IL192991A0 - Use of tetrahydrocarbazole derivatives for the manufacture of medicanents for treating gonadotropin-releasing hormone - Google Patents
Use of tetrahydrocarbazole derivatives for the manufacture of medicanents for treating gonadotropin-releasing hormoneInfo
- Publication number
- IL192991A0 IL192991A0 IL192991A IL19299108A IL192991A0 IL 192991 A0 IL192991 A0 IL 192991A0 IL 192991 A IL192991 A IL 192991A IL 19299108 A IL19299108 A IL 19299108A IL 192991 A0 IL192991 A0 IL 192991A0
- Authority
- IL
- Israel
- Prior art keywords
- medicanents
- manufacture
- releasing hormone
- tetrahydrocarbazole derivatives
- gonadotropin
- Prior art date
Links
- XKLNOVWDVMWTOB-UHFFFAOYSA-N 2,3,4,9-tetrahydro-1h-carbazole Chemical class N1C2=CC=CC=C2C2=C1CCCC2 XKLNOVWDVMWTOB-UHFFFAOYSA-N 0.000 title 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 title 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 title 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title 1
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Pregnancy & Childbirth (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10164564A DE10164564B4 (en) | 2001-12-14 | 2001-12-14 | Tetrahydrocarbazole derivatives as ligands for G-protein coupled receptors (GPCR) |
| US34187801P | 2001-12-21 | 2001-12-21 | |
| PCT/EP2002/014344 WO2003051837A2 (en) | 2001-12-14 | 2002-12-16 | Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL192991A0 true IL192991A0 (en) | 2011-08-01 |
Family
ID=26010882
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16162602A IL161626A0 (en) | 2001-12-14 | 2002-12-16 | Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr) |
| IL192991A IL192991A0 (en) | 2001-12-14 | 2008-07-23 | Use of tetrahydrocarbazole derivatives for the manufacture of medicanents for treating gonadotropin-releasing hormone |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16162602A IL161626A0 (en) | 2001-12-14 | 2002-12-16 | Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr) |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1453803A2 (en) |
| JP (1) | JP2005518375A (en) |
| CN (1) | CN100500654C (en) |
| AR (1) | AR037863A1 (en) |
| AU (1) | AU2002361430B2 (en) |
| BR (1) | BR0214958A (en) |
| CA (1) | CA2468880A1 (en) |
| HR (1) | HRP20040609A2 (en) |
| HU (1) | HUP0500014A3 (en) |
| IL (2) | IL161626A0 (en) |
| MX (1) | MXPA04005768A (en) |
| NO (1) | NO326692B1 (en) |
| NZ (1) | NZ533430A (en) |
| PL (1) | PL373400A1 (en) |
| RU (1) | RU2319692C2 (en) |
| TW (1) | TWI246423B (en) |
| WO (1) | WO2003051837A2 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05012459A (en) * | 2003-05-19 | 2006-02-22 | Irm Llc | Immunosuppressant compounds and compositions. |
| US7351733B2 (en) * | 2003-06-10 | 2008-04-01 | Smithkline Beecham Corporation | Tetrahydrocarbazole derivatives and their pharmaceutical use |
| US20060074124A1 (en) * | 2003-09-12 | 2006-04-06 | Andrew Napper | Methods of treating a disorder |
| CA2538759C (en) * | 2003-09-12 | 2015-11-03 | Elixir Pharmaceuticals, Inc. | Substituted heterocyclic compounds as sirtuin inhitibitors |
| CA2560700A1 (en) * | 2004-03-26 | 2005-10-06 | Henrietta Dehmlow | Tetrahydrocarbazoles and derivatives |
| RU2430088C2 (en) * | 2004-07-14 | 2011-09-27 | Центарис Гмбх | Tetrahydrocarbazole derivatives and pharmaceutical composition based on said derivatives |
| DE102004033902A1 (en) * | 2004-07-14 | 2006-02-16 | Zentaris Gmbh | New tetrahydrocarbazole compounds are neurokinin-1 receptor antagonists useful to treat or prevent e.g. pubertas praecox, hirsutism, polycystic ovary syndrome, hormone dependent neoplastic diseases and Alzheimer's disease |
| AU2005320964B2 (en) * | 2004-12-27 | 2011-12-15 | Actelion Pharmaceuticals Ltd. | 2,3,4,9-tetrahydro-1H-carbazole derivatives as CRTH2 receptor antagonists |
| MX2007015905A (en) * | 2005-06-24 | 2008-03-06 | Lilly Co Eli | Tetrahydrocarbazole derivatives useful as androgen receptor modulators. |
| NZ574705A (en) * | 2006-08-07 | 2011-12-22 | Actelion Pharmaceuticals Ltd | (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives |
| EP1967202A1 (en) * | 2007-03-05 | 2008-09-10 | AEterna Zentaris GmbH | Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity |
| EP1988098A1 (en) * | 2007-04-27 | 2008-11-05 | AEterna Zentaris GmbH | Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors |
| EP2095818A1 (en) * | 2008-02-29 | 2009-09-02 | AEterna Zentaris GmbH | Use of LHRH antagonists at non-castrating doses |
| EP2558447B1 (en) | 2010-03-22 | 2014-09-17 | Actelion Pharmaceuticals Ltd. | 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators |
| MX338516B (en) | 2011-04-14 | 2016-04-20 | Actelion Pharmaceuticals Ltd | 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators. |
| KR101864060B1 (en) | 2014-03-17 | 2018-06-01 | 이도르시아 파마슈티컬스 리미티드 | Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
| AU2015233046A1 (en) | 2014-03-18 | 2016-11-03 | Idorsia Pharmaceuticals Ltd | Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators |
| KR20180053345A (en) | 2015-09-15 | 2018-05-21 | 이도르시아 파마슈티컬스 리미티드 | Crystalline form |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1418703A (en) * | 1973-06-02 | 1975-12-24 | Pfizer Ltd | 3-alkyl-9-substituted-1,2,3,4-tetrahydrocarbazoles |
| BG25793A3 (en) * | 1973-07-18 | 1978-12-12 | Schering Aktiengesellschaft | METHOD FOR OBTAINING CARBAZOLE DERIVATIVES |
| DE3786030T2 (en) * | 1986-03-27 | 1993-12-02 | Merck Frosst Canada Inc | Tetrahydrocarbazole esters. |
| US5607939A (en) * | 1994-04-28 | 1997-03-04 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
| JP2002502427A (en) * | 1997-06-05 | 2002-01-22 | メルク エンド カンパニー インコーポレーテッド | Gonadotropin-releasing hormone antagonist |
-
2002
- 2002-12-16 AU AU2002361430A patent/AU2002361430B2/en not_active Ceased
- 2002-12-16 IL IL16162602A patent/IL161626A0/en unknown
- 2002-12-16 MX MXPA04005768A patent/MXPA04005768A/en active IP Right Grant
- 2002-12-16 RU RU2004121776/04A patent/RU2319692C2/en not_active IP Right Cessation
- 2002-12-16 CA CA002468880A patent/CA2468880A1/en not_active Abandoned
- 2002-12-16 TW TW091136440A patent/TWI246423B/en not_active IP Right Cessation
- 2002-12-16 BR BR0214958-3A patent/BR0214958A/en not_active IP Right Cessation
- 2002-12-16 CN CNB028241487A patent/CN100500654C/en not_active Expired - Fee Related
- 2002-12-16 PL PL02373400A patent/PL373400A1/en not_active Application Discontinuation
- 2002-12-16 EP EP02796648A patent/EP1453803A2/en not_active Withdrawn
- 2002-12-16 HU HU0500014A patent/HUP0500014A3/en unknown
- 2002-12-16 NZ NZ533430A patent/NZ533430A/en unknown
- 2002-12-16 WO PCT/EP2002/014344 patent/WO2003051837A2/en not_active Ceased
- 2002-12-16 HR HR20040609A patent/HRP20040609A2/en not_active Application Discontinuation
- 2002-12-16 JP JP2003552724A patent/JP2005518375A/en active Pending
- 2002-12-17 AR ARP020104893A patent/AR037863A1/en unknown
-
2004
- 2004-05-26 NO NO20042198A patent/NO326692B1/en not_active IP Right Cessation
-
2008
- 2008-07-23 IL IL192991A patent/IL192991A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL373400A1 (en) | 2005-08-22 |
| HUP0500014A2 (en) | 2005-04-28 |
| HRP20040609A2 (en) | 2005-06-30 |
| WO2003051837A8 (en) | 2004-05-06 |
| NO326692B1 (en) | 2009-02-02 |
| WO2003051837A2 (en) | 2003-06-26 |
| RU2319692C2 (en) | 2008-03-20 |
| RU2004121776A (en) | 2005-05-10 |
| CN1599720A (en) | 2005-03-23 |
| MXPA04005768A (en) | 2004-09-10 |
| AU2002361430B2 (en) | 2007-09-13 |
| AR037863A1 (en) | 2004-12-09 |
| EP1453803A2 (en) | 2004-09-08 |
| CN100500654C (en) | 2009-06-17 |
| NZ533430A (en) | 2005-12-23 |
| WO2003051837A3 (en) | 2004-02-26 |
| JP2005518375A (en) | 2005-06-23 |
| BR0214958A (en) | 2004-12-28 |
| IL161626A0 (en) | 2004-09-27 |
| CA2468880A1 (en) | 2003-06-26 |
| NO20042198L (en) | 2004-07-09 |
| HUP0500014A3 (en) | 2010-06-28 |
| TWI246423B (en) | 2006-01-01 |
| AU2002361430A1 (en) | 2003-06-30 |
| TW200305405A (en) | 2003-11-01 |
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