[go: up one dir, main page]

IE811832L - Indoles. - Google Patents

Indoles.

Info

Publication number
IE811832L
IE811832L IE811832A IE183281A IE811832L IE 811832 L IE811832 L IE 811832L IE 811832 A IE811832 A IE 811832A IE 183281 A IE183281 A IE 183281A IE 811832 L IE811832 L IE 811832L
Authority
IE
Ireland
Prior art keywords
group
alkyl
hydrogen atom
cycloalkyl
represent
Prior art date
Application number
IE811832A
Other versions
IE51493B1 (en
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IE811832L publication Critical patent/IE811832L/en
Publication of IE51493B1 publication Critical patent/IE51493B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Compounds are disclosed of general formula (I> <IMAGE> wherein R1 represents a group CHO, COR8, CO2R8, CONR9R10, CSNR9R10 or SO2NR9R10, where R8 represents an alkyl, cycloalkyl, aryl or aralkyl group, R9 represents a hydrogen atom or an alkyl group, and R10 represents a hydrogen atom or an alkyl, cycloalkyl, aryl or aralkyl group; R2, R3, R4, R6 and R7, which may be the same or different, each represents a hydrogen atom or a C1-3 alkyl group; R5 represents a hydrogen atom or an alkyl, cycloalkyl, alkenyl or an aralkyl group or R4 and R5 together form an aralkylidene group or R4 and R5 together with the nitrogen atom to which they are attached form a saturated monocyclic 5- to 7-membered ring; n is zero or 1; and Alk represents an alkylene chain containing two or three carbon atoms which may be unsubstituted or substituted by not more than two C1-3 alkyl groups; with the provisos that, when n is zero and (i) R4 and R5, both represent alkyl groups, R1 does not represent the group CHO or COR8; and (ii) R1 does not represent the group SO2NH2; and physiologically acceptable salts, solvates and bioprecursors thereof. The compounds are described as potentially useful for the treatment of migraine. [GB2083463A]
IE1832/81A 1980-08-12 1981-08-11 Heterocyclic compounds IE51493B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8026288 1980-08-12
GB8026287 1980-08-12

Publications (2)

Publication Number Publication Date
IE811832L true IE811832L (en) 1982-02-12
IE51493B1 IE51493B1 (en) 1987-01-07

Family

ID=26276534

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1832/81A IE51493B1 (en) 1980-08-12 1981-08-11 Heterocyclic compounds

Country Status (12)

Country Link
AU (1) AU550010B2 (en)
CH (1) CH652394A5 (en)
DE (1) DE3131752A1 (en)
DK (1) DK157995C (en)
ES (2) ES504694A0 (en)
FR (1) FR2488606A1 (en)
GB (1) GB2083463B (en)
IE (1) IE51493B1 (en)
IT (1) IT1171450B (en)
NL (1) NL8103764A (en)
NZ (1) NZ197998A (en)
SE (1) SE454777B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1170387B (en) * 1982-06-07 1987-06-03 Glaxo Group Ltd HETEROCYCLIC COMPOUNDS, PROCEDURE TO PREPARE THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PT78358B (en) * 1983-04-07 1986-05-30 Smith Kline French Lab Chemical process
HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
SK278998B6 (en) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Imidazole, triazole and tetrazole derivatives, method of producing same, their use and pharmaceutical compositons on their base
GB9104136D0 (en) * 1991-02-27 1991-04-17 Merck Sharp & Dohme Therapeutic agents
DK0635015T3 (en) * 1992-04-10 1997-03-17 Pfizer Acylaminoindole derivatives as 5-Htl agonists
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme 4-substituted 1, 2, 4-triazole derivatives, their preparation and pharmaceutical compositions containing them
ES2070772B1 (en) * 1993-08-09 1996-02-16 Pfizer DERIVATIVES OF ACILAMINOINDOL
EP0796258A1 (en) * 1994-12-06 1997-09-24 MERCK SHARP &amp; DOHME LTD. Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists
FR2731224B1 (en) * 1995-03-02 1997-05-30 Pf Medicament NOVEL BI-TRYPTAMINIC SULFONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2870162A (en) * 1954-04-28 1959-01-20 Upjohn Co Production of certain tryptamines and compounds produced in the process
FR1203195A (en) * 1958-07-25 1960-01-15 Chimiotherapie Lab Franc Process for the preparation of a new derivative of tryptamine
NL7316677A (en) * 1972-12-21 1974-06-25
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
AU550010B2 (en) 1986-02-27
AU7399581A (en) 1982-02-18
DK357281A (en) 1982-02-13
ES8405371A1 (en) 1984-06-01
ES513934A0 (en) 1984-06-01
CH652394A5 (en) 1985-11-15
DE3131752A1 (en) 1982-06-16
SE454777B (en) 1988-05-30
FR2488606A1 (en) 1982-02-19
DK157995B (en) 1990-03-12
GB2083463A (en) 1982-03-24
IT8149085A0 (en) 1981-08-11
IT1171450B (en) 1987-06-10
FR2488606B1 (en) 1984-10-26
GB2083463B (en) 1984-05-10
DK157995C (en) 1990-08-06
IE51493B1 (en) 1987-01-07
NL8103764A (en) 1982-03-01
DE3131752C2 (en) 1992-04-23
NZ197998A (en) 1985-08-16
ES8300699A1 (en) 1982-11-01
IT8149085A1 (en) 1983-02-11
ES504694A0 (en) 1982-11-01
SE8104783L (en) 1982-02-13

Similar Documents

Publication Publication Date Title
IE811832L (en) Indoles.
IE811831L (en) Indoles.
ES8205398A1 (en) Hydantoin derivatives and medicines containing the same
ES8106142A1 (en) Indole compounds and use thereof
ES8500902A1 (en) Indole-5-acetamides for treatment of migraine
ES8405398A1 (en) Diazabicyclo(3.3.1)nonanes.
ES438303A1 (en) PROCEDURE FOR PREPARING BENZO (B) THIOPHENE DERIVATIVES.
AU631743B2 (en) New chalcones, process for preparing these and pharmaceutical compositions containing them
ES433902A1 (en) Benzylamine derivatives and process for preparing them
ES466532A1 (en) Antihypertensive 1-substituted-4-(2-oxo-1-imidazolidinyl) piperidines
ES8700253A1 (en) 5-Alkyl-1-phenyl-2-piperazino alkylpyrazolin-3-one compounds as well as processes and intermediates for their preparation and medicaments containing these compounds.
ES489823A1 (en) Catalyst, its preparation and process for polymerizing butadiene.
ES8102106A1 (en) 4,1-Benzoxazepines
MX170732B (en) COMPOSITION OF SUCCINIMIDE DERIVATIVES AND THEIR USE
DE3372095D1 (en) Novel phenylpiperazine derivatives and process for producing the same
DK515687D0 (en) PROCEDURE FOR NETWORKING
ES2002663A6 (en) Substituted diazaoxaspirodecanes, their preparation and their use as stabilizers for polymers.
ES471267A1 (en) Lower alkyl 2-tri-(lower)alkylsilylacetylene-N-carbethoxyglycinates and process for using same
FI811424L (en) CYCLIC AMIDER
ES8301963A1 (en) Piperidinoquinazolines and a process for the preparation thereof.
ES8306150A1 (en) Brominated Derivatives of Vincamine
ES460515A3 (en) Procedure for the obtaining of s- (alyloxy) thiocarbamates. (Machine-translation by Google Translate, not legally binding)
ES466032A1 (en) Process for the production of basic substituted alkyl theophylline
RO92582B (en) PROCESS FOR THE PREPARATION OF 5,6-DIALCOXY-4-ALCYL-2 (1H) -CHINAZOLINE