IL132377A0 - Method for solution phase synthesis of oligonucleotides - Google Patents
Method for solution phase synthesis of oligonucleotidesInfo
- Publication number
- IL132377A0 IL132377A0 IL13237798A IL13237798A IL132377A0 IL 132377 A0 IL132377 A0 IL 132377A0 IL 13237798 A IL13237798 A IL 13237798A IL 13237798 A IL13237798 A IL 13237798A IL 132377 A0 IL132377 A0 IL 132377A0
- Authority
- IL
- Israel
- Prior art keywords
- oligonucleotides
- phase synthesis
- solution phase
- solution
- synthesis
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84382097A | 1997-04-21 | 1997-04-21 | |
| PCT/US1998/008192 WO1998047910A1 (en) | 1997-04-21 | 1998-04-20 | Method for solution phase synthesis of oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL132377A0 true IL132377A0 (en) | 2001-03-19 |
Family
ID=25291099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13237798A IL132377A0 (en) | 1997-04-21 | 1998-04-20 | Method for solution phase synthesis of oligonucleotides |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0979233A4 (en) |
| JP (1) | JP2001520660A (en) |
| AU (1) | AU7152098A (en) |
| CA (1) | CA2286320A1 (en) |
| IL (1) | IL132377A0 (en) |
| WO (1) | WO1998047910A1 (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7427678B2 (en) | 1998-01-08 | 2008-09-23 | Sigma-Aldrich Co. | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method |
| GB9825687D0 (en) * | 1998-11-25 | 1999-01-20 | Link Technologies Ltd | Oligonucleotide conjugation |
| WO2001084234A1 (en) * | 2000-05-01 | 2001-11-08 | Proligo Llc | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method |
| DE10041221A1 (en) * | 2000-08-22 | 2002-03-14 | Deutsches Krebsforsch | Process for the preparation of water-soluble saccharide conjugates and saccharide mimetics by the Diels-Alder reaction and their use as therapeutics or diagnostics |
| US7172905B2 (en) | 2001-08-07 | 2007-02-06 | The University Of Chicago | Polypeptide immobilization |
| AU2003210629A1 (en) | 2002-01-23 | 2003-09-02 | Proligo, Llc | Methods for the integrated synthesis and purification of oligonucleotides |
| GB0229423D0 (en) | 2002-12-18 | 2003-01-22 | Avecia Ltd | Process |
| WO2004058794A1 (en) | 2002-12-31 | 2004-07-15 | Proligo Llc | Methods and compositions for the tandem synthesis of two or more oligonuleotides on the same solid support |
| JP4945129B2 (en) * | 2004-01-27 | 2012-06-06 | 株式会社キラルジェン | Fluorous carrier and method for producing oligonucleotide derivative using the same |
| EP1904553A4 (en) * | 2005-07-06 | 2013-04-24 | Molly S Shoichet | Method of biomolecule immobilization on polymers using click-type chemistry |
| US8759508B2 (en) | 2007-05-18 | 2014-06-24 | Ge Healthcare Dharmacon, Inc. | Chromophoric silyl protecting groups and their use in the chemical synthesis of oligonucleotides |
| DE102010001992A1 (en) * | 2010-02-16 | 2011-08-18 | Evonik Röhm GmbH, 64293 | Functional materials with controllable viscosity |
| DE102010001987A1 (en) | 2010-02-16 | 2011-08-18 | Evonik Röhm GmbH, 64293 | Functional materials with reversible crosslinking |
| JP5705512B2 (en) * | 2010-11-26 | 2015-04-22 | 農工大ティー・エル・オー株式会社 | Oligonucleotide synthesis using highly dispersible liquid phase support |
| WO2015061246A1 (en) * | 2013-10-21 | 2015-04-30 | Isis Pharmaceuticals, Inc. | Method for solution phase detritylation of oligomeric compounds |
| KR101889893B1 (en) * | 2015-06-12 | 2018-08-22 | 애니젠 주식회사 | Triphenylmethane Derivatives Having Selective Solubility and Their Uses |
| US10947262B2 (en) * | 2016-06-14 | 2021-03-16 | Biogen Ma Inc. | Hydrophobic interaction chromatography for purification of oligonucleotides |
| ES2895120T3 (en) * | 2016-06-20 | 2022-02-17 | Sekisui Medical Co Ltd | New diphenylmethane protective agent |
| JP6322350B1 (en) * | 2016-11-11 | 2018-05-09 | 積水メディカル株式会社 | New trityl protecting agent |
| EP3539968B1 (en) * | 2016-11-11 | 2021-07-14 | Sekisui Medical Co., Ltd. | Novel trityl protecting agent |
| EP3730497B1 (en) * | 2017-12-19 | 2022-11-16 | Sekisui Medical Co., Ltd. | Novel alkyl diphenylmethane protection agent |
| CN116710491A (en) | 2021-01-05 | 2023-09-05 | 伊鲁米纳公司 | Compositions comprising functional groups coupled to substrates and methods of making same |
| CN119462542B (en) * | 2024-06-24 | 2025-09-19 | 九江善水科技股份有限公司 | A kind of cyanuric chloride oxime ester and its synthesis method |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU627134A1 (en) * | 1977-06-16 | 1978-10-05 | Предприятие П/Я М-5885 | Tetrafurfuryloxysilane producing method |
| AU6893691A (en) * | 1990-01-26 | 1991-08-21 | Isp Investments Inc. | Alkenyl ethers and radiation curable compositions |
| GB9307014D0 (en) * | 1993-04-02 | 1993-05-26 | Laporte Plc | Protecting group for use in oligodeoxyribonucleotide synthesis |
| EP0644196B1 (en) * | 1993-09-17 | 1997-11-05 | Novartis AG | TTTr as a protecting group in nucleotide synthesis |
| US5597909A (en) * | 1994-08-25 | 1997-01-28 | Chiron Corporation | Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use |
| US5580731A (en) * | 1994-08-25 | 1996-12-03 | Chiron Corporation | N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith |
| WO1997014706A1 (en) * | 1995-10-19 | 1997-04-24 | Nexstar Pharmaceuticals, Inc. | Method for solution phase synthesis of oligonucleotides |
| US5874532A (en) * | 1997-01-08 | 1999-02-23 | Nexstar Pharmaceuticals, Inc. | Method for solution phase synthesis of oligonucleotides and peptides |
| CA2277159A1 (en) * | 1997-01-08 | 1998-07-16 | Wolfgang Pieken | Bioconjugation of macromolecules |
-
1998
- 1998-04-20 JP JP54450398A patent/JP2001520660A/en active Pending
- 1998-04-20 EP EP98918629A patent/EP0979233A4/en not_active Withdrawn
- 1998-04-20 CA CA002286320A patent/CA2286320A1/en not_active Abandoned
- 1998-04-20 WO PCT/US1998/008192 patent/WO1998047910A1/en not_active Ceased
- 1998-04-20 IL IL13237798A patent/IL132377A0/en unknown
- 1998-04-20 AU AU71520/98A patent/AU7152098A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998047910A1 (en) | 1998-10-29 |
| AU7152098A (en) | 1998-11-13 |
| EP0979233A1 (en) | 2000-02-16 |
| CA2286320A1 (en) | 1998-10-29 |
| JP2001520660A (en) | 2001-10-30 |
| EP0979233A4 (en) | 2001-03-21 |
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