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IL138670A - Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections - Google Patents

Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections

Info

Publication number
IL138670A
IL138670A IL13867000A IL13867000A IL138670A IL 138670 A IL138670 A IL 138670A IL 13867000 A IL13867000 A IL 13867000A IL 13867000 A IL13867000 A IL 13867000A IL 138670 A IL138670 A IL 138670A
Authority
IL
Israel
Prior art keywords
trisubstituted
treatment
triazine derivatives
hiv infections
hiv
Prior art date
Application number
IL13867000A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL138670A publication Critical patent/IL138670A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/66—Derivatives of melamine in which a hetero atom is directly attached to a nitrogen atom of melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/70—Other substituted melamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL13867000A 1998-03-27 2000-09-25 Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections IL138670A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7963398P 1998-03-27 1998-03-27
EP98201589A EP0945447A1 (en) 1998-03-27 1998-05-14 Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections

Publications (1)

Publication Number Publication Date
IL138670A true IL138670A (en) 2005-12-18

Family

ID=22151790

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13867000A IL138670A (en) 1998-03-27 2000-09-25 Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections

Country Status (32)

Country Link
US (3) US6150360A (et)
EP (2) EP0945447A1 (et)
JP (1) JP2002511390A (et)
KR (1) KR100593396B1 (et)
CN (1) CN1157386C (et)
AP (1) AP1475A (et)
AR (1) AR018169A1 (et)
AT (1) ATE295355T1 (et)
AU (1) AU758624C (et)
BG (1) BG64903B1 (et)
BR (1) BR9909197A (et)
CA (1) CA2324921C (et)
DE (1) DE69925256T2 (et)
DK (1) DK1066269T3 (et)
EA (1) EA004540B1 (et)
EE (1) EE200000535A (et)
ES (1) ES2243056T3 (et)
HR (1) HRP20000621A2 (et)
HU (1) HUP0101372A3 (et)
ID (1) ID26043A (et)
IL (1) IL138670A (et)
NO (1) NO317425B1 (et)
NZ (1) NZ506787A (et)
OA (1) OA11493A (et)
PL (1) PL194660B1 (et)
PT (1) PT1066269E (et)
SI (1) SI1066269T1 (et)
SK (1) SK14052000A3 (et)
TR (1) TR200002761T2 (et)
TW (1) TW570917B (et)
WO (1) WO1999050256A1 (et)
ZA (1) ZA200006042B (et)

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CA2407754C (en) 2000-05-08 2009-09-15 Janssen Pharmaceutica N.V. Prodrugs of hiv replication inhibiting pyrimidines
US6858608B2 (en) * 2001-01-09 2005-02-22 Aventis Pharma S.A. Chemical derivatives and their application as antitelomerase agents
US6887873B2 (en) * 2001-03-23 2005-05-03 Aventis Pharma S.A. Triazine derivatives and their application as antitelomerase agents
US6958211B2 (en) 2001-08-08 2005-10-25 Tibotech Bvba Methods of assessing HIV integrase inhibitor therapy
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
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US7169785B2 (en) * 2001-09-21 2007-01-30 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
US7173032B2 (en) * 2001-09-21 2007-02-06 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
US7112587B2 (en) * 2001-09-21 2006-09-26 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
KR20040088457A (ko) * 2001-09-21 2004-10-16 레디 유에스 테라퓨틱스 인코포레이티드 신규 트리아진 화합물 제조방법 및 조성물
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US20070232572A1 (en) * 2003-02-07 2007-10-04 Aventis Pharma S.A. Chemical derivatives as antitelomerase agents which bind specifically to the G-quadruplex DNA structures and their application as a specific anticancer agent
AU2004213173B2 (en) * 2003-02-07 2010-07-29 Janssen Pharmaceutica N.V. HIV inhibiting 1,2,4-triazines
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US6875781B2 (en) 2003-04-04 2005-04-05 Cell Therapeutics, Inc. Pyridines and uses thereof
DK1648467T3 (en) 2003-07-17 2018-06-25 Janssen Sciences Ireland Uc PROCEDURE FOR MANUFACTURING PARTICLES CONTAINING AN ANTIVIRUS AGENT
WO2005009980A1 (en) * 2003-07-22 2005-02-03 Neurogen Corporation Substituted pyridin-2-ylamine analogues
US7335770B2 (en) * 2004-03-24 2008-02-26 Reddy U5 Therapeutics, Inc. Triazine compounds and their analogs, compositions, and methods
JP5031564B2 (ja) * 2004-08-10 2012-09-19 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｈｉｖ抑制１，２，４−トリアジン−６−オン誘導体
WO2006035068A2 (en) 2004-09-30 2006-04-06 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 5-carbo- or heterocyclic substituted pyrimidines
ATE520680T1 (de) 2004-09-30 2011-09-15 Tibotec Pharm Ltd Hiv-hemmende 5-heterocyclylpyrimidine
ATE542802T1 (de) 2004-09-30 2012-02-15 Tibotec Pharm Ltd Hiv-inhibierende 5-substituierte pyrimidine
MX2007005159A (es) 2004-10-29 2007-06-26 Tibotec Pharm Ltd Derivados de pirimidina biciclicos inhibidores del vih.
US7592451B2 (en) * 2005-06-23 2009-09-22 New York University Treatment for diabetes and obesity as well as method of screening compounds useful for such treatments
CN101245051B (zh) * 2005-12-22 2011-04-20 中国科学院上海药物研究所 2，4-二取代氨基-6-取代-[1，3，5]三嗪类化合物、其制备方法、药物组合物及用途
AU2007233737B2 (en) 2006-03-30 2012-11-29 Janssen Sciences Ireland Uc HIV inhibiting 5-amido substituted pyrimidines
JP5185283B2 (ja) 2006-12-29 2013-04-17 テイボテク・フアーマシユーチカルズ Ｈｉｖ阻害６−置換ピリミジン
BRPI0722079B8 (pt) 2006-12-29 2021-05-25 Janssen R & D Ireland pirimidinas 5,6-substituídas inibidoras de hiv e composição farmacêutica que as compreende
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GB201119358D0 (en) 2011-11-10 2011-12-21 Lewi Paulus J Disubstituted triazine dimers for treatment and/or prevention of infectious diseases
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US9914709B2 (en) * 2013-06-21 2018-03-13 Yale University Compositions and methods of treating HIV-1 infections using same
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Also Published As

Publication number Publication date
EA004540B1 (ru) 2004-06-24
EP1066269B1 (en) 2005-05-11
KR20010034270A (ko) 2001-04-25
DK1066269T3 (da) 2005-09-05
KR100593396B1 (ko) 2006-06-28
AP2000001913A0 (en) 2000-09-30
PL343195A1 (en) 2001-07-30
US6372729B1 (en) 2002-04-16
EP1066269A1 (en) 2001-01-10
BG104716A (en) 2001-04-30
NZ506787A (en) 2003-02-28
ES2243056T3 (es) 2005-11-16
EA200000993A1 (ru) 2001-04-23
NO20004809L (no) 2000-11-24
DE69925256T2 (de) 2006-02-23
AU758624B2 (en) 2003-03-27
CN1157386C (zh) 2004-07-14
NO317425B1 (no) 2004-10-25
ID26043A (id) 2000-11-16
EP0945447A1 (en) 1999-09-29
BR9909197A (pt) 2000-12-05
WO1999050256A1 (en) 1999-10-07
TW570917B (en) 2004-01-11
PT1066269E (pt) 2005-09-30
HK1032394A1 (en) 2001-07-20
HUP0101372A2 (hu) 2001-10-28
AU3599799A (en) 1999-10-18
CA2324921A1 (en) 1999-10-07
HRP20000621A2 (en) 2001-04-30
CA2324921C (en) 2009-05-12
JP2002511390A (ja) 2002-04-16
ZA200006042B (en) 2001-10-26
EE200000535A (et) 2002-04-15
NO20004809D0 (no) 2000-09-26
ATE295355T1 (de) 2005-05-15
US6774235B2 (en) 2004-08-10
AU758624C (en) 2004-03-11
US6150360A (en) 2000-11-21
AP1475A (en) 2005-10-03
OA11493A (en) 2004-05-07
SK14052000A3 (sk) 2001-06-11
US20020115668A1 (en) 2002-08-22
DE69925256D1 (de) 2005-06-16
TR200002761T2 (tr) 2001-01-22
BG64903B1 (bg) 2006-08-31
HUP0101372A3 (en) 2003-02-28
PL194660B1 (pl) 2007-06-29
AR018169A1 (es) 2001-10-31
SI1066269T1 (en) 2005-10-31
CN1295566A (zh) 2001-05-16

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