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IL100476A0 - Amines,processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents

Amines,processes for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
IL100476A0
IL100476A0 IL100476A IL10047691A IL100476A0 IL 100476 A0 IL100476 A0 IL 100476A0 IL 100476 A IL100476 A IL 100476A IL 10047691 A IL10047691 A IL 10047691A IL 100476 A0 IL100476 A0 IL 100476A0
Authority
IL
Israel
Prior art keywords
carboxyl
group
possibly
pct
hydroxyl
Prior art date
Application number
IL100476A
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of IL100476A0 publication Critical patent/IL100476A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PCT No. PCT/EP91/02456 Sec. 371 Date Jun. 21, 1993 Sec. 102(e) Date Jun. 21, 1993 PCT Filed Dec. 19, 1991 PCT Pub. No. WO92/11234 PCT Pub. Date Jul. 9, 1992.Compounds of the formula I <IMAGE> (I) in which R1 signifies an aryl, aralkyl or an aralkenyl group, the aryl radical of which can, in each case, be substituted one or more times by halogen, cyano, alkyl, trifluoromethyl, alkoxy, alkylthio, trifluoromethoxy, hydroxyl or carboxyl, m a whole number from 1 to 3, n a whole number from 1 to 5, R2 hydrogen, an alkyl, aralkyl or acyl group, Q a bond or an oxygen atom, R3 hydrogen or a lower alkyl radical which is possibly terminally substituted by carboxyl or by a hydroxyl group and R4 hydrogen, a lower alkyl group with 1-4 C-atoms, which is possibly terminally substituted by carboxyl or hydroxyl, a possibly substituted phenyl, heteroaryl, cycloalkyl or acyl group or a group <IMAGE> in which R5 represents a straight-chained or branched alkyl chain with 1-4 C-atoms which is possibly terminally substituted by carboxyl, alkoxycarbonyl, aminocarbonyl, hydroxyl, mercapto, alkylthio or imidazolyl and Y a carboxyl, an alkoxycarbonyl, aminocarbonyl or cyano, formyl, hydroxymethyl, aminomethyl or ortho ester group, whereby R3 and R4 can also be component of a 5- or 6-membered saturated or unsaturated possibly substituted heterocycle with 1-4 heteroatoms which can be annellated with further ring compounds via one or more bonds, as well as their salts, esters and amides, processes for their preparation and medicaments with thromboxane-antagonistic action which contain these compounds.
IL100476A 1990-12-24 1991-12-23 Amines,processes for the preparation thereof and pharmaceutical compositions containing them IL100476A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4041780A DE4041780A1 (en) 1990-12-24 1990-12-24 NEW AMINES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

Publications (1)

Publication Number Publication Date
IL100476A0 true IL100476A0 (en) 1992-09-06

Family

ID=6421442

Family Applications (1)

Application Number Title Priority Date Filing Date
IL100476A IL100476A0 (en) 1990-12-24 1991-12-23 Amines,processes for the preparation thereof and pharmaceutical compositions containing them

Country Status (16)

Country Link
US (1) US5446065A (en)
EP (1) EP0564499B1 (en)
JP (1) JPH06503822A (en)
AT (1) ATE121076T1 (en)
AU (1) AU662308B2 (en)
CA (1) CA2098929A1 (en)
DE (2) DE4041780A1 (en)
FI (1) FI932895A7 (en)
HU (1) HUT68720A (en)
IE (1) IE914467A1 (en)
IL (1) IL100476A0 (en)
MX (1) MX9102772A (en)
NZ (1) NZ241117A (en)
PT (1) PT99924A (en)
WO (1) WO1992011234A1 (en)
ZA (1) ZA9110040B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996036611A1 (en) * 1995-05-19 1996-11-21 Chiroscience Limited 3,4-disubstituted-phenylsulphonamides and their therapeutic use
BE1012386A3 (en) 1999-01-15 2000-10-03 Univ Liege SULFONAMIDES benzene DERIVATIVES AND USES THEREOF.
ES2273725T3 (en) * 1999-09-04 2007-05-16 Astrazeneca Ab HYDROXYACETAMIDOBENCENOSULFONAMIDE DERIVATIVES.
NZ541234A (en) * 2002-12-20 2008-06-30 Amgen Inc Asthma and allergic inflammation modulators
OA13344A (en) * 2003-12-19 2007-04-13 Pfizer Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-HSD-1) for the treatment of diabetes and obesity.
EP2111223A4 (en) * 2007-11-01 2012-08-15 Acucela Inc AMIN DERIVATIVE COMPOUNDS FOR THE TREATMENT OF EYE DISEASES AND DRESSES

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003929A (en) * 1975-03-11 1977-01-18 Pfizer Inc. Antiviral substituted phenylenedimethylene diamines
US4064125A (en) * 1976-10-29 1977-12-20 E. R. Squibb And Sons, Inc. Substituted amides having antiinflammatory activity
DE2809377A1 (en) * 1978-03-04 1979-09-13 Boehringer Mannheim Gmbh PHENOXYALKYL CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4539426A (en) * 1984-05-11 1985-09-03 American Home Products Corporation Anti-arrhythmic agents
DE68909958D1 (en) * 1988-01-19 1993-11-25 Tanabe Seiyaku Co Phenoxyacetic acid derivatives, their preparation, pharmaceutical compositions containing them and their use.
DE3829431A1 (en) * 1988-08-31 1990-03-01 Boehringer Mannheim Gmbh SULPHONAMID WITH TETRAZOLYL RESIDUE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
WO1992011234A1 (en) 1992-07-09
IE914467A1 (en) 1992-07-01
ZA9110040B (en) 1992-10-28
JPH06503822A (en) 1994-04-28
PT99924A (en) 1993-01-29
ATE121076T1 (en) 1995-04-15
EP0564499A1 (en) 1993-10-13
DE59105207D1 (en) 1995-05-18
NZ241117A (en) 1994-11-25
HU9301853D0 (en) 1993-09-28
CA2098929A1 (en) 1992-06-25
DE4041780A1 (en) 1992-06-25
FI932895A0 (en) 1993-06-23
MX9102772A (en) 1992-06-01
FI932895A7 (en) 1993-06-23
US5446065A (en) 1995-08-29
AU9088991A (en) 1992-07-22
EP0564499B1 (en) 1995-04-12
HUT68720A (en) 1995-07-28
AU662308B2 (en) 1995-08-31

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