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IL146411A0 - Buforin i as a specific inhibitor and therapeutic agent for botulinum toxin b and tetanus neurotoxins - Google Patents

Buforin i as a specific inhibitor and therapeutic agent for botulinum toxin b and tetanus neurotoxins

Info

Publication number
IL146411A0
IL146411A0 IL14641100A IL14641100A IL146411A0 IL 146411 A0 IL146411 A0 IL 146411A0 IL 14641100 A IL14641100 A IL 14641100A IL 14641100 A IL14641100 A IL 14641100A IL 146411 A0 IL146411 A0 IL 146411A0
Authority
IL
Israel
Prior art keywords
buforin
therapeutic agent
botulinum toxin
specific inhibitor
tetanus neurotoxins
Prior art date
Application number
IL14641100A
Original Assignee
Us Army Med Res Mat Command
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Army Med Res Mat Command filed Critical Us Army Med Res Mat Command
Publication of IL146411A0 publication Critical patent/IL146411A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL14641100A 1999-05-14 2000-05-11 Buforin i as a specific inhibitor and therapeutic agent for botulinum toxin b and tetanus neurotoxins IL146411A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13421699P 1999-05-14 1999-05-14
PCT/US2000/012909 WO2000069895A2 (en) 1999-05-14 2000-05-11 Bufornin 1 as a specific inhibitor and therapeutic agent for botulinum toxin b and tetanus neurotoxins

Publications (1)

Publication Number Publication Date
IL146411A0 true IL146411A0 (en) 2002-07-25

Family

ID=22462297

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14641100A IL146411A0 (en) 1999-05-14 2000-05-11 Buforin i as a specific inhibitor and therapeutic agent for botulinum toxin b and tetanus neurotoxins

Country Status (6)

Country Link
EP (1) EP1179022A2 (en)
JP (1) JP2003502023A (en)
AU (1) AU781608B2 (en)
CA (1) CA2369369A1 (en)
IL (1) IL146411A0 (en)
WO (1) WO2000069895A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7563874B2 (en) 1998-08-31 2009-07-21 The Regents Of The University Of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
KR20020051124A (en) * 2000-12-22 2002-06-28 이한웅 Anti-cancer Agent Comprising Bufforin Derivatives
JP2003009897A (en) 2001-07-03 2003-01-14 Keiji Oguma Method for separating and purifying botulinus toxin
CN101146554B (en) 2005-01-27 2012-10-10 加州大学评议会 Therapeutic monoclonal antibodies that neutralize botulinum neurotoxin
EP2134749B1 (en) 2007-03-22 2013-11-06 The Regents of the University of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
EP2313434A4 (en) 2008-07-31 2013-03-27 Univ California NEUTRALIZING ANTIBODIES OF BOTULINIC NEUROTOXINS
WO2012047427A2 (en) 2010-08-31 2012-04-12 The Regents Of The University Of California Antibodies for botulinum neurotoxins
KR102336515B1 (en) * 2018-10-25 2021-12-07 애니젠 주식회사 Buforin derivatives and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9411138D0 (en) * 1994-06-03 1994-07-27 Microbiological Res Authority Toxin assay
US5936063A (en) * 1996-08-24 1999-08-10 Samyang Genex Co., Ltd. Antimicrobial peptide isolated from Bufo bufo gargarizans
KR100263583B1 (en) * 1997-05-28 2000-08-01 박종헌 Mass production of antimicrobial peptides and plasmid beta useful therein
KR100314721B1 (en) * 1998-01-22 2001-11-23 김일웅 Biologically active peptides

Also Published As

Publication number Publication date
WO2000069895A3 (en) 2001-08-09
AU6197500A (en) 2000-12-05
JP2003502023A (en) 2003-01-21
WO2000069895A2 (en) 2000-11-23
EP1179022A2 (en) 2002-02-13
CA2369369A1 (en) 2000-11-23
AU781608B2 (en) 2005-06-02

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