IL124951A - Taxane derivatives having a pyridyl substituted c13 side chain, a process for their preparation and pharmaceutical compositions containing the same - Google Patents
Taxane derivatives having a pyridyl substituted c13 side chain, a process for their preparation and pharmaceutical compositions containing the sameInfo
- Publication number
- IL124951A IL124951A IL12495197A IL12495197A IL124951A IL 124951 A IL124951 A IL 124951A IL 12495197 A IL12495197 A IL 12495197A IL 12495197 A IL12495197 A IL 12495197A IL 124951 A IL124951 A IL 124951A
- Authority
- IL
- Israel
- Prior art keywords
- microtubules
- pct
- taxol
- depolymerisation
- mitosis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004076 pyridyl group Chemical group 0.000 title 1
- 102000029749 Microtubule Human genes 0.000 abstract 5
- 108091022875 Microtubule Proteins 0.000 abstract 5
- 210000004688 microtubule Anatomy 0.000 abstract 5
- 229930012538 Paclitaxel Natural products 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000011278 mitosis Effects 0.000 abstract 3
- 229960001592 paclitaxel Drugs 0.000 abstract 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 3
- 239000003053 toxin Substances 0.000 abstract 3
- 231100000765 toxin Toxicity 0.000 abstract 3
- 108700012359 toxins Proteins 0.000 abstract 3
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 abstract 2
- 102000004243 Tubulin Human genes 0.000 abstract 2
- 108090000704 Tubulin Proteins 0.000 abstract 2
- 230000001472 cytotoxic effect Effects 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical group NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- 229940122803 Vinca alkaloid Drugs 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 150000001637 borneol derivatives Chemical class 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 229960001338 colchicine Drugs 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 210000005170 neoplastic cell Anatomy 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 150000004579 taxol derivatives Chemical class 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19605024A DE19605024A1 (de) | 1996-01-31 | 1996-01-31 | Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| PCT/EP1997/000440 WO1997028156A1 (en) | 1996-01-31 | 1997-01-31 | Taxane derivatives having a pyridyl substituted c13 side chain, their preparation and their use as anti-tumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL124951A0 IL124951A0 (en) | 1999-01-26 |
| IL124951A true IL124951A (en) | 2003-12-10 |
Family
ID=7785142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12495197A IL124951A (en) | 1996-01-31 | 1997-01-31 | Taxane derivatives having a pyridyl substituted c13 side chain, a process for their preparation and pharmaceutical compositions containing the same |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6162920A (xx) |
| EP (1) | EP0896577B1 (xx) |
| JP (1) | JP2001505527A (xx) |
| KR (1) | KR19990082151A (xx) |
| CN (1) | CN1073108C (xx) |
| AT (1) | ATE233757T1 (xx) |
| AU (1) | AU714313B2 (xx) |
| BR (1) | BR9708295A (xx) |
| CA (1) | CA2244746A1 (xx) |
| CZ (1) | CZ292504B6 (xx) |
| DE (2) | DE19605024A1 (xx) |
| DK (1) | DK0896577T3 (xx) |
| ES (1) | ES2192261T3 (xx) |
| HU (1) | HUP9901027A3 (xx) |
| IL (1) | IL124951A (xx) |
| NO (1) | NO983509D0 (xx) |
| PL (1) | PL186796B1 (xx) |
| PT (1) | PT896577E (xx) |
| RU (1) | RU2163599C2 (xx) |
| SK (1) | SK101198A3 (xx) |
| TR (1) | TR199801415T2 (xx) |
| TW (1) | TW444015B (xx) |
| UA (1) | UA49007C2 (xx) |
| WO (1) | WO1997028156A1 (xx) |
| ZA (1) | ZA97847B (xx) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100851515B1 (ko) | 2001-03-07 | 2008-08-11 | 다이이찌 세이야꾸 가부시기가이샤 | 2-아제티디논 유도체의 제조방법 |
| DE60328486D1 (de) * | 2002-05-24 | 2009-09-03 | Angiotech Int Ag | Zusammensetzungen und verfahren zur beschichtung medizinischer implantate |
| CN1678310A (zh) * | 2002-08-24 | 2005-10-05 | 赞塔里斯有限公司 | 用于治疗良性和恶性肿瘤疾病的含有disorazole及其衍生物的药物 |
| US20040220655A1 (en) | 2003-03-03 | 2004-11-04 | Sinus Rhythm Technologies, Inc. | Electrical conduction block implant device |
| CN1296391C (zh) * | 2004-03-04 | 2007-01-24 | 中国人民解放军第二军医大学 | 氟代羧烷基环糊精醚类化合物及其制备方法和应用 |
| KR101223366B1 (ko) | 2004-05-03 | 2013-01-16 | 헤르메스 바이오사이언스, 인코포레이티드 | 약물 전달에 유용한 리포좀 |
| US8658203B2 (en) | 2004-05-03 | 2014-02-25 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for drug delivery to the brain |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| KR20180037210A (ko) | 2015-08-20 | 2018-04-11 | 입센 바이오팜 리미티드 | 암 치료를 위한 리포좀 이리노테칸 및 parp 저해제를 이용하는 조합요법 |
| KR102714060B1 (ko) | 2015-08-21 | 2024-10-08 | 입센 바이오팜 리미티드 | 리포솜 이리노테칸 및 옥살리플라틴을 포함하는 병용 치료를 이용하여 전이성 췌장암을 치료하는 방법 |
| NZ741291A (en) | 2015-10-16 | 2022-10-28 | Ipsen Biopharm Ltd | Stabilizing camptothecin pharmaceutical compositions |
| WO2018083470A1 (en) | 2016-11-02 | 2018-05-11 | Ipsen Biopharm Ltd. | Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2017744C1 (ru) * | 1987-09-21 | 1994-08-15 | Фудзисава Фармасьютикал Ко., Лтд. | Способ получения соединений цефема или их кислотно-аддитивных солей |
| US5489601A (en) * | 1991-09-23 | 1996-02-06 | Florida State University | Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them |
| US5227400A (en) * | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| WO1994021252A1 (en) * | 1993-03-22 | 1994-09-29 | Florida State University | Taxanes having a pyridyl substituted side-chain |
| US5415869A (en) * | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
| FR2715307B1 (fr) * | 1994-01-25 | 1996-04-05 | Commissariat Energie Atomique | Procédé de solubilisation dans un milieu aqueux d'agents antitumoraux de la famille du taxol, et cyclodextrines ramifiées utilisables pour cette solubilisation. |
| DE69504843T2 (de) * | 1994-06-28 | 1999-02-11 | Pharmacia & Upjohn Co., Kalamazoo, Mich. | 7-äther-taxol ähnliche verbindungen antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen |
-
1996
- 1996-01-31 DE DE19605024A patent/DE19605024A1/de not_active Withdrawn
-
1997
- 1997-01-31 DE DE69719502T patent/DE69719502T2/de not_active Expired - Lifetime
- 1997-01-31 BR BR9708295A patent/BR9708295A/pt not_active Application Discontinuation
- 1997-01-31 EP EP97902286A patent/EP0896577B1/en not_active Expired - Lifetime
- 1997-01-31 SK SK1011-98A patent/SK101198A3/sk unknown
- 1997-01-31 CZ CZ19982426A patent/CZ292504B6/cs not_active IP Right Cessation
- 1997-01-31 IL IL12495197A patent/IL124951A/xx not_active IP Right Cessation
- 1997-01-31 DK DK97902286T patent/DK0896577T3/da active
- 1997-01-31 PL PL97328055A patent/PL186796B1/pl not_active IP Right Cessation
- 1997-01-31 UA UA98084638A patent/UA49007C2/uk unknown
- 1997-01-31 JP JP52730897A patent/JP2001505527A/ja active Pending
- 1997-01-31 CN CN97192006A patent/CN1073108C/zh not_active Expired - Fee Related
- 1997-01-31 KR KR1019980705874A patent/KR19990082151A/ko not_active Ceased
- 1997-01-31 ES ES97902286T patent/ES2192261T3/es not_active Expired - Lifetime
- 1997-01-31 AT AT97902286T patent/ATE233757T1/de not_active IP Right Cessation
- 1997-01-31 HU HU9901027A patent/HUP9901027A3/hu unknown
- 1997-01-31 WO PCT/EP1997/000440 patent/WO1997028156A1/en not_active Ceased
- 1997-01-31 RU RU98116122/04A patent/RU2163599C2/ru not_active IP Right Cessation
- 1997-01-31 ZA ZA9700847A patent/ZA97847B/xx unknown
- 1997-01-31 PT PT97902286T patent/PT896577E/pt unknown
- 1997-01-31 TR TR1998/01415T patent/TR199801415T2/xx unknown
- 1997-01-31 AU AU15984/97A patent/AU714313B2/en not_active Ceased
- 1997-01-31 CA CA002244746A patent/CA2244746A1/en not_active Abandoned
- 1997-01-31 TW TW086101169A patent/TW444015B/zh active
- 1997-01-31 US US09/117,506 patent/US6162920A/en not_active Expired - Fee Related
-
1998
- 1998-07-30 NO NO983509A patent/NO983509D0/no unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |