IL126871A0 - Process of purification of cyclosporin - Google Patents

Process of purification of cyclosporin

Info

Publication number: IL126871A0
Authority: IL; Israel
Prior art keywords: cyclosporin; silica gel; column filled; purification; crude product
Prior art date: 1997-03-25

Application number

IL12687198A

Other languages

English (en)

Original Assignee

Biogal Gyogyzergyar Rt

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-25

Filing date

1998-03-23

Publication date

1999-09-22

1998-03-23 Application filed by Biogal Gyogyzergyar Rt filed Critical Biogal Gyogyzergyar Rt

1999-09-22 Publication of IL126871A0 publication Critical patent/IL126871A0/xx

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
229930105110 Cyclosporin A Natural products 0.000 title abstract 3
108010036949 Cyclosporine Proteins 0.000 title abstract 3
229960001265 ciclosporin Drugs 0.000 title abstract 3
229930182912 cyclosporin Natural products 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000000746 purification Methods 0.000 title 1
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
239000000741 silica gel Substances 0.000 abstract 2
229910002027 silica gel Inorganic materials 0.000 abstract 2
238000004587 chromatography analysis Methods 0.000 abstract 1
239000012043 crude product Substances 0.000 abstract 1
239000011877 solvent mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Pain & Pain Management (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
Separation Using Semi-Permeable Membranes (AREA)
Silicon Compounds (AREA)
Saccharide Compounds (AREA)

IL12687198A 1997-03-25 1998-03-23 Process of purification of cyclosporin IL126871A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU9700645A HU223054B1 (hu)	1997-03-25	1997-03-25	Tisztítási eljárás nagytisztaságú ciklosporin A előállítására
PCT/HU1998/000029 WO1998042734A1 (en)	1997-03-25	1998-03-23	Process of purification of cyclosporin

Publications (1)

Publication Number	Publication Date
IL126871A0 true IL126871A0 (en)	1999-09-22

Family

ID=89994909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12687198A IL126871A0 (en)	1997-03-25	1998-03-23	Process of purification of cyclosporin

Country Status (21)

Country	Link
EP (1)	EP0920447B1 (xx)
JP (1)	JP2000511939A (xx)
AT (1)	ATE223434T1 (xx)
AU (1)	AU737260B2 (xx)
BG (1)	BG64215B1 (xx)
CA (1)	CA2255062C (xx)
CZ (1)	CZ293687B6 (xx)
DE (1)	DE69807635T2 (xx)
DK (1)	DK0920447T3 (xx)
ES (1)	ES2180159T3 (xx)
HU (1)	HU223054B1 (xx)
IL (1)	IL126871A0 (xx)
NO (1)	NO322211B1 (xx)
NZ (1)	NZ332718A (xx)
PL (1)	PL194252B1 (xx)
PT (1)	PT920447E (xx)
RU (1)	RU2182577C2 (xx)
SK (1)	SK283672B6 (xx)
UA (1)	UA58511C2 (xx)
WO (1)	WO1998042734A1 (xx)
YU (1)	YU49468B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ512599A (en)	1998-12-30	2003-10-31	Dexcel Ltd	Formulation for cyclosporin administration featuring a hydrophilic solvent and a surfactant with a HLB of less than 5
RU2272643C2 (ru) *	2004-06-11	2006-03-27	Маргарита Васильевна Бибикова	Высокоактивный кристаллический препарат циклоспорина а и способ его получения
EP2151450A1 (de) *	2008-07-29	2010-02-10	Sandoz AG	Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
DE102009037551A1 (de)	2009-08-17	2011-02-24	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Cyclosporinderivate
HUP1500502A2 (en) *	2015-10-26	2017-04-28	Rotachrom Tech Kft	Process for the purification of cyclosporin-a
CN114653350A (zh) *	2022-02-25	2022-06-24	江苏九阳生物制药有限公司	一种环孢素a层析硅胶的再生方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU201577B (en) *	1988-12-20	1990-11-28	Gyogyszerkutato Intezet	Process for producing cyclosporin antibiotics
EP0507968B1 (de) *	1991-04-06	1995-09-06	Arzneimittelwerk Dresden Gmbh	Verfahren zur fermentativen Herstellung und Isolierung von Cyclosporin A sowie neue Cyclosporin- bildende Stämme
GB9208712D0 (en) *	1992-04-22	1992-06-10	Sandoz Ltd	Pharmaceutical compositions containing cyclosporin derivates
HU213553B (en) *	1992-05-25	1997-07-28	Biogal Gyogyszergyar	Process for isolating of cyclosporin-a
FI92334C (fi) *	1992-12-30	1994-10-25	Leiras Oy	Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta
KR100304324B1 (ko) *	1994-10-13	2001-11-22	김용규	사이클로스포린a의제조방법

1997
- 1997-03-25 HU HU9700645A patent/HU223054B1/hu not_active IP Right Cessation
1998
- 1998-03-23 SK SK1618-98A patent/SK283672B6/sk unknown
- 1998-03-23 YU YU53598A patent/YU49468B/sh unknown
- 1998-03-23 AU AU68482/98A patent/AU737260B2/en not_active Ceased
- 1998-03-23 PT PT98913969T patent/PT920447E/pt unknown
- 1998-03-23 UA UA98116251A patent/UA58511C2/uk unknown
- 1998-03-23 IL IL12687198A patent/IL126871A0/xx unknown
- 1998-03-23 WO PCT/HU1998/000029 patent/WO1998042734A1/en not_active Ceased
- 1998-03-23 PL PL98330142A patent/PL194252B1/pl not_active IP Right Cessation
- 1998-03-23 DK DK98913969T patent/DK0920447T3/da active
- 1998-03-23 ES ES98913969T patent/ES2180159T3/es not_active Expired - Lifetime
- 1998-03-23 RU RU98123499/04A patent/RU2182577C2/ru active
- 1998-03-23 EP EP98913969A patent/EP0920447B1/en not_active Expired - Lifetime
- 1998-03-23 CZ CZ19983814A patent/CZ293687B6/cs not_active IP Right Cessation
- 1998-03-23 NZ NZ332718A patent/NZ332718A/xx unknown
- 1998-03-23 DE DE69807635T patent/DE69807635T2/de not_active Expired - Fee Related
- 1998-03-23 JP JP10545312A patent/JP2000511939A/ja not_active Ceased
- 1998-03-23 CA CA002255062A patent/CA2255062C/en not_active Expired - Fee Related
- 1998-03-23 AT AT98913969T patent/ATE223434T1/de not_active IP Right Cessation
- 1998-11-10 BG BG102911A patent/BG64215B1/bg unknown
- 1998-11-24 NO NO19985483A patent/NO322211B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU6848298A (en)	1998-10-20
CZ381498A3 (cs)	1999-02-17
ATE223434T1 (de)	2002-09-15
RU2182577C2 (ru)	2002-05-20
ES2180159T3 (es)	2003-02-01
DK0920447T3 (da)	2002-12-16
UA58511C2 (uk)	2003-08-15
NO985483L (no)	1998-11-24
WO1998042734A1 (en)	1998-10-01
CZ293687B6 (cs)	2004-07-14
AU737260B2 (en)	2001-08-16
DE69807635D1 (de)	2002-10-10
HUP9700645A2 (hu)	1999-06-28
NO322211B1 (no)	2006-08-28
PL194252B1 (pl)	2007-05-31
SK161898A3 (en)	1999-05-07
HU9700645D0 (en)	1997-05-28
JP2000511939A (ja)	2000-09-12
HUP9700645A3 (en)	2001-11-28
DE69807635T2 (de)	2003-08-07
HK1020740A1 (en)	2000-05-19
BG64215B1 (bg)	2004-05-31
EP0920447B1 (en)	2002-09-04
HU223054B1 (hu)	2004-03-01
CA2255062C (en)	2008-06-17
YU53598A (en)	1999-11-22
PL330142A1 (en)	1999-04-26
NZ332718A (en)	2000-04-28
PT920447E (pt)	2002-11-29
YU49468B (sh)	2006-05-25
BG102911A (en)	1999-09-30
NO985483D0 (no)	1998-11-24
SK283672B6 (sk)	2003-11-04
CA2255062A1 (en)	1998-10-01
EP0920447A1 (en)	1999-06-09

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