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IL122377A - Anti-viral 5-benzoyl-1h-benzimidazoles, process for their preparation and pharmaceutical compositions containing them - Google Patents

Anti-viral 5-benzoyl-1h-benzimidazoles, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL122377A
IL122377A IL12237796AA IL12237796A IL122377A IL 122377 A IL122377 A IL 122377A IL 12237796A A IL12237796A A IL 12237796AA IL 12237796 A IL12237796 A IL 12237796A IL 122377 A IL122377 A IL 122377A
Authority
IL
Israel
Prior art keywords
benzimidazoles
benzoyl
viral
preparation
pharmaceutical compositions
Prior art date
Application number
IL12237796AA
Other languages
English (en)
Other versions
IL122377A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL122377A0 publication Critical patent/IL122377A0/xx
Publication of IL122377A publication Critical patent/IL122377A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL12237796AA 1995-06-07 1996-06-05 Anti-viral 5-benzoyl-1h-benzimidazoles, process for their preparation and pharmaceutical compositions containing them IL122377A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/482,041 US5545653A (en) 1995-06-07 1995-06-07 Anti-viral compounds
PCT/US1996/008830 WO1996040124A1 (en) 1995-06-07 1996-06-05 Anti-viral compounds

Publications (2)

Publication Number Publication Date
IL122377A0 IL122377A0 (en) 1998-06-15
IL122377A true IL122377A (en) 2001-01-11

Family

ID=23914403

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12237796AA IL122377A (en) 1995-06-07 1996-06-05 Anti-viral 5-benzoyl-1h-benzimidazoles, process for their preparation and pharmaceutical compositions containing them

Country Status (10)

Country Link
US (1) US5545653A (xx)
EP (1) EP0862430A4 (xx)
JP (1) JPH11506772A (xx)
KR (1) KR19990022363A (xx)
AU (1) AU5982496A (xx)
BR (1) BR9608571A (xx)
CA (1) CA2223299A1 (xx)
HU (1) HUP9900865A3 (xx)
IL (1) IL122377A (xx)
WO (1) WO1996040124A1 (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891874A (en) * 1996-06-05 1999-04-06 Eli Lilly And Company Anti-viral compound
US5821242A (en) * 1996-06-06 1998-10-13 Eli Lilly And Company Anti-viral compounds
IL118657A0 (en) * 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
WO1998031363A1 (en) * 1997-01-22 1998-07-23 Eli Lilly And Company Anti-viral compounds
DE69814049T2 (de) 1997-02-25 2004-02-19 The Government of the United States of America, as represented by the Secretary National Institute of Health, Office of Technology Transfer Substituierte benzimidazole als nicht-nucleoside reverse transcriptase inhibitore
AU7715198A (en) * 1997-06-04 1998-12-21 Eli Lilly And Company Anti-viral compounds
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
US6699705B2 (en) 1999-02-01 2004-03-02 National Research Council Of Canada Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics
US7030150B2 (en) * 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
WO2004043913A2 (en) * 2002-11-08 2004-05-27 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
ES2328700T3 (es) * 2003-12-18 2009-11-17 Tibotec Pharmaceuticals Ltd. Aminobenzimidazoles y benzimidazoles como inhibidores de la replicacion del virus respiratorio sincital.
EP1711496A4 (en) * 2004-01-28 2009-02-11 Smithkline Beecham Corp THIAZOLE COMPOUNDS
BRPI0912038A2 (pt) * 2008-05-27 2017-06-20 Biota Scient Management Pty Ltd composto, mistura, composição farmacêutica, uso do composto, e, métodos para tratar e evitar uma infecção por picornavírus, e para formar o composto
CN104394835B (zh) 2012-07-13 2018-09-07 莱雅公司 化妆品组合物
CA3075477A1 (en) * 2017-08-07 2019-02-14 Joint Stock Company "Biocad" Novel heterocyclic compounds as cdk8/19 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR61627B (en) * 1975-08-28 1978-12-04 Lilly Co Eli Preparation process of carbonyl-substituted 1-sulfonylbenzimidazoles
US4174454A (en) * 1975-08-28 1979-11-13 Eli Lilly And Company Alkylidenylmethyl-substituted 1-sulfonylbenzimidazoles
US4420479A (en) * 1982-04-08 1983-12-13 Eli Lilly And Company Olefinic benzimidazoles, formulations, and antiviral methods
US4434288A (en) * 1982-04-08 1984-02-28 Eli Lilly And Company Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminobenzimidazoles
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles

Also Published As

Publication number Publication date
HUP9900865A2 (hu) 1999-07-28
IL122377A0 (en) 1998-06-15
US5545653A (en) 1996-08-13
CA2223299A1 (en) 1996-12-19
JPH11506772A (ja) 1999-06-15
HUP9900865A3 (en) 2000-02-28
EP0862430A1 (en) 1998-09-09
WO1996040124A1 (en) 1996-12-19
BR9608571A (pt) 1998-12-29
KR19990022363A (ko) 1999-03-25
EP0862430A4 (en) 1999-03-24
AU5982496A (en) 1996-12-30

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees