IL168287A - Disposable medicament/cosmetic container for topical application and arrangements and package units comprising the same - Google Patents
Disposable medicament/cosmetic container for topical application and arrangements and package units comprising the sameInfo
- Publication number
- IL168287A IL168287A IL168287A IL16828705A IL168287A IL 168287 A IL168287 A IL 168287A IL 168287 A IL168287 A IL 168287A IL 16828705 A IL16828705 A IL 16828705A IL 168287 A IL168287 A IL 168287A
- Authority
- IL
- Israel
- Prior art keywords
- container
- melatonin
- agent
- derivative
- arrangement
- Prior art date
Links
- 239000002537 cosmetic Substances 0.000 title claims description 16
- 239000003814 drug Substances 0.000 title claims description 12
- 230000000699 topical effect Effects 0.000 title claims description 10
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims description 61
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 claims description 42
- 229960003987 melatonin Drugs 0.000 claims description 42
- 239000003795 chemical substances by application Substances 0.000 claims description 27
- 239000002974 melatonin derivative Substances 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 20
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 12
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 11
- 229910052782 aluminium Inorganic materials 0.000 claims description 11
- 239000013543 active substance Substances 0.000 claims description 10
- -1 polyethylene Polymers 0.000 claims description 8
- 244000194101 Ginkgo biloba Species 0.000 claims description 7
- 229960002685 biotin Drugs 0.000 claims description 6
- 235000020958 biotin Nutrition 0.000 claims description 6
- 239000011616 biotin Substances 0.000 claims description 6
- 239000004033 plastic Substances 0.000 claims description 6
- 229920003023 plastic Polymers 0.000 claims description 6
- 239000004698 Polyethylene Substances 0.000 claims description 5
- 229920000573 polyethylene Polymers 0.000 claims description 5
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 4
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 4
- 239000012669 liquid formulation Substances 0.000 claims description 4
- 230000009885 systemic effect Effects 0.000 claims description 4
- 235000019155 vitamin A Nutrition 0.000 claims description 4
- 239000011719 vitamin A Substances 0.000 claims description 4
- 229940045997 vitamin a Drugs 0.000 claims description 4
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims description 3
- 229930002330 retinoic acid Natural products 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 239000004793 Polystyrene Substances 0.000 claims description 2
- 239000011888 foil Substances 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 2
- 239000004800 polyvinyl chloride Substances 0.000 claims description 2
- 150000002266 vitamin A derivatives Chemical class 0.000 claims description 2
- 201000004384 Alopecia Diseases 0.000 description 5
- 230000036470 plasma concentration Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000004761 scalp Anatomy 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- JTEJPPKMYBDEMY-UHFFFAOYSA-N 5-methoxytryptamine Chemical compound COC1=CC=C2NC=C(CCN)C2=C1 JTEJPPKMYBDEMY-UHFFFAOYSA-N 0.000 description 2
- QQEILXDLZRLTME-UHFFFAOYSA-N 6-sulfatoxymelatonin Chemical compound C1=C(OS(O)(=O)=O)C(OC)=CC2=C1NC=C2CCNC(C)=O QQEILXDLZRLTME-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 231100000360 alopecia Toxicity 0.000 description 2
- 206010068168 androgenetic alopecia Diseases 0.000 description 2
- 201000002996 androgenic alopecia Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 229920003050 poly-cycloolefin Polymers 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- QLWKTGDEPLRFAT-UHFFFAOYSA-N 5-Methoxytryptophol Chemical compound COC1=CC=C2NC=C(CCO)C2=C1 QLWKTGDEPLRFAT-UHFFFAOYSA-N 0.000 description 1
- 229940097276 5-methoxytryptamine Drugs 0.000 description 1
- KVNPSKDDJARYKK-JTQLQIEISA-N 5-methoxytryptophan Chemical compound COC1=CC=C2NC=C(C[C@H](N)C(O)=O)C2=C1 KVNPSKDDJARYKK-JTQLQIEISA-N 0.000 description 1
- OMYMRCXOJJZYKE-UHFFFAOYSA-N 6-hydroxymelatonin Chemical compound C1=C(O)C(OC)=CC2=C1NC=C2CCNC(C)=O OMYMRCXOJJZYKE-UHFFFAOYSA-N 0.000 description 1
- 208000003024 Diffuse alopecia Diseases 0.000 description 1
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 239000003617 indole-3-acetic acid Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Packages (AREA)
Description
o D»ii m*w ηπ>η>ι o>jpiirn ,» ?» ia>ob oovip vwaftfionn >ova *m A disposable medicament/cosmetic container for topical application, and arrangements and package units comprising the same ASAT AG Applied Science & Technology C.192081 168287/2 The present invention relates to a disposable container for a medicament or cosmetic agent for topical application, containing a single dose of melatonin or of a melatonin derivative which corresponds to a locally effective dose but which does not cause any systemic effect.
Melatonin-containing agents can be used for various medical and cosmetic purposes. For example, the document DE 101 10 418 Al discloses compositions for topical application to the skin and in the hair, which contains a combination of melatonin and Vitamin A. US 4,746,674 describes a method for topical treatment of the skin or scalp of a human subject, by administration of a composition containing melatonin at 10"4 to 1% by weight. US 6,281,241 discloses the use of melatonin and melatonin-containing compositions for the treatment of androgenetic female alopecia, the compositions being provided in light-protected aluminum bottles.
The subject of the present invention is a disposable container for a medicament or cosmetic agent for topical application, containing a single dose of melatonin or melatonin derivative which is locally effective but which does not cause any systemic effect, wherein the single dose is 0.01 to 0.2 mg of melatonin or melatonin derivative and corresponds to a daily dose. -la- 168287/1 The disposable container according to the invention permits application of a dose of melatonin or of a melatonin derivative which is locally .effective but which causes no undesired change in the normal melatonin plasma level. The single dose of melatonin or of melatonin derivative which is applied according to the invention causes no significant elevation of the melatonin plasma level for example.
The expression "melatonin or melatonin derivative", as it is used in the context of this applicationr includes melatonin and/or melatonin derivatives and salts, esters or complexes thereof. Preferred melatonin derivatives include, for example, 5-methoxytryptamine , 5-methoxytryptophan , 5-methoxytryptophol , 5-methoxy- - 2 -indole-3-acetic acid and 6-hydroxymelatonin .
The single dose according to the invention represents a dose which permits a positive cosmetic and/or therapeutic effect without significant changes in the plasma level. According to the invention, a single dose of from approximately 0.001 to approximately 1.0 mg of melatonin is preferred, and more preferably a single dose of from approximately 0.01 to approximately 0.2 mg of melatonin. Depending on the application area or the intended use of the agent, a single dose can be applied once or several times daily. In a preferred embodiment, the single dose corresponds to a daily dose, particularly preferably a daily dose to be used in the evenings.
The medicament or cosmetic agent is preferably present as a liquid formulation. Examples of suitable formulations for topical application of the agent are solutions, suspensions, emulsions, microemulsions, nanosystems, creams, gels, lotions, sprays, foams or ointments, and any other formulation which can be applied topically. The agent is particularly preferably provided in the form of a cosmetic solution.
Depending on its intended use, the medicament or cosmetic agent contained in the disposable container according to the invention can have different concentrations of melatonin or of a melatonin derivative. The agent preferably contains a concentration of approximately 0.001 to approximately 0.01% (by weight), more preferably approximately 0.003 to 0.004% (by weight) of melatonin or of a melatonin derivative. A particularly preferred concentration is approximately 0.0033% (by weight). - In one embodiment, the therapeutic or cosmetic agent contains melatonin or a melatonin derivative as sole active substance. The agent can, however, also contain - 3 -one or more further active substances such as vitamin A, vitamin A acid or other vitamin A derivatives, biotin and/or gingko biloba.
In a preferred embodiment, the medicament or cosmetic agent contains a combination of the active substances melatonin or melatonin derivative with biotin and/or gingko biloba. The active substances in this embodiment can be in different dosages. A particularly preferred dosage of this combination is from approximately 0.05 to approximately 0.2 mg, particularly preferably approximately 0.1 mg of melatonin or melatonin derivative, from approximately 0.2 to approximately 0.4 mg, particularly preferably approximately 0.3 mg of biotin, and from approximately 1.3 to approximately 1.7 mg, particularly preferably approximately 1.5 mg of gingko biloba. Gingko biloba can in this case be contained for example as an extract, in particular as a dry extract, and/or in the form of one or more ingredients.
In a further preferred embodiment, the agent contains a combination of the active substances melatonin or melatonin derivative and vitamin A, vitamin A acid or another derivative of vitamin A. In this preferred active substance combination, the dosage of melatonin or melatonin derivative is preferably from approximately 0.05 to 0.2 mg, particularly preferably approximately 0.1 mg of melatonin.
The medicament or cosmetic agent can also contain on or more cosmetic and/or pharmaceutical auxiliaries o additives, for example thickeners, minerals o perfumes .
The composition according to the invention can be,, used to promote hair growth, in particular to prevent and/or treat alopecia in men or in women. Particularly preferred indications are male pattern androgenetic alopecia, female pattern androgenetic alopecia, male pattern diffuse - 4 -alopecia and female pattern diffuse alopecia.
Depending on the intended application or use, the disposable container according to the invention can contain different volumes of the medicament or cosmetic agent. In a preferred embodiment, the disposable container contains approximately 2.5 to approximately 3.5 ml, preferably approximately 2.9 to approximately 3.2 ml of the agent. A particularly preferred volume is approximately 3.0 ml.
The therapeutic or cosmetic agent can be filled into the container using any suitable method known in the prior art. The agent is preferably filled into the container under GMP conditions. In this way it is possible to ensure that the agent is sterile and that, when the agent is applied, no problems arise in respect of bacterial contamination.
The disposable container according to the invention can in principle be made of any desired material, in particular a material approved for packaging of food products and pharmaceutical products. Examples of preferred materials are plastics and mixtures of plastics. Examples of particularly suitable plastics are polyethylene, polyvinyl chloride, polystyrene, polypropylene, polycycloolefins or mixtures or copolymers thereof, with particular preference being given to polyethylene or polycycloolefins .
Depending on its desired outward appearance, the disposable container can be transparent, non-transparent, colorless or colored. Any desired dyes can for example be added to the plastic in order to obtain a colored container. A non-transparent container is preferred for use if the agent contains light-sensitive substances, because a non-transparent container additionally affords protection from light. - 5 - The disposable container according to the invention can in principle have any desired shape. Examples of preferred containers are shown in Figures 1 and 2. A suitable disposable container preferably comprises a part in which the agent is contained, and a disposable closure piece which is connected to the lower part via a predetermined break line.
Simple and safe handling of the container is advantageously ensured by the fact that it preferably has, on its head, a disposable closure piece which is opened by turning it. The container can thus be easily opened. In addition, after opening, the agent can emerge only if pressure is applied. This pressure can for example be exerted by hand during the application. This property allows the user to correctly dose the agent and position it in a targeted manner. If the agent is to be applied to the scalp or hair, the opened container can be guided directly through the hair like a comb. This permits straightforward and safe handling of the container and correct dosing of the agent.
Depending on the intended use, the disposable container carries lettering either printed on or embossed and/or is provided with a label.
Two or more disposable containers can furthermore be connected to one another in a detachable manner. For example, 5 or 10 containers are preferably connected to one another and form an arrangement. A container or an arrangement of containers can also be packed, preferably in a lightproof package, particularly preferably in an aluminum bag for example.
The expression "aluminum bag", as it is used here, includes bags made of aluminum and also bags which for example are coated with aluminum on the outside or. inside. For example, bags made of one or more layers of plastic and/or paper can be coated with aluminum. A - 6 -preferred bag comprises, for example, an aluminum-containing laminated foil which additionally includes polyethylene, polyester and/or paper.
A package, in particular a lightproof package, permits storage over a fairly long period of time without loss of efficacy of the agent. Furthermore, such a package can provide protection against gas loss.
Depending on the intended use, an aluminum bag in which one or more disposable containers are packed can be printed on and/or provided with a label.
In a further embodiment of the invention, a package unit comprising several arrangements of disposable containers is provided.
The invention is further explained by attached Figures 1 and 2 and examples.
Fig. 1 shows an arrangement of 5 disposable containers connected to one another in a detachable manner and in a preferred configuration. 1A shows a front view, IB a plan view, 1C a side view, and ID a perspective view obliquely from above.
Fig. 2A shows a front view of an individual disposable container in a preferred configuration. 2B shows a front view of an arrangement of 10 disposable containers connected to one another in a detachable manner, 2C shows a side view, and 2D shows a plan view of said arrangement.
Examples Example 1 : Composition of a formulation according to the invention containing melatonin, gingko biloba and biotin as active substances The composition contains 0.05% by weight of gingko biloba dry extract, 0.01% by weight of biotin, 0.0033% by weight of melatonin and other additives, water, and ethanol. The pH of the composition is between 3.5 and 4.
Example 2: Clinical study The composition described in Example 1 was tested on 8 healthy female patients in a randomized double-blind study with placebo control and a crossover design. The daily dose was 0.1 mg of melatonin (3 ml of the composition) which was applied to the scalp each day before bedtime, for a period of 14 days.
Urine and blood samples were taken from the patients and were assayed for melatonin and the metabolite 6-hydroxymelatonin sulfate.
It was found that the melatonin plasma profiles of the patients treated with melatonin or placebo corresponded to the concentration/time profiles described in the literature for endogenous melatonin. This confirms that topical application of the melatonin-containing composition for 14 days does not alter endogenous melatonin secretion.
Administration of the composition for 14 days did not increase the plasma concentration of melatonin, or the concentration of 6-hydroxymelatonin sulfate in urine, above physiological concentrations. Topical application of the melatonin-containing composition was not associated with side effects. Nor were any effects found on reaction times or on cortical excitation parameters .
All things considered, it must be concluded that administration of the composition does not induce any systemic effects.
Claims (26)
1. A disposable container for a medicament or cosmetic agent for topical application, containing a single dose of melatonin or of a melatonin derivative which is a locally effective dose but which does not cause any systemic effect, wherein said single dose is 0.01 to 0.2 mg of melatonin or melatonin derivative and corresponds to a daily dose.
2. The container as claimed in claim 1, characterized in that the agent is present as a liquid formulation.
3. The container as claimed in claim 2, characterized in that the liquid formulation has a concentration of 0.001 to 0.01% (by weight) of melatonin.
4. The container as claimed in claim 3, characterized in that the liquid formulation has a concentration of 0.003 to 0.004% (by weight) of melatonin.
5. The container as claimed in claim 1, characterized in that the agent contains, as sole active substance, melatonin or a melatonin derivative.
6. The container as claimed in claim 1, characterized in that the agent contains, as active substances, a combination of melatonin or a melatonin derivative together with biotin and/or gingko biloba.
7. The container as claimed in claim 1, characterized in that the agent contains, as active substance, a combination of melatonin or a melatonin derivative and vitamin A, vitamin A acid, or another derivative of vitamin A.
8. The container as claimed in claim 1, characterized in that it contains 2.5 to 3.5 ml of the agent.
9. The container as claimed in claim 8, characterized in that it contains 2.9 to 3.2 ml of the agent. - 10 - 168287/2
10. The container as claimed in claim 1, characterized in that the agent is filled into the container under GMP conditions.
11. The container as claimed in claim 1, characterized in that it is made of a plastic.
12. The container as claimed in claim 11, characterized in that it is made of polyethylene, polypropylene, polyvinyl chloride, polystyrene or a mixture of these.
13. The container as claimed in claim 1, characterized in that it is colorless.
14. The container as claimed in claim 1, characterized in that it is colored.
15. The container as claimed in claim 1, characterized in that it is transparent.
16. The container as claimed in claim 1, characterized in that it is non-transparent.
17. The container as claimed in claim 1, characterized in that it has, on its head, a disposable closure piece which is opened by turning it.
18. The container as claimed in claim 1, characterized in that, after opening, the agent emerges only when pressure is applied.
19. The container as claimed in claim 1, characterized in that it carries lettering either printed on or embossed and/or is provided with a label.
20. An arrangement of several containers, as claimed in claim 1, which are connected to one another in a detachable manner.
21. The arrangement as claimed in claim 20, characterized in that 5 containers are connected to one another in a detachable manner.
22. The arrangement as claimed in claim 20, characterized in that 10 containers are connected to one another in a detachable manner. - 11 - 168287/2
23. The arrangement as claimed in claim 20, characterized in that it is packed into an aluminum bag.
24. The arrangement as claimed in claim 23, characterized in that the bag consists of an aluminum-containing laminated foil and additionally includes polyethylene, polyester and/or paper.
25. The arrangement as claimed in claim 23, characterized in that the aluminum bag is printed on and/or is provided with a label.
26. A package unit comprising several arrangements as claimed in claim 20. For the Applicants, NHOLD COHN AND PARTNERS
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10250646A DE10250646A1 (en) | 2002-10-30 | 2002-10-30 | Cosmetic and/or pharmaceutical hair treatment compositions, especially for promoting hair growth, containing melatonin (or derivative) and Gingko biloba and biotin as potentiating agents |
| DE20217814U DE20217814U1 (en) | 2002-11-18 | 2002-11-18 | Melatonin daily dosage units |
| US10/353,056 US20040094449A1 (en) | 2002-11-18 | 2003-01-29 | Melatonin daily dosage units |
| PCT/EP2003/012099 WO2004039369A1 (en) | 2002-10-30 | 2003-10-30 | Daily melatonin dosing units |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL168287A true IL168287A (en) | 2011-06-30 |
Family
ID=35873180
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL168288A IL168288A (en) | 2002-10-30 | 2005-04-28 | Formulations containing melatonin, ginkgo biloba and biotin for promoting hair growth |
| IL168287A IL168287A (en) | 2002-10-30 | 2005-04-28 | Disposable medicament/cosmetic container for topical application and arrangements and package units comprising the same |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL168288A IL168288A (en) | 2002-10-30 | 2005-04-28 | Formulations containing melatonin, ginkgo biloba and biotin for promoting hair growth |
Country Status (10)
| Country | Link |
|---|---|
| CN (2) | CN102283835A (en) |
| AT (1) | ATE489073T1 (en) |
| CR (1) | CR7819A (en) |
| CY (1) | CY1111179T1 (en) |
| DE (1) | DE50313285D1 (en) |
| DK (1) | DK1562585T3 (en) |
| IL (2) | IL168288A (en) |
| PT (2) | PT1569724E (en) |
| RU (2) | RU2336890C2 (en) |
| SI (1) | SI1562585T1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2488388C1 (en) | 2012-05-24 | 2013-07-27 | Ооо "Валента Интеллект" | Pharmaceutical composition for preventing and treating mental, behaviour and cognitive disorders |
| CN107205908B (en) * | 2015-01-30 | 2020-03-10 | 现代药品株式会社 | Melatonin-containing composition for hair growth, hair growth or growth promotion with improved stability |
| US10342735B2 (en) * | 2015-06-11 | 2019-07-09 | Tokitae Llc | Multi-monodose containers |
| CN116549366A (en) * | 2023-05-31 | 2023-08-08 | 乐泰药业(兰西)有限公司 | Composition for promoting growth and improving hair quality for androgenetic alopecia and preparation method thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4746674A (en) * | 1985-08-27 | 1988-05-24 | Cellena (Cell Engineering) Ag | Melatonin compositions and uses thereof |
| US5750107A (en) * | 1993-02-12 | 1998-05-12 | Nomura; Manabu | Hair growth promoter |
| DE19509354A1 (en) * | 1994-12-08 | 1996-06-13 | Klett Loch Lore M | Combination preparation for promoting hair growth and possibly skin and nail growth and for preventing or eliminating hair loss |
| CN2223996Y (en) * | 1995-07-26 | 1996-04-10 | 沈言华 | Clean enemator |
| US6602526B2 (en) * | 1996-02-23 | 2003-08-05 | Medical Doctors Research Institute | Oral compositions containing lotus |
| EP0867181A1 (en) * | 1997-03-26 | 1998-09-30 | Franciscus Wilhelmus Henricus Maria Merkus | Nasal melatonin composition |
| US6030948A (en) * | 1997-12-19 | 2000-02-29 | Mann; Morris A. | Hair regeneration compositions for treatment of alopecia and methods of application related thereto |
| DE19957710A1 (en) * | 1999-11-30 | 2001-05-31 | Asat Ag Applied Science & Tech | Treating female type androgenetic or diffuse alopecia by topical administration of melatonin, causing e.g. reduction of telogen rate and increase of anagen rate, hair diameter and tensile strength |
| US6524619B2 (en) * | 2000-01-27 | 2003-02-25 | Chronorx, Inc. | Dosage forms useful for modifying conditions and functions associated with hearing loss and/or tinnitus |
| US6596266B2 (en) * | 2000-02-18 | 2003-07-22 | Natural Science, Inc. | Compositions containing minoxidil and saw palmetto for treating baldness |
| GB0019327D0 (en) * | 2000-08-08 | 2000-09-27 | Buchanan Baillie Hamilton Paul | Slimming system |
| DE10110418A1 (en) * | 2001-03-05 | 2002-09-12 | Asat Ag Applied Science & Tech | Melatonin Vitamin A supplements |
-
2003
- 2003-10-30 DE DE50313285T patent/DE50313285D1/en not_active Expired - Lifetime
- 2003-10-30 DK DK03769477.5T patent/DK1562585T3/en active
- 2003-10-30 RU RU2005116264/15A patent/RU2336890C2/en not_active IP Right Cessation
- 2003-10-30 CN CN2011101545581A patent/CN102283835A/en active Pending
- 2003-10-30 SI SI200331934T patent/SI1562585T1/en unknown
- 2003-10-30 PT PT03775265T patent/PT1569724E/en unknown
- 2003-10-30 AT AT03769477T patent/ATE489073T1/en active
- 2003-10-30 RU RU2005116263/15A patent/RU2336873C2/en not_active IP Right Cessation
- 2003-10-30 CN CN2009102541491A patent/CN101897736A/en active Pending
- 2003-10-30 PT PT03769477T patent/PT1562585E/en unknown
-
2005
- 2005-04-28 IL IL168288A patent/IL168288A/en not_active IP Right Cessation
- 2005-04-28 IL IL168287A patent/IL168287A/en not_active IP Right Cessation
- 2005-04-29 CR CR7819A patent/CR7819A/en not_active Application Discontinuation
-
2011
- 2011-02-09 CY CY20111100147T patent/CY1111179T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1074793A1 (en) | 2005-11-25 |
| RU2336873C2 (en) | 2008-10-27 |
| CY1111179T1 (en) | 2015-06-11 |
| CR7819A (en) | 2007-10-22 |
| RU2005116263A (en) | 2006-01-27 |
| PT1562585E (en) | 2011-02-23 |
| DK1562585T3 (en) | 2011-03-14 |
| PT1569724E (en) | 2009-04-03 |
| DE50313285D1 (en) | 2011-01-05 |
| RU2336890C2 (en) | 2008-10-27 |
| IL168288A (en) | 2014-08-31 |
| ATE489073T1 (en) | 2010-12-15 |
| CN101897736A (en) | 2010-12-01 |
| CN102283835A (en) | 2011-12-21 |
| RU2005116264A (en) | 2006-01-20 |
| SI1562585T1 (en) | 2011-02-28 |
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