2008-12-04 2010-07-23 Genome editing of addiction-related genes in animals
US12/842,694 US20110023146A1 (en) 2008-12-04 2010-07-23 Genomic editing of genes involved in secretase-associated disorders
US12/842,991 US20110023152A1 (en) 2008-12-04 2010-07-23 Genome editing of cognition related genes in animals
US12/842,708 US20110016540A1 (en) 2008-12-04 2010-07-23 Genome editing of genes associated with trinucleotide repeat expansion disorders in animals
US12/842,678 US20110023145A1 (en) 2008-12-04 2010-07-23 Genomic editing of genes involved in autism spectrum disorders
US12/842,208 US20110023140A1 (en) 2008-12-04 2010-07-23 Rabbit genome editing with zinc finger nucleases
US12/842,982 US20110023151A1 (en) 2008-12-04 2010-07-23 Genome editing of abc transporters
US12/842,620 US20110016539A1 (en) 2008-12-04 2010-07-23 Genome editing of neurotransmission-related genes in animals
US12/842,188 US20110023158A1 (en) 2008-12-04 2010-07-23 Bovine genome editing with zinc finger nucleases
US12/842,719 US20110016541A1 (en) 2008-12-04 2010-07-23 Genome editing of sensory-related genes in animals
US12/842,204 US20110023159A1 (en) 2008-12-04 2010-07-23 Ovine genome editing with zinc finger nucleases
US12/842,578 US20110023143A1 (en) 2008-12-04 2010-07-23 Genomic editing of neurodevelopmental genes in animals
US12/842,999 US20110016543A1 (en) 2008-12-04 2010-07-23 Genomic editing of genes involved in inflammation
US12/842,994 US20110030072A1 (en) 2008-12-04 2010-07-23 Genome editing of immunodeficiency genes in animals
US12/842,839 US20110016542A1 (en) 2008-12-04 2010-07-23 Canine genome editing with zinc finger nucleases
PCT/US2010/043167 WO2011011767A1 (en) 2009-07-24 2010-07-23 Method for genome editing
US12/842,269 US20110023154A1 (en) 2008-12-04 2010-07-23 Silkworm genome editing with zinc finger nucleases
US12/842,713 US20110023147A1 (en) 2008-12-04 2010-07-23 Genomic editing of prion disorder-related genes in animals
US12/842,666 US20110023144A1 (en) 2008-12-04 2010-07-23 Genomic editing of genes involved in amyotrophyic lateral sclerosis disease
US12/842,893 US20110016546A1 (en) 2008-12-04 2010-07-23 Porcine genome editing with zinc finger nucleases

Publications (1)

Publication Number Publication Date
IL217409A0 true IL217409A0 (en) 2012-02-29

Family

ID=43499447

Family Applications (1)

Application Number Title Priority Date Filing Date
IL217409A IL217409A0 (en) 2009-07-24 2012-01-05 Method for genome editing

Country Status (8)

Country Link
EP (1) EP2456877A1 (en)
JP (1) JP2013500018A (en)
KR (1) KR20120097483A (en)
AU (1) AU2010275432A1 (en)
CA (1) CA2767377A1 (en)
IL (1) IL217409A0 (en)
SG (1) SG177711A1 (en)
WO (1) WO2011011767A1 (en)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5866283B2 (en) * 2009-07-28 2016-02-17 サンガモ バイオサイエンシーズ， インコーポレイテッド Methods and compositions for treating trinucleotide repeat disease
HRP20200254T1 (en) * 2010-05-03 2020-05-29 Sangamo Therapeutics, Inc. PREPARATIONS FOR CONNECTING ZINC FINGER MODULE
US9512444B2 (en) 2010-07-23 2016-12-06 Sigma-Aldrich Co. Llc Genome editing using targeting endonucleases and single-stranded nucleic acids
US10920242B2 (en) 2011-02-25 2021-02-16 Recombinetics, Inc. Non-meiotic allele introgression
US9528124B2 (en) 2013-08-27 2016-12-27 Recombinetics, Inc. Efficient non-meiotic allele introgression
JP2014509195A (en) * 2011-02-25 2014-04-17 リコンビネティクス・インコーポレイテッド Genetically modified animal and method for producing the same
CN102296073B (en) * 2011-08-11 2014-04-23 中国农业科学院北京畜牧兽医研究所 Zinc finger nuclease site-directed knockout of the specific target site of Myostatin gene
IL277027B (en) * 2011-09-21 2022-07-01 Sangamo Therapeutics Inc Methods and preparations for regulating transgene expression
US8895264B2 (en) 2011-10-27 2014-11-25 Sangamo Biosciences, Inc. Methods and compositions for modification of the HPRT locus
JP6073916B2 (en) 2011-12-05 2017-02-01 ファクター バイオサイエンス インコーポレイテッド Methods and products for transfecting cells
US8497124B2 (en) * 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
GB201122458D0 (en) 2011-12-30 2012-02-08 Univ Wageningen Modified cascade ribonucleoproteins and uses thereof
WO2013112595A2 (en) * 2012-01-23 2013-08-01 Sangamo Biosciences, Inc. Methods and compositions for gene editing of a pathogen
CN102660642A (en) * 2012-04-24 2012-09-12 西北农林科技大学 Screening system for screening zinc finger protein
EP2847338B1 (en) * 2012-05-07 2018-09-19 Sangamo Therapeutics, Inc. Methods and compositions for nuclease-mediated targeted integration of transgenes
PT3241902T (en) 2012-05-25 2018-05-28 Univ California METHODS AND COMPOSITIONS FOR MODIFICATION OF TARGETED TARGET DNA BY RNA AND FOR MODULATION DIRECTED BY TRANSCRIPTION RNA
JP6279562B2 (en) * 2012-06-12 2018-02-14 ジェネンテック， インコーポレイテッド Methods and compositions for generating conditional knockout alleles
AR091482A1 (en) * 2012-06-21 2015-02-04 Recombinetics Inc GENETICALLY MODIFIED CELLS AND METHODS FOR OBTAINING
US10648001B2 (en) 2012-07-11 2020-05-12 Sangamo Therapeutics, Inc. Method of treating mucopolysaccharidosis type I or II
DK2872625T3 (en) 2012-07-11 2017-02-06 Sangamo Biosciences Inc METHODS AND COMPOSITIONS FOR TREATING LYSOSOMAL STORAGE DISEASES
NZ629578A (en) * 2012-10-30 2017-06-30 Recombinetics Inc Control of sexual maturation in animals
AU2013355327A1 (en) * 2012-12-05 2015-06-11 Sangamo Therapeutics, Inc. Methods and compositions for regulation of metabolic disorders
CN108715602A (en) 2012-12-06 2018-10-30 西格马-奥尔德里奇有限责任公司 Genomic modification based on CRISPR and regulation and control
EP2931899A1 (en) 2012-12-12 2015-10-21 The Broad Institute, Inc. Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
SG10201707569YA (en) 2012-12-12 2017-10-30 Broad Inst Inc Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications
EP3434776A1 (en) 2012-12-12 2019-01-30 The Broad Institute, Inc. Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
AU2014218931C1 (en) 2013-02-20 2020-05-14 Regeneron Pharmaceuticals, Inc. Genetic modification of rats
NZ712727A (en) 2013-03-14 2017-05-26 Caribou Biosciences Inc Compositions and methods of nucleic acid-targeting nucleic acids
AU2014235968B2 (en) * 2013-03-21 2018-05-24 Ospedale San Raffaele Srl Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
CN105121650A (en) 2013-04-02 2015-12-02 拜尔作物科学公司 Targeted genome engineering in eukaryotes
HRP20181648T1 (en) 2013-04-16 2019-01-25 Regeneron Pharmaceuticals, Inc. TARGET GENOMIC TARGET MODIFICATION
CA2910427C (en) * 2013-05-10 2024-02-20 Sangamo Biosciences, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
CA2910489A1 (en) * 2013-05-15 2014-11-20 Sangamo Biosciences, Inc. Methods and compositions for treatment of a genetic condition
US20140359796A1 (en) * 2013-05-31 2014-12-04 Recombinetics, Inc. Genetically sterile animals
JP6738728B2 (en) 2013-06-17 2020-08-19 ザ・ブロード・インスティテュート・インコーポレイテッド Delivery and use of CRISPR-Cas systems, vectors and compositions for liver targeting and therapy
AU2014281031B2 (en) 2013-06-17 2020-05-21 Massachusetts Institute Of Technology Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for targeting disorders and diseases using viral components
WO2014204724A1 (en) 2013-06-17 2014-12-24 The Broad Institute Inc. Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
WO2014204725A1 (en) 2013-06-17 2014-12-24 The Broad Institute Inc. Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
WO2014204727A1 (en) 2013-06-17 2014-12-24 The Broad Institute Inc. Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
US20160264995A1 (en) * 2013-11-06 2016-09-15 Hiroshima University Vector for Nucleic Acid Insertion
US9951353B2 (en) * 2013-11-15 2018-04-24 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Engineering neural stem cells using homologous recombination
JP6300302B2 (en) * 2013-11-27 2018-03-28 国立研究開発法人農業・食品産業技術総合研究機構 Silkworm sericin 1 mutant strain
MX2016007325A (en) 2013-12-12 2017-07-19 Broad Inst Inc Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders.
WO2015089473A1 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
JP2017527256A (en) 2013-12-12 2017-09-21 ザ・ブロード・インスティテュート・インコーポレイテッド Delivery, use and therapeutic applications of CRISPR-Cas systems and compositions for HBV and viral diseases and disorders
JP6793547B2 (en) 2013-12-12 2020-12-02 ザ・ブロード・インスティテュート・インコーポレイテッド Optimization Function Systems, methods and compositions for sequence manipulation with the CRISPR-Cas system
WO2015089364A1 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Crystal structure of a crispr-cas system, and uses thereof
MX374529B (en) 2013-12-12 2025-03-06 Broad Inst Inc SUPPLY, USE AND THERAPEUTIC APPLICATIONS OF CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR GENOME EDITING.
CA2943109A1 (en) * 2014-01-17 2015-07-23 Nariyoshi Shinomiya Molecule associated with onset of gout, and method and kit for evaluating diathesis of uric acid-related disease and inflammation-related diseases, and inspection object and drug
WO2015127439A1 (en) 2014-02-24 2015-08-27 Sangamo Biosciences, Inc. Methods and compositions for nuclease-mediated targeted integration
NO2785538T3 (en) * 2014-05-07 2018-08-04
CN104450887B (en) * 2014-11-12 2017-07-25 兰州百源基因技术有限公司 DNA probe, genetic chip and its application for detecting carcinoma of endometrium
EP3985115A1 (en) 2014-12-12 2022-04-20 The Broad Institute, Inc. Protected guide rnas (pgrnas)
EP3237615B2 (en) 2014-12-24 2023-07-26 The Broad Institute, Inc. Crispr having or associated with destabilization domains
WO2016112961A1 (en) * 2015-01-13 2016-07-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Caspase-2 conditional knockouts and methods
WO2016205759A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
CA2989830A1 (en) 2015-06-18 2016-12-22 The Broad Institute, Inc. Crispr enzyme mutations reducing off-target effects
EP3330710B1 (en) * 2015-07-31 2020-09-09 Sapporo Medical University Method and kit for evaluating prognosis, distant recurrence risk and invasion of glioma, and pharmaceutical composition for treating glioma
WO2017152023A1 (en) 2016-03-04 2017-09-08 Indoor Biotechnologies Inc. Fel d 1 knockouts and associated compositions and methods based on crispr-cas9 genomic editing
PT4180519T (en) 2016-04-15 2025-09-04 Memorial Sloan Kettering Cancer Center Transgenic t cell and chimeric antigen receptor t cell compositions and related methods
US11801313B2 (en) 2016-07-06 2023-10-31 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
EP3481857B1 (en) * 2016-07-06 2026-02-11 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
US11608570B2 (en) * 2016-07-29 2023-03-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Targeted in situ protein diversification by site directed DNA cleavage and repair
US20200140875A1 (en) * 2017-05-31 2020-05-07 22Nd Century Limited, Llc Genome editing methods for producing low-nicotine tobacco products
US20210062260A1 (en) * 2017-12-21 2021-03-04 Livestock Improvement Corporation Limited Genetic markers and uses therefor
US11179479B2 (en) * 2018-01-05 2021-11-23 Animatus Biosciences, Llc Enhanced cardiomyocyte regeneration
CN111684078B (en) * 2018-02-12 2024-04-19 豪夫迈·罗氏有限公司 Methods for predicting response to treatment by assessing tumor genetic heterogeneity
CN108441577B (en) * 2018-05-25 2021-05-14 兰州大学 Primer pair, kit and application thereof, and method for detecting whether alfalfa product contains soybeans
US11827877B2 (en) 2018-06-28 2023-11-28 Crispr Therapeutics Ag Compositions and methods for genomic editing by insertion of donor polynucleotides
AU2019360270B2 (en) 2018-10-18 2025-08-07 Intellia Therapeutics, Inc. Compositions and methods for expressing factor IX.
CN114746125B (en) 2019-11-08 2025-08-08 瑞泽恩制药公司 CRISPR and AAV strategies for the treatment of X-linked juvenile retinoschisis
WO2022240649A1 (en) * 2021-05-12 2022-11-17 Alkahest, Inc. Methods and compositions for treating aging-associated impairments with trefoil factor family member 2 modulators
CN111073900B (en) * 2019-12-09 2023-05-02 温氏食品集团股份有限公司 Method for improving development efficiency of pig cloned embryo
CN111172274B (en) * 2020-01-22 2021-10-15 清华大学 Use of Synaptotagmin-7 in the Diagnosis and Treatment of Bipolar Disorder
WO2021168412A1 (en) * 2020-02-21 2021-08-26 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Non-human animal models for aging and/or neurodegeneration
CN111235153B (en) * 2020-04-01 2023-05-26 陕西慧康生物科技有限责任公司 sgRNA targeting knockout of human MC1R gene and its constructed cell line
CN111235154A (en) * 2020-04-01 2020-06-05 陕西慧康生物科技有限责任公司 sgRNA targeting knockout of human MC1R gene and its constructed cell line
WO2022145495A1 (en) * 2021-01-04 2022-07-07 Modalis Therapeutics Corporation Method for treating spinocerebellar ataxias (sca) by targeting atxn7 gene
IL282597B (en) * 2021-04-22 2022-08-01 B G Negev Technologies And Applications Ltd At Ben Gurion Univ Birds for creating female offspring and methods for creating them
CN113355356A (en) * 2021-07-05 2021-09-07 西北农林科技大学 CSN1S1 gene knockout vector and preparation method of CSN1S1 gene knockout mammary epithelial cell
CN113881646B (en) * 2021-09-28 2023-08-04 北京市农林科学院 Related protein TaFAH1 involved in plant disease resistance and its gene and application
CN113916754B (en) * 2021-10-12 2023-11-10 四川大学华西医院 Cell surface marker for detecting circulating tumor cells of breast cancer patient and application thereof
WO2024196232A1 (en) * 2023-03-21 2024-09-26 주식회사 키베이직 Composition for diagnosing cognitive dysfunction of companion animal by using nasal fluid
CN118943377B (en) * 2024-07-18 2025-05-06 江阴纳力新材料科技有限公司 Composite current collector, pole piece and secondary battery using the same
CN119372338B (en) * 2024-12-11 2025-08-01 广东省农业科学院动物科学研究所 ULK1 gene SNP molecular marker related to muscovy duck reproductive traits and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8106255B2 (en) * 2002-01-23 2012-01-31 Dana Carroll Targeted chromosomal mutagenasis using zinc finger nucleases
US20090203140A1 (en) * 2007-09-27 2009-08-13 Sangamo Biosciences, Inc. Genomic editing in zebrafish using zinc finger nucleases

Also Published As

Publication number Publication date
EP2456877A4 (en) 2012-05-30
SG177711A1 (en) 2012-02-28
CA2767377A1 (en) 2011-01-27
EP2456877A1 (en) 2012-05-30
AU2010275432A1 (en) 2012-02-02
WO2011011767A1 (en) 2011-01-27
JP2013500018A (en) 2013-01-07
KR20120097483A (en) 2012-09-04

Similar Documents

Publication Publication Date Title
IL217409A0 (en) Method for genome editing
ZA202006532B (en) Method for decreasing immunogenicity
GB0905953D0 (en) Document editing method
AP3630A (en) Improved method for synthesizing pirfenidone
PT2096102E (en) Method for creating methylene-diphenyl-diisocyanates
GB0905140D0 (en) Method
GB0911905D0 (en) Method
GB0902476D0 (en) Method
GB0910707D0 (en) Method
IL214647A0 (en) Method for inhibiting neurodegeneration
GB0913525D0 (en) Method
GB0913433D0 (en) Method
GB0901444D0 (en) Method
GB0903316D0 (en) Method
IL214287A0 (en) Method for producing 2-aminobiphenylene
GB0905367D0 (en) Method
IL215986A0 (en) Method for repairing neurodegeneration
GB0908770D0 (en) Method
GB0902034D0 (en) Method
GB0911362D0 (en) Method
GB0904946D0 (en) Method
GB0900560D0 (en) Method
EP2420492A4 (en) Method for producing 2-halogeno-6-substituted-4-trifluoromethylpyridine
GB0914702D0 (en) Method
GB0908816D0 (en) Method