[go: up one dir, main page]

IL161942A0 - (+)-2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol - Google Patents

(+)-2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol

Info

Publication number
IL161942A0
IL161942A0 IL16194299A IL16194299A IL161942A0 IL 161942 A0 IL161942 A0 IL 161942A0 IL 16194299 A IL16194299 A IL 16194299A IL 16194299 A IL16194299 A IL 16194299A IL 161942 A0 IL161942 A0 IL 161942A0
Authority
IL
Israel
Prior art keywords
morpholinol
chlorophenyl
trimethyl
Prior art date
Application number
IL16194299A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9801230.5A external-priority patent/GB9801230D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IL161942A0 publication Critical patent/IL161942A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL16194299A 1998-01-21 1999-01-20 (+)-2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol IL161942A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9801230.5A GB9801230D0 (en) 1998-01-21 1998-01-21 Pharmaceutically active morpholinol
US7218098P 1998-01-22 1998-01-22
PCT/US1999/001134 WO1999037305A1 (en) 1998-01-21 1999-01-20 Pharmaceutically active morpholinol

Publications (1)

Publication Number Publication Date
IL161942A0 true IL161942A0 (en) 2005-11-20

Family

ID=26312986

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16194299A IL161942A0 (en) 1998-01-21 1999-01-20 (+)-2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol
IL13734699A IL137346A0 (en) 1998-01-21 1999-01-20 Pharmaceutically active morpholinol

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL13734699A IL137346A0 (en) 1998-01-21 1999-01-20 Pharmaceutically active morpholinol

Country Status (30)

Country Link
US (2) US6274579B1 (is)
EP (2) EP1829544A1 (is)
JP (1) JP2002501025A (is)
KR (1) KR100568063B1 (is)
CN (2) CN1255389C (is)
AP (1) AP1229A (is)
AT (1) ATE365042T1 (is)
AU (1) AU755536B2 (is)
BR (1) BR9907203A (is)
CA (1) CA2318268A1 (is)
CY (1) CY1106828T1 (is)
DE (1) DE69936335T2 (is)
DK (1) DK1047428T3 (is)
EA (1) EA002410B1 (is)
EE (1) EE04452B1 (is)
ES (1) ES2288012T3 (is)
HR (2) HRP20051024A2 (is)
HU (1) HUP0100900A3 (is)
ID (1) ID26334A (is)
IL (2) IL161942A0 (is)
IS (1) IS2494B (is)
NO (2) NO326878B1 (is)
NZ (3) NZ520349A (is)
PL (1) PL193622B1 (is)
PT (1) PT1047428E (is)
SG (1) SG115489A1 (is)
SK (1) SK10912000A3 (is)
TR (1) TR200002126T2 (is)
WO (1) WO1999037305A1 (is)
YU (1) YU67102A (is)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7098206B2 (en) * 1998-01-21 2006-08-29 Smithkline Beecham Corporation Pharmaceutically active morpholinol
US6998400B2 (en) * 1998-01-22 2006-02-14 Smithkline Beecham Corporation Pharmaceutically active morpholinol
WO1999038503A1 (en) * 1998-01-29 1999-08-05 Sepracor Inc. Pharmacological uses of optically pure (+)-bupropion
US6110973A (en) 1998-01-29 2000-08-29 Sepracor Methods for treating obesity and weight gain using optically pure (-)-bupropion
US6855820B2 (en) 1999-01-20 2005-02-15 Smithkline Beecham Corporation Pharmaceutically active morpholinol
US6734213B2 (en) 1999-01-20 2004-05-11 Smithkline Beecham Corporation Pharmaceutically active morpholinol
US6342496B1 (en) * 1999-03-01 2002-01-29 Sepracor Inc. Bupropion metabolites and methods of use
US6337328B1 (en) * 1999-03-01 2002-01-08 Sepracor, Inc. Bupropion metabolites and methods of use
WO2001026641A2 (en) * 1999-10-13 2001-04-19 Glaxo Group Limited Morpholinol derivatives for the treatment of obesity
GB0003232D0 (en) * 2000-02-11 2000-04-05 Smithkline Beecham Plc Novel composition
CA2365428C (en) * 2000-12-21 2008-10-21 Brasscorp Limited Method of producing an ultra-violet or near ultra-violet light source for non-destructive inspection or testing
US6979104B2 (en) 2001-12-31 2005-12-27 R.J. Doran & Co. LTD LED inspection lamp
US20050215552A1 (en) * 2002-05-17 2005-09-29 Gadde Kishore M Method for treating obesity
EP2301537A1 (en) * 2002-05-17 2011-03-30 Duke University Zonisamide for the treatment of obesity
GB0219687D0 (en) * 2002-08-23 2002-10-02 Lilly Co Eli Benzyl morpholine derivatives
US7384941B2 (en) * 2002-08-23 2008-06-10 Eli Lilly And Company 2-(phenoxymethyl)-and 2-(phenylthiomethyl)-morpholine derivatives for use as selective norepinephrine reuptake inhibitors
DK2316456T3 (en) 2003-04-29 2017-09-11 Orexigen Therapeutics Inc Compositions for affecting weight loss comprising an opioid antagonist and bupropion
WO2005044809A1 (en) * 2003-10-27 2005-05-19 Smithkline Beecham Corporation Diastereomeric dynamic kinetic resolution process for preparing (+)-(2s, 3s)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol, salts, and solvates thereof
GB0325055D0 (en) * 2003-10-27 2003-12-03 Smithkline Beecham Corp New process
GB0326148D0 (en) * 2003-11-10 2003-12-17 Lilly Co Eli Morpholine derivatives
GB0327195D0 (en) * 2003-11-21 2003-12-24 Smithkline Beecham Corp Novel use
GB0327619D0 (en) * 2003-11-27 2003-12-31 Smithkline Beecham Corp New use
EP1734955A2 (en) * 2004-01-13 2006-12-27 Duke University Compositions of an anticonvulsant and an antipsychotic drug for affecting weigt loss
US7713959B2 (en) * 2004-01-13 2010-05-11 Duke University Compositions of an anticonvulsant and mirtazapine to prevent weight gain
BRPI0510593A (pt) * 2004-05-03 2007-11-20 Univ Duke composições para afetar a perda de peso
FI117283B (fi) 2005-02-04 2006-08-31 Kone Corp Hissijärjestelmä
JP5180092B2 (ja) 2005-11-22 2013-04-10 オレキシジェン・セラピューティクス・インコーポレーテッド インスリン感受性を増すための組成物および方法
US7763612B2 (en) * 2006-01-03 2010-07-27 Algebra, Inc. Therapeutic amine-arylsulfonamide conjugate compounds
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
AU2007319471B9 (en) 2006-11-09 2012-10-04 Nalpropion Pharmaceuticals Llc Layered pharmaceutical formulations comprising an intermediate rapidly dissolving layer
AU2007319472B2 (en) 2006-11-09 2013-01-17 Nalpropion Pharmaceuticals Llc Methods Of Administering Weight Loss Medications
US20090075994A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched radafaxine
CA2725930A1 (en) 2008-05-30 2009-12-30 Orexigen Therapeutics, Inc. Methods for treating visceral fat conditions
JP5711724B2 (ja) 2009-04-15 2015-05-07 リサーチ・トライアングル・インスティチュート モノアミン再取り込み阻害剤
ES2762113T3 (es) 2010-01-11 2020-05-22 Nalpropion Pharmaceuticals Inc Métodos de proporcionar terapia de pérdida de peso en pacientes con depresión mayor
JP2013526583A (ja) 2010-05-21 2013-06-24 リサーチ・トライアングル・インスティチュート フェニルモルホリンおよびその類似体
ES2546492T3 (es) * 2010-05-21 2015-09-24 Research Triangle Institute Derivados de 1-fenilmorfolina como análogos de hidroxibupropion para tratar drogodependencia
US9510405B2 (en) 2011-06-30 2016-11-29 Schneider Electric Industries Sas Dual power SMPS for a modular lighting system
CN102670617B (zh) * 2012-04-13 2013-03-20 湖南大学 布洛芬2-(2-芳基吗啉-4-基)乙酯作为制备抗抑郁药物的应用
KR20210012056A (ko) 2012-06-06 2021-02-02 오렉시젠 세러퓨틱스 인크. 과체중 및 비만의 치료 방법
CN105949142B (zh) * 2016-05-21 2018-03-27 南华大学 具有抗抑郁活性的单一手性化合物及其制备方法和应用
RU2763728C1 (ru) * 2021-06-17 2021-12-30 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) Применение 3-(2-(4-нитрофенил)-2-оксоэтилиден)морфолин-2-она в качестве средства, обладающего противомикробной активностью

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US170430A (en) * 1875-11-30 Improvement in furnaces for heating steel in tempering
GB8417170D0 (en) 1984-07-05 1984-08-08 Wellcome Found Heterocyclic pharmaceutical compounds
GB9108629D0 (en) 1991-04-23 1991-06-12 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
US6337328B1 (en) 1999-03-01 2002-01-08 Sepracor, Inc. Bupropion metabolites and methods of use

Also Published As

Publication number Publication date
DK1047428T3 (da) 2007-10-08
NO326878B1 (no) 2009-03-09
DE69936335D1 (de) 2007-08-02
US6274579B1 (en) 2001-08-14
EA200000691A1 (ru) 2001-04-23
PL342012A1 (en) 2001-05-07
EA002410B1 (ru) 2002-04-25
EP1047428A4 (en) 2001-12-19
AP1229A (en) 2003-12-04
IS5568A (is) 2000-07-20
NZ529316A (en) 2004-05-28
EP1829544A1 (en) 2007-09-05
BR9907203A (pt) 2000-10-17
US20020019396A1 (en) 2002-02-14
NO20003721D0 (no) 2000-07-20
HUP0100900A3 (en) 2002-08-28
AU2328099A (en) 1999-08-09
NZ520349A (en) 2004-02-27
NO20003721L (no) 2000-09-19
US6391875B2 (en) 2002-05-21
SG115489A1 (en) 2005-10-28
PT1047428E (pt) 2007-09-07
KR100568063B1 (ko) 2006-04-07
PL193622B1 (pl) 2007-02-28
CN1203858C (zh) 2005-06-01
HRP20051024A2 (hr) 2006-04-30
HUP0100900A2 (hu) 2002-05-29
JP2002501025A (ja) 2002-01-15
HRP20000494A2 (en) 2000-12-31
ATE365042T1 (de) 2007-07-15
KR20010034285A (ko) 2001-04-25
YU67102A (sh) 2004-12-31
CN1255389C (zh) 2006-05-10
EE04452B1 (et) 2005-04-15
WO1999037305A1 (en) 1999-07-29
EE200000438A (et) 2001-12-17
CA2318268A1 (en) 1999-07-29
IS2494B (is) 2009-02-15
CN1528753A (zh) 2004-09-15
IL137346A0 (en) 2001-07-24
AP2000001869A0 (en) 2000-09-30
NZ505809A (en) 2002-09-27
CN1294513A (zh) 2001-05-09
CY1106828T1 (el) 2012-05-23
DE69936335T2 (de) 2008-02-28
EP1047428A1 (en) 2000-11-02
NO20083529L (no) 2000-09-19
AU755536B2 (en) 2002-12-12
TR200002126T2 (tr) 2000-12-21
SK10912000A3 (sk) 2001-04-09
HRP20000494B1 (en) 2009-02-28
ID26334A (id) 2000-12-14
ES2288012T3 (es) 2007-12-16
EP1047428B1 (en) 2007-06-20

Similar Documents

Publication Publication Date Title
IL161942A0 (en) (+)-2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol
DE69941083D1 (en) 12,13-cyclopropan-epothilonderivate
HRP20010454B1 (en) 1,2-annelated quinoline derivatives
GB9929000D0 (en) Reamer shoe
HUP0102483A3 (en) Pharmaceutical compositions containing androst-5-ene-3betha,17betha-diol
GB9814325D0 (en) Headwear
ZA200005510B (en) Pharmaceutical composition.
ZA200005369B (en) Calcilytic compounds.
GB9817235D0 (en) Compound,composition and use
PL352285A1 (en) Phenoxy fluoropyrimidines
GB9903447D0 (en) Compound, composition and use
ZA992899B (en) Novel compound.
AU2656799A (en) Metal-thiols as imminomodulating agents
GB0100361D0 (en) Compound, composition and use
ZA200006118B (en) Novel composition.
AU2964899A (en) 2,4-dioxo-5-arylidenimino-1,3-pyrimidines
ZA991761B (en) New agent.
ZA993225B (en) Cooling reservoir.
AU3196000A (en) 3,3'-diketotrehalose
ZA99985B (en) New compound.
IL158978A (en) Salts and solvates of the compound (+)-(2s,3s)-2-(3-chlorophenyl) -3,5,5- trimethyl-2-morpholinol
ZA99925B (en) Composition.
ZA997202B (en) Pharmaceutical composition.
GB9826627D0 (en) Alloy
GB9800135D0 (en) Torche's cybermometer moodle,autoreceptionist zero-2000 nad loopcheck