IL137757A0 - Method of controlling proliferation and differentiation of stem and progenitor cells - Google Patents
Method of controlling proliferation and differentiation of stem and progenitor cellsInfo
- Publication number
- IL137757A0 IL137757A0 IL13775799A IL13775799A IL137757A0 IL 137757 A0 IL137757 A0 IL 137757A0 IL 13775799 A IL13775799 A IL 13775799A IL 13775799 A IL13775799 A IL 13775799A IL 137757 A0 IL137757 A0 IL 137757A0
- Authority
- IL
- Israel
- Prior art keywords
- stem
- stem cells
- differentiation
- progenitor cells
- expanded
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title abstract 7
- 230000004069 differentiation Effects 0.000 title 1
- 230000035755 proliferation Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical group [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/22—Zinc; Zn chelators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2419598A | 1998-02-17 | 1998-02-17 | |
| US13036798A | 1998-08-07 | 1998-08-07 | |
| PCT/US1999/002664 WO1999040783A1 (en) | 1998-02-17 | 1999-02-08 | Method of controlling proliferation and differentiation of stem and progenitor cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL137757A0 true IL137757A0 (en) | 2001-10-31 |
Family
ID=26698157
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13775799A IL137757A0 (en) | 1998-02-17 | 1999-02-08 | Method of controlling proliferation and differentiation of stem and progenitor cells |
| IL137757A IL137757A (en) | 1998-02-17 | 2000-08-08 | Method of controlling proliferation and differentiation of stem and progenitor cells |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL137757A IL137757A (en) | 1998-02-17 | 2000-08-08 | Method of controlling proliferation and differentiation of stem and progenitor cells |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP1069821B1 (de) |
| JP (1) | JP3810273B2 (de) |
| AT (1) | ATE511752T1 (de) |
| AU (1) | AU759522C (de) |
| CA (1) | CA2320073C (de) |
| ES (1) | ES2391055T3 (de) |
| IL (2) | IL137757A0 (de) |
| WO (1) | WO1999040783A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6962698B1 (en) | 1998-02-17 | 2005-11-08 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
| CA2344653A1 (en) | 1998-09-29 | 2000-04-06 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
| NL1017973C2 (nl) * | 2000-05-10 | 2002-11-08 | Tristem Trading Cyprus Ltd | Inrichting. |
| IL152904A0 (en) * | 2002-01-24 | 2003-06-24 | Gamida Cell Ltd | Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations |
| EP1465982A4 (de) | 2002-01-25 | 2006-06-07 | Gamida Cell Ltd | Verfahren zur expansion von stamm- und vorläuferzellen und damit erhaltene expandierte zellpopulationen |
| EP1601759A4 (de) * | 2003-03-07 | 2007-02-14 | Gamida Cell Ltd | Expansion erneuerbarer stammzellpopulationen unter verwendung von modulatoren der pi-3-kinase |
| WO2005007799A2 (en) * | 2003-07-17 | 2005-01-27 | Gamida-Cell Ltd. | Methods for ex-vivo expanding stem/progenitor cells |
| IL161903A0 (en) * | 2003-07-17 | 2005-11-20 | Gamida Cell Ltd | Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs |
| US7417026B2 (en) | 2003-08-13 | 2008-08-26 | Children's Hospital Medical Center | Mobilization of hematopoietic cells |
| JP2007535479A (ja) | 2003-08-13 | 2007-12-06 | チルドレンズ ホスピタル メディカル センター | ＧＴＰａｓｅを調節するためのキメラペプチド |
| WO2006030442A2 (en) | 2004-09-16 | 2006-03-23 | Gamida-Cell Ltd. | Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells |
| US8846393B2 (en) | 2005-11-29 | 2014-09-30 | Gamida-Cell Ltd. | Methods of improving stem cell homing and engraftment |
| WO2007108689A2 (en) * | 2006-03-21 | 2007-09-27 | Stichting Skeletal Tissue Engineering | Method for induction of differentiation of stem and progenitor cells |
| JP5573160B2 (ja) | 2007-12-05 | 2014-08-20 | 日産化学工業株式会社 | ヘテロ環化合物による造血幹細胞の増幅方法 |
| EP2228435A4 (de) | 2007-12-05 | 2013-01-23 | Nissan Chemical Ind Ltd | Amplifikationsmethode für hämatopoetischen Stammzellen mit heterocyclischen Verbindung |
| JP5573161B2 (ja) | 2007-12-05 | 2014-08-20 | 日産化学工業株式会社 | ヘテロ環化合物による造血幹細胞の増幅方法 |
| WO2009072635A1 (ja) | 2007-12-06 | 2009-06-11 | Nissan Chemical Industries, Ltd. | ヘテロ環化合物による造血幹細胞の増幅方法 |
| WO2010140685A1 (ja) | 2009-06-04 | 2010-12-09 | 日産化学工業株式会社 | ヘテロ環化合物及び造血幹細胞の増幅剤 |
| WO2011158806A1 (ja) | 2010-06-14 | 2011-12-22 | 日産化学工業株式会社 | 造血幹細胞の製造方法 |
| WO2012074068A1 (ja) | 2010-12-01 | 2012-06-07 | 日産化学工業株式会社 | ピラゾール化合物による造血幹細胞の製造方法 |
| EP2814950A1 (de) | 2012-02-13 | 2014-12-24 | Gamida-Cell Ltd. | Durch mesenchymale stammzellen konditioniertes medium und verfahren zur herstellung und verwendung davon |
| US9175266B2 (en) | 2012-07-23 | 2015-11-03 | Gamida Cell Ltd. | Enhancement of natural killer (NK) cell proliferation and activity |
| US9567569B2 (en) | 2012-07-23 | 2017-02-14 | Gamida Cell Ltd. | Methods of culturing and expanding mesenchymal stem cells |
| JP7292434B2 (ja) * | 2020-01-21 | 2023-06-16 | 株式会社エビデント | 赤血球分化モニタリング装置および赤血球分化モニタリング方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01222780A (ja) * | 1988-03-02 | 1989-09-06 | Tosoh Corp | ウロキナーゼ前駆体様蛋白質のリフォールディング方法 |
| US5631219A (en) * | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
| AU2197897A (en) * | 1996-03-01 | 1997-09-16 | Imclone Systems Incorporated | Use of delta-like protein to inhibit the differentiation of stem cells |
| CA2248142A1 (en) * | 1996-03-12 | 1997-09-18 | Life Technologies, Inc. | Hematopoietic cell culture nutrient supplement |
| US6962698B1 (en) * | 1998-02-17 | 2005-11-08 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
| CA2344653A1 (en) * | 1998-09-29 | 2000-04-06 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
-
1999
- 1999-02-08 ES ES03003275T patent/ES2391055T3/es not_active Expired - Lifetime
- 1999-02-08 EP EP99906799A patent/EP1069821B1/de not_active Expired - Lifetime
- 1999-02-08 AT AT99906799T patent/ATE511752T1/de not_active IP Right Cessation
- 1999-02-08 CA CA2320073A patent/CA2320073C/en not_active Expired - Fee Related
- 1999-02-08 AU AU26624/99A patent/AU759522C/en not_active Ceased
- 1999-02-08 EP EP03003275A patent/EP1332673B1/de not_active Expired - Lifetime
- 1999-02-08 JP JP2000531059A patent/JP3810273B2/ja not_active Expired - Fee Related
- 1999-02-08 WO PCT/US1999/002664 patent/WO1999040783A1/en not_active Ceased
- 1999-02-08 IL IL13775799A patent/IL137757A0/xx active IP Right Grant
-
2000
- 2000-08-08 IL IL137757A patent/IL137757A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002502617A (ja) | 2002-01-29 |
| IL137757A (en) | 2006-08-20 |
| EP1069821A1 (de) | 2001-01-24 |
| CA2320073C (en) | 2011-11-01 |
| HK1057976A1 (en) | 2004-04-30 |
| EP1069821A4 (de) | 2001-11-21 |
| AU759522B2 (en) | 2003-04-17 |
| EP1069821B1 (de) | 2011-06-08 |
| EP1332673B1 (de) | 2012-05-30 |
| WO1999040783A1 (en) | 1999-08-19 |
| AU2662499A (en) | 1999-08-30 |
| HK1034162A1 (en) | 2001-10-19 |
| ES2391055T3 (es) | 2012-11-21 |
| JP3810273B2 (ja) | 2006-08-16 |
| AU759522C (en) | 2005-05-12 |
| ATE511752T1 (de) | 2011-06-15 |
| CA2320073A1 (en) | 1999-08-19 |
| EP1332673A1 (de) | 2003-08-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |