IL214407A0 - Derivatives of 6-(6-o-cycloalkyl or 6-nh-cycloalkyl-triazolopyridazine-sulfanyl)benzothiazoles and benzoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors - Google Patents

Derivatives of 6-(6-o-cycloalkyl or 6-nh-cycloalkyl-triazolopyridazine-sulfanyl)benzothiazoles and benzoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors

Info

Publication number: IL214407A0
Authority: IL; Israel
Prior art keywords: cycloalkyl; benzoles; triazolopyridazine; benzothiazoles; sulfanyl
Prior art date: 2009-02-06

Application number

IL214407A

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-02-06

Filing date

2011-08-02

Publication date

2011-09-27

2011-08-02 Application filed by Sanofi Sa filed Critical Sanofi Sa

2011-09-27 Publication of IL214407A0 publication Critical patent/IL214407A0/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Neurology (AREA)
Hematology (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Oncology (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Thiazole And Isothizaole Compounds (AREA)

IL214407A 2009-02-06 2011-08-02 Derivatives of 6-(6-o-cycloalkyl or 6-nh-cycloalkyl-triazolopyridazine-sulfanyl)benzothiazoles and benzoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors IL214407A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0900510A FR2941949B1 (en)	2009-02-06	2009-02-06	DERIVATIVES OF 6- (6-O-CYCLOALKYL OR 6-NH-CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS INHIBITORS OF MET.
PCT/FR2010/050177 WO2010089506A1 (en)	2009-02-06	2010-02-04	Derivatives of 6-(6-o-cycloalkyl or 6-nh-cycloalkyl-triazolopyridazine-sulfanyl) benzothiazoles and benzimidazoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors

Publications (1)

Publication Number	Publication Date
IL214407A0 true IL214407A0 (en)	2011-09-27

Family

ID=40863635

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL214407A IL214407A0 (en)	2009-02-06	2011-08-02	Derivatives of 6-(6-o-cycloalkyl or 6-nh-cycloalkyl-triazolopyridazine-sulfanyl)benzothiazoles and benzoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors

Country Status (18)

Country	Link
EP (1)	EP2393790A1 (en)
JP (1)	JP2012517407A (en)
KR (1)	KR20110126660A (en)
CN (1)	CN102388029A (en)
AR (1)	AR075248A1 (en)
AU (1)	AU2010212231A1 (en)
BR (1)	BRPI1011354A2 (en)
CA (1)	CA2751525A1 (en)
CO (1)	CO6400222A2 (en)
EA (1)	EA201171010A1 (en)
FR (1)	FR2941949B1 (en)
IL (1)	IL214407A0 (en)
MA (1)	MA33102B1 (en)
MX (1)	MX2011008312A (en)
SG (1)	SG173558A1 (en)
TW (1)	TW201040187A (en)
UY (1)	UY32419A (en)
WO (1)	WO2010089506A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2755976B1 (en)	2011-09-15	2018-07-18	Novartis AG	6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1298125A1 (en)	2001-09-26	2003-04-02	Aventis Pharma S.A.	Substituted benzimidazole compounds and their use for the treatment of cancer
EP1963329B1 (en) *	2005-11-30	2013-01-23	Vertex Pharmaceuticals Incorporated	Inhibitors of c-met and uses thereof
ZA200804681B (en) *	2005-11-30	2009-11-25	Vertex Pharma Inc	Inhibitors of C-Met and uses thereof
RS55630B1 (en) *	2005-12-21	2017-06-30	Janssen Pharmaceutica Nv	TRIAZOLOPYRIDASINES AS TYROSINE KINASE MODULATORS
CA2651979A1 (en) *	2006-05-30	2007-12-06	Pfizer Products Inc.	Triazolopyridazine derivatives
PE20121506A1 (en) *	2006-07-14	2012-11-26	Amgen Inc	TRIAZOLOPYRIDINE COMPOUNDS AS C-MET INHIBITORS
MX2009004059A (en) *	2006-10-23	2009-04-27	Sgx Pharmaceuticals Inc	Bicyclic triazoles as protein kinase modulators.
PA8792501A1 (en) *	2007-08-09	2009-04-23	Sanofi Aventis	NEW DERIVATIVES OF 6-TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS.

2009
- 2009-02-06 FR FR0900510A patent/FR2941949B1/en not_active Expired - Fee Related
2010
- 2010-02-04 BR BRPI1011354A patent/BRPI1011354A2/en not_active IP Right Cessation
- 2010-02-04 MA MA34147A patent/MA33102B1/en unknown
- 2010-02-04 WO PCT/FR2010/050177 patent/WO2010089506A1/en not_active Ceased
- 2010-02-04 JP JP2011548750A patent/JP2012517407A/en not_active Withdrawn
- 2010-02-04 KR KR1020117020676A patent/KR20110126660A/en not_active Withdrawn
- 2010-02-04 CA CA2751525A patent/CA2751525A1/en not_active Abandoned
- 2010-02-04 EA EA201171010A patent/EA201171010A1/en unknown
- 2010-02-04 SG SG2011056470A patent/SG173558A1/en unknown
- 2010-02-04 AU AU2010212231A patent/AU2010212231A1/en not_active Abandoned
- 2010-02-04 CN CN2010800150530A patent/CN102388029A/en active Pending
- 2010-02-04 EP EP10708277A patent/EP2393790A1/en not_active Withdrawn
- 2010-02-04 MX MX2011008312A patent/MX2011008312A/en not_active Application Discontinuation
- 2010-02-05 AR ARP100100316A patent/AR075248A1/en unknown
- 2010-02-05 UY UY0001032419A patent/UY32419A/en not_active Application Discontinuation
- 2010-02-05 TW TW099103558A patent/TW201040187A/en unknown
2011
- 2011-08-02 IL IL214407A patent/IL214407A0/en unknown
- 2011-08-05 CO CO11099121A patent/CO6400222A2/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
CO6400222A2 (en)	2012-03-15
BRPI1011354A2 (en)	2019-09-24
AR075248A1 (en)	2011-03-16
EA201171010A1 (en)	2012-03-30
CA2751525A1 (en)	2010-08-12
TW201040187A (en)	2010-11-16
MX2011008312A (en)	2011-11-02
AU2010212231A1 (en)	2011-08-25
UY32419A (en)	2010-09-30
SG173558A1 (en)	2011-09-29
JP2012517407A (en)	2012-08-02
FR2941949B1 (en)	2011-04-01
EP2393790A1 (en)	2011-12-14
CN102388029A (en)	2012-03-21
KR20110126660A (en)	2011-11-23
FR2941949A1 (en)	2010-08-13
WO2010089506A1 (en)	2010-08-12
MA33102B1 (en)	2012-03-01

Publication	Publication Date	Title
IL214406A0 (en)	2011-09-27	Derivatives of 6-(6-o-substituted-triazolopyridazine-sulfanyl) benzothiazoles and benzimidazoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors
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IL214822A0 (en)	2011-11-30	Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof
ZA201001051B (en)	2011-04-28	Benzylbenzene derivatives and methods of use
IL236830A0 (en)	2015-03-31	Diazahomoadamantane derivatives and methods of use thereof
ZA200906062B (en)	2010-05-26	Benzimidazole derivatives and methods of use thereof
PL2413913T3 (en)	2022-09-26	Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making the same
EP2536283B8 (en)	2015-11-04	Phenyl-heteroaryl derivatives and methods of use thereof
IL219155A0 (en)	2012-06-28	Pharmaceutical formulations of nitrite and uses thereof
EP2507253A4 (en)	2013-05-22	6-substituted estradiol derivatives and methods of use
ZA201107104B (en)	2012-05-30	Derivatives of benzothiazines,preparation thereof and application thereof as drugs
EP2320738A4 (en)	2011-08-24	Substituted aminothiazole derivatives, pharmaceutical compositions, and methods of use
IL219934A0 (en)	2012-07-31	Quinazolin-4(3a)-one derivatives and methods of use thereof
IL214408A0 (en)	2011-09-27	Derivatives of 6-(6-substituted-triazolopyidazine-sulfanyl) 5-fluoro-benzothiazoles and 5-fluoro-benzimidazoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors
IL219935A0 (en)	2012-07-31	Small pyrimidine derivatives and methods of use thereof
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IL214404A0 (en)	2011-09-27	Derivatives of 6-(6-nh-substituted-triazolopyridazine-sulfanyl)benzothiazoles and benzimidazoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors
IL209903A0 (en)	2011-02-28	Derivatives of 2-oxo-alkyl-1-piperazin-2-one, preparation method thereof and therapeutic use of same
EP2424533A4 (en)	2012-10-17	Substituted isoquinoline derivatives, pharmaceutical compositions, and methods of use as -secretase inhibitors
IL214407A0 (en)	2011-09-27	Derivatives of 6-(6-o-cycloalkyl or 6-nh-cycloalkyl-triazolopyridazine-sulfanyl)benzothiazoles and benzoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors
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HK1163692A (en)	2012-09-14	Derivatives of 6-(6-o-substituted-triazolopyridazine-sulfanyl) benzothiazoles and benzimidazoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors
HK1163667A (en)	2012-09-14	Derivatives of 6-(6-nh-substituted-triazolopyridazine-sulfanyl) benzothiazoles and benzimidazoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors
HK1163691A (en)	2012-09-14	Derivatives of 6-(6-substituted-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles and 5-fluoro-benzimidazoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors
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