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IL117684A - Intermediates and Process for Production of History of Kempotocin (CPT-11) and Related Compounds - Google Patents

Intermediates and Process for Production of History of Kempotocin (CPT-11) and Related Compounds

Info

Publication number
IL117684A
IL117684A IL11768496A IL11768496A IL117684A IL 117684 A IL117684 A IL 117684A IL 11768496 A IL11768496 A IL 11768496A IL 11768496 A IL11768496 A IL 11768496A IL 117684 A IL117684 A IL 117684A
Authority
IL
Israel
Prior art keywords
formula
cpt
substituted
solvent
compound
Prior art date
Application number
IL11768496A
Other languages
English (en)
Hebrew (he)
Other versions
IL117684A0 (en
Original Assignee
Pharmacia & Upjohn Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Inc filed Critical Pharmacia & Upjohn Inc
Publication of IL117684A0 publication Critical patent/IL117684A0/xx
Publication of IL117684A publication Critical patent/IL117684A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Lubricants (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Paper (AREA)
IL11768496A 1995-04-07 1996-03-27 Intermediates and Process for Production of History of Kempotocin (CPT-11) and Related Compounds IL117684A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41964395A 1995-04-07 1995-04-07

Publications (2)

Publication Number Publication Date
IL117684A0 IL117684A0 (en) 1996-07-23
IL117684A true IL117684A (en) 2002-02-10

Family

ID=23663114

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11768496A IL117684A (en) 1995-04-07 1996-03-27 Intermediates and Process for Production of History of Kempotocin (CPT-11) and Related Compounds

Country Status (25)

Country Link
US (3) US6121451A (fr)
EP (1) EP0835257B1 (fr)
JP (2) JP4281075B2 (fr)
KR (1) KR100423627B1 (fr)
CN (5) CN1434043B (fr)
AT (1) ATE224899T1 (fr)
AU (1) AU717179B2 (fr)
CA (1) CA2214793C (fr)
CZ (1) CZ297862B6 (fr)
DE (1) DE69623960T2 (fr)
DK (1) DK0835257T3 (fr)
ES (1) ES2183943T3 (fr)
HK (2) HK1054234B (fr)
HU (1) HUP9801436A3 (fr)
IL (1) IL117684A (fr)
MX (1) MX9707706A (fr)
NO (2) NO320482B1 (fr)
NZ (1) NZ306664A (fr)
PL (2) PL186564B1 (fr)
PT (1) PT835257E (fr)
RU (1) RU2164917C2 (fr)
SI (1) SI0835257T1 (fr)
TW (1) TW438775B (fr)
WO (1) WO1996031513A1 (fr)
ZA (1) ZA962747B (fr)

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SG103322A1 (en) 1996-10-30 2004-04-29 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
WO2000020405A1 (fr) * 1998-10-07 2000-04-13 Mitsubishi Chemical Corporation Melanges d'isomeres optiques de 2,3-epoxypropanes disubstitues en 1,2, leur procede de production, pesticides les contenant sous forme de principe actif et intermediaire de ceux-ci
FR2794123B1 (fr) 1999-05-28 2001-07-27 Aventis Pharma Sa Preparation de derives de la camptothecine et de la nothapodytine
WO2001024763A2 (fr) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions et methodes de traitement du cancer utilisant des immunoconjugues et des agents chimiotherapeutiques
US6855294B2 (en) 2000-11-22 2005-02-15 Resonance, Inc. Apparatus and methods for efficient generation of chlorine dioxide
AR035684A1 (es) 2001-02-21 2004-06-23 Yakult Honsha Kk Procedimiento para preparar 2'-amino-5'-hidroxipropiofenona, uso de la misma para la preparacion de analogos de camptotecina, procedimiento para prepararlos, compuestos intermediarios, procedimiento para preparar una cetona triciclica utilizada en la sintesis de analogos de camptotecina
US6723853B2 (en) * 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
CN1646491A (zh) 2002-04-17 2005-07-27 法玛西雅公司 可用于制备喜树碱衍生物的化合物
CN100344633C (zh) 2003-05-12 2007-10-24 台湾神隆股份有限公司 用于制备7－烷基－10－羟基－20(s)－喜树碱的方法
CZ299329B6 (cs) 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
US8394365B2 (en) * 2003-09-17 2013-03-12 Nektar Therapeutics Multi-arm polymer prodrugs
JP5632119B2 (ja) * 2003-09-17 2014-11-26 ウェルズ ファーゴ バンク ナショナル アソシエイション 多分岐ポリマーのプロドラッグ
CZ299593B6 (cs) 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US20050197355A1 (en) * 2004-03-02 2005-09-08 Henegar Kevin E. Compounds useful in preparing camptothecin derivatives
US20050267141A1 (en) * 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
US20050272757A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
EP1791846A1 (fr) * 2004-08-09 2007-06-06 Shilpa Medicare Limited Procédé amélioré de preparation de chlorhydrate trihydraté d'irinotécan
US20060046993A1 (en) * 2004-09-01 2006-03-02 Pharmacia Italia S.P.A. Crystalline polymorphic form of irinotecan hydrochloride
ATE446299T1 (de) 2005-02-07 2009-11-15 Fermion Oy Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin
CA2591071C (fr) 2005-02-08 2014-04-29 Fermion Oy Procede de production de chlorure de [1,4'] bipiperidinyl-1'-carbonyl ou d'hydrochlorure correspondant
WO2006084941A2 (fr) 2005-02-08 2006-08-17 Fermion Oy Procede d'elaboration
TWI375678B (en) 2005-06-09 2012-11-01 Yakult Honsha Kk A method of preparation of a tricyclic ketone
EP1803725A1 (fr) * 2005-12-13 2007-07-04 W.C. Heraeus GmbH Procédé pour la preparation d'irinotecan
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
CA2669541C (fr) 2006-11-30 2014-11-18 Nektar Therapeutics Al, Corporation Procede de preparation d'un conjugue de polymere
US7928095B2 (en) * 2007-02-09 2011-04-19 Enzon Pharmaceuticals, Inc. Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
EP2664632A1 (fr) * 2008-07-31 2013-11-20 The Lubrizol Corporation Nouveaux copolymères et compositions lubrifiantes correspondantes
CA2732508C (fr) 2008-08-11 2016-03-15 Nektar Therapeutics Conjugues d'alcanoate polymere a multiples bras
TW201010732A (en) * 2008-08-29 2010-03-16 Enzon Pharmaceuticals Inc Method of treating RAS associated cancer
EP2349346B1 (fr) 2008-09-23 2019-08-28 Nektar Therapeutics Methode pour le dosage metronomique avec des prodrugs de captothecin (p.ex. peg-irinotecan)
CA2738807A1 (fr) * 2008-10-21 2010-04-29 Enzon Pharmaceuticals, Inc. Traitement de neuroblastomes avec des conjugues polymeres multi-bras de 7-ethyl-10-hydroxycamptothecine
WO2012032531A1 (fr) * 2010-09-06 2012-03-15 Avra Laboratories Pvt. Ltd. Procédé de production d'hydrochlorure d'irinotécane par synthèse totale
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
HUE043951T2 (hu) 2014-07-18 2019-09-30 Sanofi Sa Eljárás rákgyanús beteg aflibercepttel történõ kezelése kimenetének elõrejelzésére
US10087194B2 (en) * 2015-10-27 2018-10-02 California Pacific Medical Center Podophyllotoxin derivatives and their use
EP3371192B1 (fr) 2015-10-27 2020-06-03 California Pacific Medical Center Dérivés de podophyllotoxine et leur utilisation
CN109195593A (zh) 2016-03-15 2019-01-11 奥莱松基因组股份有限公司 用于治疗实体瘤的lsd1抑制剂的组合
CN105965710B (zh) * 2016-06-28 2019-03-22 常州大学 一种硅棒金钢线切割树脂板的制备方法及应用
US11434196B2 (en) 2019-01-15 2022-09-06 Laurus Labs Limited Process for preparation of 2-Amino-5-hydroxy propiophenone
CN112300184B (zh) * 2019-08-02 2022-12-06 华东师范大学 一种三元环化合物的制备方法

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JPS5217499A (en) * 1975-07-31 1977-02-09 Nippon Chemiphar Co Ltd Preparation of mappicine
EP0220601B1 (fr) * 1985-10-21 1991-12-11 Daiichi Seiyaku Co., Ltd. Dérivés de la pyranoindolizine et procédé de préparation
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5053512A (en) * 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US5883255A (en) * 1990-10-31 1999-03-16 Smithkline Beecham Corporation Substituted indolizino 1,2-b!quinolinones
US5405963A (en) * 1993-06-10 1995-04-11 Smithkline Beecham Corporation Process for asymmetric total synthesis of camptothecin analogues
GB9316352D0 (en) * 1993-08-06 1993-09-22 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
GB9319944D0 (en) * 1993-09-28 1993-11-17 Erba Carlo Spa Process for the preparation of 9-amino camptothecin

Also Published As

Publication number Publication date
KR100423627B1 (ko) 2004-07-27
CN1434044A (zh) 2003-08-06
WO1996031513A1 (fr) 1996-10-10
CA2214793C (fr) 2009-10-20
TW438775B (en) 2001-06-07
PL322651A1 (en) 1998-02-16
NO974608D0 (no) 1997-10-06
JP4281075B2 (ja) 2009-06-17
RU2164917C2 (ru) 2001-04-10
CN1434043A (zh) 2003-08-06
CA2214793A1 (fr) 1996-10-10
HK1009448A1 (en) 1999-09-10
SI0835257T1 (en) 2003-04-30
AU717179B2 (en) 2000-03-16
NO320482B1 (no) 2005-12-12
PT835257E (pt) 2003-01-31
JP2008069170A (ja) 2008-03-27
CN1181083A (zh) 1998-05-06
CN1434043B (zh) 2010-04-28
NO329776B1 (no) 2010-12-13
HK1054236A1 (zh) 2003-11-21
DE69623960T2 (de) 2003-06-05
HK1054234B (zh) 2010-12-24
HUP9801436A3 (en) 1998-11-30
MX9707706A (es) 1997-12-31
US6235907B1 (en) 2001-05-22
IL117684A0 (en) 1996-07-23
CZ311097A3 (cs) 1998-03-18
CN100537538C (zh) 2009-09-09
HK1055118A1 (zh) 2003-12-24
DK0835257T3 (da) 2003-02-03
EP0835257B1 (fr) 2002-09-25
US6121451A (en) 2000-09-19
PL186564B1 (pl) 2004-01-30
NZ306664A (en) 1999-11-29
ATE224899T1 (de) 2002-10-15
US6444820B1 (en) 2002-09-03
CN1434037A (zh) 2003-08-06
KR19980703691A (ko) 1998-12-05
CN1100058C (zh) 2003-01-29
CN1241926C (zh) 2006-02-15
NO974608L (no) 1997-12-08
CZ297862B6 (cs) 2007-04-18
HUP9801436A2 (hu) 1998-10-28
DE69623960D1 (de) 2002-10-31
HK1055119A1 (en) 2003-12-24
NO20050408L (no) 1997-12-08
CN100396682C (zh) 2008-06-25
CN1434046A (zh) 2003-08-06
AU5527896A (en) 1996-10-23
PL186446B1 (pl) 2004-01-30
ES2183943T3 (es) 2003-04-01
HK1054234A1 (zh) 2003-11-21
HK1054236B (zh) 2010-02-05
ZA962747B (en) 1998-04-06
EP0835257A1 (fr) 1998-04-15
JPH11503156A (ja) 1999-03-23

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