IL198829A0 - Gm-csf antagonist use in treating chronic inflammatory diseases - Google Patents
Gm-csf antagonist use in treating chronic inflammatory diseasesInfo
- Publication number
- IL198829A0 IL198829A0 IL198829A IL19882909A IL198829A0 IL 198829 A0 IL198829 A0 IL 198829A0 IL 198829 A IL198829 A IL 198829A IL 19882909 A IL19882909 A IL 19882909A IL 198829 A0 IL198829 A0 IL 198829A0
- Authority
- IL
- Israel
- Prior art keywords
- inflammatory diseases
- chronic inflammatory
- treating chronic
- csf antagonist
- antagonist use
- Prior art date
Links
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 title 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 208000037976 chronic inflammation Diseases 0.000 title 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86078006P | 2006-11-21 | 2006-11-21 | |
| US90274207P | 2007-02-21 | 2007-02-21 | |
| PCT/US2007/085402 WO2008064321A2 (en) | 2006-11-21 | 2007-11-21 | Methods of treating chronic inflammatory diseases using a gm-csf antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL198829A0 true IL198829A0 (en) | 2010-02-17 |
Family
ID=39386167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL198829A IL198829A0 (en) | 2006-11-21 | 2009-05-19 | Gm-csf antagonist use in treating chronic inflammatory diseases |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20080206241A1 (en) |
| EP (2) | EP2402013A1 (en) |
| JP (1) | JP5410293B2 (en) |
| KR (1) | KR101517251B1 (en) |
| CN (2) | CN101605547A (en) |
| AU (1) | AU2007323541B2 (en) |
| BR (1) | BRPI0719109A2 (en) |
| CA (1) | CA2670288C (en) |
| EA (1) | EA200900709A1 (en) |
| ES (1) | ES2432173T3 (en) |
| IL (1) | IL198829A0 (en) |
| MX (1) | MX2009005398A (en) |
| NZ (1) | NZ598345A (en) |
| SG (1) | SG176503A1 (en) |
| WO (1) | WO2008064321A2 (en) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101605547A (en) | 2006-11-21 | 2009-12-16 | 卡罗拜奥斯制药公司 | Methods of treating chronic inflammatory diseases using GM-CSF antagonists |
| EP2222846B1 (en) * | 2007-08-10 | 2017-05-03 | Protelix, Inc. | Universal fibronectin type iii binding-domain libraries |
| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| TW200918553A (en) * | 2007-09-18 | 2009-05-01 | Amgen Inc | Human GM-CSF antigen binding proteins |
| PT2215119E (en) | 2007-11-13 | 2013-02-11 | Boehringer Ingelheim Int | Monoclonal antibodies that bind to hgm-csf and medical compositions comprising same |
| ATE555131T1 (en) * | 2008-01-15 | 2012-05-15 | Kalobios Pharmaceuticals Inc | METHOD FOR TREATING BONE DEPOSITIVE DISEASES USING A GM-CSF ANTAGONIST |
| US8075885B2 (en) * | 2008-04-07 | 2011-12-13 | Kalobios Pharmaceuticals, Inc. | Methods of treating heart failure using an anti-GM-CSF antibody |
| EP2280732B1 (en) | 2008-04-28 | 2018-10-17 | Humanigen, Inc. | Antibodies to granulocyte-macrophage colony-stimulating factor |
| PL2376121T5 (en) * | 2008-12-22 | 2021-09-27 | The University Of Melbourne | Osteoarthritis treatment |
| CA2747206C (en) | 2008-12-22 | 2018-04-24 | The University Of Melbourne | Pain treatment |
| AU2015224416B2 (en) * | 2008-12-22 | 2017-04-20 | The University Of Melbourne | Osteoarthritis treatment |
| WO2010093814A1 (en) * | 2009-02-11 | 2010-08-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a gm-csf antagonist |
| CN102459340A (en) * | 2009-04-23 | 2012-05-16 | 特罗科隆科学有限公司 | Granulocyte-macrophage colony-stimulating factor (gm-csf) neutralizing antibodies |
| AU2010244525B2 (en) * | 2009-05-05 | 2013-03-28 | Morphosys Ag | Treatment for multiple sclerosis |
| JP2014520784A (en) * | 2011-07-06 | 2014-08-25 | モルフォシス・アー・ゲー | Therapeutic combination of anti-CD20 antibody and anti-GM-CSF antibody and use thereof |
| KR20210021153A (en) * | 2012-09-20 | 2021-02-24 | 모르포시스 아게 | Treatment for rheumatoid arthritis |
| MY175388A (en) * | 2012-09-20 | 2020-06-23 | Morphosys Ag | Treatment for rheumatoid arthritis |
| AR093297A1 (en) * | 2012-10-31 | 2015-05-27 | Amgen Res Munich Gmbh | LIQUID FORMULATION THAT INCLUDES A GM-CSF NEUTRALIZING COMPOUND |
| WO2015028657A1 (en) * | 2013-08-30 | 2015-03-05 | Takeda Gmbh | Antibodies neutralizing gm-csf for use in the treatment of rheumatoid arthritis or as analgesics |
| JP6360696B2 (en) * | 2014-03-18 | 2018-07-18 | 日本光電工業株式会社 | Blood test apparatus and blood test method |
| CN106456761A (en) * | 2014-05-19 | 2017-02-22 | 免疫医疗有限公司 | Treatment for rheumatoid arthritis |
| US20180236098A1 (en) * | 2016-08-12 | 2018-08-23 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
| KR101953706B1 (en) | 2016-09-19 | 2019-03-05 | 아이-맵 | Anti-GM-CSF antibody and its use |
| EP3691663A4 (en) * | 2017-10-02 | 2021-08-18 | Humanigen, Inc. | METHOD OF TREATING IMMUNOTHERAPY ASSOCIATED TOXICITY USING GM-CSF ANTAGONIST |
| US10927168B2 (en) | 2017-10-02 | 2021-02-23 | Humanicen, Inc. | Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab |
| US10899831B2 (en) | 2017-10-02 | 2021-01-26 | Humanigen, Inc. | Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity |
| US11130805B2 (en) | 2017-10-02 | 2021-09-28 | Humanigen, Inc. | Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist |
| US20220040229A1 (en) * | 2018-10-31 | 2022-02-10 | Humanigen, Inc. | Materials and methods for treating cancer |
| CN115605508A (en) * | 2020-03-08 | 2023-01-13 | 赫曼尼根公司(Us) | Methods for treating coronavirus infection and resulting inflammation-induced lung injury |
| CA3198765A1 (en) * | 2020-12-04 | 2022-06-09 | Catherine Mary Owczarek | Methods for treating inflammatory skin conditions |
| US20240317846A1 (en) * | 2021-03-08 | 2024-09-26 | Humanigen, Inc. | Methods for treating coronavirus infection and resulting inflammation-induced lung injury |
| WO2023138499A1 (en) * | 2022-01-20 | 2023-07-27 | 舒泰神(北京)生物制药股份有限公司 | Antibody preparation for specifically recognizing granulocyte-macrophage colony-stimulating factor receptor and use thereof |
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| NZ234479A (en) * | 1989-07-14 | 1992-03-26 | Schering Corp | Antagonists of gm-csf derived from the carboxyl terminus, antibodies, hybridomas and pharmaceutical compositions containing anti-idiotypic antibodies |
| WO1994009149A1 (en) | 1990-08-10 | 1994-04-28 | Amrad Corporation Limited | Monoclonal antibody |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| JP2938569B2 (en) | 1990-08-29 | 1999-08-23 | ジェンファーム インターナショナル,インコーポレイティド | Method for producing xenogeneic immunoglobulin and transgenic mouse |
| US6258562B1 (en) | 1996-02-09 | 2001-07-10 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| US5770380A (en) | 1996-09-13 | 1998-06-23 | University Of Pittsburgh | Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold |
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-
2007
- 2007-11-21 CN CNA2007800495322A patent/CN101605547A/en active Pending
- 2007-11-21 CA CA2670288A patent/CA2670288C/en not_active Expired - Fee Related
- 2007-11-21 BR BRPI0719109-0A2A patent/BRPI0719109A2/en not_active IP Right Cessation
- 2007-11-21 MX MX2009005398A patent/MX2009005398A/en active IP Right Grant
- 2007-11-21 EA EA200900709A patent/EA200900709A1/en unknown
- 2007-11-21 AU AU2007323541A patent/AU2007323541B2/en not_active Ceased
- 2007-11-21 US US11/944,162 patent/US20080206241A1/en not_active Abandoned
- 2007-11-21 EP EP11182971A patent/EP2402013A1/en not_active Withdrawn
- 2007-11-21 EP EP07868831.4A patent/EP2101780B1/en not_active Revoked
- 2007-11-21 ES ES07868831T patent/ES2432173T3/en active Active
- 2007-11-21 WO PCT/US2007/085402 patent/WO2008064321A2/en not_active Ceased
- 2007-11-21 CN CN201510674256.5A patent/CN105435223A/en active Pending
- 2007-11-21 KR KR1020097012906A patent/KR101517251B1/en not_active Expired - Fee Related
- 2007-11-21 SG SG2011085834A patent/SG176503A1/en unknown
- 2007-11-21 NZ NZ598345A patent/NZ598345A/en not_active IP Right Cessation
- 2007-11-21 JP JP2009538506A patent/JP5410293B2/en not_active Expired - Fee Related
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2009
- 2009-05-19 IL IL198829A patent/IL198829A0/en unknown
-
2015
- 2015-05-14 US US14/712,627 patent/US20150246121A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0719109A2 (en) | 2013-12-10 |
| KR101517251B1 (en) | 2015-05-07 |
| JP2010510323A (en) | 2010-04-02 |
| AU2007323541B2 (en) | 2012-01-19 |
| SG176503A1 (en) | 2011-12-29 |
| MX2009005398A (en) | 2009-08-20 |
| KR20090110827A (en) | 2009-10-22 |
| NZ598345A (en) | 2013-09-27 |
| CA2670288A1 (en) | 2008-05-29 |
| ES2432173T3 (en) | 2013-12-02 |
| US20080206241A1 (en) | 2008-08-28 |
| CN101605547A (en) | 2009-12-16 |
| WO2008064321A2 (en) | 2008-05-29 |
| EP2101780A2 (en) | 2009-09-23 |
| CA2670288C (en) | 2015-10-27 |
| EP2101780B1 (en) | 2013-10-09 |
| AU2007323541A1 (en) | 2008-05-29 |
| CN105435223A (en) | 2016-03-30 |
| WO2008064321A3 (en) | 2008-10-02 |
| JP5410293B2 (en) | 2014-02-05 |
| EA200900709A1 (en) | 2009-12-30 |
| EP2402013A1 (en) | 2012-01-04 |
| US20150246121A1 (en) | 2015-09-03 |
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