IL128546A0 - Cycloalkyl inhibitors of protein farnesyltransferase - Google Patents
Cycloalkyl inhibitors of protein farnesyltransferaseInfo
- Publication number
- IL128546A0 IL128546A0 IL12854697A IL12854697A IL128546A0 IL 128546 A0 IL128546 A0 IL 128546A0 IL 12854697 A IL12854697 A IL 12854697A IL 12854697 A IL12854697 A IL 12854697A IL 128546 A0 IL128546 A0 IL 128546A0
- Authority
- IL
- Israel
- Prior art keywords
- protein farnesyltransferase
- inhibitors
- cycloalkyl
- cycloalkyl inhibitors
- protein
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108010054353 p21(ras) farnesyl-protein transferase Proteins 0.000 title abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3366196P | 1996-12-17 | 1996-12-17 | |
| US5683197P | 1997-08-22 | 1997-08-22 | |
| PCT/US1997/023280 WO1998027109A1 (en) | 1996-12-17 | 1997-12-16 | Cycloalkyl inhibitors of protein farnesyltransferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL128546A0 true IL128546A0 (en) | 2000-01-31 |
Family
ID=26709973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12854697A IL128546A0 (en) | 1996-12-17 | 1997-12-16 | Cycloalkyl inhibitors of protein farnesyltransferase |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6281194B1 (pt) |
| EP (1) | EP0951471B1 (pt) |
| JP (1) | JP2001506265A (pt) |
| KR (1) | KR20000057601A (pt) |
| AT (1) | ATE261987T1 (pt) |
| AU (1) | AU721786C (pt) |
| BR (1) | BR9713744A (pt) |
| CA (1) | CA2264207A1 (pt) |
| CO (1) | CO4920227A1 (pt) |
| DE (1) | DE69728165T2 (pt) |
| DK (1) | DK0951471T3 (pt) |
| ES (1) | ES2216189T3 (pt) |
| HR (1) | HRP970693B1 (pt) |
| ID (1) | ID19142A (pt) |
| IL (1) | IL128546A0 (pt) |
| NO (1) | NO992933L (pt) |
| NZ (1) | NZ334702A (pt) |
| PE (1) | PE46999A1 (pt) |
| PT (1) | PT951471E (pt) |
| TW (1) | TW552259B (pt) |
| WO (1) | WO1998027109A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE46999A1 (es) | 1996-12-17 | 1999-05-20 | Warner Lambert Co | Inhibidores de cicloalquilo de la enzima farnesiltransferasa de las proteinas |
| AU759492B2 (en) * | 1998-04-27 | 2003-04-17 | Warner-Lambert Company | Functionalized alkyl and alkenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors |
| US6455734B1 (en) * | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
| AU2002332640B2 (en) * | 2001-08-24 | 2007-11-08 | University Of South Florida | Piperazinone compounds as anti-tumor and anti-cancer agents and methods of treatment |
| AU2007229363B2 (en) * | 2001-08-24 | 2009-06-04 | University Of South Florida | Piperazinone Compounds as Anti-Tumor and Anti-Cancer Agents and the Methods of Treatment |
| WO2005049589A2 (en) * | 2003-10-14 | 2005-06-02 | Cadila Healthcare Limited | Heterocyclic compounds for the treatment of hyperlipidemia, diabetes, obesity and similar diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ275691A (en) * | 1993-11-05 | 1998-03-25 | Warner Lambert Co | Di and tripeptides and compositions thereof which inhibit farnesyl transferase |
| US5571792A (en) | 1994-06-30 | 1996-11-05 | Warner-Lambert Company | Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase |
| PE46999A1 (es) | 1996-12-17 | 1999-05-20 | Warner Lambert Co | Inhibidores de cicloalquilo de la enzima farnesiltransferasa de las proteinas |
-
1997
- 1997-12-16 PE PE1997001119A patent/PE46999A1/es not_active Application Discontinuation
- 1997-12-16 JP JP52794298A patent/JP2001506265A/ja not_active Abandoned
- 1997-12-16 CO CO97073366A patent/CO4920227A1/es unknown
- 1997-12-16 KR KR1019990705384A patent/KR20000057601A/ko not_active Ceased
- 1997-12-16 US US09/319,422 patent/US6281194B1/en not_active Expired - Fee Related
- 1997-12-16 DK DK97954575T patent/DK0951471T3/da active
- 1997-12-16 ES ES97954575T patent/ES2216189T3/es not_active Expired - Lifetime
- 1997-12-16 IL IL12854697A patent/IL128546A0/xx unknown
- 1997-12-16 BR BR9713744A patent/BR9713744A/pt not_active Application Discontinuation
- 1997-12-16 WO PCT/US1997/023280 patent/WO1998027109A1/en not_active Ceased
- 1997-12-16 AT AT97954575T patent/ATE261987T1/de not_active IP Right Cessation
- 1997-12-16 CA CA002264207A patent/CA2264207A1/en not_active Abandoned
- 1997-12-16 AU AU58990/98A patent/AU721786C/en not_active Ceased
- 1997-12-16 DE DE69728165T patent/DE69728165T2/de not_active Expired - Fee Related
- 1997-12-16 PT PT97954575T patent/PT951471E/pt unknown
- 1997-12-16 EP EP97954575A patent/EP0951471B1/en not_active Expired - Lifetime
- 1997-12-16 NZ NZ334702A patent/NZ334702A/xx unknown
- 1997-12-17 ID IDP973902A patent/ID19142A/id unknown
- 1997-12-17 HR HR970693A patent/HRP970693B1/xx not_active IP Right Cessation
-
1998
- 1998-05-26 TW TW086119079A patent/TW552259B/zh active
-
1999
- 1999-06-16 NO NO992933A patent/NO992933L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2264207A1 (en) | 1998-06-25 |
| EP0951471B1 (en) | 2004-03-17 |
| AU5899098A (en) | 1998-07-15 |
| DK0951471T3 (da) | 2004-07-19 |
| EP0951471A1 (en) | 1999-10-27 |
| WO1998027109A1 (en) | 1998-06-25 |
| HRP970693B1 (en) | 2002-06-30 |
| JP2001506265A (ja) | 2001-05-15 |
| CO4920227A1 (es) | 2000-05-29 |
| NZ334702A (en) | 2000-11-24 |
| US6281194B1 (en) | 2001-08-28 |
| ES2216189T3 (es) | 2004-10-16 |
| KR20000057601A (ko) | 2000-09-25 |
| DE69728165D1 (de) | 2004-04-22 |
| AU721786C (en) | 2001-08-02 |
| PE46999A1 (es) | 1999-05-20 |
| BR9713744A (pt) | 2000-03-21 |
| AU721786B2 (en) | 2000-07-13 |
| NO992933D0 (no) | 1999-06-16 |
| TW552259B (en) | 2003-09-11 |
| PT951471E (pt) | 2004-08-31 |
| ID19142A (id) | 1998-06-18 |
| NO992933L (no) | 1999-06-16 |
| HRP970693A2 (en) | 1998-10-31 |
| DE69728165T2 (de) | 2005-01-20 |
| ATE261987T1 (de) | 2004-04-15 |
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