IL102361A - Benzomorphan derivatives their preparation and pharmaceutical compositions containing them - Google Patents

Benzomorphan derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number: IL102361A
Authority: IL; Israel
Prior art keywords: alkyl; preparation; pharmaceutical compositions; compositions containing; benzomorphan derivatives
Prior art date: 1991-07-02

Application number

IL10236192A

Other languages

English (en)

Other versions

IL102361A0 (en

Original Assignee

Boehringer Ingelheim Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-02

Filing date

1992-06-30

Publication date

1997-02-18

1992-06-30 Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg

1993-01-14 Publication of IL102361A0 publication Critical patent/IL102361A0/xx

1997-02-18 Publication of IL102361A publication Critical patent/IL102361A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

IL10236192A 1991-07-02 1992-06-30 Benzomorphan derivatives their preparation and pharmaceutical compositions containing them IL102361A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4121821A DE4121821A1 (de)	1991-07-02	1991-07-02	Neue benzomorphane und ihre verwendung als arzneimittel

Publications (2)

Publication Number	Publication Date
IL102361A0 IL102361A0 (en)	1993-01-14
IL102361A true IL102361A (en)	1997-02-18

Family

ID=6435223

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10236192A IL102361A (en)	1991-07-02	1992-06-30	Benzomorphan derivatives their preparation and pharmaceutical compositions containing them

Country Status (24)

Country	Link
EP (1)	EP0521422B1 (fr)
JP (1)	JP3324785B2 (fr)
KR (1)	KR100251256B1 (fr)
AT (1)	ATE137749T1 (fr)
AU (1)	AU657330B2 (fr)
CA (1)	CA2072814C (fr)
CZ (1)	CZ286949B6 (fr)
DE (2)	DE4121821A1 (fr)
DK (1)	DK0521422T3 (fr)
ES (1)	ES2086585T3 (fr)
FI (1)	FI105913B (fr)
GR (1)	GR3020124T3 (fr)
HK (1)	HK1003111A1 (fr)
HU (1)	HU220873B1 (fr)
IE (1)	IE74400B1 (fr)
IL (1)	IL102361A (fr)
MX (1)	MX9203845A (fr)
NO (1)	NO178263C (fr)
NZ (1)	NZ243388A (fr)
PH (1)	PH31430A (fr)
SG (1)	SG43001A1 (fr)
SK (1)	SK280776B6 (fr)
TW (1)	TW214547B (fr)
ZA (1)	ZA924883B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19528472A1 (de) *	1995-08-03	1997-02-06	Boehringer Ingelheim Kg	Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan
DE19740110A1 (de)	1997-09-12	1999-03-18	Boehringer Ingelheim Pharma	Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JPH1196519A (ja) *	1997-09-17	1999-04-09	Alps Electric Co Ltd	スピンバルブ型薄膜素子およびその製造方法
US6136980A (en) *	1998-05-01	2000-10-24	Boehringer Ingelheim Kg	Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
DE19826365A1 (de) *	1998-06-12	1999-12-16	Gruenenthal Gmbh	Verwendung von Benzomorphanderivaten als Analgetikum
DE19957156A1 (de) *	1999-11-27	2001-05-31	Boehringer Ingelheim Pharma	Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
US6355652B1 (en)	1999-11-27	2002-03-12	Boehringer Ingelheim Pharma Kg	Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions
DE10204276A1 (de) *	2002-02-02	2003-08-07	Boehringer Ingelheim Pharma	N-Allyloxyethyl-1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
EP1506174B1 (fr)	2002-05-17	2015-09-30	Taiwanj Pharmaceuticals Co., Ltd.	Utilisation de la naltrexone pour le traitement de lésions hépatiques et rénales
US7501433B2 (en)	2002-05-17	2009-03-10	Jenken Biosciences, Inc.	Opioid and opioid-like compounds and uses thereof
US7923454B2 (en)	2002-05-17	2011-04-12	Jenken Biosciences, Inc.	Opioid and opioid-like compounds and uses thereof
US8017622B2 (en)	2003-05-16	2011-09-13	Jenken Biosciences, Inc.	Opioid and opioid-like compounds and uses thereof
TW200927115A (en) *	2007-11-16	2009-07-01	Boehringer Ingelheim Int	Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
WO2015097545A1 (fr)	2013-12-26	2015-07-02	Purdue Pharma L.P.	Morphinanes oxabicyclo[2.2.2]octane modulateurs des récepteurs aux opiacés

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7804509A (nl) *	1978-04-26	1979-10-30	Acf Chemiefarma Nv	Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) *	1978-06-26	1980-01-10	Boehringer Sohn Ingelheim	2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
NL7907800A (nl) *	1979-10-23	1981-04-27	Acf Chemiefarma Nv	Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.

1991
- 1991-07-02 DE DE4121821A patent/DE4121821A1/de not_active Withdrawn
1992
- 1992-06-03 TW TW081104377A patent/TW214547B/zh not_active IP Right Cessation
- 1992-06-27 SG SG1996002082A patent/SG43001A1/en unknown
- 1992-06-27 AT AT92110923T patent/ATE137749T1/de active
- 1992-06-27 EP EP92110923A patent/EP0521422B1/fr not_active Expired - Lifetime
- 1992-06-27 DK DK92110923.7T patent/DK0521422T3/da active
- 1992-06-27 ES ES92110923T patent/ES2086585T3/es not_active Expired - Lifetime
- 1992-06-27 DE DE59206212T patent/DE59206212D1/de not_active Expired - Lifetime
- 1992-06-30 IL IL10236192A patent/IL102361A/xx not_active IP Right Cessation
- 1992-06-30 MX MX9203845A patent/MX9203845A/es unknown
- 1992-06-30 CA CA002072814A patent/CA2072814C/fr not_active Expired - Lifetime
- 1992-06-30 AU AU18686/92A patent/AU657330B2/en not_active Expired
- 1992-06-30 NZ NZ243388A patent/NZ243388A/en not_active IP Right Cessation
- 1992-07-01 HU HU9202199A patent/HU220873B1/hu unknown
- 1992-07-01 KR KR1019920011664A patent/KR100251256B1/ko not_active Expired - Lifetime
- 1992-07-01 IE IE922144A patent/IE74400B1/en not_active IP Right Cessation
- 1992-07-01 JP JP17447992A patent/JP3324785B2/ja not_active Expired - Lifetime
- 1992-07-01 FI FI923050A patent/FI105913B/fi not_active IP Right Cessation
- 1992-07-01 NO NO922603A patent/NO178263C/no not_active IP Right Cessation
- 1992-07-01 ZA ZA924883A patent/ZA924883B/xx unknown
- 1992-07-02 SK SK2075-92A patent/SK280776B6/sk not_active IP Right Cessation
- 1992-07-02 PH PH44606A patent/PH31430A/en unknown
- 1992-07-02 CZ CS19922075A patent/CZ286949B6/cs not_active IP Right Cessation
1996
- 1996-05-31 GR GR960401503T patent/GR3020124T3/el unknown
1998
- 1998-03-16 HK HK98102148A patent/HK1003111A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE59206212D1 (de)	1996-06-13
IE922144A1 (en)	1993-01-13
CZ207592A3 (en)	1993-08-11
PH31430A (en)	1998-11-03
HU220873B1 (en)	2002-06-29
HU9202199D0 (en)	1992-10-28
IL102361A0 (en)	1993-01-14
ZA924883B (en)	1993-02-24
SK280776B6 (sk)	2000-07-11
GR3020124T3 (en)	1996-08-31
NO178263B (no)	1995-11-13
ATE137749T1 (de)	1996-05-15
EP0521422B1 (fr)	1996-05-08
NO178263C (no)	1996-02-21
KR100251256B1 (ko)	2000-05-01
SK207592A3 (en)	1997-01-08
NO922603D0 (no)	1992-07-01
NO922603L (no)	1993-01-04
TW214547B (fr)	1993-10-11
FI105913B (fi)	2000-10-31
JP3324785B2 (ja)	2002-09-17
FI923050A0 (fi)	1992-07-01
AU657330B2 (en)	1995-03-09
DE4121821A1 (de)	1993-01-14
DK0521422T3 (da)	1996-06-10
EP0521422A1 (fr)	1993-01-07
MX9203845A (es)	1993-01-01
ES2086585T3 (es)	1996-07-01
CZ286949B6 (cs)	2000-08-16
HK1003111A1 (en)	1998-10-09
IE74400B1 (en)	1997-07-30
CA2072814A1 (fr)	1993-01-03
KR930002321A (ko)	1993-02-22
JPH05201987A (ja)	1993-08-10
NZ243388A (en)	1994-11-25
CA2072814C (fr)	2003-09-23
FI923050L (fi)	1993-01-03
SG43001A1 (en)	1997-10-17
HUT66410A (en)	1994-11-28
AU1868692A (en)	1993-01-07

Publication	Publication Date	Title
IL102361A (en)	1997-02-18	Benzomorphan derivatives their preparation and pharmaceutical compositions containing them
ATE201019T1 (de)	2001-05-15	9-deoxotaxan verbindungen
IL128690A0 (en)	2000-01-31	Cyclic amine derivatives pharmaceutical compositions containing the same and use thereof
MXPA02012425A (es)	2003-04-25	Compuestos nuevos.
DE69706112D1 (de)	2001-09-20	Substituierte Biphenyl- oder Phenylpyridinderivate, Verfahren zu deren Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
DE19875032I2 (de)	2007-04-19	Mometason-Furoate-Monohydrat, Verfahren zu seiner Herstellung und das enthaltende pharmazeutische Zusammensetzungen
AP9801274A0 (en)	1998-06-30	Lactone derivatives of 17, beta.carboxy, carbothio and amide androstane derivatives.
DK0671156T3 (da)	2002-02-04	Kosmetiske eller farmaceutiske præparater indeholdende liposomer
NZ334954A (en)	2000-08-25	Substituted heterocycles as anti-tumor agents
GR3015266T3 (en)	1995-06-30	Immunosuppressant and process for preparing the same.
TW365604B (en)	1999-08-01	Anthracyclinone derivatives
IL101358A0 (en)	1992-11-15	Crystalline tiagabine hydrochloride monohydrate,its preparation and pharmaceutical compositions containing it
IL140070A0 (en)	2002-02-10	Benzamide derivatives and pharmaceutical compositions containing the same
RU2000102672A (ru)	2001-12-10	Производные 4-оксо-3,5-дигидро-4н-пиридазино[4,5-b]индол-1-ацетамида, их получение и применение в терапии
IL108444A0 (en)	1994-04-12	C2 taxane derivatives and pharmaceutical compositions containing them
FR2749845B1 (fr)	1998-08-21	Nouveaux derives benzyl substitue(s) de polyalkylene-polyamines et leur utilisation dans des compositions cosmetiques et pharmaceutiques
HUP9700104A2 (hu)	1999-06-28	1,3,4-Tiadiazol-származékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények, és eljárás a hatóanyag előállítására
ES2158809A1 (es)	2001-09-01	Nuevos derivados sulfonados como inhibidores de la ciclooxigenasa ii.
SE0002330D0 (sv)	2000-06-20	Novel compounds

Legal Events

Date	Code	Title
1997-08-14	FF	Patent granted
1998-01-04	KB	Patent renewed
1998-12-06	KB	Patent renewed
2001-06-14	RH	Patent void
2002-08-14	KB	Patent renewed
2006-09-05	KB	Patent renewed
2010-11-30	KB	Patent renewed
2013-02-03	EXP	Patent expired