IE813110L - N-substituted iminodiacetic acids. - Google Patents
N-substituted iminodiacetic acids.Info
- Publication number
- IE813110L IE813110L IE813110A IE311081A IE813110L IE 813110 L IE813110 L IE 813110L IE 813110 A IE813110 A IE 813110A IE 311081 A IE311081 A IE 311081A IE 813110 L IE813110 L IE 813110L
- Authority
- IE
- Ireland
- Prior art keywords
- iminodiacetic acids
- substituted iminodiacetic
- substituted
- gb2090252a
- technetium
- Prior art date
Links
- -1 N-substituted iminodiacetic acids Chemical class 0.000 title 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940056501 technetium 99m Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
New compounds having the formula <IMAGE> or a pharmaceutically acceptable, water soluble salt thereof, wherein R1 and R4 are each independently hydrogen, methyl or ethyl; one of R2 and R3 is alkyl of 1 to 4 carbons and the other is bromine or iodine; and n is 0, 1 or 2, when complexed with technetium-99m in the presence of a reducing agent provide compositions which are useful for the external imaging of the hepatobiliary system.
[GB2090252A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22115580A | 1980-12-29 | 1980-12-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE813110L true IE813110L (en) | 1982-06-29 |
| IE52900B1 IE52900B1 (en) | 1988-04-13 |
Family
ID=22826582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE3110/81A IE52900B1 (en) | 1980-12-29 | 1981-12-18 | N-substituted iminodiacetic acids |
Country Status (15)
| Country | Link |
|---|---|
| JP (2) | JPS58948A (en) |
| AT (1) | AT377975B (en) |
| AU (1) | AU539726B2 (en) |
| BE (1) | BE891534A (en) |
| CA (1) | CA1187897A (en) |
| CH (1) | CH649761A5 (en) |
| DE (1) | DE3151686A1 (en) |
| FR (1) | FR2497197B1 (en) |
| GB (1) | GB2090252B (en) |
| IE (1) | IE52900B1 (en) |
| IT (1) | IT1140400B (en) |
| LU (1) | LU83856A1 (en) |
| NL (1) | NL193318C (en) |
| SE (2) | SE461015B (en) |
| ZA (1) | ZA818943B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4454107A (en) * | 1982-08-30 | 1984-06-12 | Merck & Co., Inc. | Tc99m-Phenida, radioscintigraphic agent for diagnosis of hepatoniliary disease |
| GB8413772D0 (en) * | 1984-05-30 | 1984-07-04 | Nyegaard & Co As | Chemical compounds |
| JPH0331486Y2 (en) * | 1985-06-24 | 1991-07-04 | ||
| JPH01143751A (en) * | 1987-11-18 | 1989-06-06 | Corns & Co Ltd | Low-pressure casting device and casting method thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3725295A (en) * | 1971-07-20 | 1973-04-03 | Atomic Energy Commission | Technetium labeling |
| US4017596A (en) * | 1975-03-03 | 1977-04-12 | Research Corporation | Radiopharmaceutical chelates and method of external imaging |
| CA1070695A (en) * | 1975-09-02 | 1980-01-29 | Michael D. Loberg | Iminodiacetic acid pharmaceutical |
| CH607920A5 (en) * | 1976-05-31 | 1978-12-15 | Solco Basel Ag | |
| PL115524B1 (en) * | 1978-04-10 | 1981-04-30 | Uniwersytet Warszawski | Process for manufacturing scintigraphic agent |
| DE2855334A1 (en) * | 1978-12-21 | 1980-07-10 | Hoechst Ag | TECHNETIUM-99M MARKED (2,4,5-TRIMETHYLACETANILIDO) IMINODIACETATE FOR LIVER FUNCTION DIAGNOSTICS AND METHOD FOR THE PRODUCTION THEREOF |
| DE2920174A1 (en) * | 1979-05-18 | 1980-11-20 | Hoechst Ag | TECHNETIUM-99M-MARKED ACETANILIDOIMINODIACETATE FOR LIVER FUNCTION DIAGNOSTICS |
-
1981
- 1981-12-10 CA CA000392015A patent/CA1187897A/en not_active Expired
- 1981-12-17 GB GB8138054A patent/GB2090252B/en not_active Expired
- 1981-12-18 IE IE3110/81A patent/IE52900B1/en not_active IP Right Cessation
- 1981-12-18 BE BE0/206879A patent/BE891534A/en not_active IP Right Cessation
- 1981-12-21 FR FR8123803A patent/FR2497197B1/en not_active Expired
- 1981-12-22 CH CH8210/81A patent/CH649761A5/en not_active IP Right Cessation
- 1981-12-23 JP JP56216075A patent/JPS58948A/en active Granted
- 1981-12-23 AU AU78808/81A patent/AU539726B2/en not_active Expired
- 1981-12-24 NL NL8105845A patent/NL193318C/en not_active IP Right Cessation
- 1981-12-24 LU LU83856A patent/LU83856A1/en unknown
- 1981-12-28 DE DE19813151686 patent/DE3151686A1/en active Granted
- 1981-12-28 ZA ZA818943A patent/ZA818943B/en unknown
- 1981-12-28 IT IT25861/81A patent/IT1140400B/en active
- 1981-12-28 SE SE8107806A patent/SE461015B/en not_active IP Right Cessation
- 1981-12-29 AT AT0561381A patent/AT377975B/en active
-
1987
- 1987-09-18 SE SE8703623A patent/SE466788B/en not_active IP Right Cessation
-
1989
- 1989-09-28 JP JP1256895A patent/JPH02160727A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| NL8105845A (en) | 1982-07-16 |
| IE52900B1 (en) | 1988-04-13 |
| DE3151686A1 (en) | 1982-07-08 |
| FR2497197A1 (en) | 1982-07-02 |
| AU539726B2 (en) | 1984-10-11 |
| AT377975B (en) | 1985-05-28 |
| NL193318C (en) | 1999-06-02 |
| IT1140400B (en) | 1986-09-24 |
| GB2090252A (en) | 1982-07-07 |
| JPH0237345B2 (en) | 1990-08-23 |
| JPH0316327B2 (en) | 1991-03-05 |
| ZA818943B (en) | 1982-11-24 |
| DE3151686C2 (en) | 1990-12-20 |
| FR2497197B1 (en) | 1986-04-11 |
| JPS58948A (en) | 1983-01-06 |
| SE8107806L (en) | 1982-06-30 |
| ATA561381A (en) | 1984-10-15 |
| SE8703623L (en) | 1987-09-18 |
| LU83856A1 (en) | 1982-07-07 |
| SE461015B (en) | 1989-12-18 |
| CH649761A5 (en) | 1985-06-14 |
| IT8125861A0 (en) | 1981-12-28 |
| GB2090252B (en) | 1985-01-03 |
| AU7880881A (en) | 1982-07-08 |
| SE8703623D0 (en) | 1987-09-18 |
| SE466788B (en) | 1992-04-06 |
| JPH02160727A (en) | 1990-06-20 |
| CA1187897A (en) | 1985-05-28 |
| NL193318B (en) | 1999-02-01 |
| BE891534A (en) | 1982-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK9A | Patent expired |