IE823036L - Azetidinones. - Google Patents
Azetidinones.Info
- Publication number
- IE823036L IE823036L IE823036A IE303682A IE823036L IE 823036 L IE823036 L IE 823036L IE 823036 A IE823036 A IE 823036A IE 303682 A IE303682 A IE 303682A IE 823036 L IE823036 L IE 823036L
- Authority
- IE
- Ireland
- Prior art keywords
- cyano
- compound
- formula
- azetidinone
- sulfo
- Prior art date
Links
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title 1
- -1 4-substituted-2-azetidinone Chemical class 0.000 abstract 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 2
- IECIGSLAYMAQPZ-LBAQZLPGSA-N (3s)-4-oxo-3-(tritylamino)azetidine-2-carbonitrile Chemical compound O=C1NC(C#N)[C@@H]1NC(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 IECIGSLAYMAQPZ-LBAQZLPGSA-N 0.000 abstract 1
- WUAHJPICVGEXFK-UHFFFAOYSA-N 4-oxoazetidine-2-carbonitrile Chemical class O=C1CC(C#N)N1 WUAHJPICVGEXFK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 102000006635 beta-lactamase Human genes 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The 4-cyano-2-azetidinone derivative of formulaI(R<1> is amino which may be acylated or protected; X is H or methoxy; W is H or sulfo). EXAMPLE:(3S, 4RS)-4-Cyano-3-tritylamino-2-azetidinone. USE:An intermediate of 4-substituted-2-azetidinone derivative, an antibacterial agent and a beta-lactamase-inhibiting agent. PROCESS:The compound of formulaIis prepared by reacting the compound of formula II[R<2> is same as R<1>; X is H or methody; W is H or sulfo; Y is halogen, group of formula -OCOR<3> (R<3> is hydrocarbon group), -SCOR<3>, or formula III (n is 1 or 2)]with a cyano compound, and if necessary, eliminating the protecting group from the product.
[JP58110563A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56212718A JPS58110563A (en) | 1981-12-25 | 1981-12-25 | 4-cyano-2-azetidinone derivative and its preparation |
| PCT/JP1982/000141 WO1983003827A1 (en) | 1982-04-27 | 1982-04-27 | 4-cyano-2-azetidinone derivatives and process for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE823036L true IE823036L (en) | 1983-06-25 |
| IE54682B1 IE54682B1 (en) | 1990-01-03 |
Family
ID=16627276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE3036/82A IE54682B1 (en) | 1981-12-25 | 1982-12-21 | 4-cyano-2-azetidinones and production thereof |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS58110563A (en) |
| DE (1) | DE3270045D1 (en) |
| IE (1) | IE54682B1 (en) |
| PH (1) | PH23731A (en) |
| ZA (1) | ZA829136B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA826089B (en) * | 1981-08-27 | 1983-07-27 | Hoffmann La Roche | Beta-lactams |
-
1981
- 1981-12-25 JP JP56212718A patent/JPS58110563A/en active Granted
-
1982
- 1982-12-13 ZA ZA829136A patent/ZA829136B/en unknown
- 1982-12-17 DE DE8282111744T patent/DE3270045D1/en not_active Expired
- 1982-12-21 IE IE3036/82A patent/IE54682B1/en unknown
- 1982-12-22 PH PH28315A patent/PH23731A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH23731A (en) | 1989-11-03 |
| IE54682B1 (en) | 1990-01-03 |
| JPS58110563A (en) | 1983-07-01 |
| JPH0424347B2 (en) | 1992-04-24 |
| DE3270045D1 (en) | 1986-04-24 |
| ZA829136B (en) | 1983-09-28 |
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