IL107915A - N-substituted azabicycloheptane derivatives and their use as medicaments - Google Patents
N-substituted azabicycloheptane derivatives and their use as medicamentsInfo
- Publication number
- IL107915A IL107915A IL107915A IL10791593A IL107915A IL 107915 A IL107915 A IL 107915A IL 107915 A IL107915 A IL 107915A IL 10791593 A IL10791593 A IL 10791593A IL 107915 A IL107915 A IL 107915A
- Authority
- IL
- Israel
- Prior art keywords
- hydrogen atom
- hydroxyl
- substituted
- unsubstituted
- atom
- Prior art date
Links
- UUAVYXKRUSVCDJ-UHFFFAOYSA-N 1-cycloheptylazepane Chemical class C1CCCCCC1N1CCCCCC1 UUAVYXKRUSVCDJ-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- -1 amino, monomethylamino, dimethylamino Chemical group 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical class CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Neuroleptic, antidepressant, CNS- protective N-substituted 3-azabicyclo £3.2.0| heptane derivatives of the formula R16 N-(CH2)n - A R213 where R1 is a phenyl, pyridyl, thienyl or pyrrolyl group which is unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, trifluoromethyl, hydroxyl, C1-C4-alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups, R2 is a hydrogen atom or a phenyl group which is unsubstituted or substituted by halogen, methoxy, hydroxyl or amino, n is the number 1, 2, 3 or 4, A is a hydrogen atom or one of the radicals R3R5 C R4 R5 -NR6-COor -CH=CH2 R3 is a hydrogen atom, a hydroxyl radical or a phenyl radical which is unsubstituted or substituted by a fluorine, chlorine or bromine atom, R4 is a hydrogen atom, or R3 and R4 together represent an oxygen atom, R5 is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl, nitro, C1-C4-alkyl or methoxy group, and R6 is a hydrogen atom or a methyl group, and salts thereof with physiologically tolerated acids.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL107915A IL107915A (en) | 1993-12-07 | 1993-12-07 | N-substituted azabicycloheptane derivatives and their use as medicaments |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL107915A IL107915A (en) | 1993-12-07 | 1993-12-07 | N-substituted azabicycloheptane derivatives and their use as medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL107915A0 IL107915A0 (en) | 1994-04-12 |
| IL107915A true IL107915A (en) | 1997-04-15 |
Family
ID=11065555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL107915A IL107915A (en) | 1993-12-07 | 1993-12-07 | N-substituted azabicycloheptane derivatives and their use as medicaments |
Country Status (1)
| Country | Link |
|---|---|
| IL (1) | IL107915A (en) |
-
1993
- 1993-12-07 IL IL107915A patent/IL107915A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IL107915A0 (en) | 1994-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |