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IL180894A0 - 1-??-halo-2,2-difluoro-2-deoxy-d-ribofuranose derivatives and processes for the preparation thereof - Google Patents

1-??-halo-2,2-difluoro-2-deoxy-d-ribofuranose derivatives and processes for the preparation thereof

Info

Publication number
IL180894A0
IL180894A0 IL180894A IL18089407A IL180894A0 IL 180894 A0 IL180894 A0 IL 180894A0 IL 180894 A IL180894 A IL 180894A IL 18089407 A IL18089407 A IL 18089407A IL 180894 A0 IL180894 A0 IL 180894A0
Authority
IL
Israel
Prior art keywords
deoxy
difluoro
halo
processes
preparation
Prior art date
Application number
IL180894A
Other versions
IL180894A (en
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/KR2005/001922 external-priority patent/WO2006011713A1/en
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of IL180894A0 publication Critical patent/IL180894A0/en
Publication of IL180894A publication Critical patent/IL180894A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/08—Deoxysugars; Unsaturated sugars; Osones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL180894A 2004-07-29 2007-01-23 1-alpha-halo-2,2-difluoro-2-deoxy-d-ribofuranose derivatives and processes for the preparation thereof IL180894A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20040059623 2004-07-29
KR1020050041278A KR100699099B1 (en) 2004-07-29 2005-05-17 1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivative and preparation method thereof
PCT/KR2005/001922 WO2006011713A1 (en) 2004-07-29 2005-06-21 1-α-HALO-2,2-DIFLUORO-2-DEOXY-D-RIBOFURANOSE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF

Publications (2)

Publication Number Publication Date
IL180894A0 true IL180894A0 (en) 2007-07-04
IL180894A IL180894A (en) 2011-09-27

Family

ID=37149831

Family Applications (1)

Application Number Title Priority Date Filing Date
IL180894A IL180894A (en) 2004-07-29 2007-01-23 1-alpha-halo-2,2-difluoro-2-deoxy-d-ribofuranose derivatives and processes for the preparation thereof

Country Status (6)

Country Link
JP (1) JP4691101B2 (en)
KR (1) KR100699099B1 (en)
CN (1) CN1989148B (en)
IL (1) IL180894A (en)
MX (1) MX2007000959A (en)
RU (1) RU2346948C2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100858842B1 (en) * 2007-03-23 2008-09-22 동우신테크 주식회사 Manufacturing method of optically active oxo ribose derivative using chiral amine
JP5349342B2 (en) 2007-03-23 2013-11-20 ドンウ シンテック カンパニー リミテッド Method for producing 2'-deoxy-2 ', 2'-difluorocytidine
CN101628927B (en) * 2009-08-07 2012-10-10 卡硼瑞（北京）科技有限公司 Method for three-dimensionally selectively preparing Beta-gemcitabine hydrochloride by using 1, 3, 5-3-O-benzoyl-Alpha-D-ribofuranose as raw materials
CN103897008A (en) * 2012-12-28 2014-07-02 石药集团中奇制药技术（石家庄）有限公司 Method for preparing decitabine and intermediate thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
CA2039403A1 (en) * 1990-04-04 1991-10-05 Gerald Saischek Process for the manufacture of 2-deoxy-d-threo-pentofuranosides, intermediates for their manufacture and their use
US5401861A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
CZ123493A3 (en) * 1992-06-22 1994-02-16 Lilly Co Eli Stereoselective anionic glycosylation process
HU214030B (en) * 1992-06-22 1997-12-29 Lilly Co Eli Process for preparing alpha-anomer enriched 1-halogen-2-deoxy-2,2-difluoro-d-ribofuranosyl derivatives
RU2131880C1 (en) * 1992-06-22 1999-06-20 Эли Лилли Энд Компани Method of preparing beta-anomer enriched nucleosides
ATE236188T1 (en) * 1997-01-24 2003-04-15 Conpharma As GEMCITABINE DERIVATIVES
JP2003055364A (en) * 2001-06-07 2003-02-26 Mitsui Chemicals Inc Novel production method relating to 2,3-dideoxy-2,3- dehydropentofuranose derivative

Also Published As

Publication number Publication date
HK1100946A1 (en) 2007-10-05
RU2346948C2 (en) 2009-02-20
IL180894A (en) 2011-09-27
RU2007107607A (en) 2008-09-10
KR100699099B1 (en) 2007-03-22
CN1989148A (en) 2007-06-27
MX2007000959A (en) 2007-04-16
JP4691101B2 (en) 2011-06-01
CN1989148B (en) 2010-05-12
KR20060047970A (en) 2006-05-18
JP2008508261A (en) 2008-03-21

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees