IL115590A - Pharmaceutical formulation comprising a growth hormone and isoleucine - Google Patents
Pharmaceutical formulation comprising a growth hormone and isoleucineInfo
- Publication number
- IL115590A IL115590A IL11559095A IL11559095A IL115590A IL 115590 A IL115590 A IL 115590A IL 11559095 A IL11559095 A IL 11559095A IL 11559095 A IL11559095 A IL 11559095A IL 115590 A IL115590 A IL 115590A
- Authority
- IL
- Israel
- Prior art keywords
- isoleucine
- growth hormone
- pharmaceutical formulation
- dissolved
- formulation
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 2
- 108010051696 Growth Hormone Proteins 0.000 title abstract 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 title abstract 2
- 239000000122 growth hormone Substances 0.000 title abstract 2
- 229960000310 isoleucine Drugs 0.000 title abstract 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000006240 deamidation Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/322,837 US5631225A (en) | 1994-10-13 | 1994-10-13 | Pharmaceutical formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL115590A0 IL115590A0 (en) | 1996-01-19 |
| IL115590A true IL115590A (en) | 2000-02-29 |
Family
ID=23256650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11559095A IL115590A (en) | 1994-10-13 | 1995-10-12 | Pharmaceutical formulation comprising a growth hormone and isoleucine |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5631225A (xx) |
| EP (1) | EP0785796B1 (xx) |
| JP (1) | JP4064454B2 (xx) |
| KR (1) | KR970706839A (xx) |
| AT (1) | ATE214614T1 (xx) |
| AU (1) | AU699345B2 (xx) |
| DE (1) | DE69525955T2 (xx) |
| ES (1) | ES2173197T3 (xx) |
| IL (1) | IL115590A (xx) |
| WO (1) | WO1996011703A1 (xx) |
| ZA (1) | ZA958604B (xx) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6022858A (en) * | 1991-12-20 | 2000-02-08 | Novo Nordisk A/S | Pharmaceutical formulation of human-growth hormone pretreated with zinc salt |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US6673335B1 (en) | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
| CA2145418A1 (en) * | 1992-09-29 | 1994-04-14 | John S. Patton | Pulmonary delivery of active fragments of parathyroid hormone |
| US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
| PT748213E (pt) | 1994-03-07 | 2004-08-31 | Nektar Therapeutics | Metodos e composicoes para administracao pulmonar de insulina |
| CN1073119C (zh) * | 1994-05-18 | 2001-10-17 | 吸入治疗系统公司 | 干扰素干粉配方的方法及组合物 |
| US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US20030035778A1 (en) * | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| PL357471A1 (en) * | 1999-11-09 | 2004-07-26 | Rappold-Hoerbrand Gudrun | Methods of treating short stature disorders related to the short stature homeobox-containing (shox) gene |
| DK1280520T4 (en) | 2000-05-10 | 2018-06-25 | Novartis Ag | Phospholipid based powders for drug delivery |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| CA2418960A1 (en) * | 2000-08-07 | 2002-02-14 | Inhale Therapeutic Systems, Inc. | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
| TWI324518B (en) | 2001-12-19 | 2010-05-11 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
| WO2009002521A2 (en) * | 2007-06-25 | 2008-12-31 | Amgen Inc. | Compositions of specific binding agents to hepatocyte growth factor |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4056520A (en) * | 1972-03-31 | 1977-11-01 | Research Corporation | Clinically active bovine growth hormone fraction |
| US4563352A (en) * | 1982-10-04 | 1986-01-07 | The Salk Institute For Biological Studies | Human pancreatic GRF |
| JPS5967228A (ja) * | 1982-10-07 | 1984-04-16 | Green Cross Corp:The | 寒冷不溶性グロブリンの凍結乾燥方法 |
| US4917685A (en) * | 1986-05-16 | 1990-04-17 | International Minerals & Chem. Corp. | Delivery device for the administration of stabilized growth promoting hormones |
| ATE82506T1 (de) * | 1987-08-21 | 1992-12-15 | Imcera Group Inc | Stabilisierung von wachstumshormonen. |
| US5096885A (en) * | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| EP0374120A3 (en) * | 1988-12-13 | 1991-07-31 | Monsanto Company | Comosition for controlled release of polypeptides |
| US5137872A (en) * | 1989-09-18 | 1992-08-11 | Pitman-Moore, Inc. | Growth hormone-releasing factor analogs |
| DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
| AU667503B2 (en) * | 1991-12-20 | 1996-03-28 | Novo Nordisk Health Care Ag | A stabilized pharmaceutical formulation comprising growth hormone and histidine |
| SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
| DK0652766T4 (da) * | 1992-07-31 | 2008-06-09 | Genentech Inc | Vandigt præparat indeholdende humant væksthormon |
-
1994
- 1994-10-13 US US08/322,837 patent/US5631225A/en not_active Expired - Lifetime
-
1995
- 1995-10-12 IL IL11559095A patent/IL115590A/xx not_active IP Right Cessation
- 1995-10-12 ZA ZA958604A patent/ZA958604B/xx unknown
- 1995-10-13 EP EP95933346A patent/EP0785796B1/en not_active Expired - Lifetime
- 1995-10-13 AT AT95933346T patent/ATE214614T1/de not_active IP Right Cessation
- 1995-10-13 AU AU36053/95A patent/AU699345B2/en not_active Ceased
- 1995-10-13 WO PCT/DK1995/000409 patent/WO1996011703A1/en not_active Ceased
- 1995-10-13 DE DE69525955T patent/DE69525955T2/de not_active Expired - Lifetime
- 1995-10-13 ES ES95933346T patent/ES2173197T3/es not_active Expired - Lifetime
- 1995-10-13 JP JP51286296A patent/JP4064454B2/ja not_active Expired - Fee Related
- 1995-10-13 KR KR1019970702430A patent/KR970706839A/ko not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0785796B1 (en) | 2002-03-20 |
| JP4064454B2 (ja) | 2008-03-19 |
| IL115590A0 (en) | 1996-01-19 |
| DE69525955D1 (de) | 2002-04-25 |
| ZA958604B (en) | 1996-05-14 |
| ES2173197T3 (es) | 2002-10-16 |
| WO1996011703A1 (en) | 1996-04-25 |
| EP0785796A1 (en) | 1997-07-30 |
| ATE214614T1 (de) | 2002-04-15 |
| AU699345B2 (en) | 1998-12-03 |
| JPH10507182A (ja) | 1998-07-14 |
| DE69525955T2 (de) | 2002-11-07 |
| US5631225A (en) | 1997-05-20 |
| KR970706839A (ko) | 1997-12-01 |
| AU3605395A (en) | 1996-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |