IL132312A0 - Use of leptin in inhibition of endothelial cell proliferation - Google Patents

Use of leptin in inhibition of endothelial cell proliferation

Info

Publication number: IL132312A0
Authority: IL; Israel
Prior art keywords: leptin; inhibition; cell proliferation; endothelial cell; endothelial
Prior art date: 1999-09-05

Application number

IL13231299A

Other languages

English (en)

Original Assignee

Yeda Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-05

Filing date

1999-10-10

Publication date

2001-03-19

1999-09-05 Priority claimed from IL13173999A external-priority patent/IL131739A0/xx

1999-10-10 Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev

1999-10-10 Priority to IL13231299A priority Critical patent/IL132312A0/xx

2000-04-09 Priority to UA2002042717A priority patent/UA74163C2/uk

2000-09-04 Priority to AT00956758T priority patent/ATE449609T1/de

2000-09-04 Priority to IL14844500A priority patent/IL148445A0/xx

2000-09-04 Priority to ARP000104622A priority patent/AR025494A1/es

2000-09-04 Priority to ES00956758T priority patent/ES2335569T3/es

2000-09-04 Priority to EP00956758A priority patent/EP1210108B1/en

2000-09-04 Priority to MXPA02002448A priority patent/MXPA02002448A/es

2000-09-04 Priority to JP2001522262A priority patent/JP2003508544A/ja

2000-09-04 Priority to DE60043391T priority patent/DE60043391D1/de

2000-09-04 Priority to AU68620/00A priority patent/AU781390B2/en

2000-09-04 Priority to CA2382941A priority patent/CA2382941C/en

2000-09-04 Priority to PCT/IL2000/000525 priority patent/WO2001018040A2/en

2000-09-04 Priority to KR1020027002112A priority patent/KR100683362B1/ko

2000-09-04 Priority to CNB00813748XA priority patent/CN1189479C/zh

2000-09-04 Priority to HK03100442.1A priority patent/HK1048075B/zh

2000-09-04 Priority to EA200200331A priority patent/EA005066B1/ru

2000-09-04 Priority to EEP200200116A priority patent/EE05262B1/xx

2000-09-04 Priority to BR0013778-2A priority patent/BR0013778A/pt

2001-03-19 Publication of IL132312A0 publication Critical patent/IL132312A0/xx

2002-02-25 Priority to NO20020920A priority patent/NO325989B1/no

Links

102000016267 Leptin Human genes 0.000 title 1
108010092277 Leptin Proteins 0.000 title 1
NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 title 1
229940039781 leptin Drugs 0.000 title 1
230000010046 negative regulation of endothelial cell proliferation Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/484—Plasmin (3.4.21.7)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Zoology (AREA)
Diabetes (AREA)
Genetics & Genomics (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL13231299A 1999-09-05 1999-10-10 Use of leptin in inhibition of endothelial cell proliferation IL132312A0 (en)

Priority Applications (20)

Application Number	Priority Date	Filing Date	Title
IL13231299A IL132312A0 (en)	1999-09-05	1999-10-10	Use of leptin in inhibition of endothelial cell proliferation
UA2002042717A UA74163C2 (uk)	1999-09-05	2000-04-09	Застосування лептину для інгібування ангіогенезу, фармацевтична композиція та спосіб інгібування ангіогенезу у ссавців
BR0013778-2A BR0013778A (pt)	1999-09-05	2000-09-04	Uso de leptina na inibição de proliferação de célula endotelial
JP2001522262A JP2003508544A (ja)	1999-09-05	2000-09-04	内皮細胞増殖の阻害剤におけるレプチンの用途
CA2382941A CA2382941C (en)	1999-09-05	2000-09-04	Use of leptin in inhibition of endothelial cell proliferation
ARP000104622A AR025494A1 (es)	1999-09-05	2000-09-04	Uso de la leptina, homologos de leptina o derivados de leptina opcionalmente junto con un inhibidor de la accion de vegf o de la sintesis del vegf y/o uninhibidor de la angiogenesis, composiciones farmaceuticas que incluyen leptina, metodo para inhibir reversiblemente la proliferacion de dichas celu
ES00956758T ES2335569T3 (es)	1999-09-05	2000-09-04	Uso de leptina junto con un inhibidor de vegf y/o un inhibidor de angiogenesis para la inhibicion de la proliferacion de celulas endonteliales.
EP00956758A EP1210108B1 (en)	1999-09-05	2000-09-04	Use of leptin together with an inhibitor of vegf and/or an inhibitor of angiogenesis for the inhibition of endothelial cell proliferation
MXPA02002448A MXPA02002448A (es)	1999-09-05	2000-09-04	Uso de leptina en la inhibicion de la poliferacion de la celula endotelial.
AT00956758T ATE449609T1 (de)	1999-09-05	2000-09-04	Verwendung von leptin mit einem vegf hemmer und/oder angiogenese hemmer zur hemmung der proliferation endothelialer zellen
DE60043391T DE60043391D1 (de)	1999-09-05	2000-09-04	Verwendung von leptin mit einem vegf hemmer und/oder angiogenese hemmer zur hemmung der proliferation endothelialer zellen
AU68620/00A AU781390B2 (en)	1999-09-05	2000-09-04	Use of leptin in inhibition of endothelial cell proliferation
IL14844500A IL148445A0 (en)	1999-09-05	2000-09-04	Use of leptin in inhibition of endothelial cell proliferation
PCT/IL2000/000525 WO2001018040A2 (en)	1999-09-05	2000-09-04	Use of leptin in inhibition of endothelial cell proliferation
KR1020027002112A KR100683362B1 (ko)	1999-09-05	2000-09-04	내피세포 증식의 저해에서 렙틴의 용도
CNB00813748XA CN1189479C (zh)	1999-09-05	2000-09-04	应用苗条蛋白抑制内皮细胞增殖
HK03100442.1A HK1048075B (zh)	1999-09-05	2000-09-04	應用苗條蛋白抑制內皮細胞增殖
EA200200331A EA005066B1 (ru)	1999-09-05	2000-09-04	Применение лептина для ингибирования пролиферации эндотелиальных клеток
EEP200200116A EE05262B1 (et)	1999-09-05	2000-09-04	Leptiini v?i selle homoloogi v?i derivaadi kasutamine, farmatseutiline kompositsioon ja segu
NO20020920A NO325989B1 (no)	1999-09-05	2002-02-25	Anvendelse av leptin, i kombinasjon med en hemmer av VEGF og/eller angiogenese, for a hemme angiogenese.

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL13173999A IL131739A0 (en)	1999-09-05	1999-09-05	Use of leptin in inhibition of endothelial cell proliferation
IL13231299A IL132312A0 (en)	1999-09-05	1999-10-10	Use of leptin in inhibition of endothelial cell proliferation

Publications (1)

Publication Number	Publication Date
IL132312A0 true IL132312A0 (en)	2001-03-19

Family

ID=26323878

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL13231299A IL132312A0 (en)	1999-09-05	1999-10-10	Use of leptin in inhibition of endothelial cell proliferation

Country Status (19)

Country	Link
EP (1)	EP1210108B1 (zh)
JP (1)	JP2003508544A (zh)
KR (1)	KR100683362B1 (zh)
CN (1)	CN1189479C (zh)
AR (1)	AR025494A1 (zh)
AT (1)	ATE449609T1 (zh)
AU (1)	AU781390B2 (zh)
BR (1)	BR0013778A (zh)
CA (1)	CA2382941C (zh)
DE (1)	DE60043391D1 (zh)
EA (1)	EA005066B1 (zh)
EE (1)	EE05262B1 (zh)
ES (1)	ES2335569T3 (zh)
HK (1)	HK1048075B (zh)
IL (1)	IL132312A0 (zh)
MX (1)	MXPA02002448A (zh)
NO (1)	NO325989B1 (zh)
UA (1)	UA74163C2 (zh)
WO (1)	WO2001018040A2 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6355237B1 (en) *	1994-09-14	2002-03-12	Progenitor, Inc.	Methods for using the obese gene and its gene product to stimulate hematopoietic development
US8633250B2 (en) *	2006-01-12	2014-01-21	Musc Foundation For Research Development	Cell repair and regeneration by suramin and related polysulfonated napthylureas
ES2474765T3 (es) *	2009-06-17	2014-07-09	National University Corporation Kumamoto University	Agente profiláctico y/o terapéutico para la dismenorrea

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2260784T3 (es) *	1996-01-23	2006-11-01	Indevus Pharmaceuticals, Inc.	Metodos de utilizacion del gen obese y su producto genico para estimular el desarrolo hematopoyetico.
IT1288388B1 (it) *	1996-11-19	1998-09-22	Angeletti P Ist Richerche Bio	Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia
IL120733A0 (en) *	1997-04-29	1997-08-14	Yeda Res & Dev	Leptin as an inhibitor of cell proliferation
AU4672199A (en) *	1998-05-20	1999-12-06	Yale University	Modulation of angiogenesis and wound healing

1999
- 1999-10-10 IL IL13231299A patent/IL132312A0/xx unknown
2000
- 2000-04-09 UA UA2002042717A patent/UA74163C2/uk unknown
- 2000-09-04 EA EA200200331A patent/EA005066B1/ru not_active IP Right Cessation
- 2000-09-04 CN CNB00813748XA patent/CN1189479C/zh not_active Expired - Fee Related
- 2000-09-04 MX MXPA02002448A patent/MXPA02002448A/es active IP Right Grant
- 2000-09-04 ES ES00956758T patent/ES2335569T3/es not_active Expired - Lifetime
- 2000-09-04 EP EP00956758A patent/EP1210108B1/en not_active Expired - Lifetime
- 2000-09-04 WO PCT/IL2000/000525 patent/WO2001018040A2/en not_active Ceased
- 2000-09-04 KR KR1020027002112A patent/KR100683362B1/ko not_active Expired - Fee Related
- 2000-09-04 AR ARP000104622A patent/AR025494A1/es unknown
- 2000-09-04 HK HK03100442.1A patent/HK1048075B/zh not_active IP Right Cessation
- 2000-09-04 DE DE60043391T patent/DE60043391D1/de not_active Expired - Lifetime
- 2000-09-04 JP JP2001522262A patent/JP2003508544A/ja active Pending
- 2000-09-04 BR BR0013778-2A patent/BR0013778A/pt not_active Application Discontinuation
- 2000-09-04 AT AT00956758T patent/ATE449609T1/de not_active IP Right Cessation
- 2000-09-04 AU AU68620/00A patent/AU781390B2/en not_active Ceased
- 2000-09-04 CA CA2382941A patent/CA2382941C/en not_active Expired - Fee Related
- 2000-09-04 EE EEP200200116A patent/EE05262B1/xx not_active IP Right Cessation
2002
- 2002-02-25 NO NO20020920A patent/NO325989B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2335569T3 (es)	2010-03-30
AU6862000A (en)	2001-04-10
JP2003508544A (ja)	2003-03-04
NO20020920D0 (no)	2002-02-25
BR0013778A (pt)	2002-05-14
NO20020920L (no)	2002-05-03
EE200200116A (et)	2003-04-15
EP1210108B1 (en)	2009-11-25
CN1189479C (zh)	2005-02-16
EP1210108A2 (en)	2002-06-05
WO2001018040A2 (en)	2001-03-15
HK1048075A1 (zh)	2003-03-21
NO325989B1 (no)	2008-09-01
MXPA02002448A (es)	2002-07-30
EA005066B1 (ru)	2004-10-28
CA2382941C (en)	2011-08-16
ATE449609T1 (de)	2009-12-15
DE60043391D1 (de)	2010-01-07
CN1377277A (zh)	2002-10-30
EE05262B1 (et)	2010-02-15
HK1048075B (zh)	2005-07-29
UA74163C2 (uk)	2005-11-15
WO2001018040A3 (en)	2001-06-14
KR100683362B1 (ko)	2007-02-15
AR025494A1 (es)	2002-11-27
KR20020040781A (ko)	2002-05-30
EA200200331A1 (ru)	2002-08-29
CA2382941A1 (en)	2001-03-15
AU781390B2 (en)	2005-05-19

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