IL128049A - Derivatives 6, 6 - Transformed heterozygosides, pharmaceutical preparations containing them, and their use in the preparation of drugs for the treatment of CRF-related disorders - Google Patents

Derivatives 6, 6 - Transformed heterozygosides, pharmaceutical preparations containing them, and their use in the preparation of drugs for the treatment of CRF-related disorders

Info

Publication number: IL128049A
Authority: IL; Israel
Prior art keywords: alkyl; phenyl; methyl; compound according; ethyl
Prior art date: 1996-08-27

Application number

IL12804997A

Other languages

English (en)

Hebrew (he)

Other versions

IL128049A0 (en

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-27

Filing date

1997-07-21

Publication date

2004-12-15

1997-07-21 Application filed by Pfizer filed Critical Pfizer

1999-11-30 Publication of IL128049A0 publication Critical patent/IL128049A0/xx

2004-12-15 Publication of IL128049A publication Critical patent/IL128049A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
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- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Reproductive Health (AREA)
Obesity (AREA)
Psychiatry (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Nutrition Science (AREA)
Virology (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Anesthesiology (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Hospice & Palliative Care (AREA)

IL12804997A 1996-08-27 1997-07-21 Derivatives 6, 6 - Transformed heterozygosides, pharmaceutical preparations containing them, and their use in the preparation of drugs for the treatment of CRF-related disorders IL128049A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2465996P	1996-08-27	1996-08-27
PCT/IB1997/000904 WO1998008846A1 (en)	1996-08-27	1997-07-21	Substituted 6,6-hetero-bicyclic derivatives

Publications (2)

Publication Number	Publication Date
IL128049A0 IL128049A0 (en)	1999-11-30
IL128049A true IL128049A (en)	2004-12-15

Family

ID=21821740

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12804997A IL128049A (en)	1996-08-27	1997-07-21	Derivatives 6, 6 - Transformed heterozygosides, pharmaceutical preparations containing them, and their use in the preparation of drugs for the treatment of CRF-related disorders

Country Status (40)

Country	Link
EP (1)	EP0925298B1 (sh)
JP (1)	JP2000502722A (sh)
KR (1)	KR100457759B1 (sh)
CN (2)	CN1138774C (sh)
AP (1)	AP1164A (sh)
AR (2)	AR009321A1 (sh)
AT (1)	ATE264327T1 (sh)
AU (1)	AU726771C (sh)
BG (1)	BG64316B1 (sh)
BR (1)	BR9711262A (sh)
CA (1)	CA2263913C (sh)
CO (1)	CO4930259A1 (sh)
CZ (1)	CZ67799A3 (sh)
DE (1)	DE69728676T2 (sh)
DK (1)	DK0925298T3 (sh)
DZ (1)	DZ2299A1 (sh)
EA (1)	EA002607B1 (sh)
ES (1)	ES2216157T3 (sh)
GT (1)	GT199700093A (sh)
HR (1)	HRP970452A2 (sh)
ID (1)	ID18189A (sh)
IL (1)	IL128049A (sh)
IS (1)	IS4970A (sh)
MY (1)	MY132671A (sh)
NO (1)	NO316273B1 (sh)
NZ (1)	NZ333728A (sh)
OA (1)	OA10980A (sh)
PA (1)	PA8435001A1 (sh)
PE (1)	PE108698A1 (sh)
PL (1)	PL331988A1 (sh)
PT (1)	PT925298E (sh)
SI (1)	SI0925298T1 (sh)
SK (1)	SK22599A3 (sh)
TN (1)	TNSN97144A1 (sh)
TR (1)	TR199900408T2 (sh)
TW (1)	TW477787B (sh)
UA (1)	UA66345C2 (sh)
WO (1)	WO1998008846A1 (sh)
YU (1)	YU35697A (sh)
ZA (1)	ZA977652B (sh)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6124289A (en) *	1996-07-24	2000-09-26	Dupont Pharmaceuticals Co.	Azolo triazines and pyrimidines
US6313124B1 (en)	1997-07-23	2001-11-06	Dupont Pharmaceuticals Company	Tetrazine bicyclic compounds
US7094782B1 (en)	1996-07-24	2006-08-22	Bristol-Myers Squibb Company	Azolo triazines and pyrimidines
US6060478A (en) *	1996-07-24	2000-05-09	Dupont Pharmaceuticals	Azolo triazines and pyrimidines
US6191131B1 (en)	1997-07-23	2001-02-20	Dupont Pharmaceuticals Company	Azolo triazines and pyrimidines
ATE232863T1 (de)	1996-08-06	2003-03-15	Pfizer	Substituierte pyrido- oder pyrimidogruppen enthaltende 6,6- oder 6,7-bicyclische derivate
WO1998035967A2 (en)	1997-02-18	1998-08-20	Neurocrine Biosciences, Inc.	Biazacyclic crf antagonists
ES2207834T3 (es)	1997-04-22	2004-06-01	Janssen Pharmaceutica N.V.	Quino- y quinazolinas antagonistas del crf.
NL1010018C2 (nl) *	1997-09-09	1999-03-10	Duphar Int Res	Chinoline en chinazoline derivaten met corticotropine releasing factor (CRF) antagonistische werking.
US6187777B1 (en)	1998-02-06	2001-02-13	Amgen Inc.	Compounds and methods which modulate feeding behavior and related diseases
CN1178941C (zh)	1998-11-12	2004-12-08	纽罗克里恩生物科学有限公司	Crf受体拮抗剂以及与其有关的方法
NZ510955A (en)	1998-11-12	2003-01-31	Neurocrine Biosciences Inc	Tricyclic nitrogen containing ring system useful as CRF receptor antagonists
AU2804400A (en) *	1999-02-12	2000-08-29	Smithkline Beecham Plc	Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
US6432989B1 (en) *	1999-08-27	2002-08-13	Pfizer Inc	Use of CRF antagonists to treat circadian rhythm disorders
PL354784A1 (en) *	1999-09-30	2004-02-23	Neurogen Corporation	Certain alkylene diamine-substituted heterocycles
EP1218023B8 (en)	1999-10-01	2006-05-03	Johnson & Johnson Consumer Companies, Inc.	Method for calming human beings using personal care compositions
CO5271670A1 (es)	1999-10-29	2003-04-30	Pfizer Prod Inc	Antagonistas del factor de liberacion de corticitropina y composiciones relacionadas
US6525067B1 (en) *	1999-11-23	2003-02-25	Pfizer Inc	Substituted heterocyclic derivatives
EP1120662B1 (fr)	2000-01-26	2006-03-01	EM Microelectronic-Marin SA	Procédé pour tester un circuit intégré comportant des parties matérielles et/ou logicielles ayant un caractère de confidentialité
KR20030016222A (ko) *	2000-02-14	2003-02-26	니뽄 다바코 산교 가부시키가이샤	수술후 스트레스 예방ㆍ치료제
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
WO2001087886A1 (en) *	2000-05-18	2001-11-22	Neurocrine Biosciences, Inc.	Crf receptor antagonists and methods relating thereto
BR0114829A (pt)	2000-10-23	2003-09-23	Smithkline Beecham Corp	Novos compostos
AU2002253357B2 (en)	2001-04-30	2006-08-24	Glaxo Group Limited	Fused pyrimidines as antagonists of the corticotropin releasing factor (crf)
GB0117396D0 (en) *	2001-07-17	2001-09-05	Glaxo Group Ltd	Chemical compounds
GB2411478A (en)	2002-01-29	2005-08-31	Johnson & Johnson Consumer	Method of measuring the stress or relaxation level of a mammal
JP4603268B2 (ja)	2002-04-19	2010-12-22	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー	新規化合物
US7067658B2 (en)	2002-09-30	2006-06-27	Bristol-Myers Squibb Company	Pyridino and pyrimidino pyrazinones
AU2004205642C1 (en)	2003-01-14	2012-01-12	Arena Pharmaceuticals, Inc.	1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
GB0308208D0 (en) *	2003-04-09	2003-05-14	Glaxo Group Ltd	Chemical compounds
AR045047A1 (es)	2003-07-11	2005-10-12	Arena Pharm Inc	Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
BRPI0412689A (pt) *	2003-07-14	2006-10-03	Arena Pharm Inc	derivados de heteroarila e arila fundida como moduladores de metabolismo e a profilaxia e tratamento de distúrbios relacionados a ele
CN1835753A (zh)	2003-08-12	2006-09-20	弗·哈夫曼-拉罗切有限公司	作为促皮质释放素(cfr)拮抗剂的螺－取代的四氢喹唑啉
DE602004009200T2 (de)	2003-08-12	2008-07-10	F. Hoffmann-La Roche Ag	Tetrahydrochinazolinderivate als cfr-antagonisten
JP2006232849A (ja) *	2003-08-13	2006-09-07	Japan Tobacco Inc	含窒素縮合環化合物及びそのｈｉｖインテグラーゼ阻害剤としての利用
TW200510425A (en)	2003-08-13	2005-03-16	Japan Tobacco Inc	Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
RU2006129307A (ru) *	2004-02-13	2008-02-20	Пфайзер Продактс Инк. (Us)	Терапевтические комбинации атипичных нейролептиков с антагонистами кортикотропин-рилизинг фактора
DE102004018198A1 (de)	2004-04-15	2005-11-03	Merck Patent Gmbh	Sulfonamide
AU2005316668B2 (en)	2004-12-13	2012-09-06	Millennium Pharmaceuticals, Inc.	Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
TWI389690B (zh)	2005-03-25	2013-03-21	Glaxo Group Ltd	新穎化合物（一）
TW200724142A (en)	2005-03-25	2007-07-01	Glaxo Group Ltd	Novel compounds
US7423042B2 (en)	2005-03-25	2008-09-09	Glaxo Group Limited	Compounds
WO2006104917A2 (en)	2005-03-25	2006-10-05	Glaxo Group Limited	Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one derivatives
AP2007004144A0 (en)	2005-03-31	2007-08-31	Pfizer Prod Inc	Cyclopentapyridine and tetrahydroquinoline derivatives
WO2007081517A2 (en)	2005-12-21	2007-07-19	Abbott Laboratories	Anti-viral compounds
DE602006015861D1 (de)	2005-12-21	2010-09-09	Abbott Lab	Antivirale verbindungen
NZ569817A (en)	2005-12-21	2011-10-28	Abbott Lab	Anti-viral compounds
EP2078016B1 (en)	2006-10-19	2012-02-01	Signal Pharmaceuticals LLC	Heteroaryl compounds, compositions thereof, and methods of treatment therewith
WO2008133753A2 (en)	2006-12-20	2008-11-06	Abbott Laboratories	Anti-viral compounds
KR101599384B1 (ko) *	2007-05-17	2016-03-03	헬퍼바이 테라퓨틱스 리미티드	임상적으로 잠복기 미생물을 사멸시키기 위한 ４（피롤리딘１일）퀴놀린 화합물의 용도
US9139592B2 (en)	2010-06-14	2015-09-22	Trt Pharma Inc.	Modulators of Nrf2 and uses thereof
CA2812061A1 (en)	2010-09-22	2012-03-29	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
CN104583197B (zh) *	2012-08-24	2017-05-17	霍夫曼-拉罗奇有限公司	新型双环吡啶衍生物
DK3096756T3 (da)	2014-01-21	2024-08-05	Neurocrine Biosciences Inc	CRF1-receptorantagonister til behandling af medfødt adrenal hyperplasi
MX386419B (es)	2015-01-06	2025-03-18	Arena Pharm Inc	Metodos de condiciones de tratamiento relacionadas con el receptor s1p1.
HUE047477T2 (hu)	2015-06-04	2020-04-28	Pfizer	Palbociclib szilárd dózisformái
MA42807A (fr)	2015-06-22	2018-07-25	Arena Pharm Inc	Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique (composé 1) pour une utilisation dans des troubles associés au récepteur de s1p1
MA45920B1 (fr)	2016-08-15	2021-08-31	Pfizer	Inhibiteurs de pyridopyrimidinone cdk2/4/6
KR102009756B1 (ko)	2017-01-06	2019-08-12	고려대학교 세종산학협력단	신규한 퀴놀리논 유도체 및 이를 유효성분으로 포함하는 천식 또는 아토피 등의 알러지성 질환의 예방 또는 치료용 약학 조성물
KR102859841B1 (ko)	2018-06-06	2025-09-12	아레나 파마슈티칼스, 인크.	S1p1 수용체와 관련된 병태의 치료 방법
TW202446384A (zh)	2018-12-07	2024-12-01	美商紐羅克里生物科學有限公司	用於治療先天性腎上腺增生之crf1受體拮抗劑、醫藥配方及其固體形式
CN114502162B (zh)	2019-09-27	2025-03-28	纽罗克里生物科学有限公司	Crf受体拮抗剂及使用方法
CN115160221B (zh) *	2022-07-26	2024-10-18	恩祺生物科技(上海)有限公司	德立替尼晶型化合物和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW444018B (en) *	1992-12-17	2001-07-01	Pfizer	Pyrazolopyrimidines
EP0674641B1 (en) *	1992-12-17	1999-03-03	Pfizer Inc.	Pyrrolopyrimidines as crf antagonists
TW574214B (en) *	1994-06-08	2004-02-01	Pfizer	Corticotropin releasing factor antagonists
PL181895B1 (pl) *	1994-06-16	2001-10-31	Pfizer	Nowe pirazolo-i pirolopirydyny _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ PL PL PL PL
EP0729758A3 (en) *	1995-03-02	1997-10-29	Pfizer	Pyrazolopyrimidines and pyrrolopyrimidines for the treatment of neuronal and other diseases
AU716993B2 (en) *	1995-05-12	2000-03-16	Neurogen Corporation	Novel deazapurine derivatives; a new class of CRF1 specific ligands
US6403599B1 (en) *	1995-11-08	2002-06-11	Pfizer Inc	Corticotropin releasing factor antagonists
ES2200039T3 (es) *	1995-12-08	2004-03-01	Pfizer Inc.	Derivados heterociclicos sustituidos como antagonistas de crf.

1997
- 1997-07-15 TW TW086109990A patent/TW477787B/zh not_active IP Right Cessation
- 1997-07-21 AT AT97929464T patent/ATE264327T1/de not_active IP Right Cessation
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Publication number	Publication date
MY132671A (en)	2007-10-31
ES2216157T3 (es)	2004-10-16
SI0925298T1 (en)	2004-08-31
AU726771C (en)	2004-11-11
IL128049A0 (en)	1999-11-30
CN1228091A (zh)	1999-09-08
PA8435001A1 (es)	2002-07-30
CA2263913C (en)	2004-06-29
EA199900166A1 (ru)	1999-08-26
HRP970452A2 (en)	1998-08-31
EA002607B1 (ru)	2002-06-27
SK22599A3 (en)	2000-07-11
BG64316B1 (bg)	2004-09-30
UA66345C2 (en)	2004-05-17
WO1998008846A1 (en)	1998-03-05
YU35697A (sh)	1999-11-22
EP0925298B1 (en)	2004-04-14
PL331988A1 (en)	1999-08-16
CN1367169A (zh)	2002-09-04
EP0925298A1 (en)	1999-06-30
TW477787B (en)	2002-03-01
CO4930259A1 (es)	2000-06-27
AR026826A1 (es)	2003-02-26
AP1164A (en)	2003-06-30
NZ333728A (en)	2000-11-24
PE108698A1 (es)	1999-01-23
PT925298E (pt)	2004-07-30
TNSN97144A1 (fr)	2005-03-15
DE69728676D1 (de)	2004-05-19
CN1138774C (zh)	2004-02-18
OA10980A (en)	2001-11-02
JP2000502722A (ja)	2000-03-07
KR100457759B1 (ko)	2004-11-18
NO316273B1 (no)	2004-01-05
AU726771B2 (en)	2000-11-23
GT199700093A (es)	1999-02-04
AR009321A1 (es)	2000-04-12
HK1019597A1 (en)	2000-02-18
DK0925298T3 (da)	2004-08-09
CZ67799A3 (cs)	1999-11-17
CN1191236C (zh)	2005-03-02
ZA977652B (en)	1999-02-26
NO990892L (no)	1999-02-25
ID18189A (id)	1998-03-12
AP9701076A0 (en)	1997-10-31
BG103192A (en)	1999-09-30
TR199900408T2 (xx)	1999-05-21
KR20000035898A (ko)	2000-06-26
ATE264327T1 (de)	2004-04-15
BR9711262A (pt)	1999-08-17
DE69728676T2 (de)	2004-09-30
CA2263913A1 (en)	1998-03-05
AU3355797A (en)	1998-03-19
DZ2299A1 (fr)	2002-12-25
IS4970A (is)	1999-02-05
NO990892D0 (no)	1999-02-25

Publication	Publication Date	Title
AP1164A (en)	2003-06-30	Substituted 6,6-hetero-bicyclic derivatives.
CA2262692C (en)	2002-06-11	Substituted pyrido- or pyrimido-containing 6,6- or 6,7-bicyclic derivatives
EP0923582B1 (en)	2006-09-20	Substituted 6,5-hetero-bicyclic derivatives
JP3457490B2 (ja)	2003-10-20	置換されたヘテロ環誘導体
JP2891544B2 (ja)	1999-05-17	ピラゾロおよびピロロピリジン類
JP2004203751A (ja)	2004-07-22	置換６，６−ヘテロ二環式誘導体
US6875769B2 (en)	2005-04-05	Substituted6,6-hetero-bicyclicderivatives
HK1019597B (en)	2004-08-27	Substituted 6, 6-hetero-bicyclic derivatives
MXPA99001309A (en)	1999-06-01	Substituted pyrido- or pyrimido-containing 6,6- or 6,7-bicyclic derivatives

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