IL162330A0 - Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar) - Google Patents

Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)

Info

Publication number: IL162330A0
Authority: IL; Israel
Prior art keywords: ppar; agonists; acid derivatives; activated receptor; receptor alpha
Prior art date: 2001-12-19

Application number

IL16233002A

Other languages

English (en)

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-19

Filing date

2002-12-18

Publication date

2005-11-20

2002-12-18 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2005-11-20 Publication of IL162330A0 publication Critical patent/IL162330A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Obesity (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Psychology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL16233002A 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar) IL162330A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE0104334A SE0104334D0 (sv)	2001-12-19	2001-12-19	Therapeutic agents
PCT/GB2002/005738 WO2003051821A1 (en)	2001-12-19	2002-12-18	Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)

Publications (1)

Publication Number	Publication Date
IL162330A0 true IL162330A0 (en)	2005-11-20

Family

ID=20286433

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL16233102A IL162331A0 (en)	2001-12-19	2002-12-18	Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
IL16233002A IL162330A0 (en)	2001-12-19	2002-12-18	Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
IL162330A IL162330A (en)	2001-12-19	2004-06-03	Substituted phenylpropionic acid derivatives, process for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments for the treatment of lipid disorders (dyslipidemias), whether or not associated with insulin resistance

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
IL16233102A IL162331A0 (en)	2001-12-19	2002-12-18	Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL162330A IL162330A (en)	2001-12-19	2004-06-03	Substituted phenylpropionic acid derivatives, process for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments for the treatment of lipid disorders (dyslipidemias), whether or not associated with insulin resistance

Country Status (30)

Country	Link
US (2)	US7256307B2 (is)
EP (2)	EP1458672B1 (is)
JP (4)	JP3820249B2 (is)
KR (2)	KR20040074092A (is)
CN (3)	CN1293044C (is)
AR (2)	AR038045A1 (is)
AT (2)	ATE338743T1 (is)
AU (2)	AU2002366315A1 (is)
BR (2)	BR0214986A (is)
CA (2)	CA2470491A1 (is)
CY (2)	CY1106276T1 (is)
DE (2)	DE60214594T2 (is)
DK (2)	DK1458672T3 (is)
ES (2)	ES2286310T3 (is)
HU (2)	HUP0402022A3 (is)
IL (3)	IL162331A0 (is)
IS (2)	IS7309A (is)
MX (2)	MXPA04006004A (is)
MY (1)	MY132565A (is)
NO (2)	NO20043023L (is)
NZ (2)	NZ533274A (is)
PL (2)	PL370672A1 (is)
PT (2)	PT1458673E (is)
RU (2)	RU2300517C2 (is)
SE (1)	SE0104334D0 (is)
SI (2)	SI1458673T1 (is)
TW (2)	TWI253444B (is)
UA (2)	UA77987C2 (is)
WO (2)	WO2003051821A1 (is)
ZA (2)	ZA200404657B (is)

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Also Published As

Publication number	Publication date
IL162330A (en)	2009-06-15
US7256307B2 (en)	2007-08-14
CN1896045A (zh)	2007-01-17
NZ533276A (en)	2006-04-28
WO2003051821A1 (en)	2003-06-26
RU2004116917A (ru)	2005-11-10
ES2286310T3 (es)	2007-12-01
TWI255807B (en)	2006-06-01
PL370673A1 (en)	2005-05-30
TW200410918A (en)	2004-07-01
AR038045A1 (es)	2004-12-22
DE60214594T2 (de)	2007-09-13
AU2002366315A1 (en)	2003-06-30
NZ533274A (en)	2005-12-23
US20050113362A1 (en)	2005-05-26
RU2300517C2 (ru)	2007-06-10
IS7313A (is)	2004-06-15
HK1068604A1 (en)	2005-04-29
EP1458673A1 (en)	2004-09-22
CY1106276T1 (el)	2011-10-12
JP2006298924A (ja)	2006-11-02
SI1458672T1 (sl)	2007-10-31
CN1620422A (zh)	2005-05-25
CN100406427C (zh)	2008-07-30
PL370672A1 (en)	2005-05-30
ATE338743T1 (de)	2006-09-15
CA2470491A1 (en)	2003-06-26
CA2469302A1 (en)	2003-06-26
DE60220441T2 (de)	2008-01-24
SI1458673T1 (sl)	2007-02-28
WO2003051822A1 (en)	2003-06-26
IS7309A (is)	2004-06-14
EP1458673B1 (en)	2006-09-06
HUP0402022A2 (hu)	2005-01-28
TW200410925A (en)	2004-07-01
KR20040074094A (ko)	2004-08-21
US20050171204A1 (en)	2005-08-04
DE60214594D1 (de)	2006-10-19
EP1458672B1 (en)	2007-05-30
JP2005336209A (ja)	2005-12-08
HUP0402133A3 (en)	2010-07-28
JP3820249B2 (ja)	2006-09-13
SE0104334D0 (sv)	2001-12-19
US7514471B2 (en)	2009-04-07
MXPA04006003A (es)	2004-09-27
JP2005526011A (ja)	2005-09-02
NO20043164L (no)	2004-07-16
JP2005526704A (ja)	2005-09-08
ZA200404657B (en)	2005-08-29
UA77460C2 (en)	2006-12-15
IL162331A0 (en)	2005-11-20
KR20040074092A (ko)	2004-08-21
AR038047A1 (es)	2004-12-22
HUP0402022A3 (en)	2009-06-29
DE60220441D1 (de)	2007-07-12
CN1293044C (zh)	2007-01-03
CY1106784T1 (el)	2012-05-23
ATE363466T1 (de)	2007-06-15
MXPA04006004A (es)	2004-09-27
RU2303031C2 (ru)	2007-07-20
PT1458673E (pt)	2006-12-29
JP3784804B2 (ja)	2006-06-14
BR0214988A (pt)	2004-12-14
BR0214986A (pt)	2004-12-14
AU2002352427A1 (en)	2003-06-30
EP1458672A1 (en)	2004-09-22
ZA200404658B (en)	2006-02-22
RU2004116918A (ru)	2005-11-10
CN1620423A (zh)	2005-05-25
UA77987C2 (en)	2007-02-15
NO20043023L (no)	2004-07-15
DK1458672T3 (da)	2007-09-17
TWI253444B (en)	2006-04-21
MY132565A (en)	2007-10-31
HUP0402133A2 (hu)	2005-02-28
DK1458673T3 (da)	2006-12-11
HK1068870A1 (en)	2005-05-06
PT1458672E (pt)	2007-07-18
ES2271381T3 (es)	2007-04-16

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SI1539746T1 (sl)	2007-04-30	Spojine n-substituirane-1h-indol-5-propionske kisline kot agonisti ppar, ki so uporabne za zdravljenje diabetesa
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