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IL136732A0 - Camptothecin tetracyclic analogues, preparation, methods, applications as medicines and pharmaceutical compositions containing them - Google Patents

Camptothecin tetracyclic analogues, preparation, methods, applications as medicines and pharmaceutical compositions containing them

Info

Publication number
IL136732A0
IL136732A0 IL13673298A IL13673298A IL136732A0 IL 136732 A0 IL136732 A0 IL 136732A0 IL 13673298 A IL13673298 A IL 13673298A IL 13673298 A IL13673298 A IL 13673298A IL 136732 A0 IL136732 A0 IL 136732A0
Authority
IL
Israel
Prior art keywords
camptothecin
medicines
applications
preparation
methods
Prior art date
Application number
IL13673298A
Other languages
English (en)
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of IL136732A0 publication Critical patent/IL136732A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
IL13673298A 1997-12-24 1998-12-16 Camptothecin tetracyclic analogues, preparation, methods, applications as medicines and pharmaceutical compositions containing them IL136732A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9716461A FR2772763B1 (fr) 1997-12-24 1997-12-24 Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
PCT/FR1998/002751 WO1999033829A1 (fr) 1997-12-24 1998-12-16 Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
IL136732A0 true IL136732A0 (en) 2001-06-14

Family

ID=9515095

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13673298A IL136732A0 (en) 1997-12-24 1998-12-16 Camptothecin tetracyclic analogues, preparation, methods, applications as medicines and pharmaceutical compositions containing them

Country Status (22)

Country Link
US (2) US6436951B1 (ru)
EP (1) EP1042323B1 (ru)
JP (1) JP2001527075A (ru)
AR (1) AR016440A1 (ru)
AT (1) ATE215951T1 (ru)
AU (1) AU749224B2 (ru)
CA (1) CA2315897C (ru)
DE (1) DE69804856T2 (ru)
DK (1) DK1042323T3 (ru)
ES (1) ES2175834T3 (ru)
FR (1) FR2772763B1 (ru)
HU (1) HUP0004628A3 (ru)
IL (1) IL136732A0 (ru)
MY (1) MY117585A (ru)
NO (1) NO316676B1 (ru)
NZ (1) NZ505339A (ru)
PL (1) PL193468B1 (ru)
PT (1) PT1042323E (ru)
RU (1) RU2220144C2 (ru)
TW (1) TW513429B (ru)
WO (1) WO1999033829A1 (ru)
ZA (1) ZA9811796B (ru)

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US20040077674A1 (en) * 2002-03-01 2004-04-22 Curran Dennis P. Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
BR0215650A (pt) * 2002-03-26 2005-01-04 Banyu Pharma Co Ltd Preparação combinada para a administração simultânea, separada, ou sequencial no tratamento do câncer, método para o tratamento do câncer, uso de pelo menos um composto, e, composição farmacêutica
DE60334015D1 (de) * 2002-10-30 2010-10-14 Merck Frosst Canada Ltd Pyridopyrrolizin- und pyridoindolizinderivate
JPWO2006061954A1 (ja) * 2004-12-08 2008-06-05 富士電機ホールディングス株式会社 有機ｅｌ素子
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
JP5126707B2 (ja) * 2007-04-23 2013-01-23 有機合成薬品工業株式会社 α−ヒドロキシアシルピリジンの製造方法
DE602008004794D1 (de) 2007-09-14 2011-03-10 Addex Pharmaceuticals Sa 1',3'-disubstituierte 4-phenyl-3,4,5,6-tetrahydro-2h,1'h-ä1,4'übipyridinyl-2'-one
EP2344470B1 (en) 2008-09-02 2013-11-06 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
CN102232074B (zh) 2008-11-28 2014-12-03 奥梅-杨森制药有限公司 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物
RU2397984C1 (ru) * 2009-03-05 2010-08-27 Государственное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ БЕНЗО[7,8]АЗОНИНО[5,4-b]ИНДОЛОВ, 7,9-ЭТЕНОАЗЕЦИНО[5,4-b]ИНДОЛОВ И 7,9-ЭТАНОАЗЕЦИНО[5,4-b]ИНДОЛОВ
WO2010130422A1 (en) 2009-05-12 2010-11-18 Ortho-Mcneil-Janssen Pharmaceuticals, Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
AR076861A1 (es) 2009-05-12 2011-07-13 Addex Pharma Sa Derivados de 1,2,4-triazolo (4,3-a)piridina y su uso como moduladores alostericos positivos de los receptores de mglur2
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
CA2814998C (en) 2010-11-08 2019-10-29 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2552455T3 (es) 2010-11-08 2015-11-30 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
JP6669499B2 (ja) 2013-02-15 2020-03-18 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
CA2900680C (en) 2013-02-20 2021-08-10 Kala Pharmaceuticals, Inc. Quinoline and quinazoline compounds and uses thereof for treating and/or preventing diseases
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
AU2014342042B2 (en) 2013-11-01 2017-08-17 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN103588660B (zh) * 2013-11-18 2016-06-01 中国医学科学院生物医学工程研究所 一种新型的酰基苯胺化合物及用途
RU2648236C2 (ru) 2013-12-13 2018-03-23 Ф. Хоффманн-Ля Рош Аг Ингибиторы тирозинкиназы брутона
PH12019500127B1 (en) 2014-01-21 2022-05-04 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
SMT201900545T1 (it) 2014-01-21 2019-11-13 Janssen Pharmaceutica Nv Combinazioni comprendenti modulatori allosterici positivi o agonisti ortosterici del recettore glutammatergico metabotropico sottotipo 2 e loro utilizzo
CA3036065A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CA3036340A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
AU2017324713B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
EP0835258B1 (fr) * 1995-06-21 2002-09-25 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds

Also Published As

Publication number Publication date
EP1042323B1 (fr) 2002-04-10
ZA9811796B (en) 1999-06-29
NO20003314L (no) 2000-06-30
CA2315897C (fr) 2010-01-19
HUP0004628A1 (hu) 2001-05-28
PL193468B1 (pl) 2007-02-28
DK1042323T3 (da) 2002-08-05
AR016440A1 (es) 2001-07-04
US20010000521A1 (en) 2001-04-26
NO20003314D0 (no) 2000-06-23
AU749224B2 (en) 2002-06-20
EP1042323A1 (fr) 2000-10-11
RU2220144C2 (ru) 2003-12-27
CA2315897A1 (fr) 1999-07-08
MY117585A (en) 2004-07-31
NZ505339A (en) 2003-01-31
WO1999033829A1 (fr) 1999-07-08
JP2001527075A (ja) 2001-12-25
AU1764599A (en) 1999-07-19
NO316676B1 (no) 2004-03-29
DE69804856T2 (de) 2002-11-07
ATE215951T1 (de) 2002-04-15
ES2175834T3 (es) 2002-11-16
FR2772763B1 (fr) 2004-01-23
DE69804856D1 (de) 2002-05-16
HUP0004628A3 (en) 2001-11-28
PT1042323E (pt) 2002-09-30
US6632946B2 (en) 2003-10-14
US6436951B1 (en) 2002-08-20
TW513429B (en) 2002-12-11
PL341288A1 (en) 2001-04-09
FR2772763A1 (fr) 1999-06-25

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees