IL134840A0 - Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists - Google Patents

Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists

Info

Publication number: IL134840A0
Authority: IL; Israel
Prior art keywords: agonists; aromatic; substituted tetrahydro; prostaglandins useful; tetrahydro prostaglandins
Prior art date: 1997-09-09

Application number

IL13484098A

Other languages

English (en)

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-09

Filing date

1998-09-04

Publication date

2001-05-20

1998-09-04 Application filed by Procter & Gamble filed Critical Procter & Gamble

2001-05-20 Publication of IL134840A0 publication Critical patent/IL134840A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Otolaryngology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

IL13484098A 1997-09-09 1998-09-04 Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists IL134840A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5825297P	1997-09-09	1997-09-09
PCT/US1998/018594 WO1999012898A1 (en)	1997-09-09	1998-09-04	Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists

Publications (1)

Publication Number	Publication Date
IL134840A0 true IL134840A0 (en)	2001-05-20

Family

ID=22015635

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL13484098A IL134840A0 (en)	1997-09-09	1998-09-04	Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists

Country Status (24)

Country	Link
US (1)	US6048895A (xx)
EP (1)	EP1012137B1 (xx)
JP (2)	JP4619531B2 (xx)
KR (1)	KR20010023838A (xx)
CN (1)	CN1269784A (xx)
AR (1)	AR017078A1 (xx)
AT (1)	ATE227266T1 (xx)
AU (1)	AU731032B2 (xx)
BR (1)	BR9812631A (xx)
CA (1)	CA2303801C (xx)
CO (1)	CO4970733A1 (xx)
DE (1)	DE69809268T2 (xx)
DK (1)	DK1012137T3 (xx)
HU (1)	HUP0004427A3 (xx)
ID (1)	ID24845A (xx)
IL (1)	IL134840A0 (xx)
NO (1)	NO20001139L (xx)
NZ (1)	NZ503738A (xx)
PE (1)	PE123099A1 (xx)
PL (1)	PL339221A1 (xx)
SK (1)	SK3382000A3 (xx)
TR (1)	TR200000673T2 (xx)
WO (1)	WO1999012898A1 (xx)
ZA (1)	ZA988232B (xx)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69714274T3 (de) *	1996-09-17	2006-06-01	Asahi Glass Co., Ltd.	Fluorierte prostaglandinderivate und medikamente
ID24845A (id) *	1997-09-09	2000-08-24	Procter & Gamble	Prostaglandin tetrahidro tersubstitusi c16-c20 aromatik yang berguna sebagai agonis fp
NZ513825A (en) *	1999-03-05	2001-09-28	Procter & Gamble	C 16 unsaturated FP-selective prostaglandins analogs
US6894175B1 (en)	1999-08-04	2005-05-17	The Procter & Gamble Company	2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
AU776375B2 (en)	1999-08-04	2004-09-09	Duke University	Novel 2-decarboxy-2-phosphinico prostaglandin F analogs
US20020013294A1 (en)	2000-03-31	2002-01-31	Delong Mitchell Anthony	Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en)	2000-03-31	2002-11-21	Delong Michell Anthony	Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020146439A1 (en) *	2000-03-31	2002-10-10	Delong Mitchell Anthony	Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
US20020037914A1 (en) *	2000-03-31	2002-03-28	Delong Mitchell Anthony	Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
KR100437873B1 (ko) *	2001-05-08	2004-06-26	연성정밀화학(주)	프로스타글란딘 유도체의 제조방법 및 그의 입체특이적출발물질
US6905827B2 (en) *	2001-06-08	2005-06-14	Expression Diagnostics, Inc.	Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US20060135609A1 (en) *	2004-10-21	2006-06-22	Duke University	Ophthamological drugs
US20070254920A1 (en) *	2006-04-26	2007-11-01	Aerie Pharmaceuticals, Inc.	Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
US8455513B2 (en)	2007-01-10	2013-06-04	Aerie Pharmaceuticals, Inc.	6-aminoisoquinoline compounds
WO2010039535A1 (en) *	2008-09-23	2010-04-08	Meta Cosmetics, Llc	Compositions and methods to treat epithelial-related conditions
AU2008319145A1 (en)	2007-10-31	2009-05-07	Pamela Lipkin	Prostaglandin analog compositions and methods to treat epithelial-related conditions
US8450344B2 (en)	2008-07-25	2013-05-28	Aerie Pharmaceuticals, Inc.	Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US8623918B2 (en) *	2008-10-29	2014-01-07	Novaer Holdings, Inc.	Amino acid salts of prostaglandins
AU2009340420A1 (en)	2008-10-29	2010-08-26	Novaer Holdings, Inc.	Amino acid salts of prostaglandins
US8722739B2 (en)	2008-10-29	2014-05-13	Novaer Holdings, Inc.	Amino acid salts of prostaglandins
US20110293549A1 (en)	2009-02-03	2011-12-01	Athena Cosmetics, Inc.	Composition, method and kit for enhancing hair
EP3053913B1 (en)	2009-05-01	2018-03-07	Aerie Pharmaceuticals, Inc.	Dual mechanism inhibitors for the treatment of disease
CN103864653A (zh) *	2012-12-10	2014-06-18	韩冰	一类降低眼压的化合物及其用途
CN105263494A (zh)	2013-03-15	2016-01-20	爱瑞制药公司	联合治疗
US9643927B1 (en)	2015-11-17	2017-05-09	Aerie Pharmaceuticals, Inc.	Process for the preparation of kinase inhibitors and intermediates thereof
CN109640966A (zh)	2016-08-31	2019-04-16	爱瑞制药公司	眼用组合物
CA3057872A1 (en)	2017-03-31	2018-10-04	Aerie Pharmaceuticals, Inc.	Aryl cyclopropyl-amino-isoquinolinyl amide compounds
AU2019337703B2 (en)	2018-09-14	2023-02-02	Aerie Pharmaceuticals, Inc.	Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3776938A (en) *	1958-05-28	1973-12-04	S Bergstrom	Dihydro-pge1
US4011262A (en) *	1972-07-13	1977-03-08	Pfizer Inc.	13,14-Dihydro-15-substituted-ω-pentanorprostaglandins of the two series
US4024179A (en) *	1972-11-08	1977-05-17	Pfizer Inc.	Substituted ω-pentanorprostaglandins
IL50310A (en) *	1972-11-08	1977-08-31	Pfizer	Dimethyl ketophosphonates
DD118856A5 (xx) *	1972-11-08	1976-03-20
JPS5720305B2 (xx) *	1973-02-28	1982-04-27
DE2365101A1 (de) *	1973-12-21	1975-07-10	Schering Ag	Neue prostansaeurederivate und verfahren zu ihrer herstellung
DE2460990A1 (de) *	1974-12-21	1976-07-01	Hoechst Ag	Neue prostaglandin-analoga und verfahren zu ihrer herstellung
GB1507211A (en) *	1975-02-14	1978-04-12	Ono Pharmaceutical Co	Prostaglandin analogues
GB1506817A (en) *	1975-03-31	1978-04-12	Upjohn Co	Prostaglandins
DE2517771A1 (de) *	1975-04-18	1976-10-28	Schering Ag	Neue prostaglandin-acetylen-analoga und verfahren zu ihrer herstellung
US4051238A (en) *	1976-06-03	1977-09-27	The Upjohn Company	Treatment of genital tract diseases of domestic animals with prostaglandins
DE2737808A1 (de) *	1976-08-27	1978-03-16	Pfizer	2-substituierte aryl-heterocyclische omega-pentanorprostaglandine
US4206151A (en) *	1978-12-21	1980-06-03	American Cyanamid Company	15-Deoxy-16-hydroxy-16-vinyl or cyclopropyl prostan-1-ols of the E, A and F series
JPS5829710A (ja) *	1981-03-25	1983-02-22	ジ・アツプジヨン・カンパニ−	Ｐｇ類による骨孔症の治療
US4621100A (en) *	1981-09-25	1986-11-04	The Upjohn Company	Treatment of osteoporosis with prostaglandins
CA1324129C (en) *	1987-04-30	1993-11-09	Ryuzo Ueno	Prostaglandins of the f series
US5166178B1 (en) *	1987-09-18	1998-07-21	R Tech Ueno Ltd	Ocular hypotensive agents
US5321128A (en) *	1988-09-06	1994-06-14	Kabi Pharmacia Ab	Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
EP1225168B8 (en) *	1988-09-06	2015-03-18	Pfizer Health AB	Prostaglandin-F-2 alpha derivative for the treatment of glaucoma or ocular hypertension
US5296504A (en) *	1988-09-06	1994-03-22	Kabi Pharmacia	Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
CA2030345C (en) *	1989-11-22	1998-12-08	Ryuji Ueno	Use of 15-keto-prostaglandin compound for improvement of encephalic function
CA2039420C (en) *	1990-04-04	1996-12-10	Ryuji Ueno	Treatment of cataract with 15-keto-prostaglandin compounds
US5302617A (en) *	1990-04-27	1994-04-12	Kabushikikaisha Ueno Seiyaku Oyo Kenkyuio	Biochemical treatment with 15-dehydroxy-16-oxoprostaglandin compounds
DE4024347A1 (de) *	1990-07-27	1992-01-30	Schering Ag	Cyclopentanderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
US5409911A (en) *	1992-09-11	1995-04-25	Merck & Co., Inc.	Prostaglandin analog for treating osteoporosis
US5688819A (en) *	1992-09-21	1997-11-18	Allergan	Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5834498A (en) *	1992-09-21	1998-11-10	Allergan	Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5332730A (en) *	1992-10-16	1994-07-26	Allergan, Inc.	Azido derivatives of cyclopentane heptanoic or heptenoic acid
AU665287B2 (en) *	1992-12-21	1995-12-21	Alcon Laboratories, Inc.	Prostaglandin combinations in glaucoma therapy
US5510383A (en) *	1993-08-03	1996-04-23	Alcon Laboratories, Inc.	Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US5545665A (en) *	1993-12-28	1996-08-13	Allergan	Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
AU7672096A (en) *	1995-06-07	1998-06-03	Alcon Laboratories, Inc.	Conformationally rigid aryl- or heteroaryl prostaglandins for use in glaucoma therapy
WO1997023225A1 (en) *	1995-12-22	1997-07-03	Alcon Laboratories, Inc.	Combinations of dp and fp type prostaglandins for lowering iop
US5703108A (en) *	1996-02-28	1997-12-30	Pfizer Inc.	Bone deposition by certain prostaglandin agonists
US5741810A (en) *	1996-02-29	1998-04-21	Allergan	Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents
DE69714698T2 (de) *	1996-06-10	2002-12-05	Sucampo Ag, Zug	Endothelin-antagonisten
DE69714274T3 (de) *	1996-09-17	2006-06-01	Asahi Glass Co., Ltd.	Fluorierte prostaglandinderivate und medikamente
US6353014B1 (en) *	1996-11-12	2002-03-05	Alcon Laboratories, Inc.	15-ketal postaglandins for the treatment of glaucoma or ocular hypertension
WO1998020880A2 (en) *	1996-11-12	1998-05-22	Alcon Laboratories, Inc.	11-halo prostaglandins for the treatment of glaucoma or ocular hypertension
US6037368A (en) *	1997-05-09	2000-03-14	Mount Sinai School Of Medicine	8-iso- prostaglandins for glaucoma therapy
ID24845A (id) *	1997-09-09	2000-08-24	Procter & Gamble	Prostaglandin tetrahidro tersubstitusi c16-c20 aromatik yang berguna sebagai agonis fp

1998
- 1998-09-04 ID IDW20000641A patent/ID24845A/id unknown
- 1998-09-04 DE DE69809268T patent/DE69809268T2/de not_active Expired - Lifetime
- 1998-09-04 CA CA002303801A patent/CA2303801C/en not_active Expired - Lifetime
- 1998-09-04 AU AU92240/98A patent/AU731032B2/en not_active Expired
- 1998-09-04 US US09/148,538 patent/US6048895A/en not_active Expired - Lifetime
- 1998-09-04 TR TR2000/00673T patent/TR200000673T2/xx unknown
- 1998-09-04 CN CN98808988A patent/CN1269784A/zh active Pending
- 1998-09-04 KR KR1020007002513A patent/KR20010023838A/ko not_active Ceased
- 1998-09-04 WO PCT/US1998/018594 patent/WO1999012898A1/en not_active Ceased
- 1998-09-04 BR BR9812631-8A patent/BR9812631A/pt not_active IP Right Cessation
- 1998-09-04 SK SK338-2000A patent/SK3382000A3/sk unknown
- 1998-09-04 AT AT98944783T patent/ATE227266T1/de not_active IP Right Cessation
- 1998-09-04 EP EP98944783A patent/EP1012137B1/en not_active Expired - Lifetime
- 1998-09-04 IL IL13484098A patent/IL134840A0/xx unknown
- 1998-09-04 HU HU0004427A patent/HUP0004427A3/hu unknown
- 1998-09-04 NZ NZ503738A patent/NZ503738A/en unknown
- 1998-09-04 PL PL98339221A patent/PL339221A1/xx unknown
- 1998-09-04 JP JP2000510710A patent/JP4619531B2/ja not_active Expired - Lifetime
- 1998-09-04 DK DK98944783T patent/DK1012137T3/da active
- 1998-09-08 AR ARP980104482A patent/AR017078A1/es unknown
- 1998-09-08 PE PE1998000844A patent/PE123099A1/es not_active Application Discontinuation
- 1998-09-09 CO CO98051815A patent/CO4970733A1/es unknown
- 1998-09-09 ZA ZA988232A patent/ZA988232B/xx unknown
2000
- 2000-03-06 NO NO20001139A patent/NO20001139L/no not_active Application Discontinuation
2010
- 2010-06-25 JP JP2010145432A patent/JP5330324B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2303801C (en)	2005-05-10
JP2010254705A (ja)	2010-11-11
NO20001139D0 (no)	2000-03-06
KR20010023838A (ko)	2001-03-26
NZ503738A (en)	2001-05-25
US6048895A (en)	2000-04-11
CA2303801A1 (en)	1999-03-18
CN1269784A (zh)	2000-10-11
PE123099A1 (es)	2000-02-02
AU9224098A (en)	1999-03-29
TR200000673T2 (tr)	2000-11-21
DE69809268T2 (de)	2003-08-28
EP1012137B1 (en)	2002-11-06
PL339221A1 (en)	2000-12-04
WO1999012898A1 (en)	1999-03-18
EP1012137A1 (en)	2000-06-28
BR9812631A (pt)	2000-08-22
ID24845A (id)	2000-08-24
ATE227266T1 (de)	2002-11-15
ZA988232B (en)	1999-03-09
JP4619531B2 (ja)	2011-01-26
AU731032B2 (en)	2001-03-22
JP5330324B2 (ja)	2013-10-30
SK3382000A3 (en)	2000-10-09
DE69809268D1 (de)	2002-12-12
JP2001515885A (ja)	2001-09-25
HUP0004427A3 (en)	2001-09-28
HUP0004427A2 (hu)	2001-05-28
NO20001139L (no)	2000-05-04
DK1012137T3 (da)	2003-03-10
CO4970733A1 (es)	2000-11-07
AR017078A1 (es)	2001-08-22

Publication	Publication Date	Title
IL134839A0 (en)	2001-05-20	Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
ZA988231B (en)	1999-03-09	Aromatic C16-C20-substituted tetrahydro prostaglandins useful as FP agonists
IL134840A0 (en)	2001-05-20	Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
AP9801356A0 (en)	1998-12-31	Prostaglandin agonists
DE69941083D1 (en)	2009-08-20	12,13-cyclopropan-epothilonderivate
ZA989537B (en)	1999-04-22	Lubricating composition
IL134108A0 (en)	2001-04-30	Substituted 1,2,3,4-tetrahydronaphthalene derivatives
GB2345916B (en)	2002-07-24	Alkaline solid block composition
ZA974359B (en)	1998-05-12	Microencapsulated compositions.
GB9715203D0 (en)	1997-09-24	Composition
PL339219A1 (en)	2000-12-04	Substituted 2-pyrolydinones as pkc activators
ZA9811502B (en)	2000-06-15	Novel composition.
ZA200006118B (en)	2002-01-30	Novel composition.
PL338017A1 (en)	2000-09-25	Novel composition
GB9800912D0 (en)	1998-03-11	New composition
GB9701031D0 (en)	1997-03-05	Composition
ZA9710576B (en)	1998-09-16	2-imidazolinylaminoindazole compounds useful as alpha-2-adrenoceptor agonists
ZA200000192B (en)	2000-08-07	Novel composition.
GB9801583D0 (en)	1998-03-25	Anti-snore gargle composition
HK1028976A (en)	2001-03-16	Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
ZA981739B (en)	1999-09-02	Composition.
ZA991829B (en)	2000-10-11	Novel composition.
GB9611276D0 (en)	1996-07-31	Self indicating composition
GB9813561D0 (en)	1998-08-19	Novel composition
GB9806685D0 (en)	1998-05-27	Novel composition