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IL139584A0 - Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory autoimmune and respiratory diseases - Google Patents

Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory autoimmune and respiratory diseases

Info

Publication number
IL139584A0
IL139584A0 IL13958499A IL13958499A IL139584A0 IL 139584 A0 IL139584 A0 IL 139584A0 IL 13958499 A IL13958499 A IL 13958499A IL 13958499 A IL13958499 A IL 13958499A IL 139584 A0 IL139584 A0 IL 139584A0
Authority
IL
Israel
Prior art keywords
vla
cell binding
dependent cell
respiratory diseases
treating inflammatory
Prior art date
Application number
IL13958499A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of IL139584A0 publication Critical patent/IL139584A0/xx

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    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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IL13958499A 1998-06-30 1999-05-31 Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory autoimmune and respiratory diseases IL139584A0 (en)

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US9118098P 1998-06-30 1998-06-30
PCT/IB1999/000973 WO2000000477A1 (fr) 1998-06-30 1999-05-31 Inhibiteurs non peptidyle de la liaison cellulaire dependant de vla-4 utiles dans le traitement des maladies inflammatoires, auto-immunes et respiratoires

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EA004792B1 (ru) * 1998-06-30 2004-08-26 Пфайзер Продактс Инк. Непептидные ингибиторы vla-4-зависимого клеточного связывания, полезные в лечении воспалительных, аутоиммунных и респираторных заболеваний
US6518292B1 (en) * 1999-03-12 2003-02-11 Bristol-Myers Squibb Co. Heterocyclic aromatic compounds usefuls as growth hormone secretagogues
JP2003503350A (ja) * 1999-06-30 2003-01-28 第一製薬株式会社 Ｖｌａ−４インヒビター化合物
US6756378B2 (en) * 1999-06-30 2004-06-29 Pharmacopeia Drug Discovery, Inc. VLA-4 inhibitor compounds
IL149758A0 (en) 1999-12-28 2002-11-10 Pfizer Prod Inc Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
AU2001234741A1 (en) * 2000-02-04 2001-08-14 Biogen, Inc. Integrin antagonists
JP2004516237A (ja) 2000-06-21 2004-06-03 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー ケモカイン受容体活性調節剤としてのピペリジンアミド類
AR035040A1 (es) * 2000-08-01 2004-04-14 Sod Conseils Rech Applic Derivados de imidazolilo, composiciones farmaceuticas que los comprenden y el uso de los mismos para la preparacion de medicamentos capaces de unir selectivamente a los subtipos del receptor de somatostatina
GB2367816A (en) * 2000-10-09 2002-04-17 Bayer Ag Urea- and thiourea-containing derivatives of beta-amino acids
RU2290403C2 (ru) 2000-12-28 2006-12-27 Дайити Фармасьютикал Ко., Лтд. Ингибиторы vla-4
DE10111877A1 (de) * 2001-03-10 2002-09-12 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
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ATE383858T1 (de) * 2001-06-06 2008-02-15 Aventis Pharma Ltd Substituierte tetrhydroisochinolin-derivate zur behandlung von entzündlichen erkrankungen
GB2377933A (en) 2001-07-06 2003-01-29 Bayer Ag Succinic acid derivatives useful as integrin antagonists
DE10137595A1 (de) 2001-08-01 2003-02-13 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
AU2002326948A1 (en) * 2001-09-18 2003-04-01 Bristol-Myers Squibb Company Piperizinones as modulators of chemokine receptor activity
EP1549640A4 (fr) 2002-06-17 2008-08-06 Merck & Co Inc 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates et 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates utilises en tant qu'agonistes du recepteur edg
EP1656368A4 (fr) 2002-07-09 2009-08-26 Bristol Myers Squibb Co Derives heterocycliqes substitues utiles comme agents antidiabetique et antiabesite et leur procede de fabrication
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TW200610754A (en) * 2004-06-14 2006-04-01 Daiichi Seiyaku Co Vla-4 inhibitor
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
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US20120258093A1 (en) 2009-08-20 2012-10-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
EP4494698A3 (fr) 2017-08-04 2025-04-23 Takeda Pharmaceutical Company Limited Inhibiteurs de la kallicréine plasmatique et leurs utilisations
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EP1091943B1 (fr) 2005-11-30
HUP0102477A3 (en) 2002-08-28
HN1999000099A (es) 1999-11-11
PA8477001A1 (es) 2000-05-24
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US6306887B1 (en) 2001-10-23
AP1236A (en) 2004-01-14
EA004792B1 (ru) 2004-08-26
OA11577A (en) 2004-07-26
JP2002519344A (ja) 2002-07-02
NO20006600D0 (no) 2000-12-22
UA66864C2 (uk) 2004-06-15
CA2336625A1 (fr) 2000-01-06
EP1091943A1 (fr) 2001-04-18
ID27414A (id) 2001-04-05
IS5720A (is) 2000-11-21
WO2000000477A1 (fr) 2000-01-06
ZA993777B (en) 2000-12-04
MA26640A1 (fr) 2004-12-20
PE20000762A1 (es) 2000-08-24
AU3841699A (en) 2000-01-17
HUP0102477A2 (hu) 2002-05-29
AP9901561A0 (en) 1999-06-30
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AR015312A1 (es) 2001-04-18
US6355662B1 (en) 2002-03-12
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ATE311371T1 (de) 2005-12-15
CN1308616A (zh) 2001-08-15
AU758939B2 (en) 2003-04-03
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