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IL136659A - New antiarrhythmic compounds and pharmaceuticals containing them - Google Patents

New antiarrhythmic compounds and pharmaceuticals containing them

Info

Publication number
IL136659A
IL136659A IL13665998A IL13665998A IL136659A IL 136659 A IL136659 A IL 136659A IL 13665998 A IL13665998 A IL 13665998A IL 13665998 A IL13665998 A IL 13665998A IL 136659 A IL136659 A IL 136659A
Authority
IL
Israel
Prior art keywords
ethyl
compounds
methyl
dimethylphenoxy
amino
Prior art date
Application number
IL13665998A
Other languages
English (en)
Hebrew (he)
Other versions
IL136659A0 (en
Original Assignee
Gyogyszerkutato Intezet
Szent Gyorgyi Albert Orvostudo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyogyszerkutato Intezet, Szent Gyorgyi Albert Orvostudo filed Critical Gyogyszerkutato Intezet
Publication of IL136659A0 publication Critical patent/IL136659A0/xx
Publication of IL136659A publication Critical patent/IL136659A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/64Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/16Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
IL13665998A 1997-12-11 1998-12-10 New antiarrhythmic compounds and pharmaceuticals containing them IL136659A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9702411A HUP9702411A2 (hu) 1997-12-11 1997-12-11 Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények
PCT/HU1998/000101 WO1999029655A1 (en) 1997-12-11 1998-12-10 Novel antiarrhythmic compounds

Publications (2)

Publication Number Publication Date
IL136659A0 IL136659A0 (en) 2001-06-14
IL136659A true IL136659A (en) 2004-08-31

Family

ID=89995855

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13665998A IL136659A (en) 1997-12-11 1998-12-10 New antiarrhythmic compounds and pharmaceuticals containing them

Country Status (22)

Country Link
US (1) US6265445B1 (pt)
EP (1) EP1037871B1 (pt)
JP (1) JP2001525388A (pt)
KR (1) KR100576905B1 (pt)
CN (1) CN1140498C (pt)
AT (1) ATE220058T1 (pt)
AU (1) AU738672B2 (pt)
BR (1) BR9814270A (pt)
CA (1) CA2313191A1 (pt)
DE (1) DE69806411T2 (pt)
DK (1) DK1037871T3 (pt)
ES (1) ES2179547T3 (pt)
HU (1) HUP9702411A2 (pt)
IL (1) IL136659A (pt)
NO (1) NO20002946L (pt)
NZ (1) NZ504982A (pt)
PL (1) PL190788B1 (pt)
PT (1) PT1037871E (pt)
RU (1) RU2193024C2 (pt)
SK (1) SK284284B6 (pt)
UA (1) UA61979C2 (pt)
WO (1) WO1999029655A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19956786A1 (de) * 1999-11-25 2001-05-31 Basf Ag Verfahren zur Herstellung optisch aktiver Amine
US20030119406A1 (en) 2001-12-20 2003-06-26 Abuto Francis Paul Targeted on-line stabilized absorbent structures
WO2003091205A1 (fr) * 2002-04-26 2003-11-06 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Sulfamidophenylalkylamines, production et utilisation de ces dernieres
CN102603543B (zh) * 2012-04-09 2014-07-02 佛山普正医药科技有限公司 一种盐酸美西律的生产方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD146749A3 (de) * 1977-12-01 1981-03-04 Dieter Lehmann Verfahren zur herstellung von phenoxyalkanolamin-derivaten
EG18188A (en) * 1986-05-01 1992-09-30 Pfizer Ltd Process for preparation anti-arhythmia agents
NO179246C (no) * 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
JPH06107614A (ja) * 1992-09-26 1994-04-19 Arakusu:Kk アリールスルホン酸アミド類またはアリールカルボン酸アミド類及びそれらの薬剤として許容される酸付加塩及びその製造法並びにそれを有効成分とする抗消化性潰瘍剤

Also Published As

Publication number Publication date
CN1284941A (zh) 2001-02-21
NO20002946L (no) 2000-08-07
PL190788B1 (pl) 2006-01-31
AU738672B2 (en) 2001-09-20
KR20010032996A (ko) 2001-04-25
DE69806411D1 (de) 2002-08-08
IL136659A0 (en) 2001-06-14
EP1037871B1 (en) 2002-07-03
AU1678999A (en) 1999-06-28
UA61979C2 (en) 2003-12-15
EP1037871A1 (en) 2000-09-27
WO1999029655A1 (en) 1999-06-17
RU2193024C2 (ru) 2002-11-20
CA2313191A1 (en) 1999-06-17
BR9814270A (pt) 2001-10-16
HK1033937A1 (en) 2001-10-05
HUP9702411A2 (hu) 2000-03-28
HU9702411D0 (en) 1998-03-02
JP2001525388A (ja) 2001-12-11
US6265445B1 (en) 2001-07-24
NZ504982A (en) 2002-07-26
KR100576905B1 (ko) 2006-05-03
PT1037871E (pt) 2002-11-29
SK284284B6 (sk) 2005-01-03
CN1140498C (zh) 2004-03-03
SK8792000A3 (en) 2001-02-12
PL341107A1 (en) 2001-03-26
NO20002946D0 (no) 2000-06-08
ATE220058T1 (de) 2002-07-15
DE69806411T2 (de) 2003-03-20
ES2179547T3 (es) 2003-01-16
DK1037871T3 (da) 2002-10-14

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