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IE950434L - Modified VP1/VP2 regions of the rhinoviral system - Google Patents

Modified VP1/VP2 regions of the rhinoviral system

Info

Publication number
IE950434L
IE950434L IE950434A IE950434A IE950434L IE 950434 L IE950434 L IE 950434L IE 950434 A IE950434 A IE 950434A IE 950434 A IE950434 A IE 950434A IE 950434 L IE950434 L IE 950434L
Authority
IE
Ireland
Prior art keywords
regions
modified
protease
trans
mutations
Prior art date
Application number
IE950434A
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of IE950434L publication Critical patent/IE950434L/en

Links

Classifications

    • C07K16/106—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32711—Rhinovirus
    • C12N2770/32722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to systems which enable mutations to be inserted in the VP1/2A region and in the total coding region of protease 2A, test systems for investigating the ''cis'' and ''trans'' activity, oligonucleotides which code the mutations, as well as the oligopeptides derived therefrom and their use. It also relates to oligopeptides which can be split off protease 2A in trans with varying efficiency, and their use. [WO9100348A3]
IE950434A 1989-06-25 1990-06-22 Modified VP1/VP2 regions of the rhinoviral system IE950434L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3920860 1989-06-25
DE4018376 1990-06-08

Publications (1)

Publication Number Publication Date
IE950434L true IE950434L (en) 1990-12-25

Family

ID=25882343

Family Applications (2)

Application Number Title Priority Date Filing Date
IE227090A IE66395B1 (en) 1989-06-25 1990-06-22 Modified VP1/P2A regions of the rhinoviral system
IE950434A IE950434L (en) 1989-06-25 1990-06-22 Modified VP1/VP2 regions of the rhinoviral system

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IE227090A IE66395B1 (en) 1989-06-25 1990-06-22 Modified VP1/P2A regions of the rhinoviral system

Country Status (17)

Country Link
EP (2) EP0602687A1 (en)
JP (1) JPH04503608A (en)
KR (1) KR920701439A (en)
AT (1) ATE114717T1 (en)
AU (2) AU644078B2 (en)
CA (1) CA2019661A1 (en)
DE (2) DE59007818D1 (en)
DK (1) DK0410147T3 (en)
ES (1) ES2064537T3 (en)
FI (1) FI903144A7 (en)
GR (1) GR3015192T3 (en)
IE (2) IE66395B1 (en)
IL (2) IL94841A0 (en)
NO (1) NO902789L (en)
NZ (1) NZ234212A (en)
PT (1) PT94458B (en)
WO (1) WO1991000348A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4136443A1 (en) * 1991-11-06 1993-05-13 Boehringer Ingelheim Int EXPRESSION OF THE TIRE PROTEINASE 2A, ITS PARTIAL CLEANING AND PROVISION OF COMPETITIVE SUBSTRATES
US8318423B2 (en) 2004-07-06 2012-11-27 Focus Diagnostics, Inc. Methods and compositions for detecting rhinoviruses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0263903A1 (en) * 1986-10-10 1988-04-20 E.I. Du Pont De Nemours And Company Method for preparing specific inhibitors of virus-specified proteases
ES2059482T3 (en) * 1987-12-23 1994-11-16 Boehringer Ingelheim Int EXPRESSION OF HRV2 PROTEASE P2A CODED BY VIRUSES.

Also Published As

Publication number Publication date
AU644078B2 (en) 1993-12-02
DE4020211A1 (en) 1991-01-17
WO1991000348A2 (en) 1991-01-10
IL112507A0 (en) 1995-05-26
NO902789D0 (en) 1990-06-22
DE59007818D1 (en) 1995-01-12
AU657205B2 (en) 1995-03-02
IE902270L (en) 1990-12-25
ES2064537T3 (en) 1995-02-01
NO902789L (en) 1990-12-27
PT94458A (en) 1991-02-08
EP0410147A1 (en) 1991-01-30
EP0410147B1 (en) 1994-11-30
DK0410147T3 (en) 1995-03-13
CA2019661A1 (en) 1990-12-25
JPH04503608A (en) 1992-07-02
ATE114717T1 (en) 1994-12-15
WO1991000348A3 (en) 2004-04-29
IL94841A0 (en) 1991-04-15
EP0602687A1 (en) 1994-06-22
FI903144A0 (en) 1990-06-21
NZ234212A (en) 1993-03-26
IE902270A1 (en) 1991-01-16
PT94458B (en) 1997-02-28
FI903144A7 (en) 1990-12-26
AU3524593A (en) 1993-05-27
GR3015192T3 (en) 1995-05-31
AU5779690A (en) 1991-01-03
IE66395B1 (en) 1995-12-27
KR920701439A (en) 1992-08-11

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